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Protein

Spondin-1

Gene

SPON1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi325CalciumBy similarity1
Metal bindingi354CalciumBy similarity1
Metal bindingi358Calcium; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-5173214. O-glycosylation of TSR domain-containing proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Spondin-1
Alternative name(s):
F-spondin
Vascular smooth muscle cell growth-promoting factor
Gene namesi
Name:SPON1
Synonyms:VSGP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Add BLAST28
ChainiPRO_000003586429 – 807Spondin-1Add BLAST779

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 128PROSITE-ProRule annotation
Disulfide bondi156 ↔ 182PROSITE-ProRule annotation
Disulfide bondi199 ↔ 336By similarity
Disulfide bondi200 ↔ 340By similarity
Disulfide bondi202 ↔ 415By similarity
Glycosylationi214N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi443 ↔ 480PROSITE-ProRule annotation
Disulfide bondi454 ↔ 489PROSITE-ProRule annotation
Disulfide bondi459 ↔ 494PROSITE-ProRule annotation
Disulfide bondi502 ↔ 538PROSITE-ProRule annotation
Disulfide bondi513 ↔ 517PROSITE-ProRule annotation
Disulfide bondi548 ↔ 554PROSITE-ProRule annotation
Disulfide bondi559 ↔ 595PROSITE-ProRule annotation
Disulfide bondi570 ↔ 574PROSITE-ProRule annotation
Disulfide bondi605 ↔ 610PROSITE-ProRule annotation
Disulfide bondi615 ↔ 650PROSITE-ProRule annotation
Disulfide bondi626 ↔ 630PROSITE-ProRule annotation
Disulfide bondi660 ↔ 665PROSITE-ProRule annotation
Glycosylationi681N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GLX9.
PRIDEiQ9GLX9.

Expressioni

Gene expression databases

BgeeiENSBTAG00000009150.

Interactioni

Subunit structurei

Binds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012059.

Structurei

3D structure databases

ProteinModelPortaliQ9GLX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 194ReelinPROSITE-ProRule annotationAdd BLAST166
Domaini195 – 388SpondinPROSITE-ProRule annotationAdd BLAST194
Domaini442 – 495TSP type-1 1PROSITE-ProRule annotationAdd BLAST54
Domaini501 – 555TSP type-1 2PROSITE-ProRule annotationAdd BLAST55
Domaini558 – 611TSP type-1 3PROSITE-ProRule annotationAdd BLAST54
Domaini614 – 666TSP type-1 4PROSITE-ProRule annotationAdd BLAST53
Domaini668 – 721TSP type-1 5PROSITE-ProRule annotationAdd BLAST54
Domaini754 – 806TSP type-1 6PROSITE-ProRule annotationAdd BLAST53

Sequence similaritiesi

Contains 1 reelin domain.PROSITE-ProRule annotation
Contains 1 spondin domain.PROSITE-ProRule annotation
Contains 6 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3539. Eukaryota.
ENOG410XQHP. LUCA.
GeneTreeiENSGT00810000125397.
HOGENOMiHOG000124667.
HOVERGENiHBG052920.
InParanoidiQ9GLX9.
OMAiKQFPDDG.
OrthoDBiEOG091G0FDA.
TreeFamiTF313353.

Family and domain databases

CDDicd08544. Reeler. 1 hit.
InterProiIPR002861. Reeler_dom.
IPR009465. Spondin_N.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF02014. Reeler. 1 hit.
PF06468. Spond_N. 1 hit.
PF00090. TSP_1. 6 hits.
[Graphical view]
SMARTiSM00209. TSP1. 6 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 6 hits.
PROSITEiPS51019. REELIN. 1 hit.
PS51020. SPONDIN. 1 hit.
PS50092. TSP1. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GLX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSPVLLRL SRGPALLALA LPLAVALAFS DETLDKVPKS EGYCSRILRV
60 70 80 90 100
QGTRREGYTE FSLRVEGDPD FYKPGTSYRV TLSAAPPSYF RGFTLIALKE
110 120 130 140 150
NREGDKEEDH AGTFQIIDEE ETQFMSNCPV AVTESTPRRR TRIQVFWIAP
160 170 180 190 200
PAGTGCVILK ASIVQKRIIY FQDEGSLTKK LCEQDSTFDG VTDKPILDCC
210 220 230 240 250
ACGTAKYRLT FYGNWSEKTH PKDYPRRANH WSAIIGGSHS KNYVLWEYGG
260 270 280 290 300
YASEGVKQVA ELGSPVKMEE EIRQQSDEVL TVIKAKAQWP AWQPLNVRAA
310 320 330 340 350
PSAEFSVDRT RHLMSFLTMM GPSPDWNVGL SAEDLCTKEC GWVQKVVQDL
360 370 380 390 400
IPWDAGTDSG VTYESPNKPT IPQEKIRPLT SLDHPQSPFY DPEGGSITQV
410 420 430 440 450
ARVVIERIAR KGEQCNIVPD NVDDIVADLA PEEKDEDDTP ETCIYSNWSP
460 470 480 490 500
WSACSSSTCD KGKRMRQRML KAQLDLSVPC PDTQDFQPCM GPGCSDEDGS
510 520 530 540 550
TCTMSEWITW SPCSISCGTG TRSRERYVKQ FPEDGSVCTL PTEETEKCTV
560 570 580 590 600
NEECSPSSCL TTEWGEWDEC SATCGMGMKK RHRMVKMSPA DGSMCKAETS
610 620 630 640 650
QAEKCMMPEC HTIPCLLSLW SEWSDCSVTC GKGMRTRQRM LKSLAELGDC
660 670 680 690 700
NEELEQVEKC MLPECPIDCE LTEWSQWSEC NKSCGKGHMI RTRMIQMEPQ
710 720 730 740 750
FGGTPCPETV QRKKCRIRKC LRNPSIQNLR WREARESRRS EQLREESDGD
760 770 780 790 800
QFPGCRMRPW TAWSECTKLC GGGIQERYMT VKKRFKSSQF TSCKDKKEIR

ACNVHPC
Length:807
Mass (Da):90,976
Last modified:March 1, 2001 - v1
Checksum:i4C484B331FB1034C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051389 mRNA. Translation: BAB18460.1.
RefSeqiNP_777168.1. NM_174743.2.
UniGeneiBt.23618.

Genome annotation databases

EnsembliENSBTAT00000012059; ENSBTAP00000012059; ENSBTAG00000009150.
GeneIDi282866.
KEGGibta:282866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051389 mRNA. Translation: BAB18460.1.
RefSeqiNP_777168.1. NM_174743.2.
UniGeneiBt.23618.

3D structure databases

ProteinModelPortaliQ9GLX9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012059.

Proteomic databases

PaxDbiQ9GLX9.
PRIDEiQ9GLX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000012059; ENSBTAP00000012059; ENSBTAG00000009150.
GeneIDi282866.
KEGGibta:282866.

Organism-specific databases

CTDi10418.

Phylogenomic databases

eggNOGiKOG3539. Eukaryota.
ENOG410XQHP. LUCA.
GeneTreeiENSGT00810000125397.
HOGENOMiHOG000124667.
HOVERGENiHBG052920.
InParanoidiQ9GLX9.
OMAiKQFPDDG.
OrthoDBiEOG091G0FDA.
TreeFamiTF313353.

Enzyme and pathway databases

ReactomeiR-BTA-5173214. O-glycosylation of TSR domain-containing proteins.

Gene expression databases

BgeeiENSBTAG00000009150.

Family and domain databases

CDDicd08544. Reeler. 1 hit.
InterProiIPR002861. Reeler_dom.
IPR009465. Spondin_N.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF02014. Reeler. 1 hit.
PF06468. Spond_N. 1 hit.
PF00090. TSP_1. 6 hits.
[Graphical view]
SMARTiSM00209. TSP1. 6 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 6 hits.
PROSITEiPS51019. REELIN. 1 hit.
PS51020. SPONDIN. 1 hit.
PS50092. TSP1. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPON1_BOVIN
AccessioniPrimary (citable) accession number: Q9GLX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2001
Last modified: October 5, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.