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Q9GZK7 (O11A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 11A1
Alternative name(s):
Hs6M1-18
Olfactory receptor 11A2
Olfactory receptor OR6-30
Gene names
Name:OR11A1
Synonyms:OR11A2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Olfactory receptor 11A1
PRO_0000150722

Regions

Topological domain1 – 2727Extracellular Potential
Transmembrane28 – 4821Helical; Name=1; Potential
Topological domain49 – 568Cytoplasmic Potential
Transmembrane57 – 7721Helical; Name=2; Potential
Topological domain78 – 10023Extracellular Potential
Transmembrane101 – 12121Helical; Name=3; Potential
Topological domain122 – 14019Cytoplasmic Potential
Transmembrane141 – 16121Helical; Name=4; Potential
Topological domain162 – 19837Extracellular Potential
Transmembrane199 – 21820Helical; Name=5; Potential
Topological domain219 – 23820Cytoplasmic Potential
Transmembrane239 – 25921Helical; Name=6; Potential
Topological domain260 – 27213Extracellular Potential
Transmembrane273 – 29321Helical; Name=7; Potential
Topological domain294 – 31522Cytoplasmic Potential

Amino acid modifications

Glycosylation81N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 190 By similarity

Natural variations

Natural variant1211Y → C.
Corresponds to variant rs16894898 [ dbSNP | Ensembl ].
VAR_053294
Natural variant1651A → T in allele 6M1-18*02. Ref.1 Ref.3
Corresponds to variant rs9257857 [ dbSNP | Ensembl ].
VAR_010955

Sequences

Sequence LengthMass (Da)Tools
Q9GZK7 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 0448A2166A301387

FASTA31535,250
        10         20         30         40         50         60 
MEIVSTGNET ITEFVLLGFY DIPELHFLFF IVFTAVYVFI IIGNMLIIVA VVSSQRLHKP 

        70         80         90        100        110        120 
MYIFLANLSF LDILYTSAVM PKMLEGFLQE ATISVAGCLL QFFIFGSLAT AECLLLAVMA 

       130        140        150        160        170        180 
YDRYLAICYP LHYPLLMGPR RYMGLVVTTW LSGFVVDGLV VALVAQLRFC GPNHIDQFYC 

       190        200        210        220        230        240 
DFMLFVGLAC SDPRVAQVTT LILSVFCLTI PFGLILTSYA RIVVAVLRVP AGASRRRAFS 

       250        260        270        280        290        300 
TCSSHLAVVT TFYGTLMIFY VAPSAVHSQL LSKVFSLLYT VVTPLFNPVI YTMRNKEVHQ 

       310 
ALRKILCIKQ TETLD 

« Hide

References

« Hide 'large scale' references
[1]"Polymorphic olfactory receptor genes and HLA loci constitute extended haplotypes."
Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B., Volz A., Younger R., Beck S.
(In) Kasahara M. (eds.); Major histocompatibility complex-evolution, structure, and function, pp.110-130, Springer-Verlag, Tokyo (2000)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-165.
[2]"Complex transcription and splicing of odorant receptor genes."
Volz A., Ehlers A., Younger R., Forbes S., Trowsdale J., Schnorr D., Beck S., Ziegler A.
J. Biol. Chem. 278:19691-19701(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-165.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ302614 Genomic DNA. Translation: CAC20534.1.
AJ302615 Genomic DNA. Translation: CAC20535.1.
AJ302616 Genomic DNA. Translation: CAC20536.1.
AJ302617 Genomic DNA. Translation: CAC20537.1.
AJ302618 Genomic DNA. Translation: CAC20538.1.
AJ302619 Genomic DNA. Translation: CAC20539.1.
AJ302620 Genomic DNA. Translation: CAC20540.1.
AJ302621 Genomic DNA. Translation: CAC20541.1.
AJ302622 Genomic DNA. Translation: CAC20542.1.
AJ302623 Genomic DNA. Translation: CAC20543.1.
AJ459857 mRNA. Translation: CAD31040.1.
AL035542 Genomic DNA. Translation: CAB44508.1.
AL662869 Genomic DNA. Translation: CAI17484.1.
AL645927 Genomic DNA. Translation: CAI18053.1.
BX004810 Genomic DNA. Translation: CAI95547.1.
BX248400 Genomic DNA. Translation: CAM25998.1.
BX927133 Genomic DNA. Translation: CAQ10414.1.
CR848056 Genomic DNA. Translation: CAQ06865.1.
CR759768 Genomic DNA. Translation: CAQ09886.1.
CR388393 Genomic DNA. Translation: CAQ10822.1.
CH471081 Genomic DNA. Translation: EAX03192.1.
BK004208 Genomic DNA. Translation: DAA04606.1.
RefSeqNP_039225.1. NM_013937.2.
XP_005249058.1. XM_005249001.1.
XP_005249059.1. XM_005249002.1.
XP_005272845.1. XM_005272788.1.
XP_005272846.1. XM_005272789.1.
XP_005274900.1. XM_005274843.1.
XP_005274901.1. XM_005274844.1.
XP_005274991.1. XM_005274934.1.
XP_005274992.1. XM_005274935.1.
XP_005275146.1. XM_005275089.1.
XP_005275147.1. XM_005275090.1.
XP_005275287.1. XM_005275230.1.
XP_005275288.1. XM_005275231.1.
XP_005275422.1. XM_005275365.1.
XP_005275423.1. XM_005275366.1.
XP_005275581.1. XM_005275524.1.
XP_005275582.1. XM_005275525.1.
UniGeneHs.676010.

