Q9GTW9 (GLK1_TRIVA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucokinase 1
EC=2.7.1.2

Alternative name(s):
Glucose kinase 1
Hexokinase-1

Gene names

Name:

GK1

Organism

Trichomonas vaginalis

Taxonomic identifier

5722 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Parabasalia › Trichomonadida › Trichomonadidae › Trichomonas

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + D-glucose = ADP + D-glucose 6-phosphate.
Subunit structure	Monomer.
Post-translational modification	The N-terminus is blocked.
Sequence similarities	Belongs to the bacterial glucokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glucokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	Glucokinase 1		PRO_0000215151
Regions
	Nucleotide binding	25 – 30	6	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9GTW9 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 229F76B24637BE21	FASTA	375	41,585
	10 20 30 40 50 60 MFSIDLIQQI KEWKRGSTLP ICLGCDVGGS GLRVRLSDFH DSAKYVDLGH AKAQKTAELL 70 80 90 100 110 120 KVLEDLQQKI LQVEPTTVCL GAAIAVAGPI KNNTVILTNW KGPAEERTLS ITQLPKGLFP 130 140 150 160 170 180 KDRSYFLNDL EAGAYGVIAA YEQSILEENF VQLFTDRAPT GPILAKGRTA VLAMGSGLGA 190 200 210 220 230 240 ALVTRTPLLK NPLVLPTELG HLQIAPNMAT HKYFQDEQEL IQHISDHYYG GKLDPEYEDI 250 260 270 280 290 300 CSGRGLQLAF QFYHKKLTGE VLPLEQIDAG DVAKKAIAGE KDAYNALRAH YIFYLRAAKA 310 320 330 340 350 360 IATSLSCESC VLSLDNQVKN HPFVMKIAKE LEEEFYEFIR PDWMTSVRVY SQKSILNFNI 370 LGTDYMAHAI ANKPQ

References

[1]

"Evolutionary relationships of the glucokinase from the amitochondriate protist, Trichomonas vaginalis." Wu G., Henze K., Mueller M. Gene 264:265-271(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION. Strain: ATCC 30001 / NIH-C1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF248652 Genomic DNA. Translation: AAG17616.1.
3D structure databases
ProteinModelPortal	Q9GTW9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG318218.
Family and domain databases
InterPro	IPR003836. Glucokinase. [Graphical view]
Pfam	PF02685. Glucokinase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLK1_TRIVA

Accession

Primary (citable) accession number: Q9GTW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)