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Protein

Protein YIPF3

Gene

YIPF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.2 Publications

GO - Biological processi

Keywordsi

Biological processDifferentiation

Protein family/group databases

TCDBi9.B.135.2.1 the membrane trafficking yip (yip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YIPF3
Alternative name(s):
Killer lineage protein 1
Natural killer cell-specific antigen KLIP1
YIP1 family member 3
Cleaved into the following chain:
Gene namesi
Name:YIPF3
Synonyms:C6orf109, KLIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000137207.11
HGNCiHGNC:21023 YIPF3
MIMi609775 gene
neXtProtiNX_Q9GZM5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 148Cytoplasmic1 PublicationAdd BLAST147
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 187LumenalCuratedAdd BLAST18
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 214CytoplasmicCurated6
Transmembranei215 – 237HelicalSequence analysisAdd BLAST23
Topological domaini238 – 240LumenalCurated3
Transmembranei241 – 263HelicalSequence analysisAdd BLAST23
Topological domaini264 – 274CytoplasmicCuratedAdd BLAST11
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Topological domaini296 – 350Lumenal1 PublicationAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi25844
OpenTargetsiENSG00000137207
PharmGKBiPA134946615

Polymorphism and mutation databases

BioMutaiYIPF3
DMDMi74752534

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002444462 – 350Protein YIPF3Add BLAST349
ChainiPRO_00004182162 – ?Protein YIPF3, 36 kDa form III

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Glycosylationi333O-linked (GalNAc...) threonine1 Publication1
Glycosylationi334O-linked (GalNAc...) threonine1 Publication1
Glycosylationi337N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi339O-linked (GalNAc...) threonine1 Publication1
Glycosylationi346O-linked (GalNAc...) threonine3 Publications1

Post-translational modificationi

N-glycosylated in the ER (40 kDa form I), then O-glycosylated in the Golgi apparatus (46 kDa form II), the C-terminal lumenal region is later removed in the Golgi apparatus to produce a 36 kDa form III. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Thr-346: HexNAc (minor), HexHexNAc (major), Hex1HexNAc2 (minor), Hex2HexNAc2 (minor) and dHex1Hex2HexNAc2 (minor).4 Publications

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

EPDiQ9GZM5
MaxQBiQ9GZM5
PaxDbiQ9GZM5
PeptideAtlasiQ9GZM5
PRIDEiQ9GZM5

PTM databases

CarbonylDBiQ9GZM5
GlyConnecti641
iPTMnetiQ9GZM5
PhosphoSitePlusiQ9GZM5
SwissPalmiQ9GZM5
UniCarbKBiQ9GZM5

Expressioni

Tissue specificityi

Expressed by nucleated hematopoietic cells (at protein level).1 Publication

Developmental stagei

Expressed in fetal liver (at protein level). Expressed in embryonic hematopoiesis sites.1 Publication

Gene expression databases

BgeeiENSG00000137207
CleanExiHS_YIPF3
ExpressionAtlasiQ9GZM5 baseline and differential
GenevisibleiQ9GZM5 HS

Organism-specific databases

HPAiHPA014859
HPA063699

Interactioni

Subunit structurei

Interacts with YIPF4 and YIPF5.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi117370, 113 interactors
IntActiQ9GZM5, 16 interactors
MINTiQ9GZM5
STRINGi9606.ENSP00000361499

Structurei

3D structure databases

ProteinModelPortaliQ9GZM5
SMRiQ9GZM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the YIP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPBK Eukaryota
ENOG4111EUH LUCA
GeneTreeiENSGT00510000047963
HOVERGENiHBG055544
InParanoidiQ9GZM5
PhylomeDBiQ9GZM5
TreeFamiTF314073

Family and domain databases

InterProiView protein in InterPro
IPR026637 YIPF3
PANTHERiPTHR15627:SF14 PTHR15627:SF14, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GZM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTAAPAGG ARNGAGPEWG GFEENIQGGG SAVIDMENMD DTSGSSFEDM
60 70 80 90 100
GELHQRLREE EVDADAADAA AAEEEDGEFL GMKGFKGQLS RQVADQMWQA
110 120 130 140 150
GKRQASRAFS LYANIDILRP YFDVEPAQVR SRLLESMIPI KMVNFPQKIA
160 170 180 190 200
GELYGPLMLV FTLVAILLHG MKTSDTIIRE GTLMGTAIGT CFGYWLGVSS
210 220 230 240 250
FIYFLAYLCN AQITMLQMLA LLGYGLFGHC IVLFITYNIH LHALFYLFWL
260 270 280 290 300
LVGGLSTLRM VAVLVSRTVG PTQRLLLCGT LAALHMLFLL YLHFAYHKVV
310 320 330 340 350
EGILDTLEGP NIPPIQRVPR DIPAMLPAAR LPTTVLNATA KAVAVTLQSH
Length:350
Mass (Da):38,248
Last modified:March 1, 2001 - v1
Checksum:iED7A566716A6B364
GO

Sequence cautioni

The sequence CAI42626 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103R → G in CAG38572 (Ref. 6) Curated1
Sequence conflicti142M → V in BAA91439 (PubMed:14702039).Curated1
Sequence conflicti161F → L in AAM21161 (PubMed:12490290).Curated1
Sequence conflicti305D → V in CAB43375 (PubMed:11230166).Curated1
Sequence conflicti305D → V in CAG38572 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0269065A → V. Corresponds to variant dbSNP:rs2231763Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162672 mRNA Translation: AAM21161.1
AK000946 mRNA Translation: BAA91439.1
AK021655 mRNA Translation: BAB13866.1
AK022757 mRNA Translation: BAB14231.1
AL355802 Genomic DNA Translation: CAI42626.1 Sequence problems.
BC019297 mRNA Translation: AAH19297.1
AL050274 mRNA Translation: CAB43375.2
CR533541 mRNA Translation: CAG38572.1
CCDSiCCDS4899.1
PIRiT08721
RefSeqiNP_056203.2, NM_015388.3
UniGeneiHs.440950

Genome annotation databases

EnsembliENST00000372422; ENSP00000361499; ENSG00000137207
GeneIDi25844
KEGGihsa:25844
UCSCiuc003ovl.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiYIPF3_HUMAN
AccessioniPrimary (citable) accession number: Q9GZM5
Secondary accession number(s): Q5JTD2
, Q6FI85, Q8NI57, Q9NWE3, Q9Y3U9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health