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Q9GZK7

- O11A1_HUMAN

UniProt

Q9GZK7 - O11A1_HUMAN

Protein

Olfactory receptor 11A1

Gene

OR11A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 11A1
    Alternative name(s):
    Hs6M1-18
    Olfactory receptor 11A2
    Olfactory receptor OR6-30
    Gene namesi
    Name:OR11A1
    Synonyms:OR11A2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:8176. OR11A1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32010.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Olfactory receptor 11A1PRO_0000150722Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9GZK7.
    PRIDEiQ9GZK7.

    PTM databases

    PhosphoSiteiQ9GZK7.

    Expressioni

    Gene expression databases

    CleanExiHS_OR11A1.
    GenevestigatoriQ9GZK7.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000399592.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GZK7.
    SMRiQ9GZK7. Positions 28-306.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 568CytoplasmicSequence Analysis
    Topological domaini78 – 10023ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini162 – 19837ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23820CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini294 – 31522CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 21820Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146972.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ9GZK7.
    KOiK04257.
    OMAiVAQLRFC.
    OrthoDBiEOG7PK904.
    PhylomeDBiQ9GZK7.
    TreeFamiTF337187.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9GZK7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIVSTGNET ITEFVLLGFY DIPELHFLFF IVFTAVYVFI IIGNMLIIVA    50
    VVSSQRLHKP MYIFLANLSF LDILYTSAVM PKMLEGFLQE ATISVAGCLL 100
    QFFIFGSLAT AECLLLAVMA YDRYLAICYP LHYPLLMGPR RYMGLVVTTW 150
    LSGFVVDGLV VALVAQLRFC GPNHIDQFYC DFMLFVGLAC SDPRVAQVTT 200
    LILSVFCLTI PFGLILTSYA RIVVAVLRVP AGASRRRAFS TCSSHLAVVT 250
    TFYGTLMIFY VAPSAVHSQL LSKVFSLLYT VVTPLFNPVI YTMRNKEVHQ 300
    ALRKILCIKQ TETLD 315
    Length:315
    Mass (Da):35,250
    Last modified:March 1, 2001 - v1
    Checksum:i0448A2166A301387
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti121 – 1211Y → C.
    Corresponds to variant rs16894898 [ dbSNP | Ensembl ].
    VAR_053294
    Natural varianti165 – 1651A → T in allele 6M1-18*02. 2 Publications
    Corresponds to variant rs9257857 [ dbSNP | Ensembl ].
    VAR_010955

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ302614 Genomic DNA. Translation: CAC20534.1.
    AJ302615 Genomic DNA. Translation: CAC20535.1.
    AJ302616 Genomic DNA. Translation: CAC20536.1.
    AJ302617 Genomic DNA. Translation: CAC20537.1.
    AJ302618 Genomic DNA. Translation: CAC20538.1.
    AJ302619 Genomic DNA. Translation: CAC20539.1.
    AJ302620 Genomic DNA. Translation: CAC20540.1.
    AJ302621 Genomic DNA. Translation: CAC20541.1.
    AJ302622 Genomic DNA. Translation: CAC20542.1.
    AJ302623 Genomic DNA. Translation: CAC20543.1.
    AJ459857 mRNA. Translation: CAD31040.1.
    AL035542 Genomic DNA. Translation: CAB44508.1.
    AL662869 Genomic DNA. Translation: CAI17484.1.
    AL645927 Genomic DNA. Translation: CAI18053.1.
    BX004810 Genomic DNA. Translation: CAI95547.1.
    BX248400 Genomic DNA. Translation: CAM25998.1.
    BX927133 Genomic DNA. Translation: CAQ10414.1.
    CR848056 Genomic DNA. Translation: CAQ06865.1.
    CR759768 Genomic DNA. Translation: CAQ09886.1.
    CR388393 Genomic DNA. Translation: CAQ10822.1.
    CH471081 Genomic DNA. Translation: EAX03192.1.
    BK004208 Genomic DNA. Translation: DAA04606.1.
    CCDSiCCDS34363.1.
    RefSeqiNP_039225.1. NM_013937.3.
    XP_005249058.1. XM_005249001.1.
    XP_005249059.1. XM_005249002.1.
    XP_005272845.1. XM_005272788.1.
    XP_005272846.1. XM_005272789.1.
    XP_005274900.1. XM_005274843.1.
    XP_005274901.1. XM_005274844.1.
    XP_005274991.1. XM_005274934.1.
    XP_005274992.1. XM_005274935.1.
    XP_005275146.1. XM_005275089.1.
    XP_005275147.1. XM_005275090.1.
    XP_005275287.1. XM_005275230.1.
    XP_005275288.1. XM_005275231.1.
    XP_005275422.1. XM_005275365.1.
    XP_005275423.1. XM_005275366.1.
    XP_005275581.1. XM_005275524.1.
    XP_005275582.1. XM_005275525.1.
    UniGeneiHs.676010.

