Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9GMC8 (CP17A_FELCA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase

EC=1.14.99.9
EC=4.1.2.30
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name=Cytochrome P450c17
Gene names
Name:CYP17A1
Synonyms:CYP17
OrganismFelis catus (Cat) (Felis silvestris catus) [Reference proteome]
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction By similarity.

Catalytic activity

A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.

17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

Cofactor

Heme group By similarity.

Pathway

Lipid metabolism; steroid biosynthesis.

Subcellular location

Membrane Potential.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Steroid 17-alpha-hydroxylase/17,20 lyase
PRO_0000051929

Sites

Metal binding4421Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9GMC8 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 413FDC4B90FA90D0

FASTA50857,625
        10         20         30         40         50         60 
MWELLVFLLF AVAYFLWPKA KCPGAKYPKS LPSLPLVGSL LFLPRSGHPH KNFFKLQKKY 

        70         80         90        100        110        120 
GPIYSFRLGT KTTVMVGDHQ LAKEVLVKKG KEFSGRPHVV TLDILSDNQK GIAFADHGAS 

       130        140        150        160        170        180 
WQMHRKLALA TFALFKDGDQ RLEKIICREI SLLCDNLAMQ DGQSIDLYLP LFLAVTNIIC 

       190        200        210        220        230        240 
LICFNSSFKN GDPALKIIQN YNEGILKTLG KDNLVDIFPV LKIFPNKTLE KMKNYVKNRD 

       250        260        270        280        290        300 
ELLREILEKH KENFSNDSIT NMLDVLIQAR MNSDNNGAAS DQDSKLLSDK HILTTIGDIF 

       310        320        330        340        350        360 
GAGVETTTSV VRWTVAFLLH HPQLYKKLQE EIDQNIGFSR TPTMSDRNQL ILLEATIREV 

       370        380        390        400        410        420 
LRIRPVAPTL IPHKAIMDSS IGEFAVDKGT NVIINLWALH HNEKEWYRPD QFMPERFLDP 

       430        440        450        460        470        480 
TRSQLISPSL SYLPFGAGPR SCLGESLARQ EVFLFMAWLL QRFDLEVPDD GQLPHLEGNP 

       490        500 
TVVFLIAPFK VKVKVRQAWR EAQAEGST 

« Hide

References

[1]"Cloning and heterologous expression of the cDNA encoding the cytochrome P450 steroid 17alpha-hydroxylase/17,20 lyase from cat."
Gilep A.A., Huryeva I.V., Guryev O.L., Usanov S.A., Estabrook R.W.
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Adrenal gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF292564 mRNA. Translation: AAG02226.1.
RefSeqNP_001009371.1. NM_001009371.2.

3D structure databases

ProteinModelPortalQ9GMC8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9685.ENSFCAP00000001165.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID493967.
KEGGfca:493967.

Organism-specific databases

CTD1586.

Phylogenomic databases

eggNOGCOG2124.
HOVERGENHBG106944.
KOK00512.

Enzyme and pathway databases

UniPathwayUPA00062.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP17A_FELCA
AccessionPrimary (citable) accession number: Q9GMC8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways