Q9GZM5 (YIPF3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein YIPF3

Alternative name(s):
Killer lineage protein 1
Natural killer cell-specific antigen KLIP1
YIP1 family member 3

Gene names

Name:	YIPF3
Synonyms:	C6orf109, KLIP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in hematopoiesis. Ref.1
Subcellular location	Cell membrane; Multi-pass membrane protein. Cytoplasm. Note: Localization to the cytoplasm or to the cell membrane is developmentally and ontogenetically regulated. Ref.1
Tissue specificity	Expressed by nucleated hematopoietic cells (at protein level). Ref.1
Developmental stage	Expressed in fetal liver (at protein level). Expressed in embryonic hematopoiesis sites. Ref.1
Post-translational modification	Not glycosylated. Ref.1
Sequence similarities	Belongs to the YIP1 family.
Sequence caution	The sequence CAI42626.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Differentiation
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell transport vesicle Inferred from direct assay. Source: LIFEdb
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Protein YIPF3		PRO_0000244446
Regions
	Transmembrane	149 – 169	21	Helical; Potential
	Transmembrane	188 – 208	21	Helical; Potential
	Transmembrane	215 – 237	23	Helical; Potential
	Transmembrane	241 – 263	23	Helical; Potential
	Transmembrane	275 – 295	21	Helical; Potential
Sites
	Site	337	1	Not glycosylated
Natural variations
	Natural variant	5	1	A → V. Corresponds to variant rs2231763 [ dbSNP | Ensembl ].		VAR_026906
Experimental info
	Sequence conflict	103	1	R → G in CAG38572. Ref.6
	Sequence conflict	142	1	M → V in BAA91439. Ref.2
	Sequence conflict	161	1	F → L in AAM21161. Ref.1
	Sequence conflict	305	1	D → V in CAB43375. Ref.5
	Sequence conflict	305	1	D → V in CAG38572. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Q9GZM5 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: ED7A566716A6B364	FASTA	350	38,248
	10 20 30 40 50 60 MATTAAPAGG ARNGAGPEWG GFEENIQGGG SAVIDMENMD DTSGSSFEDM GELHQRLREE 70 80 90 100 110 120 EVDADAADAA AAEEEDGEFL GMKGFKGQLS RQVADQMWQA GKRQASRAFS LYANIDILRP 130 140 150 160 170 180 YFDVEPAQVR SRLLESMIPI KMVNFPQKIA GELYGPLMLV FTLVAILLHG MKTSDTIIRE 190 200 210 220 230 240 GTLMGTAIGT CFGYWLGVSS FIYFLAYLCN AQITMLQMLA LLGYGLFGHC IVLFITYNIH 250 260 270 280 290 300 LHALFYLFWL LVGGLSTLRM VAVLVSRTVG PTQRLLLCGT LAALHMLFLL YLHFAYHKVV 310 320 330 340 350 EGILDTLEGP NIPPIQRVPR DIPAMLPAAR LPTTVLNATA KAVAVTLQSH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a novel hematopoietic marker expressed from early embryonic hematopoietic stem cells to adult mature lineages." Prost S., LeDiscorde M., Haddad R., Gluckman J.-C., Canque B., Kirszenbaum M. Blood Cells Mol. Dis. 29:236-248(2002) [PubMed: 12490290] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, GLYCOSYLATION, SUBCELLULAR LOCATION. Tissue: Lung.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[5]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-350. Tissue: Fetal kidney.
[6]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 36-350.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF162672 mRNA. Translation: AAM21161.1. AK000946 mRNA. Translation: BAA91439.1. AK021655 mRNA. Translation: BAB13866.1. AK022757 mRNA. Translation: BAB14231.1. AL355802 Genomic DNA. Translation: CAI42626.1. Sequence problems. BC019297 mRNA. Translation: AAH19297.1. AL050274 mRNA. Translation: CAB43375.2. CR533541 mRNA. Translation: CAG38572.1.
IPI	IPI00329688.
PIR	T08721.
RefSeq	NP_056203.2. NM_015388.3.
UniGene	Hs.440950.
3D structure databases
ProteinModelPortal	Q9GZM5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9GZM5. 2 interactions.
MINT	MINT-1454282.
STRING	Q9GZM5.
Polymorphism databases
DMDM	74752534.
Proteomic databases
PRIDE	Q9GZM5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000259737; ENSP00000259737; ENSG00000137207.
GeneID	25844.
KEGG	hsa:25844.
UCSC	uc003ovl.1. human.
Organism-specific databases
CTD	25844.
GeneCards	GC06M043479.
H-InvDB	HIX0005906.
HGNC	HGNC:21023. YIPF3.
HPA	HPA014859.
MIM	609775. gene.
neXtProt	NX_Q9GZM5.
PharmGKB	PA134946615.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18303.
GeneTree	ENSGT00510000047963.
HOGENOM	HBG714269.
HOVERGEN	HBG055544.
InParanoid	Q9GZM5.
OMA	GKRQASK.
OrthoDB	EOG47H5QC.
PhylomeDB	Q9GZM5.
Gene expression databases
ArrayExpress	Q9GZM5.
Bgee	Q9GZM5.
CleanEx	HS_YIPF3.
Genevestigator	Q9GZM5.
GermOnline	ENSG00000137207. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	47175.
SOURCE	Search...

Entry information

Entry name

YIPF3_HUMAN

Accession

Primary (citable) accession number: Q9GZM5
Secondary accession number(s): Q5JTD2 , Q6FI85, Q8NI57, Q9NWE3, Q9Y3U9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.