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Protein

DNA-directed RNA polymerase II subunit RPB11-b1

Gene

POLR2J2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase II subunit RPB11-b1
Short name:
RNA polymerase II subunit B11-b1
Short name:
RPB11b1
Alternative name(s):
DNA-directed RNA polymerase II subunit J2
Gene namesi
Name:POLR2J2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000228049.7.
HostDB:ENSG00000267645.5.
HGNCiHGNC:23208. POLR2J2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164724655.

Polymorphism and mutation databases

BioMutaiPOLR2J2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003169461 – 115DNA-directed RNA polymerase II subunit RPB11-b1Add BLAST115

Proteomic databases

MaxQBiQ9GZM3.
PaxDbiQ9GZM3.
PeptideAtlasiQ9GZM3.
PRIDEiQ9GZM3.

PTM databases

iPTMnetiQ9GZM3.
PhosphoSitePlusiQ9GZM3.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000228049.
ExpressionAtlasiQ9GZM3. baseline.
GenevisibleiQ9GZM3. HS.

Organism-specific databases

HPAiHPA044010.
HPA046970.

Interactioni

Subunit structurei

Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128910. 1 interactor.
STRINGi9606.ENSP00000418603.

Structurei

3D structure databases

ProteinModelPortaliQ9GZM3.
SMRiQ9GZM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4392. Eukaryota.
COG1761. LUCA.
GeneTreeiENSGT00550000074975.
HOGENOMiHOG000179862.
HOVERGENiHBG073419.
InParanoidiQ9GZM3.
KOiK03008.
OrthoDBiEOG091G0VZF.

Family and domain databases

Gene3Di3.30.1360.10. 1 hit.
InterProiView protein in InterPro
IPR036603. RBP11-like.
IPR009025. RBP11-like_dimer.
IPR008193. RNA_pol_Rpb11_13-16kDa_CS.
PfamiView protein in Pfam
PF13656. RNA_pol_L_2. 1 hit.
SUPFAMiSSF55257. SSF55257. 1 hit.
PROSITEiView protein in PROSITE
PS01154. RNA_POL_L_13KD. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9GZM3-1) [UniParc]FASTAAdd to basket
Also known as: RPB11b1-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNAPPAFESF LLFEGEKITI NKDTKVPKAC LFTINKEDHT LGNIIKSQLL
60 70 80 90 100
KDPQVLFAGY KVPHPLEHKI IIRVQTTPDY SPQEAFTNAI TDLISELSLL
110
EERFRTCLLP LRLLP
Length:115
Mass (Da):13,088
Last modified:April 16, 2014 - v2
Checksum:i05310B30C071AD1E
GO
Isoform 2 (identifier: Q9GZM3-2) [UniParc]FASTAAdd to basket
Also known as: RPB11b1-beta

The sequence of this isoform differs from the canonical sequence as follows:
     48-115: QLLKDPQVLF...TCLLPLRLLP → RACFPFAFCR...SRPVQQPQHL

Show »
Length:116
Mass (Da):12,733
Checksum:iFD0CDC23780535EA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07080728K → N2 PublicationsCorresponds to variant dbSNP:rs74556368Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03082048 – 115QLLKD…LRLLP → RACFPFAFCRDCQFPEASPA TLPVQPAELCPRAHQLCAPA LKRHLGGEAHPVHLHAGAAS RPVQQPQHL in isoform 2. 2 PublicationsAdd BLAST68

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277931 Genomic DNA. Translation: CAC18332.1.
AJ277739 mRNA. Translation: CAC18329.1.
AJ277740 mRNA. Translation: CAC18330.1.
AC105052 Genomic DNA. No translation available.
BC086857 mRNA. Translation: AAH86857.1.
CCDSiCCDS43627.1. [Q9GZM3-1]
RefSeqiNP_001091084.2. NM_001097615.2.
NP_116581.3. NM_032959.5. [Q9GZM3-1]
XP_016867861.1. XM_017012372.1.
XP_016867862.1. XM_017012373.1.
UniGeneiHs.610255.
Hs.656696.
Hs.700609.
Hs.732239.

Genome annotation databases

EnsembliENST00000333432; ENSP00000330898; ENSG00000228049. [Q9GZM3-1]
GeneIDi246721.
548644.
KEGGihsa:246721.
hsa:548644.
UCSCiuc003vah.4. human. [Q9GZM3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRPB1B_HUMAN
AccessioniPrimary (citable) accession number: Q9GZM3
Secondary accession number(s): F6W009, Q9H1A8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 16, 2014
Last modified: October 25, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families