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Q9GZN0 (GPR88_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 88
Alternative name(s):
Striatum-specific G-protein coupled receptor
Gene names
Name:GPR88
Synonyms:STRG
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed almost exclusively in striatum. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Probable G-protein coupled receptor 88
PRO_0000069597

Regions

Topological domain1 – 3535Extracellular Potential
Transmembrane36 – 5621Helical; Name=1; Potential
Topological domain57 – 7317Cytoplasmic Potential
Transmembrane74 – 9421Helical; Name=2; Potential
Topological domain95 – 11622Extracellular Potential
Transmembrane117 – 13620Helical; Name=3; Potential
Topological domain137 – 15822Cytoplasmic Potential
Transmembrane159 – 17921Helical; Name=4; Potential
Topological domain180 – 19516Extracellular Potential
Transmembrane196 – 21621Helical; Name=5; Potential
Topological domain217 – 28569Cytoplasmic Potential
Transmembrane286 – 30621Helical; Name=6; Potential
Topological domain307 – 3104Extracellular Potential
Transmembrane311 – 33121Helical; Name=7; Potential
Topological domain332 – 38453Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential

Natural variations

Natural variant1901V → I. Ref.1 Ref.2
Corresponds to variant rs2809819 [ dbSNP | Ensembl ].
VAR_054767
Natural variant3181Q → H. Ref.1
Corresponds to variant rs3001995 [ dbSNP | Ensembl ].
VAR_054768

Sequences

Sequence LengthMass (Da)Tools
Q9GZN0 [UniParc].

Last modified March 24, 2009. Version 2.
Checksum: 2BCB6B1B9691B455

FASTA38440,246
        10         20         30         40         50         60 
MTNSSSTSTS STTGGSLLLL CEEEESWAGR RIPVSLLYSG LAIGGTLANG MVIYLVSSFR 

        70         80         90        100        110        120 
KLQTTSNAFI VNGCAADLSV CALWMPQEAV LGLLPTGSAE PPADWDGAGG SYRLLRGGLL 

       130        140        150        160        170        180 
GLGLTVSLLS HCLVALNRYL LITRAPATYQ ALYQRRHTAG MLALSWALAL GLVLLLPPWA 

       190        200        210        220        230        240 
PRPGAAPPRV HYPALLAAAA LLAQTALLLH CYLGIVRRVR VSVKRVSVLN FHLLHQLPGC 

       250        260        270        280        290        300 
AAAAAAFPGA QHAPGPGGAA HPAQAQPLPP ALHPRRAQRR LSGLSVLLLC CVFLLATQPL 

       310        320        330        340        350        360 
VWVSLASGFS LPVPWGVQAA SWLLCCALSA LNPLLYTWRN EEFRRSVRSV LPGVGDAAAA 

       370        380 
AVAATAVPAV SQAQLGTRAA GQHW 

« Hide

References

« Hide 'large scale' references
[1]"A novel G-protein-coupled receptor gene expressed in striatum."
Mizushima K., Miyamoto Y., Tsukahara F., Hirai M., Sakaki Y., Ito T.
Genomics 69:314-321(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, VARIANTS ILE-190 AND HIS-318.
[2]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-190.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-357.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB042410 mRNA. Translation: BAB18247.1.
AB042411 Genomic DNA. Translation: BAB18248.1.
AY336999 Genomic DNA. Translation: AAQ76787.1.
AC099670 Genomic DNA. No translation available.
BC036775 mRNA. Translation: AAH36775.1.
RefSeqNP_071332.2. NM_022049.2.
UniGeneHs.170053.

3D structure databases

ProteinModelPortalQ9GZN0.
SMRQ9GZN0. Positions 32-354.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000314223.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9GZN0.

Polymorphism databases

DMDM229464740.

Proteomic databases

PaxDbQ9GZN0.
PRIDEQ9GZN0.

Protocols and materials databases

DNASU54112.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000315033; ENSP00000314223; ENSG00000181656.
GeneID54112.
KEGGhsa:54112.
UCSCuc001dth.3. human.

Organism-specific databases

CTD54112.
GeneCardsGC01P101003.
HGNCHGNC:4539. GPR88.
HPAHPA007488.
MIM607468. gene.
neXtProtNX_Q9GZN0.
PharmGKBPA28932.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG253450.
HOGENOMHOG000060315.
HOVERGENHBG051821.
InParanoidQ9GZN0.
KOK08422.
OMAEPPGDWD.
OrthoDBEOG7ZD1WN.
PhylomeDBQ9GZN0.
TreeFamTF336499.

Gene expression databases

BgeeQ9GZN0.
CleanExHS_GPR88.
GenevestigatorQ9GZN0.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR88.
GenomeRNAi54112.
NextBio56484.
PROQ9GZN0.
SOURCESearch...

Entry information

Entry nameGPR88_HUMAN
AccessionPrimary (citable) accession number: Q9GZN0
Secondary accession number(s): Q29S24, Q6VN48
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 24, 2009
Last modified: April 16, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries