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Protein

Atypical chemokine receptor 1

Gene

ACKR1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Atypical chemokine receptor 1
Alternative name(s):
Duffy antigen/chemokine receptor
CD_antigen: CD234
Gene namesi
Name:ACKR1
Synonyms:DARC, FY
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Early endosome By similarity
  • Recycling endosome By similarity
  • Membrane; Multi-pass membrane protein

  • Note: Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5757ExtracellularSequence analysisAdd
BLAST
Transmembranei58 – 7821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini79 – 8911CytoplasmicSequence analysisAdd
BLAST
Transmembranei90 – 11021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini111 – 12313ExtracellularSequence analysisAdd
BLAST
Transmembranei124 – 14724Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini148 – 16013CytoplasmicSequence analysisAdd
BLAST
Transmembranei161 – 18121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini182 – 20120ExtracellularSequence analysisAdd
BLAST
Transmembranei202 – 22221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini223 – 23816CytoplasmicSequence analysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini260 – 28122ExtracellularSequence analysisAdd
BLAST
Transmembranei282 – 30221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini303 – 33028CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Atypical chemokine receptor 1PRO_0000152582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence analysis
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence analysis
Disulfide bondi45 ↔ 270By similarity
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence analysis
Disulfide bondi123 ↔ 189By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GLX0.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004179.

Structurei

3D structure databases

ProteinModelPortaliQ9GLX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHK3. Eukaryota.
ENOG41119V5. LUCA.
HOGENOMiHOG000112293.
HOVERGENiHBG051419.
InParanoidiQ9GLX0.
KOiK06574.

Family and domain databases

InterProiIPR005384. Duffy_chemokine_rcpt.
[Graphical view]
PANTHERiPTHR14181. PTHR14181. 1 hit.
PRINTSiPR01559. DUFFYANTIGEN.

Sequencei

Sequence statusi: Complete.

Q9GLX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNCLYPVAD DNSTKLAIKE DFLIDFPEDY YPDYNETDVE AAAPCHSCSL
60 70 80 90 100
LNYSSLPFFI LVSILGILAS GTILYALLRP LFRWQLYQDR STLVQLAVGS
110 120 130 140 150
ALFSIVVPIL ARGLSGALIT SLCHLAHLVA YGSAFAQALL IGYHACLGPQ
160 170 180 190 200
LGAGQVPGLR LGVTVGLWGV AALLSLPVVL GSDTSQGLCT VTFSGEWETL
210 220 230 240 250
RYIHAAACFA IFVLLPLGLL GTKGLKTVLG RAPCPWVDVL WVWFIFWWPQ
260 270 280 290 300
GMTLGLDSLV RSKAIVVSTC PAQQALDMLL DVAEALAILH CVATPLLLAW
310 320 330
VCYQATHTSP PSLPLPTTQT SHLDTLGGKS
Length:330
Mass (Da):35,414
Last modified:November 13, 2007 - v2
Checksum:i7AA0064485C21F17
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti150 – 1501Q → R in AAG31021 (Ref. 1) Curated
Sequence conflicti328 – 3281G → S in AAG31021 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109158 Genomic DNA. Translation: AAG31021.1.
BT021079 mRNA. Translation: AAX09096.1.
BC142464 mRNA. Translation: AAI42465.1.
RefSeqiNP_001015634.1. NM_001015634.1.
UniGeneiBt.27077.

Genome annotation databases

GeneIDi528076.
KEGGibta:528076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109158 Genomic DNA. Translation: AAG31021.1.
BT021079 mRNA. Translation: AAX09096.1.
BC142464 mRNA. Translation: AAI42465.1.
RefSeqiNP_001015634.1. NM_001015634.1.
UniGeneiBt.27077.

3D structure databases

ProteinModelPortaliQ9GLX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004179.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ9GLX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi528076.
KEGGibta:528076.

Organism-specific databases

CTDi2532.

Phylogenomic databases

eggNOGiENOG410IHK3. Eukaryota.
ENOG41119V5. LUCA.
HOGENOMiHOG000112293.
HOVERGENiHBG051419.
InParanoidiQ9GLX0.
KOiK06574.

Family and domain databases

InterProiIPR005384. Duffy_chemokine_rcpt.
[Graphical view]
PANTHERiPTHR14181. PTHR14181. 1 hit.
PRINTSiPR01559. DUFFYANTIGEN.
ProtoNetiSearch...

Entry informationi

Entry nameiACKR1_BOVIN
AccessioniPrimary (citable) accession number: Q9GLX0
Secondary accession number(s): A5PKF0, Q5E941
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: November 13, 2007
Last modified: June 8, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.