Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 11A1

Gene

OR11A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11A1
Alternative name(s):
Hs6M1-18
Olfactory receptor 11A2
Olfactory receptor OR6-30
Gene namesi
Name:OR11A1
Synonyms:OR11A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:8176. OR11A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence Analysis
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 10023ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini162 – 19837ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 21820Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 23820CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini294 – 31522CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Olfactory receptor 11A1PRO_0000150722Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZK7.
PRIDEiQ9GZK7.

PTM databases

PhosphoSiteiQ9GZK7.

Expressioni

Gene expression databases

CleanExiHS_OR11A1.
ExpressionAtlasiQ9GZK7. baseline.
GenevestigatoriQ9GZK7.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000399592.

Structurei

3D structure databases

ProteinModelPortaliQ9GZK7.
SMRiQ9GZK7. Positions 28-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146972.
GeneTreeiENSGT00780000121870.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ9GZK7.
KOiK04257.
OMAiVAQLRFC.
OrthoDBiEOG7PK904.
PhylomeDBiQ9GZK7.
TreeFamiTF337187.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GZK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIVSTGNET ITEFVLLGFY DIPELHFLFF IVFTAVYVFI IIGNMLIIVA
60 70 80 90 100
VVSSQRLHKP MYIFLANLSF LDILYTSAVM PKMLEGFLQE ATISVAGCLL
110 120 130 140 150
QFFIFGSLAT AECLLLAVMA YDRYLAICYP LHYPLLMGPR RYMGLVVTTW
160 170 180 190 200
LSGFVVDGLV VALVAQLRFC GPNHIDQFYC DFMLFVGLAC SDPRVAQVTT
210 220 230 240 250
LILSVFCLTI PFGLILTSYA RIVVAVLRVP AGASRRRAFS TCSSHLAVVT
260 270 280 290 300
TFYGTLMIFY VAPSAVHSQL LSKVFSLLYT VVTPLFNPVI YTMRNKEVHQ
310
ALRKILCIKQ TETLD
Length:315
Mass (Da):35,250
Last modified:March 1, 2001 - v1
Checksum:i0448A2166A301387
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti121 – 1211Y → C.
Corresponds to variant rs16894898 [ dbSNP | Ensembl ].
VAR_053294
Natural varianti165 – 1651A → T in allele 6M1-18*02. 2 Publications
Corresponds to variant rs9257857 [ dbSNP | Ensembl ].
VAR_010955

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302614 Genomic DNA. Translation: CAC20534.1.
AJ302615 Genomic DNA. Translation: CAC20535.1.
AJ302616 Genomic DNA. Translation: CAC20536.1.
AJ302617 Genomic DNA. Translation: CAC20537.1.
AJ302618 Genomic DNA. Translation: CAC20538.1.
AJ302619 Genomic DNA. Translation: CAC20539.1.
AJ302620 Genomic DNA. Translation: CAC20540.1.
AJ302621 Genomic DNA. Translation: CAC20541.1.
AJ302622 Genomic DNA. Translation: CAC20542.1.
AJ302623 Genomic DNA. Translation: CAC20543.1.
AJ459857 mRNA. Translation: CAD31040.1.
AL035542 Genomic DNA. Translation: CAB44508.1.
AL662869 Genomic DNA. Translation: CAI17484.1.
AL645927 Genomic DNA. Translation: CAI18053.1.
BX004810 Genomic DNA. Translation: CAI95547.1.
BX248400 Genomic DNA. Translation: CAM25998.1.
BX927133 Genomic DNA. Translation: CAQ10414.1.
CR848056 Genomic DNA. Translation: CAQ06865.1.
CR759768 Genomic DNA. Translation: CAQ09886.1.
CR388393 Genomic DNA. Translation: CAQ10822.1.
CH471081 Genomic DNA. Translation: EAX03192.1.
BK004208 Genomic DNA. Translation: DAA04606.1.
CCDSiCCDS34363.1.
RefSeqiNP_039225.1. NM_013937.3.
XP_005249058.1. XM_005249001.1.
XP_005249059.1. XM_005249002.1.
XP_005272845.1. XM_005272788.1.
XP_005272846.1. XM_005272789.1.
XP_005274900.1. XM_005274843.1.
XP_005274901.1. XM_005274844.1.
XP_005274991.1. XM_005274934.1.
XP_005274992.1. XM_005274935.1.
XP_005275146.1. XM_005275089.1.
XP_005275147.1. XM_005275090.1.
XP_005275287.1. XM_005275230.1.
XP_005275288.1. XM_005275231.1.
XP_005275422.1. XM_005275365.1.
XP_005275423.1. XM_005275366.1.
XP_005275581.1. XM_005275524.1.
XP_005275582.1. XM_005275525.1.
UniGeneiHs.676010.

Genome annotation databases

EnsembliENST00000377147; ENSP00000366352; ENSG00000204694.
ENST00000377148; ENSP00000366353; ENSG00000204694.
ENST00000377149; ENSP00000366354; ENSG00000204694.
ENST00000383551; ENSP00000373043; ENSG00000206472.
ENST00000383645; ENSP00000373141; ENSG00000206517.
ENST00000400696; ENSP00000383532; ENSG00000206472.
ENST00000400715; ENSP00000383550; ENSG00000206517.
ENST00000411967; ENSP00000409994; ENSG00000223898.
ENST00000418485; ENSP00000400657; ENSG00000234347.
ENST00000418560; ENSP00000404787; ENSG00000223898.
ENST00000419773; ENSP00000399062; ENSG00000234347.
ENST00000421634; ENSP00000400331; ENSG00000237258.
ENST00000427264; ENSP00000403427; ENSG00000230780.
ENST00000428144; ENSP00000399592; ENSG00000237258.
ENST00000435232; ENSP00000398659; ENSG00000232289.
ENST00000440485; ENSP00000392324; ENSG00000232289.
ENST00000444884; ENSP00000412097; ENSG00000230780.
ENST00000546665; ENSP00000447956; ENSG00000206472.
ENST00000547506; ENSP00000447215; ENSG00000206517.
ENST00000547645; ENSP00000450263; ENSG00000230780.
ENST00000548813; ENSP00000447267; ENSG00000223898.
ENST00000549749; ENSP00000447745; ENSG00000232289.
ENST00000551986; ENSP00000447627; ENSG00000234347.
ENST00000552225; ENSP00000447222; ENSG00000237258.
GeneIDi26531.
KEGGihsa:26531.
UCSCiuc003nmg.3. human.

Polymorphism databases

DMDMi14423802.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302614 Genomic DNA. Translation: CAC20534.1.
AJ302615 Genomic DNA. Translation: CAC20535.1.
AJ302616 Genomic DNA. Translation: CAC20536.1.
AJ302617 Genomic DNA. Translation: CAC20537.1.
AJ302618 Genomic DNA. Translation: CAC20538.1.
AJ302619 Genomic DNA. Translation: CAC20539.1.
AJ302620 Genomic DNA. Translation: CAC20540.1.
AJ302621 Genomic DNA. Translation: CAC20541.1.
AJ302622 Genomic DNA. Translation: CAC20542.1.
AJ302623 Genomic DNA. Translation: CAC20543.1.
AJ459857 mRNA. Translation: CAD31040.1.
AL035542 Genomic DNA. Translation: CAB44508.1.
AL662869 Genomic DNA. Translation: CAI17484.1.
AL645927 Genomic DNA. Translation: CAI18053.1.
BX004810 Genomic DNA. Translation: CAI95547.1.
BX248400 Genomic DNA. Translation: CAM25998.1.
BX927133 Genomic DNA. Translation: CAQ10414.1.
CR848056 Genomic DNA. Translation: CAQ06865.1.
CR759768 Genomic DNA. Translation: CAQ09886.1.
CR388393 Genomic DNA. Translation: CAQ10822.1.
CH471081 Genomic DNA. Translation: EAX03192.1.
BK004208 Genomic DNA. Translation: DAA04606.1.
CCDSiCCDS34363.1.
RefSeqiNP_039225.1. NM_013937.3.
XP_005249058.1. XM_005249001.1.
XP_005249059.1. XM_005249002.1.
XP_005272845.1. XM_005272788.1.
XP_005272846.1. XM_005272789.1.
XP_005274900.1. XM_005274843.1.
XP_005274901.1. XM_005274844.1.
XP_005274991.1. XM_005274934.1.
XP_005274992.1. XM_005274935.1.
XP_005275146.1. XM_005275089.1.
XP_005275147.1. XM_005275090.1.
XP_005275287.1. XM_005275230.1.
XP_005275288.1. XM_005275231.1.
XP_005275422.1. XM_005275365.1.
XP_005275423.1. XM_005275366.1.
XP_005275581.1. XM_005275524.1.
XP_005275582.1. XM_005275525.1.
UniGeneiHs.676010.

3D structure databases

ProteinModelPortaliQ9GZK7.
SMRiQ9GZK7. Positions 28-306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000399592.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9GZK7.

Polymorphism databases

DMDMi14423802.

Proteomic databases

PaxDbiQ9GZK7.
PRIDEiQ9GZK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377147; ENSP00000366352; ENSG00000204694.
ENST00000377148; ENSP00000366353; ENSG00000204694.
ENST00000377149; ENSP00000366354; ENSG00000204694.
ENST00000383551; ENSP00000373043; ENSG00000206472.
ENST00000383645; ENSP00000373141; ENSG00000206517.
ENST00000400696; ENSP00000383532; ENSG00000206472.
ENST00000400715; ENSP00000383550; ENSG00000206517.
ENST00000411967; ENSP00000409994; ENSG00000223898.
ENST00000418485; ENSP00000400657; ENSG00000234347.
ENST00000418560; ENSP00000404787; ENSG00000223898.
ENST00000419773; ENSP00000399062; ENSG00000234347.
ENST00000421634; ENSP00000400331; ENSG00000237258.
ENST00000427264; ENSP00000403427; ENSG00000230780.
ENST00000428144; ENSP00000399592; ENSG00000237258.
ENST00000435232; ENSP00000398659; ENSG00000232289.
ENST00000440485; ENSP00000392324; ENSG00000232289.
ENST00000444884; ENSP00000412097; ENSG00000230780.
ENST00000546665; ENSP00000447956; ENSG00000206472.
ENST00000547506; ENSP00000447215; ENSG00000206517.
ENST00000547645; ENSP00000450263; ENSG00000230780.
ENST00000548813; ENSP00000447267; ENSG00000223898.
ENST00000549749; ENSP00000447745; ENSG00000232289.
ENST00000551986; ENSP00000447627; ENSG00000234347.
ENST00000552225; ENSP00000447222; ENSG00000237258.
GeneIDi26531.
KEGGihsa:26531.
UCSCiuc003nmg.3. human.

Organism-specific databases

CTDi26531.
GeneCardsiGC06M029393.
GC06Mi29393.
GC06Mj29389.
GC06Mk29393.
GC06Ml29392.
GC06Mm29393.
GC06Mn29393.
GC06Mo29392.
H-InvDBHIX0167453.
HGNCiHGNC:8176. OR11A1.
neXtProtiNX_Q9GZK7.
PharmGKBiPA32010.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG146972.
GeneTreeiENSGT00780000121870.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ9GZK7.
KOiK04257.
OMAiVAQLRFC.
OrthoDBiEOG7PK904.
PhylomeDBiQ9GZK7.
TreeFamiTF337187.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR11A1.
GenomeRNAii26531.
NextBioi48876.
PROiQ9GZK7.

Gene expression databases

CleanExiHS_OR11A1.
ExpressionAtlasiQ9GZK7. baseline.
GenevestigatoriQ9GZK7.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Polymorphic olfactory receptor genes and HLA loci constitute extended haplotypes."
    Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B., Volz A., Younger R., Beck S.
    (In) Kasahara M. (eds.); Major histocompatibility complex-evolution, structure, and function, pp.110-130, Springer-Verlag, Tokyo (2000)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-165.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-165.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO11A1_HUMAN
AccessioniPrimary (citable) accession number: Q9GZK7
Secondary accession number(s): A2BF33
, A6NFQ3, B0S7T2, Q5ST16, Q9GZK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: February 4, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.