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Q9GMC8

- CP17A_FELCA

UniProt

Q9GMC8 - CP17A_FELCA

Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

CYP17A1

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction By similarity.By similarity

    Catalytic activityi

    A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.
    17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

    Cofactori

    Heme group.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB-EC
    2. heme binding Source: UniProtKB
    3. iron ion binding Source: InterPro
    4. steroid 17-alpha-monooxygenase activity Source: UniProtKB

    GO - Biological processi

    1. hormone biosynthetic process Source: UniProtKB
    2. progesterone metabolic process Source: UniProtKB
    3. steroid biosynthetic process Source: UniProtKB-UniPathway
    4. steroid metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Lyase, Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Steroidogenesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00062.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.99.9, EC:4.1.2.30)
    Alternative name(s):
    17-alpha-hydroxyprogesterone aldolase
    CYPXVII
    Cytochrome P450 17A1
    Cytochrome P450-C17
    Short name:
    Cytochrome P450c17
    Gene namesi
    Name:CYP17A1
    Synonyms:CYP17
    OrganismiFelis catus (Cat) (Felis silvestris catus)
    Taxonomic identifieri9685 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
    ProteomesiUP000011712: Unplaced

    Subcellular locationi

    Membrane Curated

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508Steroid 17-alpha-hydroxylase/17,20 lyasePRO_0000051929Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi9685.ENSFCAP00000001165.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GMC8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOVERGENiHBG106944.
    KOiK00512.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9GMC8-1 [UniParc]FASTAAdd to Basket

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    MWELLVFLLF AVAYFLWPKA KCPGAKYPKS LPSLPLVGSL LFLPRSGHPH    50
    KNFFKLQKKY GPIYSFRLGT KTTVMVGDHQ LAKEVLVKKG KEFSGRPHVV 100
    TLDILSDNQK GIAFADHGAS WQMHRKLALA TFALFKDGDQ RLEKIICREI 150
    SLLCDNLAMQ DGQSIDLYLP LFLAVTNIIC LICFNSSFKN GDPALKIIQN 200
    YNEGILKTLG KDNLVDIFPV LKIFPNKTLE KMKNYVKNRD ELLREILEKH 250
    KENFSNDSIT NMLDVLIQAR MNSDNNGAAS DQDSKLLSDK HILTTIGDIF 300
    GAGVETTTSV VRWTVAFLLH HPQLYKKLQE EIDQNIGFSR TPTMSDRNQL 350
    ILLEATIREV LRIRPVAPTL IPHKAIMDSS IGEFAVDKGT NVIINLWALH 400
    HNEKEWYRPD QFMPERFLDP TRSQLISPSL SYLPFGAGPR SCLGESLARQ 450
    EVFLFMAWLL QRFDLEVPDD GQLPHLEGNP TVVFLIAPFK VKVKVRQAWR 500
    EAQAEGST 508
    Length:508
    Mass (Da):57,625
    Last modified:March 1, 2001 - v1
    Checksum:i413FDC4B90FA90D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF292564 mRNA. Translation: AAG02226.1.
    RefSeqiNP_001009371.1. NM_001009371.2.

    Genome annotation databases

    GeneIDi493967.
    KEGGifca:493967.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF292564 mRNA. Translation: AAG02226.1 .
    RefSeqi NP_001009371.1. NM_001009371.2.

    3D structure databases

    ProteinModelPortali Q9GMC8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9685.ENSFCAP00000001165.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 493967.
    KEGGi fca:493967.

    Organism-specific databases

    CTDi 1586.

    Phylogenomic databases

    eggNOGi COG2124.
    HOVERGENi HBG106944.
    KOi K00512.

    Enzyme and pathway databases

    UniPathwayi UPA00062 .

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and heterologous expression of the cDNA encoding the cytochrome P450 steroid 17alpha-hydroxylase/17,20 lyase from cat."
      Gilep A.A., Huryeva I.V., Guryev O.L., Usanov S.A., Estabrook R.W.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Adrenal gland.

    Entry informationi

    Entry nameiCP17A_FELCA
    AccessioniPrimary (citable) accession number: Q9GMC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3