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Q9GZH3

- IMDH_CAEEL

UniProt

Q9GZH3 - IMDH_CAEEL

Protein

Inosine-5'-monophosphate dehydrogenase

Gene

T22D1.3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.UniRule annotation

    Catalytic activityi

    Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

    Cofactori

    Potassium.UniRule annotation

    Enzyme regulationi

    Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi344 – 3441Potassium; via carbonyl oxygenUniRule annotation
    Metal bindingi346 – 3461Potassium; via carbonyl oxygenUniRule annotation
    Binding sitei347 – 3471IMPUniRule annotation
    Active sitei349 – 3491Thioimidate intermediateUniRule annotation
    Metal bindingi349 – 3491Potassium; via carbonyl oxygenUniRule annotation
    Binding sitei461 – 4611IMPUniRule annotation
    Metal bindingi520 – 5201Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation
    Metal bindingi521 – 5211Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation
    Metal bindingi522 – 5221Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi292 – 2943NADUniRule annotation
    Nucleotide bindingi342 – 3443NADUniRule annotation

    GO - Molecular functioni

    1. adenyl nucleotide binding Source: InterPro
    2. IMP dehydrogenase activity Source: UniProtKB-HAMAP
    3. metal ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. GMP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    GMP biosynthesis, Purine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Potassium

    Enzyme and pathway databases

    UniPathwayiUPA00601; UER00295.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inosine-5'-monophosphate dehydrogenaseUniRule annotation (EC:1.1.1.205UniRule annotation)
    Short name:
    IMP dehydrogenaseUniRule annotation
    Short name:
    IMPDUniRule annotation
    Short name:
    IMPDHUniRule annotation
    Gene namesi
    ORF Names:T22D1.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiT22D1.3a; CE30188; WBGene00020682.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 534534Inosine-5'-monophosphate dehydrogenasePRO_0000415680Add
    BLAST

    Proteomic databases

    PRIDEiQ9GZH3.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    IntActiQ9GZH3. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GZH3.
    SMRiQ9GZH3. Positions 18-534.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini117 – 18165CBS 1UniRule annotationAdd
    BLAST
    Domaini190 – 25566CBS 2UniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni382 – 3843IMP bindingUniRule annotation
    Regioni405 – 4062IMP bindingUniRule annotation
    Regioni430 – 4345IMP bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the IMPDH/GMPR family.UniRule annotation
    Contains 2 CBS domains.UniRule annotation

    Keywords - Domaini

    CBS domain, Repeat

    Phylogenomic databases

    GeneTreeiENSGT00530000062923.
    HOGENOMiHOG000165752.
    InParanoidiQ9GZH3.
    KOiK00088.
    OMAiIMATYRI.
    PhylomeDBiQ9GZH3.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01964. IMPDH.
    InterProiIPR013785. Aldolase_TIM.
    IPR000644. CBS_dom.
    IPR005990. IMP_DH.
    IPR015875. IMP_DH/GMP_Rdtase_CS.
    IPR001093. IMP_DH_GMPRt.
    [Graphical view]
    PANTHERiPTHR11911:SF6. PTHR11911:SF6. 1 hit.
    PfamiPF00571. CBS. 2 hits.
    PF00478. IMPDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000130. IMPDH. 1 hit.
    SMARTiSM00116. CBS. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
    PROSITEiPS51371. CBS. 2 hits.
    PS00487. IMP_DH_GMP_RED. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9GZH3-1 [UniParc]FASTAAdd to Basket

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    MVRPEDFNSL ELDNSLTDGE TVHEMMAHKA GLTYNDFNIL PGFINFGVHD    50
    VSLETNITKD LKIKAPLVSS PMDTVTESGM AIVMALYGGI GIIHGNFPKP 100
    EDQAAEVLKV KRFKQGYVMQ PHCLSRDSTA FDMIQIKKKY GYTGAPVTED 150
    GRVGSKLIGM VTSRDFDFIT MDVAGQKGTP ISDTNDVTPT TPITRIMVSV 200
    DQLHLGHIND APELSQKKLK EHRLGKLPIV NDNGELCALL CRSDLLKARD 250
    YPMASYDSKG QLLCGAAVNT RGESQYTVDR VVEAGVDVLI IDSSNGSSTY 300
    QISMLRYIKE KHPHVQVIAG NVVTRAQAKL LIDQGADGLR IGMGSGSICI 350
    TQDVMAVGRA QGTAVYDVAR YANQRGIPIV ADGGIRDVGY ITKAISLGAS 400
    AVMMGGLLAA TTEAPGEYFW GPGGVRVKKY RGMGSLDAME AHASSQDRYF 450
    TAESDQIKVA QGVSATMKDR GSCHKFIPYL IRGVQHGMQD IGVRSLRDFR 500
    EKVDNGIVKF ERRSTNAQLE GGVHSLHSFE KRLY 534
    Length:534
    Mass (Da):58,170
    Last modified:March 1, 2002 - v2
    Checksum:i9462FBEE9119FD0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080211 Genomic DNA. Translation: CCD62017.1.
    RefSeqiNP_001023395.1. NM_001028224.3.
    UniGeneiCel.17245.

    Genome annotation databases

    EnsemblMetazoaiT22D1.3a; T22D1.3a; WBGene00020682.
    GeneIDi177457.
    KEGGicel:CELE_T22D1.3.
    UCSCiT22D1.3b.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080211 Genomic DNA. Translation: CCD62017.1 .
    RefSeqi NP_001023395.1. NM_001028224.3.
    UniGenei Cel.17245.

    3D structure databases

    ProteinModelPortali Q9GZH3.
    SMRi Q9GZH3. Positions 18-534.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9GZH3. 1 interaction.

    Proteomic databases

    PRIDEi Q9GZH3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T22D1.3a ; T22D1.3a ; WBGene00020682 .
    GeneIDi 177457.
    KEGGi cel:CELE_T22D1.3.
    UCSCi T22D1.3b.1. c. elegans.

    Organism-specific databases

    CTDi 177457.
    WormBasei T22D1.3a ; CE30188 ; WBGene00020682 .

    Phylogenomic databases

    GeneTreei ENSGT00530000062923.
    HOGENOMi HOG000165752.
    InParanoidi Q9GZH3.
    KOi K00088.
    OMAi IMATYRI.
    PhylomeDBi Q9GZH3.

    Enzyme and pathway databases

    UniPathwayi UPA00601 ; UER00295 .

    Miscellaneous databases

    NextBioi 896908.
    PROi Q9GZH3.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01964. IMPDH.
    InterProi IPR013785. Aldolase_TIM.
    IPR000644. CBS_dom.
    IPR005990. IMP_DH.
    IPR015875. IMP_DH/GMP_Rdtase_CS.
    IPR001093. IMP_DH_GMPRt.
    [Graphical view ]
    PANTHERi PTHR11911:SF6. PTHR11911:SF6. 1 hit.
    Pfami PF00571. CBS. 2 hits.
    PF00478. IMPDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000130. IMPDH. 1 hit.
    SMARTi SM00116. CBS. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
    PROSITEi PS51371. CBS. 2 hits.
    PS00487. IMP_DH_GMP_RED. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiIMDH_CAEEL
    AccessioniPrimary (citable) accession number: Q9GZH3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2012
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3