Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 2B2

Gene

OR2B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168131-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2B2
Alternative name(s):
Hs6M1-10
Olfactory receptor 2B9
Olfactory receptor 6-1
Short name:
OR6-1
Gene namesi
Name:OR2B2
Synonyms:OR2B9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13966. OR2B2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 357CytoplasmicSequence analysisAdd BLAST65

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81697.
OpenTargetsiENSG00000168131.
PharmGKBiPA32141.

Polymorphism and mutation databases

BioMutaiOR2B2.
DMDMi14423800.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504601 – 357Olfactory receptor 2B2Add BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZK3.
PRIDEiQ9GZK3.

PTM databases

iPTMnetiQ9GZK3.
PhosphoSitePlusiQ9GZK3.

Expressioni

Gene expression databases

BgeeiENSG00000168131.
CleanExiHS_OR2B2.
ExpressionAtlasiQ9GZK3. baseline and differential.
GenevisibleiQ9GZK3. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000304419.

Structurei

3D structure databases

ProteinModelPortaliQ9GZK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVUR. Eukaryota.
ENOG41117FE. LUCA.
GeneTreeiENSGT00740000115013.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ9GZK3.
KOiK04257.
OMAiVMFLFSY.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ9GZK3.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GZK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWVNKSVPQ EFILLVFSDQ PWLEIPPFVM FLFSYILTIF GNLTIILVSH
60 70 80 90 100
VDFKLHTPMY FFLSNLSLLD LCYTTSTVPQ MLVNICNTRK VISYGGCVAQ
110 120 130 140 150
LFIFLALGST ECLLLAVMCF DRFVAICRPL HYSIIMHQRL CFQLAAASWI
160 170 180 190 200
SGFSNSVLQS TWTLKMPLCG HKEVDHFFCE VPALLKLSCV DTTANEAELF
210 220 230 240 250
FISVLFLLIP VTLILISYAF IVQAVLRIQS AEGQRKAFGT CGSHLIVVSL
260 270 280 290 300
FYGTAISMYL QPPSPSSKDR GKMVSLFCGI IAPMLNPLIY TLRNKEVKEA
310 320 330 340 350
FKRLVAKSLL NQEIRNMQMI SFAKDTVLTY LTNFSASCPI FVITIENYCN

LPQRKFP
Length:357
Mass (Da):40,412
Last modified:March 1, 2001 - v1
Checksum:i53E2F82820EC440A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057536183A → P.Corresponds to variant rs9368537dbSNPEnsembl.1
Natural variantiVAR_010943234Q → R in allele 6M1-10*02. 1 PublicationCorresponds to variant rs34957169dbSNPEnsembl.1
Natural variantiVAR_062014300A → S.Corresponds to variant rs34788973dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302584 Genomic DNA. Translation: CAC20504.1.
AJ302585 Genomic DNA. Translation: CAC20505.1.
AJ302586 Genomic DNA. Translation: CAC20506.1.
AJ302587 Genomic DNA. Translation: CAC20507.1.
AJ302588 Genomic DNA. Translation: CAC20508.1.
AJ302589 Genomic DNA. Translation: CAC20509.1.
AJ302590 Genomic DNA. Translation: CAC20510.1.
AJ302591 Genomic DNA. Translation: CAC20511.1.
AJ302592 Genomic DNA. Translation: CAC20512.1.
AJ302593 Genomic DNA. Translation: CAC20513.1.
Z98744 Genomic DNA. Translation: CAD24079.1.
CH471081 Genomic DNA. Translation: EAX03125.1.
BC136881 mRNA. Translation: AAI36882.1.
BC136901 mRNA. Translation: AAI36902.1.
CCDSiCCDS4641.1.
RefSeqiNP_149046.2. NM_033057.2.
UniGeneiHs.307111.

Genome annotation databases

EnsembliENST00000303324; ENSP00000304419; ENSG00000168131.
GeneIDi81697.
KEGGihsa:81697.
UCSCiuc011dkw.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302584 Genomic DNA. Translation: CAC20504.1.
AJ302585 Genomic DNA. Translation: CAC20505.1.
AJ302586 Genomic DNA. Translation: CAC20506.1.
AJ302587 Genomic DNA. Translation: CAC20507.1.
AJ302588 Genomic DNA. Translation: CAC20508.1.
AJ302589 Genomic DNA. Translation: CAC20509.1.
AJ302590 Genomic DNA. Translation: CAC20510.1.
AJ302591 Genomic DNA. Translation: CAC20511.1.
AJ302592 Genomic DNA. Translation: CAC20512.1.
AJ302593 Genomic DNA. Translation: CAC20513.1.
Z98744 Genomic DNA. Translation: CAD24079.1.
CH471081 Genomic DNA. Translation: EAX03125.1.
BC136881 mRNA. Translation: AAI36882.1.
BC136901 mRNA. Translation: AAI36902.1.
CCDSiCCDS4641.1.
RefSeqiNP_149046.2. NM_033057.2.
UniGeneiHs.307111.

3D structure databases

ProteinModelPortaliQ9GZK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000304419.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9GZK3.
PhosphoSitePlusiQ9GZK3.

Polymorphism and mutation databases

BioMutaiOR2B2.
DMDMi14423800.

Proteomic databases

PaxDbiQ9GZK3.
PRIDEiQ9GZK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303324; ENSP00000304419; ENSG00000168131.
GeneIDi81697.
KEGGihsa:81697.
UCSCiuc011dkw.2. human.

Organism-specific databases

CTDi81697.
DisGeNETi81697.
GeneCardsiOR2B2.
HGNCiHGNC:13966. OR2B2.
neXtProtiNX_Q9GZK3.
OpenTargetsiENSG00000168131.
PharmGKBiPA32141.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVUR. Eukaryota.
ENOG41117FE. LUCA.
GeneTreeiENSGT00740000115013.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ9GZK3.
KOiK04257.
OMAiVMFLFSY.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ9GZK3.
TreeFamiTF336512.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168131-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2B2.
GenomeRNAii81697.
PROiQ9GZK3.

Gene expression databases

BgeeiENSG00000168131.
CleanExiHS_OR2B2.
ExpressionAtlasiQ9GZK3. baseline and differential.
GenevisibleiQ9GZK3. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2B2_HUMAN
AccessioniPrimary (citable) accession number: Q9GZK3
Secondary accession number(s): B2RNH2, Q9GZL2, Q9Y299
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.