Q9GLM7 (APOE_PONPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Apolipoprotein E
Short name=Apo-E

Gene names

Name:

APOE

Organism

Pongo pygmaeus (Bornean orangutan)

Taxonomic identifier

9600 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues By similarity.
Subcellular location	Secreted.
Post-translational modification	Phosphorylation sites are present in the extracellular medium By similarity.
Sequence similarities	Belongs to the apolipoprotein A1/A4/E family.

Ontologies

Keywords
Biological process	Lipid transport Transport
Cellular component	Chylomicron HDL Secreted VLDL
Domain	Repeat Signal
Ligand	Heparin-binding
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological_process	induction of apoptosis Inferred from sequence or structural similarity. Source: UniProtKB lipid transport Inferred from electronic annotation. Source: UniProtKB-KW lipoprotein metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	chylomicron Inferred from electronic annotation. Source: UniProtKB-KW high-density lipoprotein particle Inferred from electronic annotation. Source: UniProtKB-KW very-low-density lipoprotein particle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	beta-amyloid binding Inferred from sequence or structural similarity. Source: UniProtKB heparin binding Inferred from electronic annotation. Source: UniProtKB-KW lipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	By similarity
	Chain	19 – 317	299	Apolipoprotein E		PRO_0000001994
Regions
	Repeat	80 – 101	22	1
	Repeat	102 – 123	22	2
	Repeat	124 – 145	22	3
	Repeat	146 – 167	22	4
	Repeat	168 – 189	22	5
	Repeat	190 – 211	22	6
	Repeat	212 – 233	22	7
	Repeat	234 – 255	22	8
	Region	80 – 255	176	8 X 22 AA approximate tandem repeats
	Region	158 – 168	11	LDL receptor binding Potential
	Region	162 – 165	4	Heparin-binding By similarity
	Region	229 – 236	8	Heparin-binding By similarity
Amino acid modifications
	Glycosylation	212	1	O-linked (GalNAc...) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9GLM7 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 6B08CEC5B033BC2D	FASTA	317	36,094
	10 20 30 40 50 60 MKVLWAALLV TFLAGCQAKV EQVVETEPEP ELRQQAEWQS GQRWELALGR FWDYLRWVQT 70 80 90 100 110 120 LSEQVQEELL SSQVTQELTA LMDETMKELK AYKSELEEQL TPVAEETRAR LSKELQAAQA 130 140 150 160 170 180 RLGADMEDVR GRLVQYRGEV QAMLGQSTEE LRARLASHLR KLRKRLLRDA DDLQKRLAVY 190 200 210 220 230 240 QAGAREGAER GVSAIRERLG PLVEQGRVRA ATVGSVAGKP LQERAQAWGE RLRARMEEMG 250 260 270 280 290 300 SRTRDRLDEV KEQVAEVRAK LEEQAQQIRL QAEAFQARLK SWFEPLVEDM QRQWAGLVEK 310 VQAAVGTSAA PVPSDNH

References

[1]	"APOE gene evolution in Hominoidea." Rogaev E.I., Dvorianchikov G.A., Riazanskaia N.N. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF200505, AF200503, AF200504 Genomic DNA. Translation: AAG28580.1.
3D structure databases
ProteinModelPortal	Q9GLM7.
SMR	Q9GLM7. Positions 30-203.
ModBase	Search...
Protein-protein interaction databases
STRING	9600.ENSPPYP00000011298.
Proteomic databases
PRIDE	Q9GLM7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG44867.
HOGENOM	HOG000034006.
HOVERGEN	HBG010582.
InParanoid	Q9GLM7.
Family and domain databases
InterPro	IPR013326. ApoA. IPR000074. ApoA1_A4_E. [Graphical view]
Pfam	PF01442. Apolipoprotein. 1 hit. [Graphical view]
SUPFAM	SSF47162. SSF47162. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APOE_PONPY

Accession

Primary (citable) accession number: Q9GLM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program