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Protein

Apolipoprotein E

Gene

APOE

Organism
Hylobates lar (Common gibbon) (White-handed gibbon)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding
Biological processLipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein E
Short name:
Apo-E
Gene namesi
Name:APOE
OrganismiHylobates lar (Common gibbon) (White-handed gibbon)
Taxonomic identifieri9580 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeHylobates

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Chylomicron, HDL, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000000198819 – 317Apolipoprotein EAdd BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei143Methionine sulfoxideBy similarity1
Modified residuei147PhosphoserineBy similarity1
Glycosylationi212O-linked (GalNAc...)By similarity1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein, Oxidation, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ9GLM6.
SMRiQ9GLM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati80 – 1011Add BLAST22
Repeati102 – 1232Add BLAST22
Repeati124 – 1453Add BLAST22
Repeati146 – 1674Add BLAST22
Repeati168 – 1895Add BLAST22
Repeati190 – 2116Add BLAST22
Repeati212 – 2337Add BLAST22
Repeati234 – 2558Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni80 – 2558 X 22 AA approximate tandem repeatsAdd BLAST176
Regioni158 – 168LDL receptor bindingBy similarityAdd BLAST11
Regioni162 – 165Heparin-bindingBy similarity4
Regioni229 – 236Heparin-bindingBy similarity8

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG010582.

Family and domain databases

InterProiView protein in InterPro
IPR000074. ApoA_E.
PfamiView protein in Pfam
PF01442. Apolipoprotein. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GLM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLWAALLV TFLAGCQAKV EQAVEPEPEP ELRQQAEWQS GQPWELALGR
60 70 80 90 100
FWDYLRWVQT LSEQVQEELL SSQVTQELTA LMDETMKELK AYRSELEEQL
110 120 130 140 150
TPVAEETRAR LSKELQAAQA RLGADMEDVR GRLVQYRGEV QAMLGQSTEE
160 170 180 190 200
LRARLASHLR KLRKRLLRDA DDLQKRLAVY QAGAREGAER GVSAIRERLG
210 220 230 240 250
PLVEQGRVRA ATVGSLAGQP LQERAQAWGE RLRARMEEVG GRTRDRLDEV
260 270 280 290 300
KEQVAEVRAK LEEQAQQIRL QAEAFQARLK SWFEPLVEDM QRQWAGLVEK
310
VQAAVGTSAA PVPSDNH
Length:317
Mass (Da):35,983
Last modified:March 1, 2001 - v1
Checksum:iFEA0C2CA6629D5B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200508, AF200506, AF200507 Genomic DNA. Translation: AAG28581.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200508, AF200506, AF200507 Genomic DNA. Translation: AAG28581.1.

3D structure databases

ProteinModelPortaliQ9GLM6.
SMRiQ9GLM6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG010582.

Family and domain databases

InterProiView protein in InterPro
IPR000074. ApoA_E.
PfamiView protein in Pfam
PF01442. Apolipoprotein. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAPOE_HYLLA
AccessioniPrimary (citable) accession number: Q9GLM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2001
Last modified: February 15, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.