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Q9GLR0

- NEC2_BOVIN

UniProt

Q9GLR0 - NEC2_BOVIN

Protein

Neuroendocrine convertase 2

Gene

PCSK2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells By similarity.By similarity

    Catalytic activityi

    Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei167 – 1671Charge relay systemBy similarity
    Active sitei208 – 2081Charge relay systemBy similarity
    Active sitei384 – 3841Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: RefGenome

    GO - Biological processi

    1. nervous system development Source: AgBase
    2. peptide hormone processing Source: AgBase
    3. protein autoprocessing Source: AgBase
    4. proteolysis Source: AgBase

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS08.073.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuroendocrine convertase 2 (EC:3.4.21.94)
    Short name:
    NEC 2
    Alternative name(s):
    Prohormone convertase 2
    Proprotein convertase 2
    Short name:
    PC2
    Gene namesi
    Name:PCSK2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Cytoplasmic vesiclesecretory vesicle By similarity
    Note: Localized in the secretion granules.By similarity

    GO - Cellular componenti

    1. extracellular space Source: RefGenome
    2. transport vesicle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Propeptidei26 – 10984Sequence AnalysisPRO_0000244608Add
    BLAST
    Chaini110 – 638529Neuroendocrine convertase 2PRO_0000244609Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi524 – 5241N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein, Zymogen

    Proteomic databases

    PRIDEiQ9GLR0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000011451.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GLR0.
    SMRiQ9GLR0. Positions 119-597.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini162 – 453292Peptidase S8Add
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S8 family. Furin subfamily.Curated
    Contains 1 peptidase S8 domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4935.
    HOGENOMiHOG000192536.
    HOVERGENiHBG008705.
    InParanoidiQ9GLR0.
    KOiK01360.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProiIPR008979. Galactose-bd-like.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view]
    PANTHERiPTHR10795. PTHR10795. 1 hit.
    PfamiPF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view]
    PRINTSiPR00723. SUBTILISIN.
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9GLR0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRGGCISQGK AAAGLLFCVM VFASAERPVF TNHFLVELHR GGEEKARQVA    50
    AEHGFGVRKL PFAEGLYHFY HNGLAKARRR RSLQHQQQLE RDPRVKRALQ 100
    QEGFNRKKRG YRDINEIDIN VNDPLFTKQW YLINTGQADG TPGLDLNVAE 150
    AWELGYTGKG VTIGIMDDGI DYLHPDLASN YNAEASYDFS SNDPYPYPRY 200
    TDDWSNSHGT RCAGEVSAAA NNNICGVGVA YGSKVAGIRM LDQPFMTDII 250
    EASSISHMPQ LIDIYSASWG PTDNGKTVDG PRELTLQAMA DGVNKGRGGK 300
    GSIYVWASGD GGSYDDCNCD GYASSMWTIS INSAINDGRT ALYDESCSST 350
    LASTFSNGRK RNPEAGVATT DLYGNCTLRH SGTSAAAPEA AGVFALALEA 400
    NLGLTWRDMQ HLTVLTSKRN QLHDEVHQWR RNGVGLEFNH LFGYGVLDAG 450
    AMVKMAKDWK TVPERFHCVG GSVQNPEKIP TTGKPVLTLT TDACEGKENF 500
    VRYLEHVQAV VTVNATRRGD LNINMTSPMG TKSILLSRRP RGDDAKVGFD 550
    KWPFMTTHTW GEDARGTWIL ELGFVGSAPQ KGVLMEWTLM LHGTQSAPYI 600
    DQVVRDYQSK LAMSKKEELE EELDEAVQRS LKSILGKD 638
    Length:638
    Mass (Da):70,247
    Last modified:March 1, 2001 - v1
    Checksum:iDFF114AD9EC2AE68
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF186406 mRNA. Translation: AAG17018.1.
    RefSeqiNP_776838.1. NM_174413.3.
    UniGeneiBt.5563.

    Genome annotation databases

    GeneIDi281968.
    KEGGibta:281968.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF186406 mRNA. Translation: AAG17018.1 .
    RefSeqi NP_776838.1. NM_174413.3.
    UniGenei Bt.5563.

    3D structure databases

    ProteinModelPortali Q9GLR0.
    SMRi Q9GLR0. Positions 119-597.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000011451.

    Protein family/group databases

    MEROPSi S08.073.

    Proteomic databases

    PRIDEi Q9GLR0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 281968.
    KEGGi bta:281968.

    Organism-specific databases

    CTDi 5126.

    Phylogenomic databases

    eggNOGi COG4935.
    HOGENOMi HOG000192536.
    HOVERGENi HBG008705.
    InParanoidi Q9GLR0.
    KOi K01360.

    Miscellaneous databases

    NextBioi 20805839.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProi IPR008979. Galactose-bd-like.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view ]
    PANTHERi PTHR10795. PTHR10795. 1 hit.
    Pfami PF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view ]
    PRINTSi PR00723. SUBTILISIN.
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEi PS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning demonstrates structural features of homologous bovine prohormone convertases 1 and 2."
      Hwang S.-R., Ng S.-M., Steineckert B., Seidah N.G., Hook V.Y.H.
      DNA Cell Biol. 19:409-419(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Adrenal medulla.

    Entry informationi

    Entry nameiNEC2_BOVIN
    AccessioniPrimary (citable) accession number: Q9GLR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3