3D structure databases

ProteinModelPortalQ9GZK7.
SMRQ9GZK7. Positions 28-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000399592.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9GZK7.

Polymorphism databases

DMDM14423802.

Proteomic databases

PaxDbQ9GZK7.
PRIDEQ9GZK7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000377147; ENSP00000366352; ENSG00000204694.
ENST00000377148; ENSP00000366353; ENSG00000204694.
ENST00000377149; ENSP00000366354; ENSG00000204694.
ENST00000383551; ENSP00000373043; ENSG00000206472.
ENST00000383645; ENSP00000373141; ENSG00000206517.
ENST00000400696; ENSP00000383532; ENSG00000206472.
ENST00000400715; ENSP00000383550; ENSG00000206517.
ENST00000411967; ENSP00000409994; ENSG00000223898.
ENST00000418485; ENSP00000400657; ENSG00000234347.
ENST00000418560; ENSP00000404787; ENSG00000223898.
ENST00000419773; ENSP00000399062; ENSG00000234347.
ENST00000421634; ENSP00000400331; ENSG00000237258.
ENST00000427264; ENSP00000403427; ENSG00000230780.
ENST00000428144; ENSP00000399592; ENSG00000237258.
ENST00000435232; ENSP00000398659; ENSG00000232289.
ENST00000440485; ENSP00000392324; ENSG00000232289.
ENST00000444884; ENSP00000412097; ENSG00000230780.
ENST00000546665; ENSP00000447956; ENSG00000206472.
ENST00000547506; ENSP00000447215; ENSG00000206517.
ENST00000547645; ENSP00000450263; ENSG00000230780.
ENST00000548813; ENSP00000447267; ENSG00000223898.
ENST00000549749; ENSP00000447745; ENSG00000232289.
ENST00000551986; ENSP00000447627; ENSG00000234347.
ENST00000552225; ENSP00000447222; ENSG00000237258.
GeneID26531.
KEGGhsa:26531.
UCSCuc003nmg.3. human.

Organism-specific databases

CTD26531.
GeneCardsGC06M029393.
GC06Mi29393.
GC06Mj29389.
GC06Mk29393.
GC06Ml29392.
GC06Mm29393.
GC06Mn29393.
GC06Mo29392.
H-InvDBHIX0167453.
HGNCHGNC:8176. OR11A1.
neXtProtNX_Q9GZK7.
PharmGKBPA32010.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146972.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ9GZK7.
KOK04257.
OMAVAQLRFC.
OrthoDBEOG7PK904.
PhylomeDBQ9GZK7.
TreeFamTF337187.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR11A1.
GenevestigatorQ9GZK7.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR11A1.
GenomeRNAi26531.
NextBio48876.
PROQ9GZK7.

Entry information

Entry nameO11A1_HUMAN
AccessionPrimary (citable) accession number: Q9GZK7
Secondary accession number(s): A2BF33 expand/collapse secondary AC list , A6NFQ3, B0S7T2, Q5ST16, Q9GZK8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries