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Q9GP38

- MPI_ECHMU

UniProt

Q9GP38 - MPI_ECHMU

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Protein

Probable mannose-6-phosphate isomerase

Gene
PMIH
Organism
Echinococcus multilocularis (Fox tapeworm)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi103 – 1031Zinc By similarity
Metal bindingi105 – 1051Zinc By similarity
Metal bindingi130 – 1301Zinc By similarity
Metal bindingi277 – 2771Zinc By similarity
Active sitei296 – 2961 By similarity

GO - Molecular functioni

  1. mannose-6-phosphate isomerase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00126; UER00423.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Name:PMIH
OrganismiEchinococcus multilocularis (Fox tapeworm)
Taxonomic identifieri6211 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesCestodaEucestodaCyclophyllideaTaeniidaeEchinococcus

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Probable mannose-6-phosphate isomerasePRO_0000194234Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9GP38.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR10309. PTHR10309. 1 hit.
PfamiPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSiPR00714. MAN6PISMRASE.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 1 hit.
PROSITEiPS00966. PMI_I_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GP38-1 [UniParc]FASTAAdd to Basket

« Hide

MLRLKCASQR YDWGKVGVNS IVYKLQVASE NPDISHVDLP YAELWMGTHP    50
SGSSCLWDNP HVTLAAHIQE NPASLGKPSL IYFGRRLPFL FKVLSVAKAL 100
SIQAHPDKKM AVRLHAEQPD LYKDGSHKPE MAIALTDFEA LLGFRPLNQI 150
LAFIQAFPEL AELTTLELPS PEEKRDVQPP SIKQLYSNLM RSSPEKVEST 200
IKSLLNRFTT GSKSVCDPPL SILGVDLQEE DVQALVDLFL RLTQAFPGDV 250
GCLSIFFLNY IRLKSGEAIF LKANTPHAYL SGDCVECMAN SDNVVRAGLT 300
PKFKDVERLL EMLDYTPLTD SLRLGATQPI PTPEGISMKS FIPPVSEFAV 350
DVIQFDAESR GFSLPSVPTA SILLFLHGQG TITCPSTGEA CSQETKFGPG 400
FVYFVPADMI VNLVSKEDRK GSLHAFRAYV NRK 433
Length:433
Mass (Da):47,858
Last modified:March 1, 2001 - v1
Checksum:i708C1268CECEB65D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ292370 mRNA. Translation: CAC18544.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ292370 mRNA. Translation: CAC18544.1 .

3D structure databases

ProteinModelPortali Q9GP38.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00423 .

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR10309. PTHR10309. 1 hit.
Pfami PF01238. PMI_typeI. 1 hit.
[Graphical view ]
PIRSFi PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSi PR00714. MAN6PISMRASE.
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR00218. manA. 1 hit.
PROSITEi PS00966. PMI_I_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "mRNA trans-splicing in the human parasitic cestode Echinococcus multilocularis."
    Brehm K., Jensen K., Frosch M.
    J. Biol. Chem. 275:38311-38318(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: H-95.

Entry informationi

Entry nameiMPI_ECHMU
AccessioniPrimary (citable) accession number: Q9GP38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2001
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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