SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9GMC8

- CP17A_FELCA

UniProt

Q9GMC8 - CP17A_FELCA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Steroid 17-alpha-hydroxylase/17,20 lyase
Gene
CYP17A1, CYP17
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction By similarity.

Catalytic activityi

A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.
17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

Cofactori

Heme group By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
  4. steroid 17-alpha-monooxygenase activity Source: UniProtKB

GO - Biological processi

  1. hormone biosynthetic process Source: UniProtKB
  2. progesterone metabolic process Source: UniProtKB
  3. steroid biosynthetic process Source: UniProtKB-UniPathway
  4. steroid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Lyase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00062.

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.99.9, EC:4.1.2.30)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Gene namesi
Name:CYP17A1
Synonyms:CYP17
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Unplaced

Subcellular locationi

Membrane Reviewed prediction

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Steroid 17-alpha-hydroxylase/17,20 lyase
PRO_0000051929Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000001165.

Structurei

3D structure databases

ProteinModelPortaliQ9GMC8.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOVERGENiHBG106944.
KOiK00512.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GMC8-1 [UniParc]FASTAAdd to Basket

« Hide

MWELLVFLLF AVAYFLWPKA KCPGAKYPKS LPSLPLVGSL LFLPRSGHPH    50
KNFFKLQKKY GPIYSFRLGT KTTVMVGDHQ LAKEVLVKKG KEFSGRPHVV 100
TLDILSDNQK GIAFADHGAS WQMHRKLALA TFALFKDGDQ RLEKIICREI 150
SLLCDNLAMQ DGQSIDLYLP LFLAVTNIIC LICFNSSFKN GDPALKIIQN 200
YNEGILKTLG KDNLVDIFPV LKIFPNKTLE KMKNYVKNRD ELLREILEKH 250
KENFSNDSIT NMLDVLIQAR MNSDNNGAAS DQDSKLLSDK HILTTIGDIF 300
GAGVETTTSV VRWTVAFLLH HPQLYKKLQE EIDQNIGFSR TPTMSDRNQL 350
ILLEATIREV LRIRPVAPTL IPHKAIMDSS IGEFAVDKGT NVIINLWALH 400
HNEKEWYRPD QFMPERFLDP TRSQLISPSL SYLPFGAGPR SCLGESLARQ 450
EVFLFMAWLL QRFDLEVPDD GQLPHLEGNP TVVFLIAPFK VKVKVRQAWR 500
EAQAEGST 508
Length:508
Mass (Da):57,625
Last modified:March 1, 2001 - v1
Checksum:i413FDC4B90FA90D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF292564 mRNA. Translation: AAG02226.1.
RefSeqiNP_001009371.1. NM_001009371.2.

Genome annotation databases

GeneIDi493967.
KEGGifca:493967.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF292564 mRNA. Translation: AAG02226.1 .
RefSeqi NP_001009371.1. NM_001009371.2.

3D structure databases

ProteinModelPortali Q9GMC8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9685.ENSFCAP00000001165.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 493967.
KEGGi fca:493967.

Organism-specific databases

CTDi 1586.

Phylogenomic databases

eggNOGi COG2124.
HOVERGENi HBG106944.
KOi K00512.

Enzyme and pathway databases

UniPathwayi UPA00062 .

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and heterologous expression of the cDNA encoding the cytochrome P450 steroid 17alpha-hydroxylase/17,20 lyase from cat."
    Gilep A.A., Huryeva I.V., Guryev O.L., Usanov S.A., Estabrook R.W.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adrenal gland.

Entry informationi

Entry nameiCP17A_FELCA
AccessioniPrimary (citable) accession number: Q9GMC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi