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Protein

Inter-alpha-trypsin inhibitor heavy chain H3

Gene

ITIH3

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Inter-alpha-trypsin inhibitor heavy chain H3
Short name:
ITI heavy chain H3
Short name:
ITI-HC3
Short name:
Inter-alpha-inhibitor heavy chain 3
Gene namesi
Name:ITIH3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000031243421 – 34By similarityAdd BLAST14
ChainiPRO_000031243535 – 663Inter-alpha-trypsin inhibitor heavy chain H3Add BLAST629
PropeptideiPRO_0000312436664 – 903By similarityAdd BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi580N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei663Aspartate 1-(chondroitin 4-sulfate)-esterBy similarity1

Post-translational modificationi

Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.By similarity

Keywords - PTMi

Glycoprotein, Proteoglycan

Proteomic databases

PRIDEiQ9GLY5.

Interactioni

Subunit structurei

I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin (By similarity).By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000018231.

Structurei

3D structure databases

ProteinModelPortaliQ9GLY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 158VITPROSITE-ProRule annotationAdd BLAST130
Domaini284 – 467VWFAPROSITE-ProRule annotationAdd BLAST184

Sequence similaritiesi

Belongs to the ITIH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
HOGENOMiHOG000000680.
HOVERGENiHBG057734.
InParanoidiQ9GLY5.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiView protein in InterPro
IPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
IPR036465. vWFA_dom_sf.
PfamiView protein in Pfam
PF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF00092. VWA. 1 hit.
SMARTiView protein in SMART
SM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiView protein in PROSITE
PS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GLY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAQWLGLV LALLSSLAAS GFPGSPFRLL GKRSLPEGAV NGIEIYSTKI
60 70 80 90 100
NCKVTSRFAH NVVTTRAVNR ADTAKEVSFD VELPKTAFIT NFTLTIDGVT
110 120 130 140 150
YPGHVKEKEV AKKQYEKAVS QGKTAGLVKA SGRKLEKFTV SVNVAAGSKV
160 170 180 190 200
TFELTYEELL KRHKGKYEMY LKVQPKQLVK HFEIDAHIFE PQGISMLDAE
210 220 230 240 250
ASFITNDLLG SALTKSFSGK KGHVSFKPSL DQQRSCPTCT DSLLNGDFTI
260 270 280 290 300
TYDVNRESPA NIQIVNGYFV HFFAPQGLPV VPKNVVFVID VSGSMYGRKL
310 320 330 340 350
EQTKDALLKI LEDMREEDHL NFILFSSDVT TWKEHLVQAT PENLQEARAF
360 370 380 390 400
VKSIQDQGST NLNDGLLRGI SMLNTAREEH RVPERSTSIV IMLTDGDANS
410 420 430 440 450
GESRPEKIQE NVRNAIGGKF PLYNLGFGNN LNYNFLESLA LENDGFARRI
460 470 480 490 500
YEDSDANLQL HGFYEEVANP LLTSVEMEYP KNAILDLTQN SYQHFYDGSE
510 520 530 540 550
IVVAGRLADE DMNSFKADVK GHGALNDLTF TEEVDLKETE AALKEREYIF
560 570 580 590 600
GNYIERLWAY LTIEQLLEKR KNARGEEKEN LTAQALDLSL KYHFVTPLTS
610 620 630 640 650
MVVTKPEDNE DQTAIADKPG EEQAQAASQT SFSAYRTSYQ PPLGSAASYQ
660 670 680 690 700
PPLGTPYYYV DGDPHFIIQV PEQDNAICFN IDEEPGTVLR LIQDPATGLT
710 720 730 740 750
VNGQIIGDKK SSPDSATRKT YFGKLGIASA HMDLRIEVTT EKISLWNEVG
760 770 780 790 800
RSTFSWLDTV TVTQDGLSMT INRKKNMVVS FGEGVTFVVI LHQVWKNHPI
810 820 830 840 850
HQDFLGFYVV DSHRMSAWTH GLLGQFFHPF DFKVSDVHPG SEPTKPDATM
860 870 880 890 900
VVKNRQLTVT RGSQRDYRMD ARAGTKVACW FVHNNGEGLI DGVHTDYIVP

NLF
Length:903
Mass (Da):100,754
Last modified:March 1, 2001 - v1
Checksum:i12D0B1518DF9C933
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050593 mRNA. Translation: BAB17302.1.
RefSeqiNP_001075477.1. NM_001082008.1.
UniGeneiOcu.2667.

Genome annotation databases

GeneIDi100008624.
KEGGiocu:100008624.

Similar proteinsi

Entry informationi

Entry nameiITIH3_RABIT
AccessioniPrimary (citable) accession number: Q9GLY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families