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Q9GP32 (ALF_ECHMU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase

EC=4.1.2.13
Gene names
Name:FBPA
OrganismEchinococcus multilocularis (Fox tapeworm)
Taxonomic identifier6211 [NCBI]
Taxonomic lineageEukaryotaMetazoaPlatyhelminthesCestodaEucestodaCyclophyllideaTaeniidaeEchinococcus

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Sequence similarities

Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandSchiff base
   Molecular functionLyase
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Fructose-bisphosphate aldolase
PRO_0000216933

Sites

Active site1881Proton acceptor By similarity
Active site2301Schiff-base intermediate with dihydroxyacetone-P By similarity
Binding site561Substrate By similarity
Binding site1471Substrate By similarity
Site3631Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

Sequences

Sequence LengthMass (Da)Tools
Q9GP32 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 37862DEC55BA2B70

FASTA36339,727
        10         20         30         40         50         60 
MSRFVPYLCA EKMKELRENA SAIVAPGKGL LAADESTNTI GKRFAAINLE NTEENRRAYR 

        70         80         90        100        110        120 
ELLFTTDPEF AKHISGVILF HETVYQKTKD GKPFVELLRE RGVLPGIKVD LGVVPLGGTA 

       130        140        150        160        170        180 
DECTTQGLDN LAQRCAQYYN DGCRFAKWRC VLKISSHNPS YLAMLENANV LARYAFICQQ 

       190        200        210        220        230        240 
NGLVPIVEPE VLPDGDHDLE TAQRVTEQVL SFVYKALADH HVYLEGTLLK PNMVTCGQSC 

       250        260        270        280        290        300 
TKKYSVEDNA RATVEALQRT VPVAVPGVVF LSGGQSELDA TRNLNAINKY PGKKPWALSF 

       310        320        330        340        350        360 
SFGRALQASA IAAWQGKPEN VKAGQAEFLQ LAKANGAASL GKFEGELKTA AGQKSLFVAN 


HAY 

« Hide

References

[1]"mRNA trans-splicing in the human parasitic cestode Echinococcus multilocularis."
Brehm K., Jensen K., Frosch M.
J. Biol. Chem. 275:38311-38318(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: H-95.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ292376 mRNA. Translation: CAC18550.1.

3D structure databases

ProteinModelPortalQ9GP32.
SMRQ9GP32. Positions 2-363.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9GP32.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00109; UER00183.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR000741. Aldolase_I.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERPTHR11627. PTHR11627. 1 hit.
PfamPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALF_ECHMU
AccessionPrimary (citable) accession number: Q9GP32
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2001
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways