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Q9GZM3

- RPB1B_HUMAN

UniProt

Q9GZM3 - RPB1B_HUMAN

Protein

DNA-directed RNA polymerase II subunit RPB11-b1

Gene

POLR2J2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. DNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro

    Keywords - Biological processi

    Transcription

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB11-b1
    Short name:
    RNA polymerase II subunit B11-b1
    Short name:
    RPB11b1
    Alternative name(s):
    DNA-directed RNA polymerase II subunit J2
    Gene namesi
    Name:POLR2J2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:23208. POLR2J2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    DNA-directed RNA polymerase, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164724655.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 115115DNA-directed RNA polymerase II subunit RPB11-b1PRO_0000316946Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9GZM3.
    PaxDbiQ9GZM3.
    PRIDEiQ9GZM3.

    PTM databases

    PhosphoSiteiQ9GZM3.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    BgeeiQ9GZM3.
    GenevestigatoriQ9GZM3.

    Organism-specific databases

    HPAiHPA044010.
    HPA046970.

    Interactioni

    Subunit structurei

    Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.

    Protein-protein interaction databases

    BioGridi139239. 1 interaction.
    STRINGi9606.ENSP00000402065.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GZM3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1761.
    HOGENOMiHOG000179862.
    HOVERGENiHBG073419.
    KOiK03008.

    Family and domain databases

    InterProiIPR009025. RBP11-like_dimer.
    IPR008193. RNA_pol_Rpb11_13-16kDa_CS.
    [Graphical view]
    SUPFAMiSSF55257. SSF55257. 1 hit.
    PROSITEiPS01154. RNA_POL_L_13KD. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9GZM3-1) [UniParc]FASTAAdd to Basket

    Also known as: RPB11b1-alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNAPPAFESF LLFEGEKITI NKDTKVPKAC LFTINKEDHT LGNIIKSQLL    50
    KDPQVLFAGY KVPHPLEHKI IIRVQTTPDY SPQEAFTNAI TDLISELSLL 100
    EERFRTCLLP LRLLP 115
    Length:115
    Mass (Da):13,088
    Last modified:April 16, 2014 - v2
    Checksum:i05310B30C071AD1E
    GO
    Isoform 2 (identifier: Q9GZM3-2) [UniParc]FASTAAdd to Basket

    Also known as: RPB11b1-beta

    The sequence of this isoform differs from the canonical sequence as follows:
         48-115: QLLKDPQVLF...TCLLPLRLLP → RACFPFAFCR...SRPVQQPQHL

    Show »
    Length:116
    Mass (Da):12,733
    Checksum:iFD0CDC23780535EA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti28 – 281K → N.2 Publications
    Corresponds to variant rs74556368 [ dbSNP | Ensembl ].
    VAR_070807

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei48 – 11568QLLKD…LRLLP → RACFPFAFCRDCQFPEASPA TLPVQPAELCPRAHQLCAPA LKRHLGGEAHPVHLHAGAAS RPVQQPQHL in isoform 2. 2 PublicationsVSP_030820Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ277931 Genomic DNA. Translation: CAC18332.1.
    AJ277739 mRNA. Translation: CAC18329.1.
    AJ277740 mRNA. Translation: CAC18330.1.
    AC105052 Genomic DNA. No translation available.
    BC086857 mRNA. Translation: AAH86857.1.
    CCDSiCCDS43627.1. [Q9GZM3-1]
    RefSeqiNP_001091084.2. NM_001097615.2.
    NP_116581.3. NM_032959.5. [Q9GZM3-1]
    XP_006716095.1. XM_006716032.1.
    XP_006716096.1. XM_006716033.1.
    UniGeneiHs.610255.
    Hs.656696.
    Hs.700609.
    Hs.732239.

    Genome annotation databases

    EnsembliENST00000333432; ENSP00000330898; ENSG00000267645. [Q9GZM3-2]
    ENST00000476151; ENSP00000418603; ENSG00000267645. [Q9GZM3-1]
    GeneIDi246721.
    548644.
    KEGGihsa:246721.
    hsa:548644.
    UCSCiuc011kkw.1. human. [Q9GZM3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ277931 Genomic DNA. Translation: CAC18332.1 .
    AJ277739 mRNA. Translation: CAC18329.1 .
    AJ277740 mRNA. Translation: CAC18330.1 .
    AC105052 Genomic DNA. No translation available.
    BC086857 mRNA. Translation: AAH86857.1 .
    CCDSi CCDS43627.1. [Q9GZM3-1 ]
    RefSeqi NP_001091084.2. NM_001097615.2.
    NP_116581.3. NM_032959.5. [Q9GZM3-1 ]
    XP_006716095.1. XM_006716032.1.
    XP_006716096.1. XM_006716033.1.
    UniGenei Hs.610255.
    Hs.656696.
    Hs.700609.
    Hs.732239.

    3D structure databases

    ProteinModelPortali Q9GZM3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 139239. 1 interaction.
    STRINGi 9606.ENSP00000402065.

    PTM databases

    PhosphoSitei Q9GZM3.

    Proteomic databases

    MaxQBi Q9GZM3.
    PaxDbi Q9GZM3.
    PRIDEi Q9GZM3.

    Protocols and materials databases

    DNASUi 548644.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333432 ; ENSP00000330898 ; ENSG00000267645 . [Q9GZM3-2 ]
    ENST00000476151 ; ENSP00000418603 ; ENSG00000267645 . [Q9GZM3-1 ]
    GeneIDi 246721.
    548644.
    KEGGi hsa:246721.
    hsa:548644.
    UCSCi uc011kkw.1. human. [Q9GZM3-1 ]

    Organism-specific databases

    CTDi 246721.
    548644.
    GeneCardsi GC07M102282.
    HGNCi HGNC:23208. POLR2J2.
    HPAi HPA044010.
    HPA046970.
    MIMi 609881. gene.
    neXtProti NX_Q9GZM3.
    PharmGKBi PA164724655.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1761.
    HOGENOMi HOG000179862.
    HOVERGENi HBG073419.
    KOi K03008.

    Miscellaneous databases

    GeneWikii POLR2J2.
    GenomeRNAii 548644.
    NextBioi 112313.
    PROi Q9GZM3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9GZM3.
    Genevestigatori Q9GZM3.

    Family and domain databases

    InterProi IPR009025. RBP11-like_dimer.
    IPR008193. RNA_pol_Rpb11_13-16kDa_CS.
    [Graphical view ]
    SUPFAMi SSF55257. SSF55257. 1 hit.
    PROSITEi PS01154. RNA_POL_L_13KD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A human RNA polymerase II subunit is encoded by a recently generated multigene family."
      Grandemange S., Schaller S., Yamano S., Du Manoir S., Shpakovski G.V., Mattei M.-G., Kedinger C., Vigneron M.
      BMC Mol. Biol. 2:14-14(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, VARIANT ASN-28.
      Tissue: Cervix carcinoma and Placenta.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASN-28.
      Tissue: Lung.
    4. "The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11."
      Durrin L.K., Krontiris T.G.
      Genomics 79:809-817(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SATB1.

    Entry informationi

    Entry nameiRPB1B_HUMAN
    AccessioniPrimary (citable) accession number: Q9GZM3
    Secondary accession number(s): F6W009, Q9H1A8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: April 16, 2014
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3