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Q9GLN7

- ACE_PANTR

UniProt

Q9GLN7 - ACE_PANTR

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Protein
Angiotensin-converting enzyme
Gene
ACE, DCP1
Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety By similarity.

Catalytic activityi

Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.

Cofactori

Binds 2 zinc ions per subunit. Isoform Testis-specific only binds 1 zinc ion per subunit By similarity.
Binds 3 chloride ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei229 – 2291Chloride 1 By similarity
Metal bindingi388 – 3881Zinc 1; catalytic By similarity
Active sitei389 – 38911 By similarity
Metal bindingi392 – 3921Zinc 1; catalytic By similarity
Metal bindingi416 – 4161Zinc 1; catalytic By similarity
Binding sitei527 – 5271Chloride 1 By similarity
Binding sitei789 – 7891Chloride 2 By similarity
Binding sitei827 – 8271Chloride 3 By similarity
Metal bindingi986 – 9861Zinc 2; catalytic By similarity
Active sitei987 – 98712 By similarity
Metal bindingi990 – 9901Zinc 2; catalytic By similarity
Metal bindingi1014 – 10141Zinc 2; catalytic By similarity
Binding sitei1088 – 10881Chloride 2 By similarity
Binding sitei1092 – 10921Chloride 2 By similarity
Binding sitei1125 – 11251Chloride 3 By similarity

GO - Molecular functioni

  1. carboxypeptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. metallopeptidase activity Source: UniProtKB-KW
  4. peptidyl-dipeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM02.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiotensin-converting enzyme (EC:3.2.1.-, EC:3.4.15.1)
Short name:
ACE
Alternative name(s):
Dipeptidyl carboxypeptidase I
Kininase II
CD_antigen: CD143
Cleaved into the following chain:
Gene namesi
Name:ACE
Synonyms:DCP1
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 12571230Extracellular Reviewed prediction
Add
BLAST
Transmembranei1258 – 127417Helical; Reviewed prediction
Add
BLAST
Topological domaini1275 – 130430Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 By similarity
Add
BLAST
Chaini28 – 13041277Angiotensin-converting enzyme
PRO_0000028545Add
BLAST
Chaini28 – 12301203Angiotensin-converting enzyme, soluble form
PRO_0000028546Add
BLAST
Propeptidei1231 – 130474Removed in secreted form By similarity
PRO_0000028547Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi52 – 521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi72 – 721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi144 – 1441N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi155 ↔ 163 By similarity
Glycosylationi158 – 1581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi316 – 3161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi440 – 4401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi443 – 4431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi507 – 5071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi675 – 6751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi693 – 6931N-linked (GlcNAc...) (complex) By similarity
Glycosylationi712 – 7121N-linked (GlcNAc...) (complex) By similarity
Disulfide bondi755 ↔ 761 By similarity
Glycosylationi758 – 7581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi940 – 9401N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi955 ↔ 973 By similarity
Disulfide bondi1141 ↔ 1153 By similarity
Glycosylationi1189 – 11891N-linked (GlcNAc...) Reviewed prediction
Modified residuei1297 – 12971Phosphoserine By similarity

Post-translational modificationi

Phosphorylated by CK2 on Ser-1297; which allows membrane retention By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000038991.

Structurei

3D structure databases

ProteinModelPortaliQ9GLN7.
SMRiQ9GLN7. Positions 28-639, 643-1226.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni28 – 628601Peptidase M2 1
Add
BLAST
Regioni629 – 1230602Peptidase M2 2
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase M2 family.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG71044.
HOVERGENiHBG000264.
KOiK01283.

