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Q9GZN0

- GPR88_HUMAN

UniProt

Q9GZN0 - GPR88_HUMAN

Protein

Probable G-protein coupled receptor 88

Gene

GPR88

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: UniProtKB
    2. locomotory behavior Source: Ensembl
    3. neuromuscular process controlling balance Source: Ensembl
    4. neuronal action potential Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 88
    Alternative name(s):
    Striatum-specific G-protein coupled receptor
    Gene namesi
    Name:GPR88
    Synonyms:STRG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:4539. GPR88.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28932.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Probable G-protein coupled receptor 88PRO_0000069597Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9GZN0.
    PRIDEiQ9GZN0.

    PTM databases

    PhosphoSiteiQ9GZN0.

    Expressioni

    Tissue specificityi

    Expressed almost exclusively in striatum.1 Publication

    Gene expression databases

    BgeeiQ9GZN0.
    CleanExiHS_GPR88.
    GenevestigatoriQ9GZN0.

    Organism-specific databases

    HPAiHPA007488.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000314223.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GZN0.
    SMRiQ9GZN0. Positions 34-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini57 – 7317CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini95 – 11622ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini137 – 15822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 19516ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini217 – 28569CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini307 – 3104ExtracellularSequence Analysis
    Topological domaini332 – 38453CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei74 – 9421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13620Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei286 – 30621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei311 – 33121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253450.
    HOGENOMiHOG000060315.
    HOVERGENiHBG051821.
    InParanoidiQ9GZN0.
    KOiK08422.
    OMAiEPPGDWD.
    OrthoDBiEOG7ZD1WN.
    PhylomeDBiQ9GZN0.
    TreeFamiTF336499.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9GZN0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNSSSTSTS STTGGSLLLL CEEEESWAGR RIPVSLLYSG LAIGGTLANG    50
    MVIYLVSSFR KLQTTSNAFI VNGCAADLSV CALWMPQEAV LGLLPTGSAE 100
    PPADWDGAGG SYRLLRGGLL GLGLTVSLLS HCLVALNRYL LITRAPATYQ 150
    ALYQRRHTAG MLALSWALAL GLVLLLPPWA PRPGAAPPRV HYPALLAAAA 200
    LLAQTALLLH CYLGIVRRVR VSVKRVSVLN FHLLHQLPGC AAAAAAFPGA 250
    QHAPGPGGAA HPAQAQPLPP ALHPRRAQRR LSGLSVLLLC CVFLLATQPL 300
    VWVSLASGFS LPVPWGVQAA SWLLCCALSA LNPLLYTWRN EEFRRSVRSV 350
    LPGVGDAAAA AVAATAVPAV SQAQLGTRAA GQHW 384
    Length:384
    Mass (Da):40,246
    Last modified:March 24, 2009 - v2
    Checksum:i2BCB6B1B9691B455
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti190 – 1901V → I.2 Publications
    Corresponds to variant rs2809819 [ dbSNP | Ensembl ].
    VAR_054767
    Natural varianti318 – 3181Q → H.1 Publication
    Corresponds to variant rs3001995 [ dbSNP | Ensembl ].
    VAR_054768

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB042410 mRNA. Translation: BAB18247.1.
    AB042411 Genomic DNA. Translation: BAB18248.1.
    AY336999 Genomic DNA. Translation: AAQ76787.1.
    AC099670 Genomic DNA. No translation available.
    BC036775 mRNA. Translation: AAH36775.1.
    CCDSiCCDS772.1.
    RefSeqiNP_071332.2. NM_022049.2.
    UniGeneiHs.170053.

    Genome annotation databases

    EnsembliENST00000315033; ENSP00000314223; ENSG00000181656.
    GeneIDi54112.
    KEGGihsa:54112.
    UCSCiuc001dth.3. human.

    Polymorphism databases

    DMDMi229464740.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB042410 mRNA. Translation: BAB18247.1 .
    AB042411 Genomic DNA. Translation: BAB18248.1 .
    AY336999 Genomic DNA. Translation: AAQ76787.1 .
    AC099670 Genomic DNA. No translation available.
    BC036775 mRNA. Translation: AAH36775.1 .
    CCDSi CCDS772.1.
    RefSeqi NP_071332.2. NM_022049.2.
    UniGenei Hs.170053.

    3D structure databases

    ProteinModelPortali Q9GZN0.
    SMRi Q9GZN0. Positions 34-177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000314223.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9GZN0.

    Polymorphism databases

    DMDMi 229464740.

    Proteomic databases

    PaxDbi Q9GZN0.
    PRIDEi Q9GZN0.

    Protocols and materials databases

    DNASUi 54112.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000315033 ; ENSP00000314223 ; ENSG00000181656 .
    GeneIDi 54112.
    KEGGi hsa:54112.
    UCSCi uc001dth.3. human.

    Organism-specific databases

    CTDi 54112.
    GeneCardsi GC01P101003.
    HGNCi HGNC:4539. GPR88.
    HPAi HPA007488.
    MIMi 607468. gene.
    neXtProti NX_Q9GZN0.
    PharmGKBi PA28932.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253450.
    HOGENOMi HOG000060315.
    HOVERGENi HBG051821.
    InParanoidi Q9GZN0.
    KOi K08422.
    OMAi EPPGDWD.
    OrthoDBi EOG7ZD1WN.
    PhylomeDBi Q9GZN0.
    TreeFami TF336499.

    Miscellaneous databases

    GeneWikii GPR88.
    GenomeRNAii 54112.
    NextBioi 56484.
    PROi Q9GZN0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9GZN0.
    CleanExi HS_GPR88.
    Genevestigatori Q9GZN0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel G-protein-coupled receptor gene expressed in striatum."
      Mizushima K., Miyamoto Y., Tsukahara F., Hirai M., Sakaki Y., Ito T.
      Genomics 69:314-321(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, VARIANTS ILE-190 AND HIS-318.
    2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-190.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-357.
      Tissue: Brain.

    Entry informationi

    Entry nameiGPR88_HUMAN
    AccessioniPrimary (citable) accession number: Q9GZN0
    Secondary accession number(s): Q29S24, Q6VN48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3