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Protein

Conotoxin Gm9.1

Gene
N/A
Organism
Conus gloriamaris (Glory-of-the-Seas cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Elicits "spasmodic" symptomatology.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionNeurotoxin, Toxin

Protein family/group databases

TCDBi8.B.22.1.1. the p-conotoxin cystine knot (p-cck) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin Gm9.1
Alternative name(s):
Gm9a
Spasmodic protein tx9a-like protein
OrganismiConus gloriamaris (Glory-of-the-Seas cone)
Taxonomic identifieri37336 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri609. GmIXA precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
PropeptideiPRO_000003501328 – 58CuratedAdd BLAST31
PeptideiPRO_000003501461 – 87Conotoxin Gm9.1Add BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 761 Publication
Disulfide bondi66 ↔ 781 Publication
Disulfide bondi72 ↔ 831 Publication
Modified residuei87Asparagine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

Secondary structure

188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi67 – 70Combined sources4
Beta strandi72 – 79Combined sources8
Beta strandi82 – 85Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IXTNMR-A61-87[»]
2MSONMR-A61-88[»]
ProteinModelPortaliQ9GU57.
SMRiQ9GU57.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9GU57.

Family & Domainsi

Domaini

The cysteine framework is IX (C-C-C-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin P superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR010012. Toxin_11.
PfamiView protein in Pfam
PF07473. Toxin_11. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GU57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLSLARSAV LMLLLLFALG NFVVVQSGLI TRDVDNGQLT DNRRNLQTEW
60 70 80
NPLSLFMSRR SCNNSCQSHS DCASHCICTF RGCGAVNG
Length:88
Mass (Da):9,687
Last modified:March 1, 2001 - v1
Checksum:iC82818A55CBC44E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193511 mRNA. Translation: AAG28407.1.

Similar proteinsi

Entry informationi

Entry nameiCP91_CONGL
AccessioniPrimary (citable) accession number: Q9GU57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: March 1, 2001
Last modified: November 22, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families