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Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

CYP17A1

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction (By similarity).By similarity

Catalytic activityi

A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.
17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

Cofactori

hemeBy similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
  4. steroid 17-alpha-monooxygenase activity Source: UniProtKB

GO - Biological processi

  1. hormone biosynthetic process Source: UniProtKB
  2. progesterone metabolic process Source: UniProtKB
  3. steroid biosynthetic process Source: UniProtKB-UniPathway
  4. steroid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Lyase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00062.

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.99.9, EC:4.1.2.30)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Gene namesi
Name:CYP17A1
Synonyms:CYP17
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712 Componenti: Unplaced

Subcellular locationi

Membrane Curated

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Steroid 17-alpha-hydroxylase/17,20 lyasePRO_0000051929Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000001165.

Structurei

3D structure databases

ProteinModelPortaliQ9GMC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOVERGENiHBG106944.
InParanoidiQ9GMC8.
KOiK00512.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GMC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWELLVFLLF AVAYFLWPKA KCPGAKYPKS LPSLPLVGSL LFLPRSGHPH
60 70 80 90 100
KNFFKLQKKY GPIYSFRLGT KTTVMVGDHQ LAKEVLVKKG KEFSGRPHVV
110 120 130 140 150
TLDILSDNQK GIAFADHGAS WQMHRKLALA TFALFKDGDQ RLEKIICREI
160 170 180 190 200
SLLCDNLAMQ DGQSIDLYLP LFLAVTNIIC LICFNSSFKN GDPALKIIQN
210 220 230 240 250
YNEGILKTLG KDNLVDIFPV LKIFPNKTLE KMKNYVKNRD ELLREILEKH
260 270 280 290 300
KENFSNDSIT NMLDVLIQAR MNSDNNGAAS DQDSKLLSDK HILTTIGDIF
310 320 330 340 350
GAGVETTTSV VRWTVAFLLH HPQLYKKLQE EIDQNIGFSR TPTMSDRNQL
360 370 380 390 400
ILLEATIREV LRIRPVAPTL IPHKAIMDSS IGEFAVDKGT NVIINLWALH
410 420 430 440 450
HNEKEWYRPD QFMPERFLDP TRSQLISPSL SYLPFGAGPR SCLGESLARQ
460 470 480 490 500
EVFLFMAWLL QRFDLEVPDD GQLPHLEGNP TVVFLIAPFK VKVKVRQAWR

EAQAEGST
Length:508
Mass (Da):57,625
Last modified:March 1, 2001 - v1
Checksum:i413FDC4B90FA90D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF292564 mRNA. Translation: AAG02226.1.
RefSeqiNP_001009371.1. NM_001009371.2.

Genome annotation databases

GeneIDi493967.
KEGGifca:493967.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF292564 mRNA. Translation: AAG02226.1.
RefSeqiNP_001009371.1. NM_001009371.2.

3D structure databases

ProteinModelPortaliQ9GMC8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000001165.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi493967.
KEGGifca:493967.

Organism-specific databases

CTDi1586.

Phylogenomic databases

eggNOGiCOG2124.
HOVERGENiHBG106944.
InParanoidiQ9GMC8.
KOiK00512.

Enzyme and pathway databases

UniPathwayiUPA00062.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and heterologous expression of the cDNA encoding the cytochrome P450 steroid 17alpha-hydroxylase/17,20 lyase from cat."
    Gilep A.A., Huryeva I.V., Guryev O.L., Usanov S.A., Estabrook R.W.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adrenal gland.

Entry informationi

Entry nameiCP17A_FELCA
AccessioniPrimary (citable) accession number: Q9GMC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.