UniProtKB - Q9GZM7 (TINAL_HUMAN)
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Tubulointerstitial nephritis antigen-like
TINAGL1
Functioni
GO - Molecular functioni
- cysteine-type peptidase activity Source: InterPro
- extracellular matrix structural constituent Source: UniProtKB
- laminin binding Source: Ensembl
- polysaccharide binding Source: InterPro
- scavenger receptor activity Source: InterPro
GO - Biological processi
- cell adhesion Source: GO_Central
- endosomal transport Source: UniProtKB
- immune response Source: InterPro
Protein family/group databases
MEROPSi | C01.975. |
Names & Taxonomyi
Protein namesi | Recommended name: Tubulointerstitial nephritis antigen-likeAlternative name(s): Glucocorticoid-inducible protein 5 Oxidized LDL-responsive gene 2 protein Short name: OLRG-2 Tubulointerstitial nephritis antigen-related protein Short name: TIN Ag-related protein Short name: TIN-Ag-RP |
Gene namesi | Name:TINAGL1 Synonyms:GIS5, LCN7, OLRG2, TINAGL ORF Names:PP6614, PSEC0088, UNQ204/PRO230 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000142910.15. |
HGNCi | HGNC:19168. TINAGL1. |
MIMi | 616064. gene. |
neXtProti | NX_Q9GZM7. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 64129. |
OpenTargetsi | ENSG00000142910. |
PharmGKBi | PA38810. |
Polymorphism and mutation databases
BioMutai | TINAGL1. |
DMDMi | 61213628. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | 2 PublicationsAdd BLAST | 21 | |
ChainiPRO_0000026482 | 22 – 467 | Tubulointerstitial nephritis antigen-likeAdd BLAST | 446 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 54 ↔ 73 | AlternatePROSITE-ProRule annotation | ||
Disulfide bondi | 71 ↔ 85 | AlternatePROSITE-ProRule annotation | ||
Disulfide bondi | 71 ↔ 73 | AlternatePROSITE-ProRule annotation | ||
Disulfide bondi | 77 ↔ 84 | PROSITE-ProRule annotation | ||
Glycosylationi | 78 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 85 ↔ 92 | AlternatePROSITE-ProRule annotation | ||
Glycosylationi | 161 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MaxQBi | Q9GZM7. |
PaxDbi | Q9GZM7. |
PeptideAtlasi | Q9GZM7. |
PRIDEi | Q9GZM7. |
PTM databases
iPTMneti | Q9GZM7. |
PhosphoSitePlusi | Q9GZM7. |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000142910. |
CleanExi | HS_TINAGL1. |
ExpressionAtlasi | Q9GZM7. baseline and differential. |
Genevisiblei | Q9GZM7. HS. |
Organism-specific databases
HPAi | HPA048695. |
Interactioni
Binary interactionsi
GO - Molecular functioni
- laminin binding Source: Ensembl
Protein-protein interaction databases
BioGridi | 122078. 21 interactors. |
IntActi | Q9GZM7. 63 interactors. |
MINTi | Q9GZM7. |
STRINGi | 9606.ENSP00000271064. |
Structurei
3D structure databases
ProteinModelPortali | Q9GZM7. |
SMRi | Q9GZM7. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 50 – 98 | SMBPROSITE-ProRule annotationAdd BLAST | 49 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1544. Eukaryota. ENOG410YN9K. LUCA. |
GeneTreei | ENSGT00900000140859. |
HOGENOMi | HOG000241342. |
HOVERGENi | HBG053961. |
InParanoidi | Q9GZM7. |
OMAi | KYWIAAN. |
OrthoDBi | EOG091G0A2N. |
PhylomeDBi | Q9GZM7. |
TreeFami | TF313765. |
Family and domain databases
InterProi | View protein in InterPro IPR025660. Pept_his_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR001212. Somatomedin_B_dom. |
PANTHERi | PTHR12411. PTHR12411. 1 hit. |
Pfami | View protein in Pfam PF00112. Peptidase_C1. 1 hit. |
SMARTi | View protein in SMART SM00645. Pept_C1. 1 hit. |
PROSITEi | View protein in PROSITE PS00524. SMB_1. 1 hit. PS50958. SMB_2. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MWRCPLGLLL LLPLAGHLAL GAQQGRGRRE LAPGLHLRGI RDAGGRYCQE
60 70 80 90 100
QDLCCRGRAD DCALPYLGAI CYCDLFCNRT VSDCCPDFWD FCLGVPPPFP
110 120 130 140 150
PIQGCMHGGR IYPVLGTYWD NCNRCTCQEN RQWQCDQEPC LVDPDMIKAI
160 170 180 190 200
NQGNYGWQAG NHSAFWGMTL DEGIRYRLGT IRPSSSVMNM HEIYTVLNPG
210 220 230 240 250
EVLPTAFEAS EKWPNLIHEP LDQGNCAGSW AFSTAAVASD RVSIHSLGHM
260 270 280 290 300
TPVLSPQNLL SCDTHQQQGC RGGRLDGAWW FLRRRGVVSD HCYPFSGRER
310 320 330 340 350
DEAGPAPPCM MHSRAMGRGK RQATAHCPNS YVNNNDIYQV TPVYRLGSND
360 370 380 390 400
KEIMKELMEN GPVQALMEVH EDFFLYKGGI YSHTPVSLGR PERYRRHGTH
410 420 430 440 450
SVKITGWGEE TLPDGRTLKY WTAANSWGPA WGERGHFRIV RGVNECDIES
460
FVLGVWGRVG MEDMGHH
The sequence of this isoform differs from the canonical sequence as follows:
1-134: Missing.
