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Protein

Probable G-protein coupled receptor 88

Gene

GPR88

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181656-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 88
Alternative name(s):
Striatum-specific G-protein coupled receptor
Gene namesi
Name:GPR88
Synonyms:STRG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:4539. GPR88.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: During cortical lamination, subcellular location shifts, on the day of birth, from expression at the plasma membrane and in the cytoplasm to the nuclei of neurons. This intranuclear localization remains throughout adulthood.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 56Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini57 – 73CytoplasmicSequence analysisAdd BLAST17
Transmembranei74 – 94Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini95 – 116ExtracellularSequence analysisAdd BLAST22
Transmembranei117 – 136Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini137 – 158CytoplasmicSequence analysisAdd BLAST22
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini180 – 195ExtracellularSequence analysisAdd BLAST16
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 285CytoplasmicSequence analysisAdd BLAST69
Transmembranei286 – 306Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini307 – 310ExtracellularSequence analysis4
Transmembranei311 – 331Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini332 – 384CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Chorea, childhood-onset, with psychomotor retardation (COCPMR)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neurodevelopmental disorder characterized by abnormal involuntary movements, marked speech delay, intellectual disability and learning difficulties.
See also OMIM:616939

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNETi54112.
MIMi616939. phenotype.
OpenTargetsiENSG00000181656.
PharmGKBiPA28932.

Chemistry databases

ChEMBLiCHEMBL3399910.
GuidetoPHARMACOLOGYi123.

Polymorphism and mutation databases

BioMutaiGPR88.
DMDMi229464740.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695971 – 384Probable G-protein coupled receptor 88Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9GZN0.
PRIDEiQ9GZN0.

PTM databases

iPTMnetiQ9GZN0.
PhosphoSitePlusiQ9GZN0.

Expressioni

Tissue specificityi

Expressed predominantly in the striatum.1 Publication

Gene expression databases

BgeeiENSG00000181656.
CleanExiHS_GPR88.
GenevisibleiQ9GZN0. HS.

Organism-specific databases

HPAiHPA007488.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000314223.

Chemistry databases

BindingDBiQ9GZN0.

Structurei

3D structure databases

ProteinModelPortaliQ9GZN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000009609.
HOGENOMiHOG000060315.
HOVERGENiHBG051821.
InParanoidiQ9GZN0.
KOiK08422.
OMAiEPPGDWD.
OrthoDBiEOG091G0JWW.
PhylomeDBiQ9GZN0.
TreeFamiTF336499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GZN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNSSSTSTS STTGGSLLLL CEEEESWAGR RIPVSLLYSG LAIGGTLANG
60 70 80 90 100
MVIYLVSSFR KLQTTSNAFI VNGCAADLSV CALWMPQEAV LGLLPTGSAE
110 120 130 140 150
PPADWDGAGG SYRLLRGGLL GLGLTVSLLS HCLVALNRYL LITRAPATYQ
160 170 180 190 200
ALYQRRHTAG MLALSWALAL GLVLLLPPWA PRPGAAPPRV HYPALLAAAA
210 220 230 240 250
LLAQTALLLH CYLGIVRRVR VSVKRVSVLN FHLLHQLPGC AAAAAAFPGA
260 270 280 290 300
QHAPGPGGAA HPAQAQPLPP ALHPRRAQRR LSGLSVLLLC CVFLLATQPL
310 320 330 340 350
VWVSLASGFS LPVPWGVQAA SWLLCCALSA LNPLLYTWRN EEFRRSVRSV
360 370 380
LPGVGDAAAA AVAATAVPAV SQAQLGTRAA GQHW
Length:384
Mass (Da):40,246
Last modified:March 24, 2009 - v2
Checksum:i2BCB6B1B9691B455
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054767190V → I.2 PublicationsCorresponds to variant rs2809819dbSNPEnsembl.1
Natural variantiVAR_054768318Q → H.1 PublicationCorresponds to variant rs3001995dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042410 mRNA. Translation: BAB18247.1.
AB042411 Genomic DNA. Translation: BAB18248.1.
AY336999 Genomic DNA. Translation: AAQ76787.1.
AC099670 Genomic DNA. No translation available.
BC036775 mRNA. Translation: AAH36775.1.
CCDSiCCDS772.1.
RefSeqiNP_071332.2. NM_022049.2.
UniGeneiHs.170053.

Genome annotation databases

EnsembliENST00000315033; ENSP00000314223; ENSG00000181656.
GeneIDi54112.
KEGGihsa:54112.
UCSCiuc001dth.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042410 mRNA. Translation: BAB18247.1.
AB042411 Genomic DNA. Translation: BAB18248.1.
AY336999 Genomic DNA. Translation: AAQ76787.1.
AC099670 Genomic DNA. No translation available.
BC036775 mRNA. Translation: AAH36775.1.
CCDSiCCDS772.1.
RefSeqiNP_071332.2. NM_022049.2.
UniGeneiHs.170053.

3D structure databases

ProteinModelPortaliQ9GZN0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000314223.

Chemistry databases

BindingDBiQ9GZN0.
ChEMBLiCHEMBL3399910.
GuidetoPHARMACOLOGYi123.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9GZN0.
PhosphoSitePlusiQ9GZN0.

Polymorphism and mutation databases

BioMutaiGPR88.
DMDMi229464740.

Proteomic databases

PaxDbiQ9GZN0.
PRIDEiQ9GZN0.

Protocols and materials databases

DNASUi54112.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315033; ENSP00000314223; ENSG00000181656.
GeneIDi54112.
KEGGihsa:54112.
UCSCiuc001dth.4. human.

Organism-specific databases

CTDi54112.
DisGeNETi54112.
GeneCardsiGPR88.
HGNCiHGNC:4539. GPR88.
HPAiHPA007488.
MIMi607468. gene.
616939. phenotype.
neXtProtiNX_Q9GZN0.
OpenTargetsiENSG00000181656.
PharmGKBiPA28932.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000009609.
HOGENOMiHOG000060315.
HOVERGENiHBG051821.
InParanoidiQ9GZN0.
KOiK08422.
OMAiEPPGDWD.
OrthoDBiEOG091G0JWW.
PhylomeDBiQ9GZN0.
TreeFamiTF336499.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181656-MONOMER.

Miscellaneous databases

GeneWikiiGPR88.
GenomeRNAii54112.
PROiQ9GZN0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181656.
CleanExiHS_GPR88.
GenevisibleiQ9GZN0. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR88_HUMAN
AccessioniPrimary (citable) accession number: Q9GZN0
Secondary accession number(s): Q29S24, Q6VN48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 24, 2009
Last modified: November 30, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.