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Protein

Olfactory receptor 8D2

Gene

OR8D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor (Potential). May be involved in taste perception.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8D2
Alternative name(s):
Olfactory receptor OR11-303
Olfactory receptor-like protein JCG2
Gene namesi
Name:OR8D2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8482. OR8D2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence analysis
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 31119CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32761.

Polymorphism and mutation databases

BioMutaiOR8D2.
DMDMi14423803.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Olfactory receptor 8D2PRO_0000150660Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZM6.
PRIDEiQ9GZM6.

PTM databases

iPTMnetiQ9GZM6.

Expressioni

Tissue specificityi

Expressed in the tongue.

Gene expression databases

CleanExiHS_OR8D2.
GenevisibleiQ9GZM6. HS.

Interactioni

Protein-protein interaction databases

BioGridi129481. 1 interaction.
IntActiQ9GZM6. 2 interactions.
STRINGi9606.ENSP00000350022.

Structurei

3D structure databases

ProteinModelPortaliQ9GZM6.
SMRiQ9GZM6. Positions 29-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8YA. Eukaryota.
ENOG411167D. LUCA.
GeneTreeiENSGT00760000118817.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ9GZM6.
KOiK04257.
OMAiVHTTRMS.
OrthoDBiEOG71K63J.
PhylomeDBiQ9GZM6.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GZM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSNHSSGA EFILAGLTQR PELQLPLFLL FLGIYVVTVV GNLGMIFLIA
60 70 80 90 100
LSSQLYPPVY YFLSHLSFID LCYSSVITPK MLVNFVPEEN IISFLECITQ
110 120 130 140 150
LYFFLIFVIA EGYLLTAMEY DRYVAICRPL LYNIVMSHRV CSIMMAVVYS
160 170 180 190 200
LGFLWATVHT TRMSVLSFCR SHTVSHYFCD ILPLLTLSCS STHINEILLF
210 220 230 240 250
IIGGVNTLAT TLAVLISYAF IFSSILGIHS TEGQSKAFGT CSSHLLAVGI
260 270 280 290 300
FFGSITFMYF KPPSSTTMEK EKVSSVFYIT IIPMLNPLIY SLRNKDVKNA
310
LKKMTRGRQS S
Length:311
Mass (Da):34,857
Last modified:March 1, 2001 - v1
Checksum:iECE606FBBC962A82
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti122 – 1221R → H.
Corresponds to variant rs2512219 [ dbSNP | Ensembl ].
VAR_024117
Natural varianti263 – 2631P → L.
Corresponds to variant rs2466620 [ dbSNP | Ensembl ].
VAR_053244

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162668 mRNA. Translation: AAG43386.1.
AF162669 Genomic DNA. Translation: AAG43387.1.
CH471065 Genomic DNA. Translation: EAW67579.1.
BC137043 mRNA. Translation: AAI37044.1.
BC137045 mRNA. Translation: AAI37046.1.
BK004202 Genomic DNA. Translation: DAA04600.1.
CCDSiCCDS31707.1.
RefSeqiNP_001002918.1. NM_001002918.1.
UniGeneiHs.504212.

Genome annotation databases

EnsembliENST00000357438; ENSP00000350022; ENSG00000197263.
ENST00000624618; ENSP00000485661; ENSG00000279116.
ENST00000624877; ENSP00000485536; ENSG00000279116.
GeneIDi283160.
KEGGihsa:283160.
UCSCiuc010sah.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162668 mRNA. Translation: AAG43386.1.
AF162669 Genomic DNA. Translation: AAG43387.1.
CH471065 Genomic DNA. Translation: EAW67579.1.
BC137043 mRNA. Translation: AAI37044.1.
BC137045 mRNA. Translation: AAI37046.1.
BK004202 Genomic DNA. Translation: DAA04600.1.
CCDSiCCDS31707.1.
RefSeqiNP_001002918.1. NM_001002918.1.
UniGeneiHs.504212.

3D structure databases

ProteinModelPortaliQ9GZM6.
SMRiQ9GZM6. Positions 29-149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129481. 1 interaction.
IntActiQ9GZM6. 2 interactions.
STRINGi9606.ENSP00000350022.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9GZM6.

Polymorphism and mutation databases

BioMutaiOR8D2.
DMDMi14423803.

Proteomic databases

PaxDbiQ9GZM6.
PRIDEiQ9GZM6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357438; ENSP00000350022; ENSG00000197263.
ENST00000624618; ENSP00000485661; ENSG00000279116.
ENST00000624877; ENSP00000485536; ENSG00000279116.
GeneIDi283160.
KEGGihsa:283160.
UCSCiuc010sah.2. human.

Organism-specific databases

CTDi283160.
GeneCardsiOR8D2.
HGNCiHGNC:8482. OR8D2.
neXtProtiNX_Q9GZM6.
PharmGKBiPA32761.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8YA. Eukaryota.
ENOG411167D. LUCA.
GeneTreeiENSGT00760000118817.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ9GZM6.
KOiK04257.
OMAiVHTTRMS.
OrthoDBiEOG71K63J.
PhylomeDBiQ9GZM6.
TreeFamiTF352753.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR8D2.
GenomeRNAii283160.
PROiQ9GZM6.

Gene expression databases

CleanExiHS_OR8D2.
GenevisibleiQ9GZM6. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "New GPCRs from a human lingual cDNA library."
    Gaudin J.-C., Breuils L., Haertle T.
    Chem. Senses 26:1157-1166(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Tongue.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR8D2_HUMAN
AccessioniPrimary (citable) accession number: Q9GZM6
Secondary accession number(s): B9EH49, Q6IFR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.