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Protein

Cathelicidin antimicrobial peptide

Gene

CAMP

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Cathelicidin antimicrobial peptideBy similarity
Alternative name(s):
18 kDa cationic antimicrobial proteinBy similarity
CAP-18By similarity
rhCAP-181 Publication
Cleaved into the following 2 chains:
Antibacterial peptide FALL-39By similarity
Alternative name(s):
FALL-39 peptide antibioticBy similarity
Antibacterial peptide LL-37By similarity
Alternative name(s):
rhLL-371 Publication
Short name:
RL-371 Publication
Gene namesi
Name:CAMP
Synonyms:CAP18, FALL39
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
PropeptideiPRO_000025176731 – 131By similarityAdd BLAST101
PeptideiPRO_0000251768132 – 170Antibacterial peptide FALL-39By similarityAdd BLAST39
PeptideiPRO_0000251769134 – 170Antibacterial peptide LL-37By similarityAdd BLAST37

Keywords - PTMi

Cleavage on pair of basic residues

Expressioni

Tissue specificityi

Expressed in epithelia of various organs. Most abundant peptide levels are found in organs lining outer or inner body surfaces, such as organs of the respiratory or gastrointestinal tract.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000013960.

Structurei

3D structure databases

ProteinModelPortaliQ9GLV5.
SMRiQ9GLV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J18R. Eukaryota.
ENOG41119S0. LUCA.
HOGENOMiHOG000093184.
HOVERGENiHBG006116.
InParanoidiQ9GLV5.
KOiK13916.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
IPR022746. Cathlecidin_C.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PfamiPF12153. CAP18_C. 1 hit.
[Graphical view]
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GLV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTQRNGPSL GRWSLVLLLL GLVMPLAIVA QVLSYQEAVL RAIDGINQRS
60 70 80 90 100
SDANLYRLLD LDPRPTMDGD PDTPKPVSFT VKETVCPRTT QKSPEDCDFK
110 120 130 140 150
EDGLVKRCVG TVILNQARDS FDISCDKDNR RSARLGNFFR KVKEKIGGGL
160 170
KKVGQKIKDF LGNLVPRTAS
Length:170
Mass (Da):18,861
Last modified:March 1, 2001 - v1
Checksum:i355AB3BF510DBB83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181954 mRNA. Translation: AAG09440.1.
RefSeqiNP_001028681.1. NM_001033509.2.
UniGeneiMmu.3602.

Genome annotation databases

GeneIDi619186.
KEGGimcc:619186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181954 mRNA. Translation: AAG09440.1.
RefSeqiNP_001028681.1. NM_001033509.2.
UniGeneiMmu.3602.

3D structure databases

ProteinModelPortaliQ9GLV5.
SMRiQ9GLV5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000013960.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi619186.
KEGGimcc:619186.

Organism-specific databases

CTDi820.

Phylogenomic databases

eggNOGiENOG410J18R. Eukaryota.
ENOG41119S0. LUCA.
HOGENOMiHOG000093184.
HOVERGENiHBG006116.
InParanoidiQ9GLV5.
KOiK13916.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
IPR022746. Cathlecidin_C.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PfamiPF12153. CAP18_C. 1 hit.
[Graphical view]
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAMP_MACMU
AccessioniPrimary (citable) accession number: Q9GLV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.