Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

GD25630

Gene

Hex-C

Organism
Drosophila simulans (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. kinase activity Source: UniProtKB-KW
  3. phosphotransferase activity, alcohol group as acceptor Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
GD25630Imported
Submitted name:
Hexokinase-CImported
Gene namesi
Name:Hex-CImported
Synonyms:Dsim\GD25630Imported
ORF Names:Dsim_GD25630Imported, GD25630Imported
OrganismiDrosophila simulans (Fruit fly)Imported
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000304 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0196916. Dsim\GD25630.
FBgn0021123. Dsim\Hex-C.

Structurei

3D structure databases

ProteinModelPortaliQ9GNF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation
Contains 1 hexokinase type-1 domain.UniRule annotation
Contains 1 hexokinase type-2 domain.UniRule annotation

Phylogenomic databases

KOiK00844.
OrthoDBiEOG7S21X5.
PhylomeDBiQ9GNF7.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.

Sequencei

Sequence statusi: Complete.

Q9GNF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDAEVRELM QPFVLSDYQV QEVYSRFCLE VARGLKRSTH PQANVKCFPT
60 70 80 90 100
YVQDLPTGDE MGKYLALDLG GTNFRVLLVS LKGHHDATVD SQIYAVPKDL
110 120 130 140 150
MVGPGVDLFD HIAGCLAKFV EKHDMKTAYL PLGFTFSFPC VQQGLKEGIL
160 170 180 190 200
VRWTKGFDCA GVEGEDVGRM LHEAIQRRGD ADIAVVAILN DTTGTLMSCA
210 220 230 240 250
HRNADCRVGV IVGTGCNACY VEDVENVDLL RADFKKTKRS VIVNAEWGAF
260 270 280 290 300
GEGGQLDFVR TEYDREIDEK SLNRSEQLFE KMTAGMYLGN LVRLVLLRAL
310 320 330 340 350
ERKLIFKQSS RRPEFASVLQ RNEEVFETRY ISEIEDDSFP EFASTRKIVK
360 370 380 390 400
NLFGLEKASV EDCQTLRYIC ECVAKRAATL VAIGVSGLVN RTSNRRVIVG
410 420 430 440 450
MDGSVYRYHP KFDAYMRQTL QKLVKADKEW DIMLSEDGSG RGAALVAAVA

SKTK
Length:454
Mass (Da):50,767
Last modified:March 1, 2001 - v1
Checksum:i410AF39A159EFF6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257623 Genomic DNA. Translation: AAG22929.1.
AF257624 Genomic DNA. Translation: AAG22930.1.
AF257625 Genomic DNA. Translation: AAG22931.1.
AF257626 Genomic DNA. Translation: AAG22932.1.
AF257627 Genomic DNA. Translation: AAG22933.1.
AF257628 Genomic DNA. Translation: AAG22934.1.
AF257629 Genomic DNA. Translation: AAG22935.1.
AF257630 Genomic DNA. Translation: AAG22936.1.
AF257631 Genomic DNA. Translation: AAG22937.1.
AF257632 Genomic DNA. Translation: AAG22938.1.
AF257633 Genomic DNA. Translation: AAG22939.1.
AF257634 Genomic DNA. Translation: AAG22940.1.
AF257635 Genomic DNA. Translation: AAG22941.1.
AF257636 Genomic DNA. Translation: AAG22942.1.
CM000362 Genomic DNA. Translation: EDX07187.1.
RefSeqiXP_002081602.1. XM_002081566.1.
UniGeneiDsi.5327.

Genome annotation databases

EnsemblMetazoaiFBtr0225540; FBpp0224032; FBgn0196916.
GeneIDi6734594.
KEGGidsi:Dsim_GD25630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257623 Genomic DNA. Translation: AAG22929.1.
AF257624 Genomic DNA. Translation: AAG22930.1.
AF257625 Genomic DNA. Translation: AAG22931.1.
AF257626 Genomic DNA. Translation: AAG22932.1.
AF257627 Genomic DNA. Translation: AAG22933.1.
AF257628 Genomic DNA. Translation: AAG22934.1.
AF257629 Genomic DNA. Translation: AAG22935.1.
AF257630 Genomic DNA. Translation: AAG22936.1.
AF257631 Genomic DNA. Translation: AAG22937.1.
AF257632 Genomic DNA. Translation: AAG22938.1.
AF257633 Genomic DNA. Translation: AAG22939.1.
AF257634 Genomic DNA. Translation: AAG22940.1.
AF257635 Genomic DNA. Translation: AAG22941.1.
AF257636 Genomic DNA. Translation: AAG22942.1.
CM000362 Genomic DNA. Translation: EDX07187.1.
RefSeqiXP_002081602.1. XM_002081566.1.
UniGeneiDsi.5327.

3D structure databases

ProteinModelPortaliQ9GNF7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0225540; FBpp0224032; FBgn0196916.
GeneIDi6734594.
KEGGidsi:Dsim_GD25630.

Organism-specific databases

FlyBaseiFBgn0196916. Dsim\GD25630.
FBgn0021123. Dsim\Hex-C.

Phylogenomic databases

KOiK00844.
OrthoDBiEOG7S21X5.
PhylomeDBiQ9GNF7.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Contrasting molecular population genetics of four hexokinases in Drosophila melanogaster, D. simulans and D. yakuba."
    Duvernell D.D., Eanes W.F.
    Genetics 156:1191-1201(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CT96_2sImported, CT96_5sImported, CT96_6sImported, DPF96_3sImported, GA96_2sImported, GA96_4sImported, GA96_5sImported, HFL97_1sImported, HFL97_2sImported, HFL97_4sImported, VA96_5sImported, VA96_6sImported, VA96_7sImported and VA96_8sImported.
  2. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MixedImported.
  3. FlyBase
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ9GNF7_DROSI
AccessioniPrimary (citable) accession number: Q9GNF7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: April 1, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.