    Genome annotation databases

    EnsembliENST00000377147; ENSP00000366352; ENSG00000204694.
    ENST00000377148; ENSP00000366353; ENSG00000204694.
    ENST00000377149; ENSP00000366354; ENSG00000204694.
    ENST00000383551; ENSP00000373043; ENSG00000206472.
    ENST00000383645; ENSP00000373141; ENSG00000206517.
    ENST00000400696; ENSP00000383532; ENSG00000206472.
    ENST00000400715; ENSP00000383550; ENSG00000206517.
    ENST00000411967; ENSP00000409994; ENSG00000223898.
    ENST00000418485; ENSP00000400657; ENSG00000234347.
    ENST00000418560; ENSP00000404787; ENSG00000223898.
    ENST00000419773; ENSP00000399062; ENSG00000234347.
    ENST00000421634; ENSP00000400331; ENSG00000237258.
    ENST00000427264; ENSP00000403427; ENSG00000230780.
    ENST00000428144; ENSP00000399592; ENSG00000237258.
    ENST00000435232; ENSP00000398659; ENSG00000232289.
    ENST00000440485; ENSP00000392324; ENSG00000232289.
    ENST00000444884; ENSP00000412097; ENSG00000230780.
    ENST00000546665; ENSP00000447956; ENSG00000206472.
    ENST00000547506; ENSP00000447215; ENSG00000206517.
    ENST00000547645; ENSP00000450263; ENSG00000230780.
    ENST00000548813; ENSP00000447267; ENSG00000223898.
    ENST00000549749; ENSP00000447745; ENSG00000232289.
    ENST00000551986; ENSP00000447627; ENSG00000234347.
    ENST00000552225; ENSP00000447222; ENSG00000237258.
    GeneIDi26531.
    KEGGihsa:26531.
    UCSCiuc003nmg.3. human.

    Polymorphism databases

    DMDMi14423802.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ302614 Genomic DNA. Translation: CAC20534.1 .
    AJ302615 Genomic DNA. Translation: CAC20535.1 .
    AJ302616 Genomic DNA. Translation: CAC20536.1 .
    AJ302617 Genomic DNA. Translation: CAC20537.1 .
    AJ302618 Genomic DNA. Translation: CAC20538.1 .
    AJ302619 Genomic DNA. Translation: CAC20539.1 .
    AJ302620 Genomic DNA. Translation: CAC20540.1 .
    AJ302621 Genomic DNA. Translation: CAC20541.1 .
    AJ302622 Genomic DNA. Translation: CAC20542.1 .
    AJ302623 Genomic DNA. Translation: CAC20543.1 .
    AJ459857 mRNA. Translation: CAD31040.1 .
    AL035542 Genomic DNA. Translation: CAB44508.1 .
    AL662869 Genomic DNA. Translation: CAI17484.1 .
    AL645927 Genomic DNA. Translation: CAI18053.1 .
    BX004810 Genomic DNA. Translation: CAI95547.1 .
    BX248400 Genomic DNA. Translation: CAM25998.1 .
    BX927133 Genomic DNA. Translation: CAQ10414.1 .
    CR848056 Genomic DNA. Translation: CAQ06865.1 .
    CR759768 Genomic DNA. Translation: CAQ09886.1 .
    CR388393 Genomic DNA. Translation: CAQ10822.1 .
    CH471081 Genomic DNA. Translation: EAX03192.1 .
    BK004208 Genomic DNA. Translation: DAA04606.1 .
    CCDSi CCDS34363.1.
    RefSeqi NP_039225.1. NM_013937.3.
    XP_005249058.1. XM_005249001.1.
    XP_005249059.1. XM_005249002.1.
    XP_005272845.1. XM_005272788.1.
    XP_005272846.1. XM_005272789.1.
    XP_005274900.1. XM_005274843.1.
    XP_005274901.1. XM_005274844.1.
    XP_005274991.1. XM_005274934.1.
    XP_005274992.1. XM_005274935.1.
    XP_005275146.1. XM_005275089.1.
    XP_005275147.1. XM_005275090.1.
    XP_005275287.1. XM_005275230.1.
    XP_005275288.1. XM_005275231.1.
    XP_005275422.1. XM_005275365.1.
    XP_005275423.1. XM_005275366.1.
    XP_005275581.1. XM_005275524.1.
    XP_005275582.1. XM_005275525.1.
    UniGenei Hs.676010.

