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Protein

DNA helicase

Gene

mcm4

Organism
Plasmodium falciparum
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotation, Hydrolase

Keywords - Biological processi

DNA replicationSAAS annotation

Keywords - Ligandi

ATP-binding, DNA-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA helicaseSAAS annotation (EC:3.6.4.12SAAS annotation)
Gene namesi
Name:mcm4Imported
OrganismiPlasmodium falciparumImported
Taxonomic identifieri5833 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ9GR06.

Interactioni

Protein-protein interaction databases

STRINGi5833.PF13_0095.

Structurei

3D structure databases

ProteinModelPortaliQ9GR06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini516 – 722207MCMInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MCM family.UniRule annotationSAAS annotation
Contains MCM domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG0478. Eukaryota.
COG1241. LUCA.

Family and domain databases

Gene3Di2.40.50.140. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR031327. MCM.
IPR008047. MCM_4.
IPR018525. MCM_CS.
IPR001208. MCM_dom.
IPR027925. MCM_N.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00493. MCM. 1 hit.
PF14551. MCM_N. 1 hit.
[Graphical view]
PRINTSiPR01657. MCMFAMILY.
PR01660. MCMPROTEIN4.
SMARTiSM00350. MCM. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00847. MCM_1. 1 hit.
PS50051. MCM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GR06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTPRRRLGQ QNNNNNSPFA LSSSNIFGSN NEIFGSNFMH TPMSSRRTKN
60 70 80 90 100
SKSFLNSMLN ESRYLNQSNA GSQFIKYGHT PLAIRRIKCA RADIGDVGRE
110 120 130 140 150
AFMEDEESGR LPHFIDSNLE QIKELFNQFF DEFNITNYSD VLDFTDEDRS
160 170 180 190 200
ISEYILLHRD NLKVYLAYYG WKMIKFIETG RQNECRLNNT NYEDDDENNE
210 220 230 240 250
NSEGIRNLEH IKSFEIDLTH IFFFNKKLYK LIIEYPSDCI SEIDKIISTK
260 270 280 290 300
YNSLLALVLE GDTRSSSSDK YPLSSTKQDY CRVRFFNKKH KDTPRKLGPN
310 320 330 340 350
QIETLVCVKG VIIRCSNIIP EMTMAAFKCT SKKRIGVNNY EKCNEEVYEH
360 370 380 390 400
VIQGEVQEPV TCSNCNNKNT FELWHNNCCF SSKQLIKLSE VTEHLKQGET
410 420 430 440 450
PQSISIYAYD DLIDYTKPGD TVELTGILKA SPVRLNPRSR CYNSVHRTYI
460 470 480 490 500
NVIHIKKENK QKMKLTEQND TANIILKRNE DGTVEENFEK LNEQGNLLFT
510 520 530 540 550
TEVIQKMEQL SKDPNIYQRL VDSIAPSIYG RGDIKKGLLC QLFGGSKITD
560 570 580 590 600
KYNNKYRSEI HILLRGDPST AKSQLLHYVH KLSPRGIYTS GKGSSSVGLT
610 620 630 640 650
AFISKDSETK EYILESGAVV LSDKGICCID EFDKMDDSAR AILHEVMEQQ
660 670 680 690 700
TVTIAKAGIV ATLNARTSIL ASANPINSRY DKNKAVVENI NLPPSLFSRF
710 720 730 740 750
DLIYLVIDQA NEDEDRKLAT VLCKNFSYNP EEEEDEDQED QEEDEPNYIT
760 770 780 790 800
QQRARKSKGT SRKNERENYY NDGDNDDDDD ISNYLNDSND AQNKRGSWAN
810 820 830 840 850
VNISYDEYNN SSNKKTSKNY LIDSNTLALY IAYCRITCNP IISLESKKII
860 870 880 890 900
IEEYIKMRCK EGTKSPTASP RQLEGLVRLS QSLAKMKLKR VVSPEEANEA
910 920 930 940 950
VRLMNIATFQ SLIDPLSGRI DFDQVNLGQT SQHKKKSDLI KDIIMNALVL
960 970 980 990 1000
KNMTKDELLT HCHETIMNDP QHTTSMDRKS FEEAFYDLEK SQEITRLCSG

LYKKK
Length:1,005
Mass (Da):115,228
Last modified:March 1, 2001 - v1
Checksum:i874FFB17C85EB9A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083323 Genomic DNA. Translation: AAG37988.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083323 Genomic DNA. Translation: AAG37988.1.

3D structure databases

ProteinModelPortaliQ9GR06.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5833.PF13_0095.

Proteomic databases

PaxDbiQ9GR06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0478. Eukaryota.
COG1241. LUCA.

Family and domain databases

Gene3Di2.40.50.140. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR031327. MCM.
IPR008047. MCM_4.
IPR018525. MCM_CS.
IPR001208. MCM_dom.
IPR027925. MCM_N.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00493. MCM. 1 hit.
PF14551. MCM_N. 1 hit.
[Graphical view]
PRINTSiPR01657. MCMFAMILY.
PR01660. MCMPROTEIN4.
SMARTiSM00350. MCM. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00847. MCM_1. 1 hit.
PS50051. MCM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Li J.-L.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 3D7AImported.
  2. "Identification of an MCM4 homologue expressed specifically in the sexual stage of Plasmodium falciparum."
    Li J.L., Cox L.S.
    Int. J. Parasitol. 31:1246-1252(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 3D7AImported.

Entry informationi

Entry nameiQ9GR06_PLAFA
AccessioniPrimary (citable) accession number: Q9GR06
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.