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Protein

Olfactory receptor 11A1

Gene

OR11A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11A1
Alternative name(s):
Hs6M1-18
Olfactory receptor 11A2
Olfactory receptor OR6-30
Gene namesi
Name:OR11A1
Synonyms:OR11A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204694.10
HGNCiHGNC:8176 OR11A1
neXtProtiNX_Q9GZK7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 100ExtracellularSequence analysisAdd BLAST23
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 198ExtracellularSequence analysisAdd BLAST37
Transmembranei199 – 218Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini219 – 238CytoplasmicSequence analysisAdd BLAST20
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 293Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini294 – 315CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26531
OpenTargetsiENSG00000204694
PharmGKBiPA32010

Polymorphism and mutation databases

BioMutaiOR11A1
DMDMi14423802

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507221 – 315Olfactory receptor 11A1Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZK7
PeptideAtlasiQ9GZK7
PRIDEiQ9GZK7

PTM databases

iPTMnetiQ9GZK7
PhosphoSitePlusiQ9GZK7

Expressioni

Gene expression databases

BgeeiENSG00000204694
CleanExiHS_OR11A1
ExpressionAtlasiQ9GZK7 baseline and differential
GenevisibleiQ9GZK7 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366352

Structurei

3D structure databases

ProteinModelPortaliQ9GZK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKX9 Eukaryota
ENOG410YBUM LUCA
GeneTreeiENSGT00900000140939
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ9GZK7
KOiK04257
OMAiGPNHIDQ
OrthoDBiEOG091G0AZH
PhylomeDBiQ9GZK7
TreeFamiTF337187

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9GZK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIVSTGNET ITEFVLLGFY DIPELHFLFF IVFTAVYVFI IIGNMLIIVA
60 70 80 90 100
VVSSQRLHKP MYIFLANLSF LDILYTSAVM PKMLEGFLQE ATISVAGCLL
110 120 130 140 150
QFFIFGSLAT AECLLLAVMA YDRYLAICYP LHYPLLMGPR RYMGLVVTTW
160 170 180 190 200
LSGFVVDGLV VALVAQLRFC GPNHIDQFYC DFMLFVGLAC SDPRVAQVTT
210 220 230 240 250
LILSVFCLTI PFGLILTSYA RIVVAVLRVP AGASRRRAFS TCSSHLAVVT
260 270 280 290 300
TFYGTLMIFY VAPSAVHSQL LSKVFSLLYT VVTPLFNPVI YTMRNKEVHQ
310
ALRKILCIKQ TETLD
Length:315
Mass (Da):35,250
Last modified:March 1, 2001 - v1
Checksum:i0448A2166A301387
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053294121Y → C. Corresponds to variant dbSNP:rs16894898Ensembl.1
Natural variantiVAR_010955165A → T in allele 6M1-18*02. 2 PublicationsCorresponds to variant dbSNP:rs9257857Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302614 Genomic DNA Translation: CAC20534.1
AJ302615 Genomic DNA Translation: CAC20535.1
AJ302616 Genomic DNA Translation: CAC20536.1
AJ302617 Genomic DNA Translation: CAC20537.1
AJ302618 Genomic DNA Translation: CAC20538.1
AJ302619 Genomic DNA Translation: CAC20539.1
AJ302620 Genomic DNA Translation: CAC20540.1
AJ302621 Genomic DNA Translation: CAC20541.1
AJ302622 Genomic DNA Translation: CAC20542.1
AJ302623 Genomic DNA Translation: CAC20543.1
AJ459857 mRNA Translation: CAD31040.1
AL035542 Genomic DNA Translation: CAB44508.1
AL662869 Genomic DNA No translation available.
AL645927 Genomic DNA No translation available.
BX004810 Genomic DNA No translation available.
BX248400 Genomic DNA No translation available.
BX927133 Genomic DNA No translation available.
CR848056 Genomic DNA No translation available.
CR759768 Genomic DNA No translation available.
CR388393 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03192.1
BK004208 Genomic DNA Translation: DAA04606.1
CCDSiCCDS34363.1
RefSeqiNP_039225.1, NM_013937.3
UniGeneiHs.676010

Genome annotation databases

EnsembliENST00000377147; ENSP00000366352; ENSG00000204694
ENST00000377148; ENSP00000366353; ENSG00000204694
ENST00000377149; ENSP00000366354; ENSG00000204694
ENST00000383551; ENSP00000373043; ENSG00000206472
ENST00000383645; ENSP00000373141; ENSG00000206517
ENST00000400696; ENSP00000383532; ENSG00000206472
ENST00000400715; ENSP00000383550; ENSG00000206517
ENST00000411967; ENSP00000409994; ENSG00000223898
ENST00000418485; ENSP00000400657; ENSG00000234347
ENST00000418560; ENSP00000404787; ENSG00000223898
ENST00000419773; ENSP00000399062; ENSG00000234347
ENST00000421634; ENSP00000400331; ENSG00000237258
ENST00000427264; ENSP00000403427; ENSG00000230780
ENST00000428144; ENSP00000399592; ENSG00000237258
ENST00000435232; ENSP00000398659; ENSG00000232289
ENST00000440485; ENSP00000392324; ENSG00000232289
ENST00000444884; ENSP00000412097; ENSG00000230780
ENST00000546665; ENSP00000447956; ENSG00000206472
ENST00000547506; ENSP00000447215; ENSG00000206517
ENST00000547645; ENSP00000450263; ENSG00000230780
ENST00000548813; ENSP00000447267; ENSG00000223898
ENST00000549749; ENSP00000447745; ENSG00000232289
ENST00000551986; ENSP00000447627; ENSG00000234347
ENST00000552225; ENSP00000447222; ENSG00000237258
ENST00000641152; ENSP00000493093; ENSG00000204694
GeneIDi26531
KEGGihsa:26531
UCSCiuc003nmg.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO11A1_HUMAN
AccessioniPrimary (citable) accession number: Q9GZK7
Secondary accession number(s): A2BF33
, A6NFQ3, B0S7T2, Q5ST16, Q9GZK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: February 28, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome