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Protein

Putative complexin-1

Gene

cpx-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Positively regulates a late step in synaptic vesicle exocytosis.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Neurotransmitter transport, Transport

Protein family/group databases

TCDBi1.F.1.1.3. the synaptosomal vesicle fusion pore (svf-pore) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative complexin-1
Gene namesi
Name:cpx-1
ORF Names:Y73E7A.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiY73E7A.4; CE26415; WBGene00022271; cpx-1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: WormBase
  • cytosol Source: UniProtKB-SubCell
  • synapse Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 143143Putative complexin-1PRO_0000240246Add
BLAST

Proteomic databases

EPDiQ9GUM7.
PaxDbiQ9GUM7.
PRIDEiQ9GUM7.

Expressioni

Gene expression databases

BgeeiWBGene00022271.

Structurei

3D structure databases

ProteinModelPortaliQ9GUM7.
SMRiQ9GUM7. Positions 48-75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili40 – 7132Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the complexin/synaphin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J0BP. Eukaryota.
ENOG4111Z4J. LUCA.
GeneTreeiENSGT00730000113875.
HOGENOMiHOG000017716.
InParanoidiQ9GUM7.
KOiK15294.
OMAiAMPQEEP.
OrthoDBiEOG091G0WGX.

Family and domain databases

InterProiIPR008849. Synaphin.
[Graphical view]
PANTHERiPTHR16705. PTHR16705. 1 hit.
PfamiPF05835. Synaphin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GUM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGFLMKQMV GNQLSEVTGG LGMKDDGGEK TETGEDPEVI AARLEQEERR
60 70 80 90 100
KEKHRKMENE REKMRQGIRD KYAIKKKEEG VAMDFTEGRI GGPRKTPEEI
110 120 130 140
AAEMNAEDDS LIGQLGLTEQ VEKAKTMATG AFETVKGFFP FGK
Length:143
Mass (Da):15,943
Last modified:March 1, 2001 - v1
Checksum:iE52A0E859D8DA625
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081821 Genomic DNA. Translation: CCD73528.1.
RefSeqiNP_490868.1. NM_058467.3.
UniGeneiCel.16280.

Genome annotation databases

EnsemblMetazoaiY73E7A.4; Y73E7A.4; WBGene00022271.
GeneIDi190666.
KEGGicel:CELE_Y73E7A.4.
UCSCiY73E7A.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081821 Genomic DNA. Translation: CCD73528.1.
RefSeqiNP_490868.1. NM_058467.3.
UniGeneiCel.16280.

3D structure databases

ProteinModelPortaliQ9GUM7.
SMRiQ9GUM7. Positions 48-75.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.F.1.1.3. the synaptosomal vesicle fusion pore (svf-pore) family.

Proteomic databases

EPDiQ9GUM7.
PaxDbiQ9GUM7.
PRIDEiQ9GUM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY73E7A.4; Y73E7A.4; WBGene00022271.
GeneIDi190666.
KEGGicel:CELE_Y73E7A.4.
UCSCiY73E7A.4. c. elegans.

Organism-specific databases

CTDi190666.
WormBaseiY73E7A.4; CE26415; WBGene00022271; cpx-1.

Phylogenomic databases

eggNOGiENOG410J0BP. Eukaryota.
ENOG4111Z4J. LUCA.
GeneTreeiENSGT00730000113875.
HOGENOMiHOG000017716.
InParanoidiQ9GUM7.
KOiK15294.
OMAiAMPQEEP.
OrthoDBiEOG091G0WGX.

Miscellaneous databases

PROiQ9GUM7.

Gene expression databases

BgeeiWBGene00022271.

Family and domain databases

InterProiIPR008849. Synaphin.
[Graphical view]
PANTHERiPTHR16705. PTHR16705. 1 hit.
PfamiPF05835. Synaphin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPLX1_CAEEL
AccessioniPrimary (citable) accession number: Q9GUM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.