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Q9GP38 (MPI_ECHMU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable mannose-6-phosphate isomerase

EC=5.3.1.8
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name=PMI
Gene names
Name:PMIH
OrganismEchinococcus multilocularis (Fox tapeworm)
Taxonomic identifier6211 [NCBI]
Taxonomic lineageEukaryotaMetazoaPlatyhelminthesCestodaEucestodaCyclophyllideaTaeniidaeEchinococcus

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.

Catalytic activity

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the mannose-6-phosphate isomerase type 1 family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
Zinc
   Molecular functionIsomerase
Gene Ontology (GO)
   Biological_processGDP-mannose biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmannose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Probable mannose-6-phosphate isomerase
PRO_0000194234

Sites

Active site2961 By similarity
Metal binding1031Zinc By similarity
Metal binding1051Zinc By similarity
Metal binding1301Zinc By similarity
Metal binding2771Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9GP38 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 708C1268CECEB65D

FASTA43347,858
        10         20         30         40         50         60 
MLRLKCASQR YDWGKVGVNS IVYKLQVASE NPDISHVDLP YAELWMGTHP SGSSCLWDNP 

        70         80         90        100        110        120 
HVTLAAHIQE NPASLGKPSL IYFGRRLPFL FKVLSVAKAL SIQAHPDKKM AVRLHAEQPD 

       130        140        150        160        170        180 
LYKDGSHKPE MAIALTDFEA LLGFRPLNQI LAFIQAFPEL AELTTLELPS PEEKRDVQPP 

       190        200        210        220        230        240 
SIKQLYSNLM RSSPEKVEST IKSLLNRFTT GSKSVCDPPL SILGVDLQEE DVQALVDLFL 

       250        260        270        280        290        300 
RLTQAFPGDV GCLSIFFLNY IRLKSGEAIF LKANTPHAYL SGDCVECMAN SDNVVRAGLT 

       310        320        330        340        350        360 
PKFKDVERLL EMLDYTPLTD SLRLGATQPI PTPEGISMKS FIPPVSEFAV DVIQFDAESR 

       370        380        390        400        410        420 
GFSLPSVPTA SILLFLHGQG TITCPSTGEA CSQETKFGPG FVYFVPADMI VNLVSKEDRK 

       430 
GSLHAFRAYV NRK 

« Hide

References

[1]"mRNA trans-splicing in the human parasitic cestode Echinococcus multilocularis."
Brehm K., Jensen K., Frosch M.
J. Biol. Chem. 275:38311-38318(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: H-95.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ292370 mRNA. Translation: CAC18544.1.

3D structure databases

ProteinModelPortalQ9GP38.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00126; UER00423.

Family and domain databases

Gene3D2.60.120.10. 3 hits.
InterProIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR10309. PTHR10309. 1 hit.
PfamPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSPR00714. MAN6PISMRASE.
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR00218. manA. 1 hit.
PROSITEPS00966. PMI_I_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPI_ECHMU
AccessionPrimary (citable) accession number: Q9GP38
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2001
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways