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Q9GLN7

- ACE_PANTR

UniProt

Q9GLN7 - ACE_PANTR

Protein

Angiotensin-converting enzyme

Gene

ACE

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.

    Cofactori

    Binds 2 zinc ions per subunit. Isoform Testis-specific only binds 1 zinc ion per subunit By similarity.By similarity
    Binds 3 chloride ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei229 – 2291Chloride 1By similarity
    Metal bindingi388 – 3881Zinc 1; catalyticBy similarity
    Active sitei389 – 38911PROSITE-ProRule annotation
    Metal bindingi392 – 3921Zinc 1; catalyticBy similarity
    Metal bindingi416 – 4161Zinc 1; catalyticBy similarity
    Binding sitei527 – 5271Chloride 1By similarity
    Binding sitei789 – 7891Chloride 2By similarity
    Binding sitei827 – 8271Chloride 3By similarity
    Metal bindingi986 – 9861Zinc 2; catalyticBy similarity
    Active sitei987 – 98712PROSITE-ProRule annotation
    Metal bindingi990 – 9901Zinc 2; catalyticBy similarity
    Metal bindingi1014 – 10141Zinc 2; catalyticBy similarity
    Binding sitei1088 – 10881Chloride 2By similarity
    Binding sitei1092 – 10921Chloride 2By similarity
    Binding sitei1125 – 11251Chloride 3By similarity

    GO - Molecular functioni

    1. carboxypeptidase activity Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. metallopeptidase activity Source: UniProtKB-KW
    4. peptidyl-dipeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM02.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Angiotensin-converting enzyme (EC:3.2.1.-, EC:3.4.15.1)
    Short name:
    ACE
    Alternative name(s):
    Dipeptidyl carboxypeptidase I
    Kininase II
    CD_antigen: CD143
    Cleaved into the following chain:
    Gene namesi
    Name:ACE
    Synonyms:DCP1
    OrganismiPan troglodytes (Chimpanzee)
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Unplaced

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cytoplasm By similarity
    Note: Detected in both cell membrane and cytoplasm in neurons.By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727By similarityAdd
    BLAST
    Chaini28 – 13041277Angiotensin-converting enzymePRO_0000028545Add
    BLAST
    Chaini28 – 12301203Angiotensin-converting enzyme, soluble formPRO_0000028546Add
    BLAST
    Propeptidei1231 – 130474Removed in secreted formBy similarityPRO_0000028547Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi155 ↔ 163By similarity
    Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi440 – 4401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi507 – 5071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi675 – 6751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi693 – 6931N-linked (GlcNAc...) (complex)By similarity
    Glycosylationi712 – 7121N-linked (GlcNAc...) (complex)By similarity
    Disulfide bondi755 ↔ 761By similarity
    Glycosylationi758 – 7581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi940 – 9401N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi955 ↔ 973By similarity
    Disulfide bondi1141 ↔ 1153By similarity
    Glycosylationi1189 – 11891N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1297 – 12971PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated by CK2 on Ser-1297; which allows membrane retention.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi9598.ENSPTRP00000038991.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GLN7.
    SMRiQ9GLN7. Positions 28-639, 643-1226.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 12571230ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1275 – 130430CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1258 – 127417HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni28 – 628601Peptidase M2 1Add
    BLAST
    Regioni629 – 1230602Peptidase M2 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase M2 family.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG71044.
    HOVERGENiHBG000264.
    KOiK01283.

    Family and domain databases

    InterProiIPR001548. Peptidase_M2.
    [Graphical view]
    PANTHERiPTHR10514. PTHR10514. 1 hit.
    PfamiPF01401. Peptidase_M2. 2 hits.
    [Graphical view]
    PRINTSiPR00791. PEPDIPTASEA.
    PROSITEiPS00142. ZINC_PROTEASE. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Somatic (identifier: Q9GLN7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGAASGRRGP GLLLPLLLLL PPQPALALDP GLQPGNFSAD EAGAQLFAQS     50
    YNSSAEQVLF QSVAASWAHD TNITAENARR QEEAALLSQE FAEAWGQKAK 100
    ELYEPVWQNF TDPQLRRIIG AVRTLGSANL PLAKRQQYNA LLSNMSRIYS 150
    TAKVCLPNKT ATCWSLDPDL TNILASSRSY AMLLFAWEGW HNAAGIPLKP 200
    LYEDFTALSN EAYKQDGFTD TGAYWRSWYN SPTFEDDLEH LYQQLEPLYL 250
    NLHAFVRRAL HRRYGDRYIN LRGPIPAHLL GDMWAQSWEN IYDMVVPFPD 300
    KPNLDVTSTM LQQGWNATHM FRVAEEFFTS LELSPMPPEF WEGSMLEKPA 350
    DGREVVCHAS AWDFYNRKDF RIKQCTRVTM DQLSTVHHEM GHIQYYLQYK 400
    DLPVSLRGGA NPGFHEAIGD VLALSVSTPA HLHKIGLLDN VTNDTESDIN 450
    YLLKMALEKI AFLPFGYLVD QWRWGVFSGR TPNSRYNFDW WYLRTKYQGI 500
    CPPVTRNETH FDAGAKFHVP NVTPYIRYFV SFVLQFQFHE ALCKEAGYEG 550
    PLHQCDIYQS TKAGAKLRKV LQAGSSRPWQ EVLKDMVGLD ALDAQPLLKY 600
    FQPVTQWLQE QNQQNGEVLG WPEYQWHPPL PDNYPEGIDL VTDEAEASKF 650
    VEEYDRTSQV VWNEYAEANW NYNTNITTET SKILLQKNMQ IANHTLKYGT 700
    QARRFDVNQL QNTTIKRIIK KVQDLERAAL PAQELEEYNK ILLDMETTYS 750
    VATVCHTNGS CLQLEPDLTN VMATSRKYED LLWAWEGWRD KAGRAILQFY 800
    PKYVELINQA ARLNGYVDAG DSWRSMYETP SLEQDLERLF QELQPLYLNL 850
    HAYVRRALHR HYGAQHINLE GPIPAHLLGN MWAQTWSNIY DLVVPFPSAP 900
    SMDTTEAMLK QGWTPRRMFK EADDFFTSLG LLPVPPEFWN KSMLEKPTDG 950
    REVVCHASAW DFYNGKDFRI KQCTTVNLED LVVAHHEMGH IQYFMQYKDL 1000
    PVALREGANP GFHEAIGDVL ALSVSTPKHL HSLNLLSSEG GSDEHDINFL 1050
    MKMALDKIAF IPFSYLVDQW RWRVFDGSIT KENYNQEWWS LRLKYQGLCP 1100
    PVPRTQGDFD PGAKFHIPSS VPYIRYFVSF IIQFQFHEAL CQAAGHTGPL 1150
    HKCDIYQSKE AGQRLATAMK LGFSRPWPEA MQLITGQPNM SASAMLSYFK 1200
    PLLDWLRTEN ELHGEKLGWP QYNWTPNSAR SEGPLPDSGR VSFLGLDLDA 1250
    QQARVGQWLL LFLGIALLVA TLGLSQRLFS IRHRSLHRHS HGPQFDSEVE 1300
    LRHS 1304
    Length:1,304
    Mass (Da):149,370
    Last modified:March 1, 2001 - v1
    Checksum:iDCF728D0BA0F1314
    GO
    Isoform Testis-specific (identifier: Q9GLN7-2) [UniParc] [UniParc]FASTAAdd to Basket

