Q9GU53 (Q9GU53_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
DNFAT EMBL AAG28468.1

Submitted name:
LD28881p EMBL AAT94496.1
Submitted name:
NFAT, isoform D EMBL ACZ95281.1

Gene names

Name:	NFAT FlyBase FBgn0030505 EMBL ACZ95281.1
Synonyms:	dNFAT EMBL AAG28468.1
ORF Names:	CG11172 FlyBase FBgn0030505, Dmel_CG11172 EMBL ACZ95281.1

Organism

Drosophila melanogaster (Fruit fly) EMBL AAG28468.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1210 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 RHD (Rel-like) domain. RuleBase RU003997

Ontologies

Keywords
Cellular component	Nucleus RuleBase RU003998
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	negative regulation of synaptic vesicle exocytosis Inferred from direct assay. Source: FlyBase response to salt stress Inferred from mutant phenotype. Source: FlyBase
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9GU53 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 99861D542A420D0F	FASTA	1,210	127,916
	10 20 30 40 50 60 MLLKFTKTSG AGPSAVPLLT TAPATVTSSA SMQATTTSYA ARGTGMRMTM STNSTMSARI 70 80 90 100 110 120 HRKGFRIPSK RQPGKGLPGK LHTITRTGPG KMVPGKRIPQ RPHPPPCDNS NDSGLGFDQH 130 140 150 160 170 180 TELRSSAGAG GVTDPAANGG SGSNSGQRSS LLVNSALTNT VAAAAAAAAA AVASNTLQQH 190 200 210 220 230 240 QQHHQQQQQQ QQQQQQQQQQ QQQQQQQQQH SPQQHLIRAI PVSRFISARN VTRVANKRQP 250 260 270 280 290 300 TTPLNSVASS NDGQVQLEIL SQPEQQHRAR YQTEGSRGAV KDRSGNGFPI VRLTGYDKVA 310 320 330 340 350 360 VLQVFIGTDI GRVAPHMFYQ ACKVAGKNST QCNEKKVDGT MVIEIDFKPE TDMTITCDCV 370 380 390 400 410 420 GILKERNVDV EHRFPEHLAQ KNKKKSTRCR MVFRTQLTRD DGTTETLQVC SNPIICTQPP 430 440 450 460 470 480 GVPEICKKSL NSCPVDGGLE LFIIGKNFLK DTHVVFQETY DSVNGDDPAT EIAVRQQLIG 490 500 510 520 530 540 GTAALWEQSV LPDKEYLHQT HLICTVPPYL HQNILKPVQV QVSIVSSGKK SEPHTFTYTA 550 560 570 580 590 600 KGQYTTLAAA STLSNTIHAQ DVSGFMDTTS ASNASGSSGW SAAGGSGNNT STGDNVEAKH 610 620 630 640 650 660 EIDSGMMPPP ITTQIPMGVR RSSLPSVTPM ITDQQLVHLN AVAASAEALK TELDDSNSHS 670 680 690 700 710 720 PLTGESTPDS PNAALQYHRF ARKPSLDTIM YDQSNSLPGF PTVVAPATAA AVAAAVDIDP 730 740 750 760 770 780 TAVAVAVELA VKNEIVKHVV QQHQQMQEQM HEQQQQQQQQ QQQQQQQQQQ QPQQQQQQQV 790 800 810 820 830 840 HKFIDELTKS TSVVSSNGTT EPALFTTSAV IDHALTDILQ AKVGIAPPNV VLERSLSLSS 850 860 870 880 890 900 TNSSSSMSGS ESSPNSSPLT QDIILNSEPA AALAGAAALG GPAPVDVTGG LSTDIIMNPA 910 920 930 940 950 960 VSPSTILCSA NGAATAVVPN ILAPHQVTMA NSILNDIAMQ PEPTQQDAAV AALALSNIMM 970 980 990 1000 1010 1020 SPPTAASGVG VGDTLPPTPA TMQPEVAATA TSTAVSNMII KAAADFITTQ EQEQHHYHHH 1030 1040 1050 1060 1070 1080 GRIHSHSPQA AVGVSGNPAE TASDPLVDLL LNHSNTPETA AAAAAAVAVE AANFQSMNHS 1090 1100 1110 1120 1130 1140 HHSHHGHHGH SHGHGHSRVT GHVSGHVTSH HRGHHLPVVP PTPQESLIVA LASENALQKS 1150 1160 1170 1180 1190 1200 VATAAVTTNG AVMTQQASAP NTAGSILPAA VGAVAAAAAV AVQPPIPQEL TTMSDQDLIS 1210 YINPSTFDQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Release 5.1 annotation of Drosophila melanogaster heterochromatin." Smith C.D., Shu S., Mungall C.J., Karpen G.H. Science 316:1586-1591(2007) [PubMed: 17569856] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Sequence finishing and mapping of Drosophila melanogaster heterochromatin." Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., Dimitri P., Karpen G.H., Celniker S.E. Science 316:1625-1628(2007) [PubMed: 17569867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Combined evidence annotation of transposable elements in genome sequences." Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D. PLoS Comput. Biol. 1:166-175(2005) [PubMed: 16110336] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[5]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[6]	"Heterochromatic sequences in a Drosophila whole-genome shotgun assembly." Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H. Genome Biol. 3:RESEARCH0085.1-RESEARCH0085.16(2002) [PubMed: 12537574] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[7]	"The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective." Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J.W., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E. Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed: 12537573] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[8]	"Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence." Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., Pacleb J.M., Park S. , Pfeiffer B.D., Richards S., Sodergren E.J., Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M. Genome Biol. 3 (12), RESEARCH0079 (2002) Cited for: NUCLEOTIDE SEQUENCE.
[9]	Drosophila Heterochromatin Genome Project Smith C.D., Shu S., Mungall C.J., Karpen G.H. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[10]	FlyBase Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[11]	"Drosophila melanogaster release 4 sequence." Berkeley Drosophila Genome Project Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[12]	Celniker S., Carlson J., Kennedy C., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Karpen G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[13]	Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[14]	"Full length Drosophila melanogaster cDNA sequence." Huang A.M., Rubin G.M., Tsang G., Evans-Holm M., Suh C. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[15]	Stapleton M., Carlson J., Frise E., Kapadia B., Park S., Wan K., Yu C., Celniker S. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAT94496.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF195496 mRNA. Translation: AAG28468.1. BT015267 mRNA. Translation: AAT94496.1. AE014298 Genomic DNA. Translation: ACZ95281.1.
RefSeq	NP_001162746.1. NM_001169275.1.
UniGene	Dm.2918.
3D structure databases
HSSP	HSSP built from PDB template 1IMH based on UniProtKB O94916.
ProteinModelPortal	Q9GU53.
SMR	Q9GU53. Positions 239-541.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9GU53.
Proteomic databases
PRIDE	Q9GU53.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0301450; FBpp0290665; FBgn0030505.
GeneID	32321.
KEGG	dme:Dmel_CG11172.
Organism-specific databases
CTD	32321.
FlyBase	FBgn0030505. NFAT.
Phylogenomic databases
GeneTree	EMGT00050000001488.
InParanoid	Q9GU53.
Gene expression databases
ArrayExpress	Q9GU53.
Bgee	Q9GU53.
Family and domain databases
InterPro	IPR011989. ARM-like. IPR013783. Ig-like_fold. IPR014756. Ig_E-set. IPR002909. IPT_TIG_rcpt. IPR008366. NFAT. IPR008967. p53-like_TF_DNA-bd. IPR011539. RHD. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 1 hit. G3DSA:2.60.40.10. Ig-like_fold. 1 hit. G3DSA:2.60.40.340. RHD. 1 hit.
KO	K04446.
PANTHER	PTHR12533. NFAT. 1 hit.
Pfam	PF00554. RHD. 1 hit. PF01833. TIG. 1 hit. [Graphical view]
SMART	SM00429. IPT. 1 hit. [Graphical view]
SUPFAM	SSF81296. Ig_E-set. 1 hit. SSF49417. P53_like_DNA_bnd. 1 hit.
PROSITE	PS50254. REL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9GU53_DROME

Accession

Primary (citable) accession number: Q9GU53

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2001
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)