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Protein

Mitochondrial brown fat uncoupling protein 1

Gene

UCP1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.By similarity

Enzyme regulationi

Has no constitutive proton transporter activity and has to be activated by long-chain fatty acids/LCFAs. Inhibited by purine nucleotides. Both purine nucleotides and LCFAs bind the cytosolic side of the transporter and directly compete to activate or inhibit it. Activated by noradrenaline and reactive oxygen species.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial brown fat uncoupling protein 1Curated
Short name:
UCP 1Curated
Alternative name(s):
Solute carrier family 25 member 7By similarity
ThermogeninBy similarity
Gene namesi
Name:UCP11 Publication
Synonyms:SLC25A7By similarity
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

  • Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10Mitochondrial intermembraneBy similarity10
Transmembranei11 – 32Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini33 – 75Mitochondrial matrixBy similarityAdd BLAST43
Transmembranei76 – 98Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini99 – 118Mitochondrial intermembraneBy similarityAdd BLAST20
Transmembranei119 – 135Helical; Name=3Sequence analysisAdd BLAST17
Topological domaini136 – 180Mitochondrial matrixBy similarityAdd BLAST45
Transmembranei181 – 197Helical; Name=4Sequence analysisAdd BLAST17
Topological domaini198 – 214Mitochondrial intermembraneBy similarityAdd BLAST17
Transmembranei215 – 234Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini235 – 268Mitochondrial matrixBy similarityAdd BLAST34
Transmembranei269 – 291Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini292 – 309Mitochondrial intermembraneBy similarityAdd BLAST18

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906551 – 309Mitochondrial brown fat uncoupling protein 1Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei256Cysteine sulfenic acid (-SOH)By similarity1

Post-translational modificationi

May undergo sulfenylation upon cold exposure. May increase the sensitivity of UCP1 thermogenic function to the activation by noradrenaline probably through structural effects.By similarity
May undergo ubiquitin-mediated proteasomal degradation.By similarity

Keywords - PTMi

Oxidation

Proteomic databases

PaxDbiQ9GMZ1.

Interactioni

Subunit structurei

Most probably functions as a monomer. Binds one purine nucleotide per monomer. However, has also been suggested to function as a homodimer or a homotetramer. Tightly associates with cardiolipin in the mitochondrion inner membrane; may stabilize and regulate its activity.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000005489.

Structurei

3D structure databases

ProteinModelPortaliQ9GMZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 104Solcar 1Add BLAST94
Repeati113 – 203Solcar 2Add BLAST91
Repeati212 – 297Solcar 3Add BLAST86

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiQ9GMZ1.
KOiK08769.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002030. Mit_uncoupling_UCP-like.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9GMZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRAPGSDAP PTLSVRIAAA AGAACLADMI TFPLDTAKVR LQIQGEGQGQ
60 70 80 90 100
PPRAPRYRGV LGTVATLART EGLQKLYSGL PAGLQRQVGF ASLRIGLYDS
110 120 130 140 150
VREWLSPGQG AAASLGSRIS AGVMTGGAAV FIGQPTEVVK VRLQAQSHLH
160 170 180 190 200
GRKPRYTGTY NAYRIIATTE GLTGLWKGTT PNLMRNVIIN CTELVTYDLM
210 220 230 240 250
KEALVKNHLL ADDLPCHFLS ALVAGFCTTV LSSPVDVVKT RFVNSVPEQY
260 270 280 290 300
TSVPNCAMTM LTKEGPLAFF KGFVPSFLRL GSWNVIMFVC FEQLKRELMK

SGRTVDCAT
Length:309
Mass (Da):33,280
Last modified:March 1, 2001 - v1
Checksum:iC4D33E2A3B08F16E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046106 mRNA. Translation: BAB11684.1.
RefSeqiNP_001003046.1. NM_001003046.1.
UniGeneiCfa.91.

Genome annotation databases

GeneIDi403574.
KEGGicfa:403574.

Similar proteinsi

Entry informationi

Entry nameiUCP1_CANLF
AccessioniPrimary (citable) accession number: Q9GMZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2001
Last modified: August 30, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families