Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tensin-1

Gene

TNS1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tensin-1
Gene namesi
Name:TNS1
Synonyms:TNS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17151715Tensin-1PRO_0000215899Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei338 – 3381PhosphoserineBy similarity
Modified residuei364 – 3641PhosphoserineBy similarity
Modified residuei366 – 3661PhosphotyrosineBy similarity
Modified residuei378 – 3781PhosphoserineBy similarity
Modified residuei433 – 4331PhosphoserineBy similarity
Modified residuei704 – 7041PhosphoserineBy similarity
Modified residuei767 – 7671PhosphoserineBy similarity
Modified residuei772 – 7721PhosphoserineBy similarity
Modified residuei797 – 7971PhosphoserineBy similarity
Modified residuei863 – 8631PhosphothreonineBy similarity
Modified residuei902 – 9021PhosphoserineBy similarity
Modified residuei906 – 9061PhosphotyrosineBy similarity
Modified residuei910 – 9101PhosphoserineBy similarity
Modified residuei966 – 9661PhosphoserineBy similarity
Modified residuei970 – 9701PhosphoserineBy similarity
Modified residuei1106 – 11061PhosphoserineBy similarity
Modified residuei1158 – 11581PhosphoserineBy similarity
Modified residuei1170 – 11701PhosphothreonineBy similarity
Modified residuei1173 – 11731PhosphoserineBy similarity
Modified residuei1248 – 12481PhosphoserineBy similarity
Modified residuei1273 – 12731PhosphoserineBy similarity
Modified residuei1288 – 12881PhosphoserineBy similarity
Modified residuei1293 – 12931PhosphoserineBy similarity
Modified residuei1360 – 13601PhosphoserineBy similarity
Modified residuei1372 – 13721PhosphoserineBy similarity
Modified residuei1426 – 14261PhosphoserineBy similarity
Modified residuei1568 – 15681PhosphoserineBy similarity

Post-translational modificationi

Rapidly cleaved by calpain II.By similarity
Tyrosine phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9GLM4.
PRIDEiQ9GLM4.

Interactioni

Subunit structurei

Binds to actin filaments and interacts with phosphotyrosine-containing proteins. Interacts with STARD8 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003229.

Structurei

3D structure databases

ProteinModelPortaliQ9GLM4.
SMRiQ9GLM4. Positions 1576-1715.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 176173Phosphatase tensin-typePROSITE-ProRule annotationAdd
BLAST
Domaini181 – 307127C2 tensin-typePROSITE-ProRule annotationAdd
BLAST
Domaini1443 – 1552110SH2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi651 – 67020Gln-richAdd
BLAST
Compositional biasi779 – 1004226Pro-richAdd
BLAST
Compositional biasi1051 – 113888Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 C2 tensin-type domain.PROSITE-ProRule annotation
Contains 1 phosphatase tensin-type domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG1930. Eukaryota.
KOG2283. Eukaryota.
COG2453. LUCA.
HOGENOMiHOG000060090.
HOVERGENiHBG060186.
InParanoidiQ9GLM4.
KOiK18080.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR003595. Tyr_Pase_cat.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM01326. PTEN_C2. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GLM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSRTTEDS CELDLVYVTE RIIAVSFPST ANEENFRSNL REVAQMLKSK
60 70 80 90 100
HGGNYLLFNL SERRPDITKL HAKVLEFGWP DLHTPALEKI CSVCKAMDTW
110 120 130 140 150
LNADPHNVVV LHNKGNRGRI GVVIAAYMHY SNISASADHA LDRFAMKRFY
160 170 180 190 200
EDKIVPIGQP SQRRYVHYFS GLLSGSIKMN NKPLFLHHVI MHGIPNFESK
210 220 230 240 250
GGCRPFLRIY QAMQPVYTSG IYNVQGDSQT SICITIEPGL LLKGDILLKC
260 270 280 290 300
YHKKFRSPAR DVIFRVQFHT CAIHDLGVVF GKEDLDDAFK DDRFPEYGKV
310 320 330 340 350
EFVFSYGPEK IQGMEHLENG PSVSVDYNTS DPLIRWHSYD NFNGHRDDGM
360 370 380 390 400
EEVVGHTPGT LDGSLYAKVK KKDSLHGSNG AVNATRPVLS ATPNHVEHTL
410 420 430 440 450
SVSSDSGNST ASTKTDKTDE PAPGPASAPA ALSPEEKREL DRLLSGFGLE
460 470 480 490 500
REKQGAMYHP QHLRSRPVGG PAAPSSGRHI VPAQVHVRGG VLSVERETDI
510 520 530 540 550
LDDELPNQDG HSVGSMGTLS SLDGVTNTSE GGYPEALSPL TNGLDKPYPM
560 570 580 590 600
EPMVNGGGYP YESASRAVSA QAGHTAPMRP SYSTQEGLAG YQREGPHPAW
610 620 630 640 650
PQSATTSHYG HDPNGMFRSQ SFPETEPQLP PAPARGGSSR EAVQRGLNSW
660 670 680 690 700
QQQQQQQQQQ QQPRPPPRQQ ERVHLESLGL SRPSPQPLAE PPMSGLPEFP
710 720 730 740 750
RAASQQEIEQ SIEALNMLML DLEPATAGAP LHKSQSVPGA WPGASPLSSQ
760 770 780 790 800
PFSGSSCQSH PLTQSRSGYI PSGHSLGTPE PAPRAPLESV PTGRPYSPYD
810 820 830 840 850
YQPCPTGPNQ SYHPKSPATS SSSSFLPTTQ SSVGPQQPPA SLPGLTTQPQ
860 870 880 890 900
LPPKEVTSDP SRTPEEEPLN LEGLVAHRVA GVQAREKQPA EPPAPLRKRA
910 920 930 940 950
ASDGQYENQS PEPTSPRSPG VRSPVQCVSP ELALTIALNP GGRPKEPHLH
960 970 980 990 1000
SYKEAFEEME GTSPTSPPPS GVRSPPGLAK TPLSALGLKP HNPADILLHP
1010 1020 1030 1040 1050
TGEPRSYVES VVRTAVAGPR TQEPEPKSFS APAAQAYGHE TPLRIGTLGG
1060 1070 1080 1090 1100
SFVSPSPLST SSPILSADST SVGSFPSGES SDQGARTPTQ PLLDSGFRSG
1110 1120 1130 1140 1150
SLGQPSPLAQ RNYQSSSPLP TAGSSYSSPD YSLQQFSSPE GQARSQFSVA
1160 1170 1180 1190 1200
GVHTVPGSPQ ARHRTVGTNT PPSPGFGRRA VNPSLAAPSS PSLSHRQVMG
1210 1220 1230 1240 1250
PLGTGFHGNT GSSPQSSAAT TPGSPSLGRH PGAQVSNLHG NVVTRPGSPS
1260 1270 1280 1290 1300
LGRHPGAHQG TLASNLHSNA VASPGSPSLG RHLGGSGSVV PGSPSLDRHV
1310 1320 1330 1340 1350
PYGGYSTPED RRPTLSRQSS ASGYQAPSTP SFPVSPAYYP GLSSPATSPS
1360 1370 1380 1390 1400
PDSAAFRQGS PTPALPEKRR MSMGDRAGSL PNYATVNGKV SSSPVASGMS
1410 1420 1430 1440 1450
SPSGGSTVSF SHTLPDFSKY SMPDNSPETR AKVKFVQDTS KYWYKPEISR
1460 1470 1480 1490 1500
EQAIALLKDQ EPGAFIIRDS HSFRGAYGLA MKVSSPPPTI MQQNKKGDMT
1510 1520 1530 1540 1550
HELVRHFLIE TGPRGVKLKG CPNEPNFGSL SALVYQHSII PLALPCKLVI
1560 1570 1580 1590 1600
PNRDPTDESK DSSGPANSTS DLLKQGAACN VLFVNSVDME SLTGPQAISK
1610 1620 1630 1640 1650
AISETLAADP TPAATIVHFK VSAQGITLTD NQRKLFFRRH YPLNTVTFCD
1660 1670 1680 1690 1700
LDPQERKWTK TEGGAPAKLF GFVARKQGSA TDNACHLFAE LDPNQPASAI
1710
VSFVSKVMLS AGQKR
Length:1,715
Mass (Da):183,508
Last modified:March 1, 2001 - v1
Checksum:iD32F16D64CEAF610
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225897 mRNA. Translation: AAG33701.1.
RefSeqiNP_777191.1. NM_174766.2.
UniGeneiBt.76111.

Genome annotation databases

GeneIDi286798.
KEGGibta:286798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225897 mRNA. Translation: AAG33701.1.
RefSeqiNP_777191.1. NM_174766.2.
UniGeneiBt.76111.

3D structure databases

ProteinModelPortaliQ9GLM4.
SMRiQ9GLM4. Positions 1576-1715.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003229.

Proteomic databases

PaxDbiQ9GLM4.
PRIDEiQ9GLM4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi286798.
KEGGibta:286798.

Organism-specific databases

CTDi7145.

Phylogenomic databases

eggNOGiKOG1930. Eukaryota.
KOG2283. Eukaryota.
COG2453. LUCA.
HOGENOMiHOG000060090.
HOVERGENiHBG060186.
InParanoidiQ9GLM4.
KOiK18080.

Miscellaneous databases

NextBioi20806452.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR003595. Tyr_Pase_cat.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM01326. PTEN_C2. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of human tensin."
    Chen H., Ishii A., Wong W.K., Chen L.B., Lo S.H.
    Biochem. J. 351:403-411(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTENS1_BOVIN
AccessioniPrimary (citable) accession number: Q9GLM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.