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Q9GLR0 (NEC2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuroendocrine convertase 2

Short name=NEC 2
EC=3.4.21.94
Alternative name(s):
Prohormone convertase 2
Proprotein convertase 2
Short name=PC2
Gene names
Name:PCSK2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length638 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells By similarity.

Catalytic activity

Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.

Subcellular location

Cytoplasmic vesiclesecretory vesicle By similarity. Note: Localized in the secretion granules By similarity.

Sequence similarities

Belongs to the peptidase S8 family. Furin subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Propeptide26 – 10984 Potential
PRO_0000244608
Chain110 – 638529Neuroendocrine convertase 2
PRO_0000244609

Regions

Region122 – 415294Catalytic

Sites

Active site1671Charge relay system By similarity
Active site2081Charge relay system By similarity
Active site3841Charge relay system By similarity

Amino acid modifications

Glycosylation3751N-linked (GlcNAc...) Potential
Glycosylation5141N-linked (GlcNAc...) Potential
Glycosylation5241N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9GLR0 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: DFF114AD9EC2AE68

FASTA63870,247
        10         20         30         40         50         60 
MRGGCISQGK AAAGLLFCVM VFASAERPVF TNHFLVELHR GGEEKARQVA AEHGFGVRKL 

        70         80         90        100        110        120 
PFAEGLYHFY HNGLAKARRR RSLQHQQQLE RDPRVKRALQ QEGFNRKKRG YRDINEIDIN 

       130        140        150        160        170        180 
VNDPLFTKQW YLINTGQADG TPGLDLNVAE AWELGYTGKG VTIGIMDDGI DYLHPDLASN 

       190        200        210        220        230        240 
YNAEASYDFS SNDPYPYPRY TDDWSNSHGT RCAGEVSAAA NNNICGVGVA YGSKVAGIRM 

       250        260        270        280        290        300 
LDQPFMTDII EASSISHMPQ LIDIYSASWG PTDNGKTVDG PRELTLQAMA DGVNKGRGGK 

       310        320        330        340        350        360 
GSIYVWASGD GGSYDDCNCD GYASSMWTIS INSAINDGRT ALYDESCSST LASTFSNGRK 

       370        380        390        400        410        420 
RNPEAGVATT DLYGNCTLRH SGTSAAAPEA AGVFALALEA NLGLTWRDMQ HLTVLTSKRN 

       430        440        450        460        470        480 
QLHDEVHQWR RNGVGLEFNH LFGYGVLDAG AMVKMAKDWK TVPERFHCVG GSVQNPEKIP 

       490        500        510        520        530        540 
TTGKPVLTLT TDACEGKENF VRYLEHVQAV VTVNATRRGD LNINMTSPMG TKSILLSRRP 

       550        560        570        580        590        600 
RGDDAKVGFD KWPFMTTHTW GEDARGTWIL ELGFVGSAPQ KGVLMEWTLM LHGTQSAPYI 

       610        620        630 
DQVVRDYQSK LAMSKKEELE EELDEAVQRS LKSILGKD 

« Hide

References

[1]"Molecular cloning demonstrates structural features of homologous bovine prohormone convertases 1 and 2."
Hwang S.-R., Ng S.-M., Steineckert B., Seidah N.G., Hook V.Y.H.
DNA Cell Biol. 19:409-419(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Adrenal medulla.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF186406 mRNA. Translation: AAG17018.1.
RefSeqNP_776838.1. NM_174413.3.
UniGeneBt.5563.

3D structure databases

ProteinModelPortalQ9GLR0.
SMRQ9GLR0. Positions 119-597.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000011451.

Protein family/group databases

MEROPSS08.073.

Proteomic databases

PRIDEQ9GLR0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID281968.
KEGGbta:281968.

Organism-specific databases

CTD5126.

Phylogenomic databases

eggNOGCOG4935.
HOGENOMHOG000192536.
HOVERGENHBG008705.
InParanoidQ9GLR0.
KOK01360.

Family and domain databases

Gene3D2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERPTHR10795. PTHR10795. 1 hit.
PfamPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSPR00723. SUBTILISIN.
SUPFAMSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805839.

Entry information

Entry nameNEC2_BOVIN
AccessionPrimary (citable) accession number: Q9GLR0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2001
Last modified: February 19, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries