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Protein

Olfactory receptor 2H1

Gene

OR2H1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-33802-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2H1
Alternative name(s):
Hs6M1-16
OLFR42A-9004.14/9026.2
Olfactory receptor 2H6
Olfactory receptor 2H8
Olfactory receptor 6-2
Short name:
OR6-2
Olfactory receptor OR6-32
Gene namesi
Name:OR2H1
Synonyms:OR2H6, OR2H8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:8252. OR2H1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 217Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini218 – 234CytoplasmicSequence analysisAdd BLAST17
Transmembranei235 – 257Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 290Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini291 – 316CytoplasmicSequence analysisAdd BLAST26

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26716.
OpenTargetsiENSG00000204688.
ENSG00000206471.
ENSG00000206516.
ENSG00000224395.
ENSG00000229125.
ENSG00000229408.
ENSG00000232984.
ENSG00000235132.
PharmGKBiPA32161.

Polymorphism and mutation databases

BioMutaiOR2H1.
DMDMi14423801.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504791 – 316Olfactory receptor 2H1Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZK4.
PRIDEiQ9GZK4.

Expressioni

Gene expression databases

BgeeiENSG00000204688.
CleanExiHS_OR2H1.
ExpressionAtlasiQ9GZK4. baseline and differential.
GenevisibleiQ9GZK4. HS.

Interactioni

Protein-protein interaction databases

BioGridi117800. 1 interactor.
IntActiQ9GZK4. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ9GZK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAPF. Eukaryota.
ENOG41117A7. LUCA.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ9GZK4.
KOiK04257.
OMAiHQQIDDF.
OrthoDBiEOG091G0EHC.
PhylomeDBiQ9GZK4.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GZK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNQSSPMGF LLLGFSEHPA LERTLFVVVF TSYLLTLVGN TLIILLSVLY
60 70 80 90 100
PRLHSPMYFF LSDLSFLDLC FTTSCVPQML VNLWGPKKTI SFLGCSVQLF
110 120 130 140 150
IFLSLGTTEC ILLTVMAFDR YVAVCQPLHY ATIIHPRLCW QLASVAWVMS
160 170 180 190 200
LVQSIVQTPS TLHLPFCPHQ QIDDFLCEVP SLIRLSCGDT SYNEIQLAVS
210 220 230 240 250
SVIFVVVPLS LILASYGATA QAVLRINSAT AWRKAFGTCS SHLTVVTLFY
260 270 280 290 300
SSVIAVYLQP KNPYAQGRGK FFGLFYAVGT PSLNPLVYTL RNKEIKRALR
310
RLLGKERDSR ESWRAA
Length:316
Mass (Da):35,339
Last modified:March 1, 2001 - v1
Checksum:i19140A7FD690CF85
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158T → K in AAC00188 (Ref. 8) Curated1
Sequence conflicti184R → G in AAC00188 (Ref. 8) Curated1
Sequence conflicti215S → Y in AAC00188 (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01094463D → N in allele 6M1-16*02. 1 PublicationCorresponds to variant rs61732185dbSNPEnsembl.1
Natural variantiVAR_053143223V → M.Corresponds to variant rs17184086dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302604 Genomic DNA. Translation: CAC20524.1.
AJ302605 Genomic DNA. Translation: CAC20525.1.
AJ302606 Genomic DNA. Translation: CAC20526.1.
AJ302607 Genomic DNA. Translation: CAC20527.1.
AJ302608 Genomic DNA. Translation: CAC20528.1.
AJ302609 Genomic DNA. Translation: CAC20529.1.
AJ302610 Genomic DNA. Translation: CAC20530.1.
AJ302611 Genomic DNA. Translation: CAC20531.1.
AJ302612 Genomic DNA. Translation: CAC20532.1.
AJ302613 Genomic DNA. Translation: CAC20533.1.
AJ459847 mRNA. Translation: CAD31039.1.
AK127984 mRNA. Translation: BAG54612.1.
AL035542 Genomic DNA. Translation: CAB44506.1.
AL645927 Genomic DNA. Translation: CAI18055.1.
AL662869 Genomic DNA. Translation: CAI17486.1.
BX000531 Genomic DNA. Translation: CAI18457.1.
BX247947 Genomic DNA. Translation: CAM26161.1.
CR759956 Genomic DNA. Translation: CAQ06738.1.
CR759768 Genomic DNA. Translation: CAQ09888.1.
BX927133 Genomic DNA. Translation: CAQ10416.1.
CR388393 Genomic DNA. Translation: CAQ10824.1.
CH471081 Genomic DNA. Translation: EAX03195.1.
BC048991 mRNA. Translation: AAH48991.1.
AF042078 Genomic DNA. Translation: AAC00184.1.
AF044491 Genomic DNA. Translation: AAC00188.1.
AF044492 Genomic DNA. Translation: AAC00189.1.
BK004209 Genomic DNA. Translation: DAA04607.1.
CCDSiCCDS4660.1.
RefSeqiNP_001304943.1. NM_001318014.1.
NP_001304951.1. NM_001318022.1.
NP_112145.1. NM_030883.4.
XP_011512772.1. XM_011514470.2.
XP_011512774.1. XM_011514472.2.
XP_011512775.1. XM_011514473.2.
XP_011512781.1. XM_011514479.2.
XP_011512785.1. XM_011514483.2.
XP_011512786.1. XM_011514484.2.
XP_016866226.1. XM_017010737.1.
XP_016866227.1. XM_017010738.1.
XP_016866228.1. XM_017010739.1.
UniGeneiHs.434715.
Hs.714219.
Hs.740793.

