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Q9GZN0

- GPR88_HUMAN

UniProt

Q9GZN0 - GPR88_HUMAN

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Protein

Probable G-protein coupled receptor 88

Gene

GPR88

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: UniProtKB
  2. locomotory behavior Source: Ensembl
  3. neuromuscular process controlling balance Source: Ensembl
  4. neuronal action potential Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 88
Alternative name(s):
Striatum-specific G-protein coupled receptor
Gene namesi
Name:GPR88
Synonyms:STRG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:4539. GPR88.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
BLAST
Transmembranei36 – 5621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini57 – 7317CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei74 – 9421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini95 – 11622ExtracellularSequence AnalysisAdd
BLAST
Transmembranei117 – 13620Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini137 – 15822CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei159 – 17921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini180 – 19516ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini217 – 28569CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei286 – 30621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini307 – 3104ExtracellularSequence Analysis
Transmembranei311 – 33121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini332 – 38453CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28932.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Probable G-protein coupled receptor 88PRO_0000069597Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9GZN0.
PRIDEiQ9GZN0.

PTM databases

PhosphoSiteiQ9GZN0.

Expressioni

Tissue specificityi

Expressed almost exclusively in striatum.1 Publication

Gene expression databases

BgeeiQ9GZN0.
CleanExiHS_GPR88.
GenevestigatoriQ9GZN0.

Organism-specific databases

HPAiHPA007488.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000314223.

Structurei

3D structure databases

ProteinModelPortaliQ9GZN0.
SMRiQ9GZN0. Positions 34-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253450.
GeneTreeiENSGT00390000009609.
HOGENOMiHOG000060315.
HOVERGENiHBG051821.
InParanoidiQ9GZN0.
KOiK08422.
OMAiEPPGDWD.
OrthoDBiEOG7ZD1WN.
PhylomeDBiQ9GZN0.
TreeFamiTF336499.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GZN0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNSSSTSTS STTGGSLLLL CEEEESWAGR RIPVSLLYSG LAIGGTLANG
60 70 80 90 100
MVIYLVSSFR KLQTTSNAFI VNGCAADLSV CALWMPQEAV LGLLPTGSAE
110 120 130 140 150
PPADWDGAGG SYRLLRGGLL GLGLTVSLLS HCLVALNRYL LITRAPATYQ
160 170 180 190 200
ALYQRRHTAG MLALSWALAL GLVLLLPPWA PRPGAAPPRV HYPALLAAAA
210 220 230 240 250
LLAQTALLLH CYLGIVRRVR VSVKRVSVLN FHLLHQLPGC AAAAAAFPGA
260 270 280 290 300
QHAPGPGGAA HPAQAQPLPP ALHPRRAQRR LSGLSVLLLC CVFLLATQPL
310 320 330 340 350
VWVSLASGFS LPVPWGVQAA SWLLCCALSA LNPLLYTWRN EEFRRSVRSV
360 370 380
LPGVGDAAAA AVAATAVPAV SQAQLGTRAA GQHW
Length:384
Mass (Da):40,246
Last modified:March 24, 2009 - v2
Checksum:i2BCB6B1B9691B455
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti190 – 1901V → I.2 Publications
Corresponds to variant rs2809819 [ dbSNP | Ensembl ].
VAR_054767
Natural varianti318 – 3181Q → H.1 Publication
Corresponds to variant rs3001995 [ dbSNP | Ensembl ].
VAR_054768

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042410 mRNA. Translation: BAB18247.1.
AB042411 Genomic DNA. Translation: BAB18248.1.
AY336999 Genomic DNA. Translation: AAQ76787.1.
AC099670 Genomic DNA. No translation available.
BC036775 mRNA. Translation: AAH36775.1.
CCDSiCCDS772.1.
RefSeqiNP_071332.2. NM_022049.2.
UniGeneiHs.170053.

Genome annotation databases

EnsembliENST00000315033; ENSP00000314223; ENSG00000181656.
GeneIDi54112.
KEGGihsa:54112.
UCSCiuc001dth.3. human.

Polymorphism databases

DMDMi229464740.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042410 mRNA. Translation: BAB18247.1 .
AB042411 Genomic DNA. Translation: BAB18248.1 .
AY336999 Genomic DNA. Translation: AAQ76787.1 .
AC099670 Genomic DNA. No translation available.
BC036775 mRNA. Translation: AAH36775.1 .
CCDSi CCDS772.1.
RefSeqi NP_071332.2. NM_022049.2.
UniGenei Hs.170053.

3D structure databases

ProteinModelPortali Q9GZN0.
SMRi Q9GZN0. Positions 34-177.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000314223.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9GZN0.

Polymorphism databases

DMDMi 229464740.

Proteomic databases

PaxDbi Q9GZN0.
PRIDEi Q9GZN0.

Protocols and materials databases

DNASUi 54112.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000315033 ; ENSP00000314223 ; ENSG00000181656 .
GeneIDi 54112.
KEGGi hsa:54112.
UCSCi uc001dth.3. human.

Organism-specific databases

CTDi 54112.
GeneCardsi GC01P101003.
HGNCi HGNC:4539. GPR88.
HPAi HPA007488.
MIMi 607468. gene.
neXtProti NX_Q9GZN0.
PharmGKBi PA28932.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG253450.
GeneTreei ENSGT00390000009609.
HOGENOMi HOG000060315.
HOVERGENi HBG051821.
InParanoidi Q9GZN0.
KOi K08422.
OMAi EPPGDWD.
OrthoDBi EOG7ZD1WN.
PhylomeDBi Q9GZN0.
TreeFami TF336499.

Miscellaneous databases

GeneWikii GPR88.
GenomeRNAii 54112.
NextBioi 56484.
PROi Q9GZN0.
SOURCEi Search...

Gene expression databases

Bgeei Q9GZN0.
CleanExi HS_GPR88.
Genevestigatori Q9GZN0.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel G-protein-coupled receptor gene expressed in striatum."
    Mizushima K., Miyamoto Y., Tsukahara F., Hirai M., Sakaki Y., Ito T.
    Genomics 69:314-321(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, VARIANTS ILE-190 AND HIS-318.
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-190.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-357.
    Tissue: Brain.

Entry informationi

Entry nameiGPR88_HUMAN
AccessioniPrimary (citable) accession number: Q9GZN0
Secondary accession number(s): Q29S24, Q6VN48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 24, 2009
Last modified: October 29, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3