ID TINAL_HUMAN Reviewed; 467 AA. AC Q9GZM7; A8K9Q5; B4DPK6; D3DPN8; Q8TEJ9; Q8WZ23; Q96GZ4; Q96JW3; DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 24-JAN-2024, entry version 182. DE RecName: Full=Tubulointerstitial nephritis antigen-like; DE AltName: Full=Glucocorticoid-inducible protein 5; DE AltName: Full=Oxidized LDL-responsive gene 2 protein; DE Short=OLRG-2; DE AltName: Full=Tubulointerstitial nephritis antigen-related protein; DE Short=TIN Ag-related protein; DE Short=TIN-Ag-RP; DE Flags: Precursor; GN Name=TINAGL1; Synonyms=GIS5, LCN7, OLRG2, TINAGL; GN ORFNames=PP6614, PSEC0088, UNQ204/PRO230; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), AND SUBCELLULAR LOCATION. RC TISSUE=Muscle; RX PubMed=10799322; DOI=10.1006/bbrc.2000.2639; RA Broemme N.C., Wex T., Wex H., Levy B., Lipyansky A., Broemme D.; RT "Cloning, characterization, and expression of the human TIN-ag-RP gene RT encoding a novel putative extracellular matrix protein."; RL Biochem. Biophys. Res. Commun. 271:474-480(2000). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 22-27, TISSUE RP SPECIFICITY, GLYCOSYLATION, AND SUBCELLULAR LOCATION. RC TISSUE=Muscle; RX PubMed=11170462; DOI=10.1021/bi002266o; RA Wex T., Lipyansky A., Broemme N.C., Wex H., Guan X.Q., Broemme D.; RT "TIN-ag-RP, a novel catalytically inactive cathepsin B-related protein with RT EGF domains, is predominantly expressed in vascular smooth muscle cells."; RL Biochemistry 40:1350-1357(2001). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RA Zhang K.M., Chen B.S.; RT "Identification of oxidized-LDL responsive gene 2 (OLRG-2), encoding a RT novel extracellular matrix protein in vascular endothelial cells."; RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1). RA Yoshida H., Takaishi K., Harada M., Nagasaka T., Tsurufuji S., RA Taniguchi M.; RT "Identification of a novel glucocorticoid-inducible cDNA partially RT homologous to tubulointerstitial nephritis antigen."; RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Placenta; RA Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.; RT "The nucleotide sequence of a long cDNA clone isolated from human spleen."; RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale effort to RT identify novel human secreted and transmembrane proteins: a bioinformatics RT assessment."; RL Genome Res. 13:2265-2270(2003). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RX PubMed=15498874; DOI=10.1073/pnas.0404089101; RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X., RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.; RT "Large-scale cDNA transfection screening for genes related to cancer RT development and progression."; RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004). RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). RC TISSUE=Kidney, Placenta, and Trachea; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [9] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Placenta; RX PubMed=16303743; DOI=10.1093/dnares/12.2.117; RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y., RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., RA Isogai T.; RT "Signal sequence and keyword trap in silico for selection of full-length RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA RT libraries."; RL DNA Res. 12:117-126(2005). RN [10] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [11] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [12] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Colon, and Pancreas; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [13] RP PROTEIN SEQUENCE OF 22-36. RX PubMed=15340161; DOI=10.1110/ps.04682504; RA Zhang Z., Henzel W.J.; RT "Signal peptide prediction based on analysis of experimentally verified RT cleavage sites."; RL Protein Sci. 13:2819-2824(2004). RN [14] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-78 AND ASN-161. RC TISSUE=Liver; RX PubMed=19159218; DOI=10.1021/pr8008012; RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; RT "Glycoproteomics analysis of human liver tissue by combination of multiple RT enzyme digestion and hydrazide chemistry."; RL J. Proteome Res. 8:651-661(2009). CC -!- FUNCTION: May be implicated in the adrenocortical zonation and in CC mechanisms for repressing the CYP11B1 gene expression in adrenocortical CC cells. This is a non catalytic peptidase C1 family protein (By CC similarity). {ECO:0000250}. CC -!- INTERACTION: CC Q9GZM7; O95429: BAG4; NbExp=3; IntAct=EBI-715869, EBI-2949658; CC Q9GZM7; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-715869, EBI-10176379; CC Q9GZM7; Q99697-2: PITX2; NbExp=3; IntAct=EBI-715869, EBI-12138495; CC Q9GZM7; O75360: PROP1; NbExp=3; IntAct=EBI-715869, EBI-9027467; CC Q9GZM7; Q15645: TRIP13; NbExp=6; IntAct=EBI-715869, EBI-358993; CC Q9GZM7-3; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-10303636, EBI-10176379; CC Q9GZM7-3; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-10303636, EBI-10172511; CC Q9GZM7-3; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10303636, EBI-945833; CC Q9GZM7-3; Q93062: RBPMS; NbExp=3; IntAct=EBI-10303636, EBI-740322; CC Q9GZM7-3; Q15645: TRIP13; NbExp=3; IntAct=EBI-10303636, EBI-358993; CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10799322, CC ECO:0000269|PubMed:11170462}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q9GZM7-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9GZM7-2; Sequence=VSP_013094, VSP_013095, VSP_013096, CC VSP_013097, VSP_013098; CC Name=3; CC IsoId=Q9GZM7-3; Sequence=VSP_043712; CC -!- TISSUE SPECIFICITY: Highly expressed in aorta, heart, placenta, kidney CC and a colorectal adenocarcinoma cell line. Moderately expressed in CC skeletal muscle, pancreas, lung, lymph nodes, adrenal gland, bone CC marrow and thyroid. Weakly expressed in colon, small intestine, ovary, CC spleen, testis and prostate. Predominantly found in vascular smooth CC muscle cells, but also in cardiac and skeletal muscle cells as well as CC kidney. {ECO:0000269|PubMed:11170462}. CC -!- PTM: Glycosylated. {ECO:0000269|PubMed:11170462, CC ECO:0000269|PubMed:19159218}. CC -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE- CC ProRule:PRU10089}. CC -!- SEQUENCE CAUTION: CC Sequence=AAH09048.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC Sequence=BAB55403.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF236155; AAG40154.1; -; Genomic_DNA. DR EMBL; AF236151; AAG40154.1; JOINED; Genomic_DNA. DR EMBL; AF236152; AAG40154.1; JOINED; Genomic_DNA. DR EMBL; AF236153; AAG40154.1; JOINED; Genomic_DNA. DR EMBL; AF236154; AAG40154.1; JOINED; Genomic_DNA. DR EMBL; AF236150; AAG38876.1; -; mRNA. DR EMBL; AF205436; AAG33699.1; -; mRNA. DR EMBL; AB050716; BAB18636.1; -; mRNA. DR EMBL; AB050719; BAB18727.1; -; Genomic_DNA. DR EMBL; AK074124; BAB84950.1; -; mRNA. DR EMBL; AY358421; AAQ88787.1; -; mRNA. DR EMBL; AF289569; AAL55753.1; -; mRNA. DR EMBL; AK027839; BAB55403.1; ALT_INIT; mRNA. DR EMBL; AK292770; BAF85459.1; -; mRNA. DR EMBL; AK298382; BAG60618.1; -; mRNA. DR EMBL; AK075398; BAC11596.1; -; mRNA. DR EMBL; AC114488; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471059; EAX07604.1; -; Genomic_DNA. DR EMBL; CH471059; EAX07605.1; -; Genomic_DNA. DR EMBL; CH471059; EAX07606.1; -; Genomic_DNA. DR EMBL; BC009048; AAH09048.1; ALT_INIT; mRNA. DR EMBL; BC064633; AAH64633.1; -; mRNA. DR CCDS; CCDS343.1; -. [Q9GZM7-1] DR CCDS; CCDS55586.1; -. [Q9GZM7-3] DR RefSeq; NP_001191343.1; NM_001204414.1. [Q9GZM7-3] DR RefSeq; NP_001191344.1; NM_001204415.1. DR RefSeq; NP_071447.1; NM_022164.2. [Q9GZM7-1] DR AlphaFoldDB; Q9GZM7; -. DR SMR; Q9GZM7; -. DR BioGRID; 122078; 68. DR IntAct; Q9GZM7; 66. DR MINT; Q9GZM7; -. DR STRING; 9606.ENSP00000271064; -. DR MEROPS; C01.975; -. DR GlyConnect; 1864; 7 N-Linked glycans (2 sites). DR GlyCosmos; Q9GZM7; 2 sites, 7 glycans. DR GlyGen; Q9GZM7; 3 sites, 7 N-linked glycans (2 sites), 1 O-linked glycan (1 site). DR iPTMnet; Q9GZM7; -. DR PhosphoSitePlus; Q9GZM7; -. DR SwissPalm; Q9GZM7; -. DR BioMuta; TINAGL1; -. DR DMDM; 61213628; -. DR EPD; Q9GZM7; -. DR jPOST; Q9GZM7; -. DR MassIVE; Q9GZM7; -. DR MaxQB; Q9GZM7; -. DR PaxDb; 9606-ENSP00000271064; -. DR PeptideAtlas; Q9GZM7; -. DR ProteomicsDB; 80089; -. [Q9GZM7-1] DR ProteomicsDB; 80090; -. [Q9GZM7-2] DR ProteomicsDB; 80091; -. [Q9GZM7-3] DR Antibodypedia; 31121; 213 antibodies from 26 providers. DR DNASU; 64129; -. DR Ensembl; ENST00000271064.12; ENSP00000271064.7; ENSG00000142910.16. [Q9GZM7-1] DR Ensembl; ENST00000457433.6; ENSP00000395137.2; ENSG00000142910.16. [Q9GZM7-3] DR GeneID; 64129; -. DR KEGG; hsa:64129; -. DR MANE-Select; ENST00000271064.12; ENSP00000271064.7; NM_022164.3; NP_071447.1. DR UCSC; uc001bta.4; human. [Q9GZM7-1] DR AGR; HGNC:19168; -. DR CTD; 64129; -. DR DisGeNET; 64129; -. DR GeneCards; TINAGL1; -. DR HGNC; HGNC:19168; TINAGL1. DR HPA; ENSG00000142910; Low tissue specificity. DR MIM; 616064; gene. DR neXtProt; NX_Q9GZM7; -. DR OpenTargets; ENSG00000142910; -. DR PharmGKB; PA38810; -. DR VEuPathDB; HostDB:ENSG00000142910; -. DR eggNOG; KOG1544; Eukaryota. DR GeneTree; ENSGT00940000160023; -. DR InParanoid; Q9GZM7; -. DR OMA; AEIYHSG; -. DR OrthoDB; 808912at2759; -. DR PhylomeDB; Q9GZM7; -. DR TreeFam; TF313765; -. DR PathwayCommons; Q9GZM7; -. DR SignaLink; Q9GZM7; -. DR BioGRID-ORCS; 64129; 14 hits in 1151 CRISPR screens. DR ChiTaRS; TINAGL1; human. DR GeneWiki; TINAGL1; -. DR GenomeRNAi; 64129; -. DR Pharos; Q9GZM7; Tbio. DR PRO; PR:Q9GZM7; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; Q9GZM7; Protein. DR Bgee; ENSG00000142910; Expressed in metanephros cortex and 138 other cell types or tissues. DR ExpressionAtlas; Q9GZM7; baseline and differential. DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL. DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005576; C:extracellular region; NAS:UniProtKB. DR GO; GO:0005615; C:extracellular space; ISS:BHF-UCL. DR GO; GO:0005201; F:extracellular matrix structural constituent; NAS:UniProtKB. DR GO; GO:0043236; F:laminin binding; IEA:Ensembl. DR GO; GO:0016197; P:endosomal transport; TAS:UniProtKB. DR CDD; cd02620; Peptidase_C1A_CathepsinB; 1. DR Gene3D; 3.90.70.10; Cysteine proteinases; 1. DR InterPro; IPR038765; Papain-like_cys_pep_sf. DR InterPro; IPR025660; Pept_his_AS. DR InterPro; IPR013128; Peptidase_C1A. DR InterPro; IPR000668; Peptidase_C1A_C. DR InterPro; IPR001212; Somatomedin_B_dom. DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1. DR PANTHER; PTHR12411:SF270; TUBULOINTERSTITIAL NEPHRITIS ANTIGEN-LIKE; 1. DR Pfam; PF00112; Peptidase_C1; 1. DR SMART; SM00645; Pept_C1; 1. DR SUPFAM; SSF54001; Cysteine proteinases; 1. DR PROSITE; PS00524; SMB_1; 1. DR PROSITE; PS50958; SMB_2; 1. DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1. DR Genevisible; Q9GZM7; HS. PE 1: Evidence at protein level; KW Alternative splicing; Direct protein sequencing; Disulfide bond; KW Glycoprotein; Reference proteome; Secreted; Signal. FT SIGNAL 1..21 FT /evidence="ECO:0000269|PubMed:11170462, FT ECO:0000269|PubMed:15340161" FT CHAIN 22..467 FT /note="Tubulointerstitial nephritis antigen-like" FT /id="PRO_0000026482" FT DOMAIN 50..98 FT /note="SMB" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350" FT CARBOHYD 78 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000269|PubMed:19159218" FT CARBOHYD 161 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000269|PubMed:19159218" FT DISULFID 54..73 FT /note="Alternate" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350" FT DISULFID 71..85 FT /note="Alternate" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350" FT DISULFID 71..73 FT /note="Alternate" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350" FT DISULFID 77..84 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350" FT DISULFID 85..92 FT /note="Alternate" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350" FT VAR_SEQ 1..134 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15498874, ECO:0000303|Ref.5" FT /id="VSP_013094" FT VAR_SEQ 126..156 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_043712" FT VAR_SEQ 135..194 FT /note="CDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSS FT VMNMHEIY -> MVLGSSTQVKIGGSWNPAAAGGLKIKLQKALDLVALQCQWAPEGQAR FT AEQEADRATFILQ (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15498874, ECO:0000303|Ref.5" FT /id="VSP_013095" FT VAR_SEQ 286 FT /note="G -> GYAATGDVGREEGKELRGHGLGHDALSLSAFAPSCCLCR (in FT isoform 2)" FT /evidence="ECO:0000303|PubMed:15498874, ECO:0000303|Ref.5" FT /id="VSP_013096" FT VAR_SEQ 365..381 FT /note="ALMEVHEDFFLYKGGIY -> GKPPYPAPWFQKLVPA (in isoform FT 2)" FT /evidence="ECO:0000303|PubMed:15498874, ECO:0000303|Ref.5" FT /id="VSP_013097" FT VAR_SEQ 382..467 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15498874, ECO:0000303|Ref.5" FT /id="VSP_013098" FT VARIANT 69 FT /note="A -> S (in dbSNP:rs17497479)" FT /id="VAR_051514" FT CONFLICT 333 FT /note="N -> Y (in Ref. 7; AAL55753)" FT /evidence="ECO:0000305" FT CONFLICT 377 FT /note="K -> E (in Ref. 8; BAB55403)" FT /evidence="ECO:0000305" SQ SEQUENCE 467 AA; 52387 MW; E9D72220E3E7B7D5 CRC64; MWRCPLGLLL LLPLAGHLAL GAQQGRGRRE LAPGLHLRGI RDAGGRYCQE QDLCCRGRAD DCALPYLGAI CYCDLFCNRT VSDCCPDFWD FCLGVPPPFP PIQGCMHGGR IYPVLGTYWD NCNRCTCQEN RQWQCDQEPC LVDPDMIKAI NQGNYGWQAG NHSAFWGMTL DEGIRYRLGT IRPSSSVMNM HEIYTVLNPG EVLPTAFEAS EKWPNLIHEP LDQGNCAGSW AFSTAAVASD RVSIHSLGHM TPVLSPQNLL SCDTHQQQGC RGGRLDGAWW FLRRRGVVSD HCYPFSGRER DEAGPAPPCM MHSRAMGRGK RQATAHCPNS YVNNNDIYQV TPVYRLGSND KEIMKELMEN GPVQALMEVH EDFFLYKGGI YSHTPVSLGR PERYRRHGTH SVKITGWGEE TLPDGRTLKY WTAANSWGPA WGERGHFRIV RGVNECDIES FVLGVWGRVG MEDMGHH //