    3D structure databases

    ProteinModelPortali Q9GZK7.
    SMRi Q9GZK7. Positions 28-306.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000399592.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9GZK7.

    Polymorphism databases

    DMDMi 14423802.

    Proteomic databases

    PaxDbi Q9GZK7.
    PRIDEi Q9GZK7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377147 ; ENSP00000366352 ; ENSG00000204694 .
    ENST00000377148 ; ENSP00000366353 ; ENSG00000204694 .
    ENST00000377149 ; ENSP00000366354 ; ENSG00000204694 .
    ENST00000383551 ; ENSP00000373043 ; ENSG00000206472 .
    ENST00000383645 ; ENSP00000373141 ; ENSG00000206517 .
    ENST00000400696 ; ENSP00000383532 ; ENSG00000206472 .
    ENST00000400715 ; ENSP00000383550 ; ENSG00000206517 .
    ENST00000411967 ; ENSP00000409994 ; ENSG00000223898 .
    ENST00000418485 ; ENSP00000400657 ; ENSG00000234347 .
    ENST00000418560 ; ENSP00000404787 ; ENSG00000223898 .
    ENST00000419773 ; ENSP00000399062 ; ENSG00000234347 .
    ENST00000421634 ; ENSP00000400331 ; ENSG00000237258 .
    ENST00000427264 ; ENSP00000403427 ; ENSG00000230780 .
    ENST00000428144 ; ENSP00000399592 ; ENSG00000237258 .
    ENST00000435232 ; ENSP00000398659 ; ENSG00000232289 .
    ENST00000440485 ; ENSP00000392324 ; ENSG00000232289 .
    ENST00000444884 ; ENSP00000412097 ; ENSG00000230780 .
    ENST00000546665 ; ENSP00000447956 ; ENSG00000206472 .
    ENST00000547506 ; ENSP00000447215 ; ENSG00000206517 .
    ENST00000547645 ; ENSP00000450263 ; ENSG00000230780 .
    ENST00000548813 ; ENSP00000447267 ; ENSG00000223898 .
    ENST00000549749 ; ENSP00000447745 ; ENSG00000232289 .
    ENST00000551986 ; ENSP00000447627 ; ENSG00000234347 .
    ENST00000552225 ; ENSP00000447222 ; ENSG00000237258 .
    GeneIDi 26531.
    KEGGi hsa:26531.
    UCSCi uc003nmg.3. human.

    Organism-specific databases

    CTDi 26531.
    GeneCardsi GC06M029393.
    GC06Mi29393.
    GC06Mj29389.
    GC06Mk29393.
    GC06Ml29392.
    GC06Mm29393.
    GC06Mn29393.
    GC06Mo29392.
    H-InvDB HIX0167453.
    HGNCi HGNC:8176. OR11A1.
    neXtProti NX_Q9GZK7.
    PharmGKBi PA32010.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146972.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q9GZK7.
    KOi K04257.
    OMAi VAQLRFC.
    OrthoDBi EOG7PK904.
    PhylomeDBi Q9GZK7.
    TreeFami TF337187.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR11A1.
    GenomeRNAii 26531.
    NextBioi 48876.
    PROi Q9GZK7.

    Gene expression databases

    CleanExi HS_OR11A1.
    Genevestigatori Q9GZK7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Polymorphic olfactory receptor genes and HLA loci constitute extended haplotypes."
      Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B., Volz A., Younger R., Beck S.
      (In) Kasahara M. (eds.); Major histocompatibility complex-evolution, structure, and function, pp.110-130, Springer-Verlag, Tokyo (2000)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-165.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-165.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: IDENTIFICATION.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO11A1_HUMAN
    AccessioniPrimary (citable) accession number: Q9GZK7
    Secondary accession number(s): A2BF33
    , A6NFQ3, B0S7T2, Q5ST16, Q9GZK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3