Reviewed, UniProtKB/Swiss-Prot Q9GME3 (DHB8_CALJA)

Names and origin

Protein names

Recommended name:
    Estradiol 17-beta-dehydrogenase 8
    EC=1.1.1.62
Alternative name(s):
    Testosterone 17-beta-dehydrogenase 8
    EC=1.1.1.63
    17-beta-hydroxysteroid dehydrogenase 8
      Short name=17-beta-HSD 8

Gene names

Name:

HSD17B8

Organism

Callithrix jacchus (Common marmoset)

Taxonomic identifier

9483 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Cebidae › Callitrichinae › Callithrix

Protein attributes

Sequence length	134 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Uses estradiol as its preferred substrate.
Catalytic activity	Estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H. Testosterone + NAD+ = androst-4-ene-3,17-dione + NADH.
Pathway	Steroid biosynthesis; estrogen biosynthesis.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Lipid synthesis Steroid biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW steroid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro estradiol 17-beta-dehydrogenase activity Inferred from electronic annotation. Source: EC testosterone 17-beta-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›134	›134	Estradiol 17-beta-dehydrogenase 8		PRO_0000054596
Sites
	Active site	51	1	Proton acceptor By similarity
	Binding site	38	1	Substrate By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	134	1

Sequences

	Sequence		Length	Mass (Da)
	Q9GME3-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 1D351CCF6D6181FF	FASTA	134	13,763
	10 20 30 40 50 60 DWDKVIAVNL KGTFLVTQAA GQALVSSGCS GSIINISSIV GKVGNMGQTN YAASKAGVIG 70 80 90 100 110 120 LTQTAARELG RHGIRCNSVL PGFIATPMTQ KVPQKVMNKI TGMIPMGHLG DPEDVADVVA 130 FLASEDSGYI TGAS

References

[1]	"Mechanisms of estradiol inactivation in primate endometrium." Husen B., Adamski J., Rune G.M., Einspanier A. Mol. Cell. Endocrinol. 171:179-185(2001) [PubMed: 11165027] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF272012 mRNA. Translation: AAG01114.1.
3D structure databases
HSSP	HSSP built from PDB template 1EDO based on UniProtKB Q93X62.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q9GME3.
Enzyme and pathway databases
BRENDA	1.1.1.62. 265156. 1.1.1.63. 265156.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHB8_CALJA

Accession

Primary (citable) accession number: Q9GME3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	March 1, 2001
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)