Q9GZK7 (O11A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 11A1

Alternative name(s):
Hs6M1-18
Olfactory receptor 11A2
Olfactory receptor OR6-30

Gene names

Name:	OR11A1
Synonyms:	OR11A2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Olfactory receptor 11A1		PRO_0000150722
Regions
	Topological domain	1 – 27	27	Extracellular Potential
	Transmembrane	28 – 48	21	Helical; Name=1; Potential
	Topological domain	49 – 56	8	Cytoplasmic Potential
	Transmembrane	57 – 77	21	Helical; Name=2; Potential
	Topological domain	78 – 100	23	Extracellular Potential
	Transmembrane	101 – 121	21	Helical; Name=3; Potential
	Topological domain	122 – 140	19	Cytoplasmic Potential
	Transmembrane	141 – 161	21	Helical; Name=4; Potential
	Topological domain	162 – 198	37	Extracellular Potential
	Transmembrane	199 – 218	20	Helical; Name=5; Potential
	Topological domain	219 – 238	20	Cytoplasmic Potential
	Transmembrane	239 – 259	21	Helical; Name=6; Potential
	Topological domain	260 – 272	13	Extracellular Potential
	Transmembrane	273 – 293	21	Helical; Name=7; Potential
	Topological domain	294 – 315	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	8	1	N-linked (GlcNAc...) Potential
	Disulfide bond	98 ↔ 190		By similarity
Natural variations
	Natural variant	121	1	Y → C. Corresponds to variant rs16894898 [ dbSNP | Ensembl ].		VAR_053294
	Natural variant	165	1	A → T in allele 6M1-18*02. Ref.1 Ref.3 Corresponds to variant rs9257857 [ dbSNP | Ensembl ].		VAR_010955

Sequences

	Sequence		Length	Mass (Da)
	Q9GZK7 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 0448A2166A301387	FASTA	315	35,250
	10 20 30 40 50 60 MEIVSTGNET ITEFVLLGFY DIPELHFLFF IVFTAVYVFI IIGNMLIIVA VVSSQRLHKP 70 80 90 100 110 120 MYIFLANLSF LDILYTSAVM PKMLEGFLQE ATISVAGCLL QFFIFGSLAT AECLLLAVMA 130 140 150 160 170 180 YDRYLAICYP LHYPLLMGPR RYMGLVVTTW LSGFVVDGLV VALVAQLRFC GPNHIDQFYC 190 200 210 220 230 240 DFMLFVGLAC SDPRVAQVTT LILSVFCLTI PFGLILTSYA RIVVAVLRVP AGASRRRAFS 250 260 270 280 290 300 TCSSHLAVVT TFYGTLMIFY VAPSAVHSQL LSKVFSLLYT VVTPLFNPVI YTMRNKEVHQ 310 ALRKILCIKQ TETLD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Polymorphic olfactory receptor genes and HLA loci constitute extended haplotypes." Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B., Volz A., Younger R., Beck S. (In) Kasahara M. (eds.); Major histocompatibility complex-evolution, structure, and function, pp.110-130, Springer-Verlag, Tokyo (2000) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-165.
[2]	"Complex transcription and splicing of odorant receptor genes." Volz A., Ehlers A., Younger R., Forbes S., Trowsdale J., Schnorr D., Beck S., Ziegler A. J. Biol. Chem. 278:19691-19701(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-165.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[6]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ302614 Genomic DNA. Translation: CAC20534.1. AJ302615 Genomic DNA. Translation: CAC20535.1. AJ302616 Genomic DNA. Translation: CAC20536.1. AJ302617 Genomic DNA. Translation: CAC20537.1. AJ302618 Genomic DNA. Translation: CAC20538.1. AJ302619 Genomic DNA. Translation: CAC20539.1. AJ302620 Genomic DNA. Translation: CAC20540.1. AJ302621 Genomic DNA. Translation: CAC20541.1. AJ302622 Genomic DNA. Translation: CAC20542.1. AJ302623 Genomic DNA. Translation: CAC20543.1. AJ459857 mRNA. Translation: CAD31040.1. AL035542 Genomic DNA. Translation: CAB44508.1. AL662869 Genomic DNA. Translation: CAI17484.1. AL645927 Genomic DNA. Translation: CAI18053.1. BX004810 Genomic DNA. Translation: CAI95547.1. BX248400 Genomic DNA. Translation: CAM25998.1. BX927133 Genomic DNA. Translation: CAQ10414.1. CR848056 Genomic DNA. Translation: CAQ06865.1. CR759768 Genomic DNA. Translation: CAQ09886.1. CR388393 Genomic DNA. Translation: CAQ10822.1. CH471081 Genomic DNA. Translation: EAX03192.1. BK004208 Genomic DNA. Translation: DAA04606.1.
IPI	IPI00026296.
RefSeq	NP_039225.1. NM_013937.2.
UniGene	Hs.676010.
3D structure databases
ProteinModelPortal	Q9GZK7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000399592.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9GZK7.
Polymorphism databases
DMDM	14423802.
Proteomic databases
PaxDb	Q9GZK7.
PRIDE	Q9GZK7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377147; ENSP00000366352; ENSG00000204694. ENST00000377148; ENSP00000366353; ENSG00000204694. ENST00000377149; ENSP00000366354; ENSG00000204694. ENST00000383551; ENSP00000373043; ENSG00000206472. ENST00000383645; ENSP00000373141; ENSG00000206517. ENST00000400696; ENSP00000383532; ENSG00000206472. ENST00000400715; ENSP00000383550; ENSG00000206517. ENST00000411967; ENSP00000409994; ENSG00000223898. ENST00000418485; ENSP00000400657; ENSG00000234347. ENST00000418560; ENSP00000404787; ENSG00000223898. ENST00000419773; ENSP00000399062; ENSG00000234347. ENST00000421634; ENSP00000400331; ENSG00000237258. ENST00000427264; ENSP00000403427; ENSG00000230780. ENST00000428144; ENSP00000399592; ENSG00000237258. ENST00000435232; ENSP00000398659; ENSG00000232289. ENST00000440485; ENSP00000392324; ENSG00000232289. ENST00000444884; ENSP00000412097; ENSG00000230780. ENST00000546665; ENSP00000447956; ENSG00000206472. ENST00000547506; ENSP00000447215; ENSG00000206517. ENST00000547645; ENSP00000450263; ENSG00000230780. ENST00000548813; ENSP00000447267; ENSG00000223898. ENST00000549749; ENSP00000447745; ENSG00000232289. ENST00000551986; ENSP00000447627; ENSG00000234347. ENST00000552225; ENSP00000447222; ENSG00000237258.
GeneID	26531.
KEGG	hsa:26531.
UCSC	uc003nmg.3. human.
Organism-specific databases
CTD	26531.
GeneCards	GC06M029393.
H-InvDB	HIX0167453.
HGNC	HGNC:8176. OR11A1.
neXtProt	NX_Q9GZK7.
PharmGKB	PA32010.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146972.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
InParanoid	Q9GZK7.
KO	K04257.
OMA	LSGFMVD.
OrthoDB	EOG480HX7.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR11A1.
Genevestigator	Q9GZK7.
GermOnline	ENSG00000204694. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	26531.
NextBio	48876.

Entry information

Entry name

O11A1_HUMAN

Accession

Primary (citable) accession number: Q9GZK7
Secondary accession number(s): A2BF33 , A6NFQ3, B0S7T2, Q5ST16, Q9GZK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.