    Also known as: ACE-T

    The sequence of this isoform differs from the canonical sequence as follows:
         1-572: Missing.
         573-639: AGSSRPWQEV...LPDNYPEGID → MGQGWATAGL...AHQTSAQSPN

    Show »
    Length:732
    Mass (Da):83,429
    Checksum:iC43D06443A47E74B
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 572572Missing in isoform Testis-specific. CuratedVSP_037640Add
    BLAST
    Alternative sequencei573 – 63967AGSSR…PEGID → MGQGWATAGLPSLLFLLLCY GHPLLVPSQEAPRQVTVTHG TSSQATTSGQTTTHQATAHQ TSAQSPN in isoform Testis-specific. CuratedVSP_037641Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193486
    , AF193462, AF193464, AF193463, AF193465, AF193467, AF193469, AF193471, AF193473, AF193482, AF193481, AF193480, AF193479, AF193478, AF193477, AF193476, AF193475, AF193474, AF193485, AF193484, AF193483, AF193472, AF193470, AF193468, AF193466 Genomic DNA. Translation: AAG31358.1.
    AF193486
    , AF193473, AF193474, AF193475, AF193476, AF193477, AF193478, AF193479, AF193480, AF193481, AF193482, AF193483, AF193484, AF193485 Genomic DNA. Translation: AAG31359.1.
    RefSeqiNP_001008995.1. NM_001008995.2. [Q9GLN7-1]
    UniGeneiPtr.6266.

    Genome annotation databases

    GeneIDi449567.
    KEGGiptr:449567.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193486
    , AF193462 , AF193464 , AF193463 , AF193465 , AF193467 , AF193469 , AF193471 , AF193473 , AF193482 , AF193481 , AF193480 , AF193479 , AF193478 , AF193477 , AF193476 , AF193475 , AF193474 , AF193485 , AF193484 , AF193483 , AF193472 , AF193470 , AF193468 , AF193466 Genomic DNA. Translation: AAG31358.1 .
    AF193486
    , AF193473 , AF193474 , AF193475 , AF193476 , AF193477 , AF193478 , AF193479 , AF193480 , AF193481 , AF193482 , AF193483 , AF193484 , AF193485 Genomic DNA. Translation: AAG31359.1 .
    RefSeqi NP_001008995.1. NM_001008995.2. [Q9GLN7-1 ]
    UniGenei Ptr.6266.

    3D structure databases

    ProteinModelPortali Q9GLN7.
    SMRi Q9GLN7. Positions 28-639, 643-1226.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9598.ENSPTRP00000038991.

    Protein family/group databases

    MEROPSi M02.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 449567.
    KEGGi ptr:449567.

    Organism-specific databases

    CTDi 1636.

    Phylogenomic databases

    eggNOGi NOG71044.
    HOVERGENi HBG000264.
    KOi K01283.

    Miscellaneous databases

    NextBioi 20832682.

    Family and domain databases

    InterProi IPR001548. Peptidase_M2.
    [Graphical view ]
    PANTHERi PTHR10514. PTHR10514. 1 hit.
    Pfami PF01401. Peptidase_M2. 2 hits.
    [Graphical view ]
    PRINTSi PR00791. PEPDIPTASEA.
    PROSITEi PS00142. ZINC_PROTEASE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human-chimpanzee DNA sequence variation in the four major genes of the renin angiotensin system."
      Dufour C., Casane D., Denton D., Wickings J., Corvol P., Jeunemaitre X.
      Genomics 69:14-26(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiACE_PANTR
    AccessioniPrimary (citable) accession number: Q9GLN7
    Secondary accession number(s): Q9GLN6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3