Q9GPN8 (Q9GPN8_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
1-beta dynein EMBL AAG29545.1

Gene names

Name:	kl-2 EMBL AAG29545.1
ORF Names:	CG17866 FlyBase FBgn0001313

Organism

Drosophila melanogaster (Fruit fly) EMBL AAG29545.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	4167 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU003299 Nucleotide-binding
Gene Ontology (GO)
Biological process	microtubule-based movement Inferred from electronic annotation. Source: InterPro
Cellular component	dynein complex Traceable author statement Ref.1. Source: FlyBase
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled Traceable author statement Ref.1. Source: FlyBase microtubule motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAG29545.1

Sequences

	Sequence		Length	Mass (Da)
	Q9GPN8 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 5FA88C54B67CC205	FASTA	4,167	483,040
	10 20 30 40 50 60 PTFVSQLIPR TIHLIRFIWL NSEQYNRRDL ITGIFRNLSN QIIRFCTEKV NVEKILSGSS 70 80 90 100 110 120 RFGIKICNMC IDCCLTYKGI YDIMSKTHAK INIRIGWSLD NAMIFNHVDA FMERLNDVID 130 140 150 160 170 180 ICESMMVFGR LDESESIPKP QFGGTSGTEF EATADNVENE FLVTLTALCT DSKEIILNVH 190 200 210 220 230 240 KNEWYEEVIK YRRTVQSMEE TVQRLMSNVF QHICNVEEAL ESLNVMIFYS YRSTIRKTFL 250 260 270 280 290 300 RQVSSAWVFF SNEIDSSVHM LMDRSKMHES WVPYYASRAL GYRVHLDRLV WLCNRLNSSD 310 320 330 340 350 360 WLPNVSEASV VLKKFESVRR EFDKEVKKSF DEWQKNCCSL LLNQKLDRYL LIRSKKKKGL 370 380 390 400 410 420 IECNIDRTIL TICEQAQHFE RLGLGVPGMV RKIYEKHETL RFVYNSVVQV CLNYNHILSA 430 440 450 460 470 480 LSEQERKLFR ALIQACDRKI APGVFKLTYG GELSDAYIAD CAKHTNKLQE TMDIYKRAIQ 490 500 510 520 530 540 NIARFCEKIC DTPMLKFNFS GAVTISIFEN HLSSYLRRVS NILRGFYSTI TDLIFAVFKE 550 560 570 580 590 600 FQAVIEDMPI EWYGFVNVFD DMLATAFLTS SKNSLNMLTN ALHRDPDMAA APILVMESDV 610 620 630 640 650 660 RERCIVLTPD IDVIANLLSG YIDRIHNILE QFPRIGIKMK LPKEHQYESF SKAFLEDSES 670 680 690 700 710 720 TQLICNIEAE INHEREEIDG YITFWNSHRM LWETTELEFT KRVKATQMTA DIFEASIEYY 730 740 750 760 770 780 SAMADDISYV DAITHVYFIL MNQNYIKSSI LDCIEKWQAL NIKILLSHSF SLIRAIYRYM 790 800 810 820 830 840 RKNERKMMMV PRTLKESLLA KQFFERIINE VPLKQAGFPP TLELFAILDK YQVEIPEEIR 850 860 870 880 890 900 VKVIGLEAAW HHYLKRLGEA DEMLDNNREE FKKILVQQAE KFKIILKEFL DDFFLKLPTS 910 920 930 940 950 960 ANINPRIALK FLRIIALKIE DCFTFEESLM RDLAVFNVNQ PESIDLRKLD FEVRIVKNIW 970 980 990 1000 1010 1020 ELIFEWQTNW EGWKKGYFWK MNINEMEDTA LNLYKEFTTL NKKFYDRHWE MLEATTKNVD 1030 1040 1050 1060 1070 1080 SFRRTLPLIT ALKNPCMRER HWNRVRDVIH VNFDENSKNF TLELIINLDF QAFSEDIQDI 1090 1100 1110 1120 1130 1140 SNSATMELQI ENSIKNIATI WKKQSFEMAF YHDGIYRIKN VEDCFQLLEE HMVQISAMKA 1150 1160 1170 1180 1190 1200 TRFVEPFITI VDYWEKTLSY ISETLEKGLT VQRQWLYLEN IFQGDDIRKQ LPEEAKRFAT 1210 1220 1230 1240 1250 1260 ITEEFRTISS KMFQAKTAVK ATNLRPPPFL LNRFSRMDER LELIQRALEI YLEAKRQLFP 1270 1280 1290 1300 1310 1320 RFYFISNDDL LEILGNSKRP DLVQTHLKKL FDNLYKLELK RVGKTLSRWQ ASGMHSDDGE 1330 1340 1350 1360 1370 1380 YVEFMMVIYI DGPSERWLKQ VEEYMLVVMK EMLKLTRGSL KKLVGNREKW ISLWPGQMVL 1390 1400 1410 1420 1430 1440 TTAQIQWTTE CTRSLIHCSM VDQKKPLRKL KKKQIKVLSK LSEMSRKDLT KTMRLKVNTL 1450 1460 1470 1480 1490 1500 ITLEIHGRDV IERMYKSNCK DTGHFEWFSQ LRFYWHRESE LCVIRQTNTE HWYGYEYTGN 1510 1520 1530 1540 1550 1560 SGRLVITPLT DRCYITLTTA LHLHRGGSPK GPAGTGKTET VKDLGKALGI WVIVTNCSEG 1570 1580 1590 1600 1610 1620 LDYKSIGKNF SGLAQSGCWG CFDEFNRINI EVLSVVAQQI MSIMAALSTK ALELMFEGQM 1630 1640 1650 1660 1670 1680 IKLKHTVGLF ITMNPGYAGR TELPDNLKSM FRPISMMVPD NIIIAENLLF SDGFTNTRNL 1690 1700 1710 1720 1730 1740 ARKVYTLYEL AKQQLSKQYH YDFGLRSMVA LLRYAGRKRR QLPNTTEEEI VYLAMKDMNV 1750 1760 1770 1780 1790 1800 ARLTANDLPL FNGIMSDIFP GVSLPTIDYS EFNIAIYEEF REAGLQPITI AVKKVIELFE 1810 1820 1830 1840 1850 1860 TKNSRHSVMI IGDTGTAKSV TWRTLQNCFY RMNSQRFSGW EAVTVYPVNP KALNLAELYG 1870 1880 1890 1900 1910 1920 EYNLSTGEWL DGVLSSIMRI ICGDEEPTQK WLLFDGPVDA VWIENMNSVM DDNKLLTLVN 1930 1940 1950 1960 1970 1980 SERITMPVQV SLLFEVGDLA VASPATVSRC GMVYNDYNDW GWKPFVNSWL QRLRIKEFAD 1990 2000 2010 2020 2030 2040 FLRIHFDYMV PKILDFKRMR CKEPVRTNEL NGVVSLCKLL EIFGTKVNGI NPINLELLEE 2050 2060 2070 2080 2090 2100 MTRLWFMFCL VWSICSSVDE DSRQRLDSFI RELESCFPIK DTVFDYFVDP NERTFLPWDS 2110 2120 2130 2140 2150 2160 KLLSSWKCDF ESPFYKIIVP TGDTVRYEYV VSKLLAEEYP VMLVGNVGTG KTSTAISVME 2170 2180 2190 2200 2210 2220 ACDKNKFCIL AVNMSAQTTA AGLQESIENR TEKRTKTQFV PIGGKRMICF MDDFNMPAKD 2230 2240 2250 2260 2270 2280 IYGSQPPLEL IRQWIDYKYW FNRKTQQKIY VQNTLLMAAM GPPGGGRQTI SSRTQSRFVL 2290 2300 2310 2320 2330 2340 LNLTFPSQET IIRIFGTMLC QKLESYPNEV REMWLPITLC TINLYVSMIS KMLPTPNKSH 2350 2360 2370 2380 2390 2400 YLFNLRDISK VFQGLLRSEK ELQNKKNFFL RLWVHECFRV FSDRLVDDSD QFWFVNTIND 2410 2420 2430 2440 2450 2460 ILGKHFEVTF HSLCPSKVPP FFGDFAHPQG FYEDLQVDFL RTFMKNQLEE YNNFPGMTRM 2470 2480 2490 2500 2510 2520 NLVFFREAIE HIVRILRVIS QPRGHILNMG IGGSGRQVLT KLAAFILEMA VFQIEVTKKY 2530 2540 2550 2560 2570 2580 KTGDFREDLK NLYKVTGIKQ RLTIFIFSSD QIAEVSFLEI TNNMLSTGEI NLFKSDEFDE 2590 2600 2610 2620 2630 2640 LKPELERPAK KNGVLLTTEA LYSYFILNVR DFLHVALCFS PIGENFRSYI RQYPALLSST 2650 2660 2670 2680 2690 2700 TPNWFRFWPQ EALLEVASHF LIGFPLNVVV SGKEDEKHRE SLVISTEAIL QRDIAYVFSV 2710 2720 2730 2740 2750 2760 IHSSVAKMSE NMYAEVKRYN YVTSPNYLQL VSGFKKLLEK KRLEVSTASN RLRNGLSKIS 2770 2780 2790 2800 2810 2820 ETQEKVSLMS EELKASSEQV KILARECEDF ISMIEIQKSE ATEQKEKVDA EAVLIRRDEI 2830 2840 2850 2860 2870 2880 ICLELAATAR ADLEVVMPMI DAAVKALDAL NKKDISEVKS YGRPPMKIEK VMEAVLILLG 2890 2900 2910 2920 2930 2940 KEPTWENAKK VLSESTFLND LKNFDRDHIS DKTLKRIAIY TKNPELEPDK VAVVSLACKS 2950 2960 2970 2980 2990 3000 LMQWIMAIEN YGKVYRIVAP KQEKLDSAMK SLEEKQAALA AAKKKLEELQ VVIEELYRQL 3010 3020 3030 3040 3050 3060 EEKTNLLNEL RAKEERLRKQ LERAIILVES LSGERERWIE TVNQLDLSFE KLPGDCLLSV 3070 3080 3090 3100 3110 3120 AFMSYLGAFD TKYREELLVK WSLLIKDLLI PATLELKVTY FLVDAVSIRE WNIQGLPADD 3130 3140 3150 3160 3170 3180 LSTENGVIVT QGSRWPLIID PQMQANNWIK NMEERNQLMT LDFGMADYLR QLERALKEGL 3190 3200 3210 3220 3230 3240 PVLLQNVGEY LDQAINPILR QSFTIQSGER LLKFNDKYIS YNNSFRFYIT TKISNPHYPP 3250 3260 3270 3280 3290 3300 EISSKTTIVN FALKQDGLEA QLLGIIVRKE KPALEEQKDE LVMTIARNKR TLIDLDNEIL 3310 3320 3330 3340 3350 3360 RLLNESRGSL LDDDELFSTL QKSRQTSVLV KESLSIAEVT EVEIDAARQE YKPASERASI 3370 3380 3390 3400 3410 3420 LFFVLMDMSK IDPMYVFSLA AYILLFTQSI ERSPRNQLVH ERIQNINEYH SYAVYRNTCR 3430 3440 3450 3460 3470 3480 GLFERHKLLF SIHMTAKILS NAGKLLEEEY DFILKGGIVL DKLGQAPNPA PWWISEQNWD 3490 3500 3510 3520 3530 3540 NITELDKVSG FHGIIDSFEQ HYKAWNGWYA TTFPEQEDLV GEWNDKLTDF QKICVLRSLR 3550 3560 3570 3580 3590 3600 PDRISFCLTQ FIITKLGPRY VDPPVLDLKA TFDESISQTP LIFVLSPGVD PAQSLISLSE 3610 3620 3630 3640 3650 3660 SVKMAQRMYS LSLGQGQAPI ATKLIMDGIK DGNWVFLANC HLSLSWMPTL DKMIATMQSM 3670 3680 3690 3700 3710 3720 KLHKKFRLWL SSSPHPDFPI SILQTSIKMT TEPPRGIKSN MKRLYNNINE ANMENCSEPS 3730 3740 3750 3760 3770 3780 KYKKLLFALC FFHTVLLERK KFLELGWNVI YSFNDSDFEV SEILLLLYLN EYEDTPWGAL 3790 3800 3810 3820 3830 3840 KYLIAGVNYG GHITDDWDRR LLITYINQFF CDQALQTRKF RLSTLPNYFI PDDGDVQSYL 3850 3860 3870 3880 3890 3900 DQIQMFPNFD KPDAFGQHSN ADIASLIGET RMLFEALLSM QVQTNSTSSN ENGETKVFDL 3910 3920 3930 3940 3950 3960 AKEILMNTPD EINYEQTAKI IGINRTPLEV VLLQEIERYN KLLVDMSTQL RDLRRGIQGL 3970 3980 3990 4000 4010 4020 VVMSSDLEDI YLAVSEGRVP LQWLKAYNSL KPLAAWARDL IHRVGHFNSW AKTLRPPILF 4030 4040 4050 4060 4070 4080 WLAAYTFPTG FVTAVLQTSA RATKTPIDEL SWDFYVFVEE DTAAARIIRE GGGVYIRSLF 4090 4100 4110 4120 4130 4140 LEGGGWLRKN QCLQDPLPME LICPLPVIHF KPVENLKKRC RGVYQCPAYY YPVRSGSFVI 4150 4160 AVDLKSGNEK ADYWIKRGTA LLLSLAN

References

[1]	"Y chromosomal fertility factors kl-2 and kl-3 of Drosophila melanogaster encode dynein heavy chain polypeptides." Carvalho A.B., Lazzaro B.P., Clark A.G. Proc. Natl. Acad. Sci. U.S.A. 97:13239-13244(2000) [PubMed: 11069293] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF313479 mRNA. Translation: AAG29545.1.
3D structure databases
ProteinModelPortal	Q9GPN8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9GPN8.
Proteomic databases
PRIDE	Q9GPN8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0001313. kl-2.
Phylogenomic databases
InParanoid	Q9GPN8.
Gene expression databases
ArrayExpress	Q9GPN8.
Bgee	Q9GPN8.
Family and domain databases
InterPro	IPR003593. ATPase_AAA+_core. IPR011704. ATPase_dyneun-rel_AAA. IPR024743. Dynein_HC_stalk. IPR004273. Dynein_heavy. IPR024317. Dynein_heavy_chain_D4_dom. IPR013594. Dynein_heavy_dom-1. IPR013602. Dynein_heavy_dom-2. [Graphical view]
Pfam	PF07728. AAA_5. 1 hit. PF12780. AAA_8. 1 hit. PF08385. DHC_N1. 1 hit. PF08393. DHC_N2. 1 hit. PF03028. Dynein_heavy. 1 hit. PF12777. MT. 1 hit. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9GPN8_DROME

Accession

Primary (citable) accession number: Q9GPN8

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2001
Last sequence update:	March 1, 2001
Last modified:	December 14, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)