Family and domain databases

InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 2 hits.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.
PROSITEiPS00142. ZINC_PROTEASE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Somatic (identifier: Q9GLN7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGAASGRRGP GLLLPLLLLL PPQPALALDP GLQPGNFSAD EAGAQLFAQS     50
YNSSAEQVLF QSVAASWAHD TNITAENARR QEEAALLSQE FAEAWGQKAK 100
ELYEPVWQNF TDPQLRRIIG AVRTLGSANL PLAKRQQYNA LLSNMSRIYS 150
TAKVCLPNKT ATCWSLDPDL TNILASSRSY AMLLFAWEGW HNAAGIPLKP 200
LYEDFTALSN EAYKQDGFTD TGAYWRSWYN SPTFEDDLEH LYQQLEPLYL 250
NLHAFVRRAL HRRYGDRYIN LRGPIPAHLL GDMWAQSWEN IYDMVVPFPD 300
KPNLDVTSTM LQQGWNATHM FRVAEEFFTS LELSPMPPEF WEGSMLEKPA 350
DGREVVCHAS AWDFYNRKDF RIKQCTRVTM DQLSTVHHEM GHIQYYLQYK 400
DLPVSLRGGA NPGFHEAIGD VLALSVSTPA HLHKIGLLDN VTNDTESDIN 450
YLLKMALEKI AFLPFGYLVD QWRWGVFSGR TPNSRYNFDW WYLRTKYQGI 500
CPPVTRNETH FDAGAKFHVP NVTPYIRYFV SFVLQFQFHE ALCKEAGYEG 550
PLHQCDIYQS TKAGAKLRKV LQAGSSRPWQ EVLKDMVGLD ALDAQPLLKY 600
FQPVTQWLQE QNQQNGEVLG WPEYQWHPPL PDNYPEGIDL VTDEAEASKF 650
VEEYDRTSQV VWNEYAEANW NYNTNITTET SKILLQKNMQ IANHTLKYGT 700
QARRFDVNQL QNTTIKRIIK KVQDLERAAL PAQELEEYNK ILLDMETTYS 750
VATVCHTNGS CLQLEPDLTN VMATSRKYED LLWAWEGWRD KAGRAILQFY 800
PKYVELINQA ARLNGYVDAG DSWRSMYETP SLEQDLERLF QELQPLYLNL 850
HAYVRRALHR HYGAQHINLE GPIPAHLLGN MWAQTWSNIY DLVVPFPSAP 900
SMDTTEAMLK QGWTPRRMFK EADDFFTSLG LLPVPPEFWN KSMLEKPTDG 950
REVVCHASAW DFYNGKDFRI KQCTTVNLED LVVAHHEMGH IQYFMQYKDL 1000
PVALREGANP GFHEAIGDVL ALSVSTPKHL HSLNLLSSEG GSDEHDINFL 1050
MKMALDKIAF IPFSYLVDQW RWRVFDGSIT KENYNQEWWS LRLKYQGLCP 1100
PVPRTQGDFD PGAKFHIPSS VPYIRYFVSF IIQFQFHEAL CQAAGHTGPL 1150
HKCDIYQSKE AGQRLATAMK LGFSRPWPEA MQLITGQPNM SASAMLSYFK 1200
PLLDWLRTEN ELHGEKLGWP QYNWTPNSAR SEGPLPDSGR VSFLGLDLDA 1250
QQARVGQWLL LFLGIALLVA TLGLSQRLFS IRHRSLHRHS HGPQFDSEVE 1300
LRHS 1304
Length:1,304
Mass (Da):149,370
Last modified:March 1, 2001 - v1
Checksum:iDCF728D0BA0F1314
GO
Isoform Testis-specific (identifier: Q9GLN7-2) [UniParc] [UniParc]FASTAAdd to Basket

Also known as: ACE-T

The sequence of this isoform differs from the canonical sequence as follows:
     1-572: Missing.
     573-639: AGSSRPWQEV...LPDNYPEGID → MGQGWATAGL...AHQTSAQSPN

Show »
Length:732
Mass (Da):83,429
Checksum:iC43D06443A47E74B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 572572Missing in isoform Testis-specific.
VSP_037640Add
BLAST
Alternative sequencei573 – 63967AGSSR…PEGID → MGQGWATAGLPSLLFLLLCY GHPLLVPSQEAPRQVTVTHG TSSQATTSGQTTTHQATAHQ TSAQSPN in isoform Testis-specific.
VSP_037641Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF193486
, AF193462, AF193464, AF193463, AF193465, AF193467, AF193469, AF193471, AF193473, AF193482, AF193481, AF193480, AF193479, AF193478, AF193477, AF193476, AF193475, AF193474, AF193485, AF193484, AF193483, AF193472, AF193470, AF193468, AF193466 Genomic DNA. Translation: AAG31358.1.
AF193486
, AF193473, AF193474, AF193475, AF193476, AF193477, AF193478, AF193479, AF193480, AF193481, AF193482, AF193483, AF193484, AF193485 Genomic DNA. Translation: AAG31359.1.
RefSeqiNP_001008995.1. NM_001008995.2. [Q9GLN7-1]
UniGeneiPtr.6266.

Genome annotation databases

GeneIDi449567.
KEGGiptr:449567.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF193486
, AF193462 , AF193464 , AF193463 , AF193465 , AF193467 , AF193469 , AF193471 , AF193473 , AF193482 , AF193481 , AF193480 , AF193479 , AF193478 , AF193477 , AF193476 , AF193475 , AF193474 , AF193485 , AF193484 , AF193483 , AF193472 , AF193470 , AF193468 , AF193466 Genomic DNA. Translation: AAG31358.1 .
AF193486
, AF193473 , AF193474 , AF193475 , AF193476 , AF193477 , AF193478 , AF193479 , AF193480 , AF193481 , AF193482 , AF193483 , AF193484 , AF193485 Genomic DNA. Translation: AAG31359.1 .
RefSeqi NP_001008995.1. NM_001008995.2. [Q9GLN7-1 ]
UniGenei Ptr.6266.

3D structure databases

ProteinModelPortali Q9GLN7.
SMRi Q9GLN7. Positions 28-639, 643-1226.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9598.ENSPTRP00000038991.

Protein family/group databases

MEROPSi M02.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 449567.
KEGGi ptr:449567.

Organism-specific databases

CTDi 1636.

Phylogenomic databases

eggNOGi NOG71044.
HOVERGENi HBG000264.
KOi K01283.

Miscellaneous databases

NextBioi 20832682.

Family and domain databases

InterProi IPR001548. Peptidase_M2.
[Graphical view ]
PANTHERi PTHR10514. PTHR10514. 1 hit.
Pfami PF01401. Peptidase_M2. 2 hits.
[Graphical view ]
PRINTSi PR00791. PEPDIPTASEA.
PROSITEi PS00142. ZINC_PROTEASE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Human-chimpanzee DNA sequence variation in the four major genes of the renin angiotensin system."
    Dufour C., Casane D., Denton D., Wickings J., Corvol P., Jeunemaitre X.
    Genomics 69:14-26(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiACE_PANTR
AccessioniPrimary (citable) accession number: Q9GLN7
Secondary accession number(s): Q9GLN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi