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Protein

Conotoxin Gm9.1

Gene
N/A
Organism
Conus gloriamaris (Glory-of-the-Seas cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Elicits "spasmodic" symptomatology.1 Publication

GO - Biological processi

Keywordsi

Molecular functionNeurotoxin, Toxin

Protein family/group databases

TCDBi8.B.22.1.1. the p-conotoxin cystine knot (p-cck) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin Gm9.1
Alternative name(s):
Gm9a
Spasmodic protein tx9a-like protein
OrganismiConus gloriamaris (Glory-of-the-Seas cone)
Taxonomic identifieri37336 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri609. GmIXA precursor.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
PropeptideiPRO_000003501328 – 58CuratedAdd BLAST31
PeptideiPRO_000003501461 – 87Conotoxin Gm9.1Add BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 761 Publication
Disulfide bondi66 ↔ 781 Publication
Disulfide bondi72 ↔ 831 Publication
Modified residuei87Asparagine amideCurated1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

Secondary structure

188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi67 – 70Combined sources4
Beta strandi72 – 79Combined sources8
Beta strandi82 – 85Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IXTNMR-A61-87[»]
2MSONMR-A61-88[»]
ProteinModelPortaliQ9GU57.
SMRiQ9GU57.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9GU57.

Family & Domainsi

Domaini

The cysteine framework is IX (C-C-C-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin P superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR010012. Toxin_11.
PfamiView protein in Pfam
PF07473. Toxin_11. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GU57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLSLARSAV LMLLLLFALG NFVVVQSGLI TRDVDNGQLT DNRRNLQTEW
60 70 80
NPLSLFMSRR SCNNSCQSHS DCASHCICTF RGCGAVNG
Length:88
Mass (Da):9,687
Last modified:March 1, 2001 - v1
Checksum:iC82818A55CBC44E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193511 mRNA. Translation: AAG28407.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193511 mRNA. Translation: AAG28407.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IXTNMR-A61-87[»]
2MSONMR-A61-88[»]
ProteinModelPortaliQ9GU57.
SMRiQ9GU57.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi8.B.22.1.1. the p-conotoxin cystine knot (p-cck) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri609. GmIXA precursor.

Miscellaneous databases

EvolutionaryTraceiQ9GU57.

Family and domain databases

InterProiView protein in InterPro
IPR010012. Toxin_11.
PfamiView protein in Pfam
PF07473. Toxin_11. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCP91_CONGL
AccessioniPrimary (citable) accession number: Q9GU57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.