Reviewed, UniProtKB/Swiss-Prot Q9GN94 (ADH_DROSE)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase
    EC=1.1.1.1

Gene names

Name:	Adh
ORF Names:	GM15656

Organism

Drosophila sechellia (Fruit fly)

Taxonomic identifier

7238 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cellular alcohol metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 256	255	Alcohol dehydrogenase		PRO_0000054493
Regions
	Nucleotide binding	12 – 35	24	NAD By similarity
Sites
	Active site	153	1	Proton acceptor By similarity
	Binding site	140	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9GN94-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 2BEC8BDBFFD7E00B	FASTA	256	27,745
	10 20 30 40 50 60 MAFTLTNKNV IFVAGLGGIG LDTSKELLKR DLKNLVILDR IENPAAIAEL KAINPKVTVT 70 80 90 100 110 120 FYPYDVTVPI AETTKLLKTI FAKLKTVDVL INGAGILDDH QIERTIAVNY TGLVNTTTAI 130 140 150 160 170 180 LDFWDKRKGG PGGIICNIGS VTGFNAIYQV PVYSGTKAAV VNFTSSLAKL APITGVTAYT 190 200 210 220 230 240 VNPGITRTTL VHKFNSWLDV EPQVAEKLLA HPTQPSLACA ENFVKAIELN QNGAIWKLDL 250 GTLEAIQWTK HWDSGI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary genetics of two sibling species, Drosophila simulans and D. sechellia." Coyne J.A., Kreitman M. Evolution 40:673-691(1985) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed: 17994087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Rob3c / Tucson 14021-0248.25.
[3]	"The population genetics of the origin and divergence of the Drosophila simulans complex species." Kliman R.M., Andolfatto P., Coyne J.A., Depaulis F., Kreitman M., Berry A.J., McCarter J., Wakeley J., Hey J. Genetics 156:1913-1931(2000) [PubMed: 11102384] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-220. Strain: 24 and SS77.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X04672 Genomic DNA. Translation: CAA28377.1. CH480818 Genomic DNA. Translation: EDW51762.1. AF284480 Genomic DNA. Translation: AAG28713.1. AF284481 Genomic DNA. Translation: AAG28714.1.
PIR	S07439.
RefSeq	XP_002035839.1.
3D structure databases
HSSP	HSSP built from PDB template 1B16 based on UniProtKB P10807.
SMR	Q9GN94. Positions 2-256.
ModBase	Search...
Genome annotation databases
GeneID	6611292.
KEGG	dse:Dsec_GM15656.
Organism-specific databases
FlyBase	FBgn0012780. Dsec\Adh.
Enzyme and pathway databases
BRENDA	1.1.1.1. 300118.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002425. Insect_ADH. IPR002424. Insect_AlcDH_fam. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01168. ALCDHDRGNASE. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
ProDom	PD000819. SRP54. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH_DROSE

Accession

Primary (citable) accession number: Q9GN94
Secondary accession number(s): B4HXI2, P07163

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 40 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project