Q9GZK3 (OR2B2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 2B2

Alternative name(s):
Hs6M1-10
Olfactory receptor 2B9
Olfactory receptor 6-1
Short name=OR6-1

Gene names

Name:	OR2B2
Synonyms:	OR2B9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Olfactory receptor 2B2		PRO_0000150460
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 49	24	Helical; Name=1; Potential
	Topological domain	50 – 57	8	Cytoplasmic Potential
	Transmembrane	58 – 79	22	Helical; Name=2; Potential
	Topological domain	80 – 100	21	Extracellular Potential
	Transmembrane	101 – 120	20	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 158	19	Helical; Name=4; Potential
	Topological domain	159 – 195	37	Extracellular Potential
	Transmembrane	196 – 219	24	Helical; Name=5; Potential
	Topological domain	220 – 236	17	Cytoplasmic Potential
	Transmembrane	237 – 259	23	Helical; Name=6; Potential
	Topological domain	260 – 272	13	Extracellular Potential
	Transmembrane	273 – 292	20	Helical; Name=7; Potential
	Topological domain	293 – 357	65	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	183	1	A → P. Corresponds to variant rs9368537 [ dbSNP | Ensembl ].		VAR_057536
	Natural variant	234	1	Q → R in allele 6M1-10*02. Ref.1 Corresponds to variant rs34957169 [ dbSNP | Ensembl ].		VAR_010943
	Natural variant	300	1	A → S. Corresponds to variant rs34788973 [ dbSNP | Ensembl ].		VAR_062014

Sequences

	Sequence		Length	Mass (Da)
	Q9GZK3 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 53E2F82820EC440A	FASTA	357	40,412
	10 20 30 40 50 60 MNWVNKSVPQ EFILLVFSDQ PWLEIPPFVM FLFSYILTIF GNLTIILVSH VDFKLHTPMY 70 80 90 100 110 120 FFLSNLSLLD LCYTTSTVPQ MLVNICNTRK VISYGGCVAQ LFIFLALGST ECLLLAVMCF 130 140 150 160 170 180 DRFVAICRPL HYSIIMHQRL CFQLAAASWI SGFSNSVLQS TWTLKMPLCG HKEVDHFFCE 190 200 210 220 230 240 VPALLKLSCV DTTANEAELF FISVLFLLIP VTLILISYAF IVQAVLRIQS AEGQRKAFGT 250 260 270 280 290 300 CGSHLIVVSL FYGTAISMYL QPPSPSSKDR GKMVSLFCGI IAPMLNPLIY TLRNKEVKEA 310 320 330 340 350 FKRLVAKSLL NQEIRNMQMI SFAKDTVLTY LTNFSASCPI FVITIENYCN LPQRKFP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Polymorphic olfactory receptor genes and HLA loci constitute extended haplotypes." Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B., Volz A., Younger R., Beck S. (In) Kasahara M. (eds.); Major histocompatibility complex-evolution, structure, and function, pp.110-130, Springer-Verlag, Tokyo (2000) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-234.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ302584 Genomic DNA. Translation: CAC20504.1. AJ302585 Genomic DNA. Translation: CAC20505.1. AJ302586 Genomic DNA. Translation: CAC20506.1. AJ302587 Genomic DNA. Translation: CAC20507.1. AJ302588 Genomic DNA. Translation: CAC20508.1. AJ302589 Genomic DNA. Translation: CAC20509.1. AJ302590 Genomic DNA. Translation: CAC20510.1. AJ302591 Genomic DNA. Translation: CAC20511.1. AJ302592 Genomic DNA. Translation: CAC20512.1. AJ302593 Genomic DNA. Translation: CAC20513.1. Z98744 Genomic DNA. Translation: CAD24079.1. CH471081 Genomic DNA. Translation: EAX03125.1. BC136881 mRNA. Translation: AAI36882.1. BC136901 mRNA. Translation: AAI36902.1.
IPI	IPI00304219.
RefSeq	NP_149046.2. NM_033057.2.
UniGene	Hs.307111.
3D structure databases
ProteinModelPortal	Q9GZK3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000304419.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	14423800.
Proteomic databases
PaxDb	Q9GZK3.
PRIDE	Q9GZK3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000303324; ENSP00000304419; ENSG00000168131.
GeneID	81697.
KEGG	hsa:81697.
UCSC	uc011dkw.2. human.
Organism-specific databases
CTD	81697.
GeneCards	GC06M027895.
HGNC	HGNC:13966. OR2B2.
neXtProt	NX_Q9GZK3.
PharmGKB	PA32141.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG272235.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
InParanoid	Q9GZK3.
KO	K04257.
OMA	DWANETF.
OrthoDB	EOG4RJG24.
PhylomeDB	Q9GZK3.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q9GZK3.
Bgee	Q9GZK3.
CleanEx	HS_OR2B2.
Genevestigator	Q9GZK3.
GermOnline	ENSG00000168131. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	81697.
NextBio	72055.

Entry information

Entry name

OR2B2_HUMAN

Accession

Primary (citable) accession number: Q9GZK3
Secondary accession number(s): B2RNH2, Q9GZL2, Q9Y299

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.