135-194: CDQEPCLVDP...SSVMNMHEIY → MVLGSSTQVK...EADRATFILQ
286-286: G → GYAATGDVGREEGKELRGHGLGHDALSLSAFAPSCCLCR
365-381: ALMEVHEDFFLYKGGIY → GKPPYPAPWFQKLVPA
382-467: Missing.
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 333 | N → Y in AAL55753 (PubMed:15498874).Curated | 1 | |
Sequence conflicti | 377 | K → E in BAB55403 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051514 | 69 | A → S. Corresponds to variant dbSNP:rs17497479Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013094 | 1 – 134 | Missing in isoform 2. 2 PublicationsAdd BLAST | 134 | |
Alternative sequenceiVSP_043712 | 126 – 156 | Missing in isoform 3. 1 PublicationAdd BLAST | 31 | |
Alternative sequenceiVSP_013095 | 135 – 194 | CDQEP…MHEIY → MVLGSSTQVKIGGSWNPAAA GGLKIKLQKALDLVALQCQW APEGQARAEQEADRATFILQ in isoform 2. 2 PublicationsAdd BLAST | 60 | |
Alternative sequenceiVSP_013096 | 286 | G → GYAATGDVGREEGKELRGHG LGHDALSLSAFAPSCCLCR in isoform 2. 2 Publications | 1 | |
Alternative sequenceiVSP_013097 | 365 – 381 | ALMEV…KGGIY → GKPPYPAPWFQKLVPA in isoform 2. 2 PublicationsAdd BLAST | 17 | |
Alternative sequenceiVSP_013098 | 382 – 467 | Missing in isoform 2. 2 PublicationsAdd BLAST | 86 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF236155 AF236154 Genomic DNA. Translation: AAG40154.1. AF236150 mRNA. Translation: AAG38876.1. AF205436 mRNA. Translation: AAG33699.1. AB050716 mRNA. Translation: BAB18636.1. AB050719 Genomic DNA. Translation: BAB18727.1. AK074124 mRNA. Translation: BAB84950.1. AY358421 mRNA. Translation: AAQ88787.1. AF289569 mRNA. Translation: AAL55753.1. AK027839 mRNA. Translation: BAB55403.1. Different initiation. AK292770 mRNA. Translation: BAF85459.1. AK298382 mRNA. Translation: BAG60618.1. AK075398 mRNA. Translation: BAC11596.1. AC114488 Genomic DNA. No translation available. CH471059 Genomic DNA. Translation: EAX07604.1. CH471059 Genomic DNA. Translation: EAX07605.1. CH471059 Genomic DNA. Translation: EAX07606.1. BC009048 mRNA. Translation: AAH09048.1. Different initiation. BC064633 mRNA. Translation: AAH64633.1. |
CCDSi | CCDS343.1. [Q9GZM7-1] CCDS55586.1. [Q9GZM7-3] |
RefSeqi | NP_001191343.1. NM_001204414.1. [Q9GZM7-3] NP_001191344.1. NM_001204415.1. NP_071447.1. NM_022164.2. [Q9GZM7-1] |
UniGenei | Hs.199368. |
Genome annotation databases
Ensembli | ENST00000271064; ENSP00000271064; ENSG00000142910. [Q9GZM7-1] ENST00000457433; ENSP00000395137; ENSG00000142910. [Q9GZM7-3] |
GeneIDi | 64129. |
KEGGi | hsa:64129. |
UCSCi | uc001bta.4. human. [Q9GZM7-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | TINAL_HUMAN | |
Accessioni | Q9GZM7Primary (citable) accession number: Q9GZM7 Secondary accession number(s): A8K9Q5 Q96JW3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2005 |
Last sequence update: | March 1, 2001 | |
Last modified: | March 28, 2018 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |