Dally-like protein - Drosophila melanogaster (Fruit fly)

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Unreviewed, UniProtKB/TrEMBL Q9GPL5 (Q9GPL5_DROME)

Last modified January 19, 2010. Version 44. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein names

Submitted name:
Dally-like protein EMBL AAG38110.1

Gene names

Name:	dlp FlyBase FBgn0041604
ORF Names:	CG32146 FlyBase FBgn0041604

Organism

Drosophila melanogaster (Fruit fly) EMBL AAG38110.1

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	765 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cell surface proteoglycan that bears heparan sulfate By similarity. RuleBase RU003519V0
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor By similarity RuleBase RU003519V0.
Sequence similarities	Belongs to the glypican family.

Ontologies

Keywords
Cellular component	Membrane
PTM	GPI-anchor RuleBase RU003519V0 Glycoprotein Heparan sulfate RuleBase RU003519V0 Lipoprotein Proteoglycan
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Ref.1 Inferred from genetic interaction. Source: FlyBase axon guidance Inferred from mutant phenotype. Source: FlyBase compound eye development Inferred from mutant phenotype. Source: FlyBase detection of light stimulus involved in visual perception Inferred from mutant phenotype. Source: FlyBase imaginal disc-derived wing margin morphogenesis Inferred from mutant phenotype. Source: FlyBase positive regulation of smoothened signaling pathway Inferred from mutant phenotype. Source: FlyBase regulation of imaginal disc growth Inferred from mutant phenotype. Source: FlyBase segment polarity determination Inferred from mutant phenotype. Source: FlyBase smoothened signaling pathway Inferred from mutant phenotype. Source: FlyBase wing disc dorsal/ventral pattern formation Inferred from expression pattern. Source: FlyBase
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proteinaceous extracellular matrix Inferred from electronic annotation. Source: InterPro
Molecular function	heparan sulfate proteoglycan binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

Q9GPL5-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 10AA23C87A31B3EB
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765

85,388

        10         20         30         40         50         60 
MLHQEQQQQH LHCRRKVTAT TTARLVIFSS PLLLLLLTTH LPSTLQADNS PAPQVAALAA 

        70         80         90        100        110        120 
PNPAGGVAGS SIIDQFSPNC SAVTHIFQAR GIDAIEIPQK PSNERVLRYC ESPSVGTCCT 

       130        140        150        160        170        180 
YNMETRMAMQ SRQQLEGHTK DQISRMSGIL GSKATKFKDI FTALLKESRT QFNSMFIRTY 

       190        200        210        220        230        240 
GVIYERNSYV FSDLFKELET YFANGRVDLL EVMDKFFNTL YQKMFTVLNT QYTFDENYMR 

       250        260        270        280        290        300 
CVSEHMKELK PFGDVPDKLS VQIKRSFVAT RTYGQALTTA SEVAKKVLNV RLNADCTGAL 

       310        320        330        340        350        360 
TKMQHCGACK GYTEKPCTNY CVNVIKGCLH YQHEFDSEWE NFAMAMDKVA ERLLGSFNIV 

       370        380        390        400        410        420 
MVVEPLNIKI SEAIMNFQDS GQDITNRVFQ GCGRPKLKKM KRSISPKLQG VQILNARSPV 

       430        440        450        460        470        480 
EADTLDIDET LDEAIVLRER RAAEPGSQET SSQQSQEQGV GKSGNGGGGG GGNNRRQQQR 

       490        500        510        520        530        540 
RKQQQQRRKQ QNNRDDNDDD DNESGGGREP ILDRIVRDIR QRVKDYKKFW SNLPHSVCSN 

       550        560        570        580        590        600 
EDIASSSDVD GMCWNGHTID RYMHSITTEH GSNPEFTGNP ASTKQTAQMA SQLSHLKNAI 

       610        620        630        640        650        660 
VHLRNAYNGQ DVEWSEQEEL PYAGSGAGSG SGSEDDEDDD EGSGLGPFEP SHKPDVERPS 

       670        680        690        700        710        720 
VDADNDDDED AGGRGHMPTH TSRPTSGVDD KNPLIHTTHF DQDHNDLDED HRQLDEDEDT 

       730        740        750        760 
DAGHDGANDN RSSDAPEKMT LRRALVVYLL PLYMAWFGGV CADLL

References

[1]	"Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless." Baeg G.H., Lin X., Khare N., Baumgartner S., Perrimon N. Development 128:87-94(2001) [PubMed: 11092814] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF317090 mRNA. Translation: AAG38110.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9GPL5.
Proteomic databases
PRIDE	Q9GPL5.
Genome annotation databases
Ensembl	FBtr0075679; FBpp0075431; FBgn0041604; Drosophila melanogaster. [Genome view] FBtr0075680; FBpp0089384; FBgn0041604; Drosophila melanogaster. [Genome view]
Organism-specific databases
FlyBase	FBgn0041604. dlp.
Phylogenomic databases
InParanoid	Q9GPL5.
Gene expression databases
ArrayExpress	Q9GPL5.
Bgee	Q9GPL5.
Family and domain databases
InterPro	IPR001863. Glypican. [Graphical view]
PANTHER	PTHR10822. Glypican. 1 hit.
Pfam	PF01153. Glypican. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9GPL5_DROME

Accession

Primary (citable) accession number: Q9GPL5

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2001
Last sequence update:	March 1, 2001
Last modified:	January 19, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information