Q9GPG0 (Q9GPG0_MANSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Juvenile hormone esterase EMBL AAG42021.2
Organism	Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) EMBL AAG42021.2
Taxonomic identifier	7130 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Amphiesmenoptera › Lepidoptera › Glossata › Neolepidoptera › Heteroneura › Ditrysia › Obtectomera › Bombycoidea › Sphingidae › Sphinginae › Sphingini › Manduca

Protein attributes

Sequence length	573 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Molecular function	Hydrolase SAAS SAAS019826 RuleBase RU003418
Technical term	3D-structure PDB 2FJ0
Gene Ontology (GO)
Molecular_function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9GPG0 [UniParc]. Last modified September 27, 2005. Version 2. Checksum: 0DDAA66CC74F375C	FASTA	573	64,572
	10 20 30 40 50 60 MDARRQVCYY VLALLCVSEL SARIPSTEEV VVRTESGWIR GLKRRAEGNK SYASFRGVPY 70 80 90 100 110 120 AKQPLGELRF KELQPLEPWQ DELDATQEGP VCQQTDVLYG RIMRPRGMSE ACIHANIHVP 130 140 150 160 170 180 YYALPRDAAD KNRFAGLPVL VFIHGGGFAF GSGDSDLHGP EYLVSKDVIV ITFNYRLNVY 190 200 210 220 230 240 GFLSLNSTSV PGNAGLRDMV TLLKWVQRNA HFFGGRPDDV TLMGQSAGAA ATHILSLSKA 250 260 270 280 290 300 ADGLFRRAIL MSGTSSSAFF TTNPVFAQYI NKLFVTNIGI TATDPEEIHQ KLIEMPAEKL 310 320 330 340 350 360 NEANRFLLEQ FGLTTFFPVV ESPINGVTTI LDGDPEQLIA KGRGKHIPLI IGFTDAECEI 370 380 390 400 410 420 FRRQFEQIDI VSKIKENPGI LVPLSVLFSS APDTVAEITK AMHEKYFKKS VDMEGYIELC 430 440 450 460 470 480 TDSYFMYPAI SLAIKRARSN GAPVYLYQFS FDGDYSVFRE VNHLNFEGAG HIEDLTYVFR 490 500 510 520 530 540 TNSMLGGHAS FPPHDKDDHM KYWMTSFITN FMKYSNPVTD AKLWPEVRAD NLRYQDIDTP 550 560 570 DVYQNVKPHS EQRDMLDFFD SIYNWNGTSY CIK

References

[1]	"Purification of juvenile hormone esterase and molecular cloning of the cDNA from Manduca sexta." Hinton A.C., Hammock B.D. Insect Biochem. Mol. Biol. 32:57-66(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"In vitro expression and biochemical characterization of juvenile hormone esterase from Manduca sexta." Hinton A.C., Hammock B.D. Insect Biochem. Mol. Biol. 33:317-329(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	Hinton A.C. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	"Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta." Wogulis M., Wheelock C.E., Kamita S.G., Hinton A.C., Whetstone P.A., Hammock B.D., Wilson D.K. Biochemistry 45:4045-4057(2006) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 23-573.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF327882 mRNA. Translation: AAG42021.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2FJ0	X-ray	2.70	A	23-573	[»]

ProteinModelPortal

Q9GPG0.

SMR

Q9GPG0. Positions 28-565.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Enzyme and pathway databases

BRENDA

3.1.1.59. 15145.

Family and domain databases

InterPro

IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
[Graphical view]

Pfam

PF00135. COesterase. 1 hit.
[Graphical view]

PROSITE

PS00122. CARBOXYLESTERASE_B_1. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChEMBL

CHEMBL1075266.

EvolutionaryTrace

Q9GPG0.

Entry information

Entry name

Q9GPG0_MANSE

Accession

Primary (citable) accession number: Q9GPG0

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2001
Last sequence update:	September 27, 2005
Last modified:	April 3, 2013
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)