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Protein

Angiotensinogen

Gene

AGT

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.By similarity
Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.By similarity
Angiotensin-3: stimulates aldosterone release.By similarity
Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Protein family/group databases

MEROPSiI04.953.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiotensinogen
Alternative name(s):
Serpin A8
Cleaved into the following 8 chains:
Alternative name(s):
Angiotensin 1-10
Angiotensin I
Short name:
Ang I
Alternative name(s):
Angiotensin 1-8
Angiotensin II
Short name:
Ang II
Alternative name(s):
Angiotensin 2-8
Angiotensin III
Short name:
Ang III
Des-Asp[1]-angiotensin II
Alternative name(s):
Angiotensin 3-8
Angiotensin IV
Short name:
Ang IV
Gene namesi
Name:AGT
Synonyms:SERPINA8
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333By similarityAdd
BLAST
Chaini34 – 485452AngiotensinogenPRO_0000032464Add
BLAST
Peptidei34 – 4310Angiotensin-1PRO_0000032465
Peptidei34 – 429Angiotensin 1-9PRO_0000420669
Peptidei34 – 418Angiotensin-2PRO_0000032466
Peptidei34 – 407Angiotensin 1-7PRO_0000420670
Peptidei34 – 385Angiotensin 1-5PRO_0000420671
Peptidei34 – 374Angiotensin 1-4PRO_0000420672
Peptidei35 – 417Angiotensin-3PRO_0000032467
Peptidei36 – 416Angiotensin-4PRO_0000420673

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence analysis
Disulfide bondi51 ↔ 171By similarity
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence analysis
Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence analysis
Glycosylationi328 – 3281N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin) (By similarity).By similarity
The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GLN8.

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000003543.

Structurei

3D structure databases

ProteinModelPortaliQ9GLN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
HOGENOMiHOG000033941.
HOVERGENiHBG004233.
InParanoidiQ9GLN8.
KOiK09821.

Family and domain databases

InterProiIPR000227. Angiotensinogen.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 2 hits.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSiPR00654. ANGIOTENSNGN.
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GLN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKRAPQSEM APAGVSLRAT ILCLVAWAGL AAGDRVYIHP FHLVIHNEST
60 70 80 90 100
CEQLAKANAG KPKDPTFIPA PIQAKTSPVD EKALQDQLVL VAAKLDTEDK
110 120 130 140 150
LRAAMVGMLA NFLGFRIYGM HSELWGVVHG ATVLSPTAIF GTLASLYLGA
160 170 180 190 200
LDHTADRLQA ILGVPWKDKN CTSRLDAHKV LSALQAVQGL LVAQGRADSQ
210 220 230 240 250
AQLLLSTVVG VFTAPGLHLK QPFVQGLALY TPVVLPRSLD FTELDVAAEK
260 270 280 290 300
IDRFMQAVTG WKTGCSLMGA SVDSTLAFNT YVHFQGKMKG FSLLAEPQEF
310 320 330 340 350
WVDNSTSVSV PMLSGMGTFQ HWSDVQDNFS VTQVPFTESA CLLLIQPHYA
360 370 380 390 400
SDLDKVEGLT FQQNSLNWMK KLSPRAIHLT MPQLVLQGSY DLQDLLAQAE
410 420 430 440 450
LPAILHTELN LQKLSNDRIR VGEVLNSIFF ELEADEREPT ESTQQLNKPE
460 470 480
VLEVTLNRPF LFAVYDQSAT ALHFLGRVAN PLSTA
Length:485
Mass (Da):53,110
Last modified:March 1, 2001 - v1
Checksum:iC14C67E49A53F05F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21R → W in AAG29056 (Ref. 2) Curated
Sequence conflicti268 – 2681M → T in AAG29056 (Ref. 2) Curated
Sequence conflicti376 – 3761A → T in AAG29056 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193461
, AF193458, AF193459, AF193460 Genomic DNA. Translation: AAG30306.1.
AF188487 mRNA. Translation: AAG29056.1.
RefSeqiNP_001009032.1. NM_001009032.1.
UniGeneiPtr.6286.

Genome annotation databases

GeneIDi450104.
KEGGiptr:450104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193461
, AF193458, AF193459, AF193460 Genomic DNA. Translation: AAG30306.1.
AF188487 mRNA. Translation: AAG29056.1.
RefSeqiNP_001009032.1. NM_001009032.1.
UniGeneiPtr.6286.

3D structure databases

ProteinModelPortaliQ9GLN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000003543.

Protein family/group databases

MEROPSiI04.953.

Proteomic databases

PaxDbiQ9GLN8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi450104.
KEGGiptr:450104.

Organism-specific databases

CTDi183.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
HOGENOMiHOG000033941.
HOVERGENiHBG004233.
InParanoidiQ9GLN8.
KOiK09821.

Family and domain databases

InterProiIPR000227. Angiotensinogen.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 2 hits.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSiPR00654. ANGIOTENSNGN.
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Human-chimpanzee DNA sequence variation in the four major genes of the renin angiotensin system."
    Dufour C., Casane D., Denton D., Wickings J., Corvol P., Jeunemaitre X.
    Genomics 69:14-26(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Germline mutations in the angiotensinogen gene cause predisposition to type 1 diabetes mellitus."
    Shattuck-Eidens D., McGrail M., Stone S.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiANGT_PANTR
AccessioniPrimary (citable) accession number: Q9GLN8
Secondary accession number(s): Q9GLP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.