Reviewed, UniProtKB/Swiss-Prot Q9GP38 (MPI_ECHMU)

Names and origin

Protein names

Recommended name:
    Probable mannose-6-phosphate isomerase
    EC=5.3.1.8
Alternative name(s):
    Phosphomannose isomerase
      Short name=PMI
    Phosphohexomutase

Gene names

Name:

PMIH

Organism

Echinococcus multilocularis

Taxonomic identifier

6211 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Platyhelminthes › Cestoda › Eucestoda › Cyclophyllidea › Taeniidae › Echinococcus

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.
Catalytic activity	D-mannose 6-phosphate = D-fructose 6-phosphate.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the mannose-6-phosphate isomerase type 1 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	mannose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 433	433	Probable mannose-6-phosphate isomerase		PRO_0000194234
Sites
	Active site	296	1	By similarity
	Metal binding	103	1	Zinc By similarity
	Metal binding	105	1	Zinc By similarity
	Metal binding	130	1	Zinc By similarity
	Metal binding	277	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9GP38-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 708C1268CECEB65D	FASTA	433	47,858
	10 20 30 40 50 60 MLRLKCASQR YDWGKVGVNS IVYKLQVASE NPDISHVDLP YAELWMGTHP SGSSCLWDNP 70 80 90 100 110 120 HVTLAAHIQE NPASLGKPSL IYFGRRLPFL FKVLSVAKAL SIQAHPDKKM AVRLHAEQPD 130 140 150 160 170 180 LYKDGSHKPE MAIALTDFEA LLGFRPLNQI LAFIQAFPEL AELTTLELPS PEEKRDVQPP 190 200 210 220 230 240 SIKQLYSNLM RSSPEKVEST IKSLLNRFTT GSKSVCDPPL SILGVDLQEE DVQALVDLFL 250 260 270 280 290 300 RLTQAFPGDV GCLSIFFLNY IRLKSGEAIF LKANTPHAYL SGDCVECMAN SDNVVRAGLT 310 320 330 340 350 360 PKFKDVERLL EMLDYTPLTD SLRLGATQPI PTPEGISMKS FIPPVSEFAV DVIQFDAESR 370 380 390 400 410 420 GFSLPSVPTA SILLFLHGQG TITCPSTGEA CSQETKFGPG FVYFVPADMI VNLVSKEDRK 430 GSLHAFRAYV NRK

References

[1]	"mRNA trans-splicing in the human parasitic cestode Echinococcus multilocularis." Brehm K., Jensen K., Frosch M. J. Biol. Chem. 275:38311-38318(2000) [PubMed: 10973970] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: H-95.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ292370 mRNA. Translation: CAC18544.1.
3D structure databases
HSSP	HSSP built from PDB template 1PMI based on UniProtKB P34948.
ModBase	Search...
Enzyme and pathway databases
BRENDA	5.3.1.8. 74242.
Family and domain databases
InterPro	IPR001250. Man6P_Isoase-1. IPR016305. Mannose-6-P_Isomerase. IPR018050. Pmannose_isomerase-type1_CS. IPR014710. RmlC-like_jellyroll. [Graphical view]
Gene3D	G3DSA:2.60.120.10. RmlC-like_jellyroll. 2 hits.
Pfam	PF01238. PMI_typeI. 1 hit. [Graphical view]
PIRSF	PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTS	PR00714. MAN6PISMRASE.
TIGRFAMs	TIGR00218. manA. 1 hit.
PROSITE	PS00965. PMI_I_1. False negative. PS00966. PMI_I_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MPI_ECHMU

Accession

Primary (citable) accession number: Q9GP38

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 25, 2003
Last sequence update:	March 1, 2001
Last modified:	September 22, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)