Genome annotation databases

EnsembliENST00000377132; ENSP00000366336; ENSG00000204688.
ENST00000377133; ENSP00000366337; ENSG00000204688.
ENST00000377136; ENSP00000366340; ENSG00000204688.
ENST00000383550; ENSP00000373042; ENSG00000206471.
ENST00000383644; ENSP00000373140; ENSG00000206516.
ENST00000396792; ENSP00000380010; ENSG00000204688.
ENST00000400689; ENSP00000383527; ENSG00000206471.
ENST00000400693; ENSP00000383529; ENSG00000206471.
ENST00000400694; ENSP00000383530; ENSG00000206471.
ENST00000400712; ENSP00000383547; ENSG00000206516.
ENST00000400713; ENSP00000383548; ENSG00000206516.
ENST00000400714; ENSP00000383549; ENSG00000206516.
ENST00000412956; ENSP00000407739; ENSG00000232984.
ENST00000415581; ENSP00000396944; ENSG00000224395.
ENST00000416582; ENSP00000395850; ENSG00000229125.
ENST00000418376; ENSP00000395567; ENSG00000229408.
ENST00000421808; ENSP00000410401; ENSG00000232984.
ENST00000431658; ENSP00000394698; ENSG00000232984.
ENST00000435958; ENSP00000397171; ENSG00000224395.
ENST00000436167; ENSP00000388844; ENSG00000235132.
ENST00000438840; ENSP00000412463; ENSG00000224395.
ENST00000439879; ENSP00000409651; ENSG00000229408.
ENST00000440557; ENSP00000413910; ENSG00000229125.
ENST00000440672; ENSP00000396414; ENSG00000235132.
ENST00000443407; ENSP00000398695; ENSG00000232984.
ENST00000444920; ENSP00000410659; ENSG00000235132.
ENST00000446161; ENSP00000389230; ENSG00000229408.
ENST00000449826; ENSP00000411617; ENSG00000229408.
ENST00000453467; ENSP00000392619; ENSG00000229125.
ENST00000454071; ENSP00000395934; ENSG00000229125.
ENST00000456657; ENSP00000408584; ENSG00000235132.
ENST00000458051; ENSP00000405714; ENSG00000224395.
GeneIDi26716.
KEGGihsa:26716.
UCSCiuc003nmj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302604 Genomic DNA. Translation: CAC20524.1.
AJ302605 Genomic DNA. Translation: CAC20525.1.
AJ302606 Genomic DNA. Translation: CAC20526.1.
AJ302607 Genomic DNA. Translation: CAC20527.1.
AJ302608 Genomic DNA. Translation: CAC20528.1.
AJ302609 Genomic DNA. Translation: CAC20529.1.
AJ302610 Genomic DNA. Translation: CAC20530.1.
AJ302611 Genomic DNA. Translation: CAC20531.1.
AJ302612 Genomic DNA. Translation: CAC20532.1.
AJ302613 Genomic DNA. Translation: CAC20533.1.
AJ459847 mRNA. Translation: CAD31039.1.
AK127984 mRNA. Translation: BAG54612.1.
AL035542 Genomic DNA. Translation: CAB44506.1.
AL645927 Genomic DNA. Translation: CAI18055.1.
AL662869 Genomic DNA. Translation: CAI17486.1.
BX000531 Genomic DNA. Translation: CAI18457.1.
BX247947 Genomic DNA. Translation: CAM26161.1.
CR759956 Genomic DNA. Translation: CAQ06738.1.
CR759768 Genomic DNA. Translation: CAQ09888.1.
BX927133 Genomic DNA. Translation: CAQ10416.1.
CR388393 Genomic DNA. Translation: CAQ10824.1.
CH471081 Genomic DNA. Translation: EAX03195.1.
BC048991 mRNA. Translation: AAH48991.1.
AF042078 Genomic DNA. Translation: AAC00184.1.
AF044491 Genomic DNA. Translation: AAC00188.1.
AF044492 Genomic DNA. Translation: AAC00189.1.
BK004209 Genomic DNA. Translation: DAA04607.1.
CCDSiCCDS4660.1.
RefSeqiNP_001304943.1. NM_001318014.1.
NP_001304951.1. NM_001318022.1.
NP_112145.1. NM_030883.4.
XP_011512772.1. XM_011514470.2.
XP_011512774.1. XM_011514472.2.
XP_011512775.1. XM_011514473.2.
XP_011512781.1. XM_011514479.2.
XP_011512785.1. XM_011514483.2.
XP_011512786.1. XM_011514484.2.
XP_016866226.1. XM_017010737.1.
XP_016866227.1. XM_017010738.1.
XP_016866228.1. XM_017010739.1.
UniGeneiHs.434715.
Hs.714219.
Hs.740793.

3D structure databases

ProteinModelPortaliQ9GZK4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117800. 1 interactor.
IntActiQ9GZK4. 1 interactor.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR2H1.
DMDMi14423801.

Proteomic databases

PaxDbiQ9GZK4.
PRIDEiQ9GZK4.

Protocols and materials databases

DNASUi26716.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377132; ENSP00000366336; ENSG00000204688.
ENST00000377133; ENSP00000366337; ENSG00000204688.
ENST00000377136; ENSP00000366340; ENSG00000204688.
ENST00000383550; ENSP00000373042; ENSG00000206471.
ENST00000383644; ENSP00000373140; ENSG00000206516.
ENST00000396792; ENSP00000380010; ENSG00000204688.
ENST00000400689; ENSP00000383527; ENSG00000206471.
ENST00000400693; ENSP00000383529; ENSG00000206471.
ENST00000400694; ENSP00000383530; ENSG00000206471.
ENST00000400712; ENSP00000383547; ENSG00000206516.
ENST00000400713; ENSP00000383548; ENSG00000206516.
ENST00000400714; ENSP00000383549; ENSG00000206516.
ENST00000412956; ENSP00000407739; ENSG00000232984.
ENST00000415581; ENSP00000396944; ENSG00000224395.
ENST00000416582; ENSP00000395850; ENSG00000229125.
ENST00000418376; ENSP00000395567; ENSG00000229408.
ENST00000421808; ENSP00000410401; ENSG00000232984.
ENST00000431658; ENSP00000394698; ENSG00000232984.
ENST00000435958; ENSP00000397171; ENSG00000224395.
ENST00000436167; ENSP00000388844; ENSG00000235132.
ENST00000438840; ENSP00000412463; ENSG00000224395.
ENST00000439879; ENSP00000409651; ENSG00000229408.
ENST00000440557; ENSP00000413910; ENSG00000229125.
ENST00000440672; ENSP00000396414; ENSG00000235132.
ENST00000443407; ENSP00000398695; ENSG00000232984.
ENST00000444920; ENSP00000410659; ENSG00000235132.
ENST00000446161; ENSP00000389230; ENSG00000229408.
ENST00000449826; ENSP00000411617; ENSG00000229408.
ENST00000453467; ENSP00000392619; ENSG00000229125.
ENST00000454071; ENSP00000395934; ENSG00000229125.
ENST00000456657; ENSP00000408584; ENSG00000235132.
ENST00000458051; ENSP00000405714; ENSG00000224395.
GeneIDi26716.
KEGGihsa:26716.
UCSCiuc003nmj.2. human.

Organism-specific databases

CTDi26716.
DisGeNETi26716.
GeneCardsiOR2H1.
HGNCiHGNC:8252. OR2H1.
neXtProtiNX_Q9GZK4.
OpenTargetsiENSG00000204688.
ENSG00000206471.
ENSG00000206516.
ENSG00000224395.
ENSG00000229125.
ENSG00000229408.
ENSG00000232984.
ENSG00000235132.
PharmGKBiPA32161.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAPF. Eukaryota.
ENOG41117A7. LUCA.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ9GZK4.
KOiK04257.
OMAiHQQIDDF.
OrthoDBiEOG091G0EHC.
PhylomeDBiQ9GZK4.
TreeFamiTF336512.

Enzyme and pathway databases

BioCyciZFISH:G66-33802-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2H1.
GenomeRNAii26716.
PROiQ9GZK4.

Gene expression databases

BgeeiENSG00000204688.
CleanExiHS_OR2H1.
ExpressionAtlasiQ9GZK4. baseline and differential.
GenevisibleiQ9GZK4. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2H1_HUMAN
AccessioniPrimary (citable) accession number: Q9GZK4
Secondary accession number(s): B0S7T4
, O43629, O43661, O43662, Q5SUN6, Q9GZK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.