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Protein

Olfactory receptor 2H1

Gene

OR2H1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2H1
Alternative name(s):
Hs6M1-16
OLFR42A-9004.14/9026.2
Olfactory receptor 2H6
Olfactory receptor 2H8
Olfactory receptor 6-2
Short name:
OR6-2
Olfactory receptor OR6-32
Gene namesi
Name:OR2H1
Synonyms:OR2H6, OR2H8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204688.9.
HGNCiHGNC:8252. OR2H1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 217Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini218 – 234CytoplasmicSequence analysisAdd BLAST17
Transmembranei235 – 257Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 290Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini291 – 316CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26716.
OpenTargetsiENSG00000204688.
PharmGKBiPA32161.

Polymorphism and mutation databases

BioMutaiOR2H1.
DMDMi14423801.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504791 – 316Olfactory receptor 2H1Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZK4.
PRIDEiQ9GZK4.

Expressioni

Gene expression databases

BgeeiENSG00000204688.
CleanExiHS_OR2H1.
ExpressionAtlasiQ9GZK4. baseline and differential.
GenevisibleiQ9GZK4. HS.

Interactioni

Protein-protein interaction databases

BioGridi117800. 1 interactor.
IntActiQ9GZK4. 1 interactor.
STRINGi9606.ENSP00000366336.

Structurei

3D structure databases

ProteinModelPortaliQ9GZK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAPF. Eukaryota.
ENOG41117A7. LUCA.
GeneTreeiENSGT00900000140946.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ9GZK4.
KOiK04257.
OMAiSYNEIQL.
OrthoDBiEOG09371L63.
PhylomeDBiQ9GZK4.
TreeFamiTF336512.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9GZK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNQSSPMGF LLLGFSEHPA LERTLFVVVF TSYLLTLVGN TLIILLSVLY
60 70 80 90 100
PRLHSPMYFF LSDLSFLDLC FTTSCVPQML VNLWGPKKTI SFLGCSVQLF
110 120 130 140 150
IFLSLGTTEC ILLTVMAFDR YVAVCQPLHY ATIIHPRLCW QLASVAWVMS
160 170 180 190 200
LVQSIVQTPS TLHLPFCPHQ QIDDFLCEVP SLIRLSCGDT SYNEIQLAVS
210 220 230 240 250
SVIFVVVPLS LILASYGATA QAVLRINSAT AWRKAFGTCS SHLTVVTLFY
260 270 280 290 300
SSVIAVYLQP KNPYAQGRGK FFGLFYAVGT PSLNPLVYTL RNKEIKRALR
310
RLLGKERDSR ESWRAA
Length:316
Mass (Da):35,339
Last modified:March 1, 2001 - v1
Checksum:i19140A7FD690CF85
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158T → K in AAC00188 (Ref. 8) Curated1
Sequence conflicti184R → G in AAC00188 (Ref. 8) Curated1
Sequence conflicti215S → Y in AAC00188 (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01094463D → N in allele 6M1-16*02. 1 PublicationCorresponds to variant dbSNP:rs61732185Ensembl.1
Natural variantiVAR_053143223V → M. Corresponds to variant dbSNP:rs17184086Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302604 Genomic DNA. Translation: CAC20524.1.
AJ302605 Genomic DNA. Translation: CAC20525.1.
AJ302606 Genomic DNA. Translation: CAC20526.1.
AJ302607 Genomic DNA. Translation: CAC20527.1.
AJ302608 Genomic DNA. Translation: CAC20528.1.
AJ302609 Genomic DNA. Translation: CAC20529.1.
AJ302610 Genomic DNA. Translation: CAC20530.1.
AJ302611 Genomic DNA. Translation: CAC20531.1.
AJ302612 Genomic DNA. Translation: CAC20532.1.
AJ302613 Genomic DNA. Translation: CAC20533.1.
AJ459847 mRNA. Translation: CAD31039.1.
AK127984 mRNA. Translation: BAG54612.1.
AL035542 Genomic DNA. Translation: CAB44506.1.
AL645927 Genomic DNA. No translation available.
AL662869 Genomic DNA. No translation available.
BX000531 Genomic DNA. No translation available.
BX247947 Genomic DNA. No translation available.
CR759956 Genomic DNA. No translation available.
CR759768 Genomic DNA. No translation available.
BX927133 Genomic DNA. No translation available.
CR388393 Genomic DNA. No translation available.
CH471081 Genomic DNA. Translation: EAX03195.1.
BC048991 mRNA. Translation: AAH48991.1.
AF042078 Genomic DNA. Translation: AAC00184.1.
AF044491 Genomic DNA. Translation: AAC00188.1.
AF044492 Genomic DNA. Translation: AAC00189.1.
BK004209 Genomic DNA. Translation: DAA04607.1.
CCDSiCCDS4660.1.
RefSeqiNP_001304943.1. NM_001318014.1.
NP_001304951.1. NM_001318022.1.
NP_112145.1. NM_030883.4.
XP_011512772.1. XM_011514470.2.
XP_011512774.1. XM_011514472.2.
XP_011512775.1. XM_011514473.2.
XP_011512781.1. XM_011514479.2.
XP_011512785.1. XM_011514483.2.
XP_011512786.1. XM_011514484.2.
XP_016866226.1. XM_017010737.1.
XP_016866227.1. XM_017010738.1.
XP_016866228.1. XM_017010739.1.
UniGeneiHs.434715.
Hs.714219.
Hs.740793.

Genome annotation databases

EnsembliENST00000377132; ENSP00000366336; ENSG00000204688.
ENST00000377133; ENSP00000366337; ENSG00000204688.
ENST00000377136; ENSP00000366340; ENSG00000204688.
ENST00000383550; ENSP00000373042; ENSG00000206471.
ENST00000383644; ENSP00000373140; ENSG00000206516.
ENST00000396792; ENSP00000380010; ENSG00000204688.
ENST00000400689; ENSP00000383527; ENSG00000206471.
ENST00000400693; ENSP00000383529; ENSG00000206471.
ENST00000400694; ENSP00000383530; ENSG00000206471.
ENST00000400712; ENSP00000383547; ENSG00000206516.
ENST00000400713; ENSP00000383548; ENSG00000206516.
ENST00000400714; ENSP00000383549; ENSG00000206516.
ENST00000412956; ENSP00000407739; ENSG00000232984.
ENST00000415581; ENSP00000396944; ENSG00000224395.
ENST00000416582; ENSP00000395850; ENSG00000229125.
ENST00000418376; ENSP00000395567; ENSG00000229408.
ENST00000421808; ENSP00000410401; ENSG00000232984.
ENST00000431658; ENSP00000394698; ENSG00000232984.
ENST00000435958; ENSP00000397171; ENSG00000224395.
ENST00000436167; ENSP00000388844; ENSG00000235132.
ENST00000438840; ENSP00000412463; ENSG00000224395.
ENST00000439879; ENSP00000409651; ENSG00000229408.
ENST00000440557; ENSP00000413910; ENSG00000229125.
ENST00000440672; ENSP00000396414; ENSG00000235132.
ENST00000443407; ENSP00000398695; ENSG00000232984.
ENST00000444920; ENSP00000410659; ENSG00000235132.
ENST00000446161; ENSP00000389230; ENSG00000229408.
ENST00000449826; ENSP00000411617; ENSG00000229408.
ENST00000453467; ENSP00000392619; ENSG00000229125.
ENST00000454071; ENSP00000395934; ENSG00000229125.
ENST00000456657; ENSP00000408584; ENSG00000235132.
ENST00000458051; ENSP00000405714; ENSG00000224395.
GeneIDi26716.
KEGGihsa:26716.
UCSCiuc003nmj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR2H1_HUMAN
AccessioniPrimary (citable) accession number: Q9GZK4
Secondary accession number(s): B0S7T4
, O43629, O43661, O43662, Q5SUN6, Q9GZK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families