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Protein

Tensin-1

Gene

TNS1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tensin-1
Gene namesi
Name:TNS1
Synonyms:TNS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002158991 – 1715Tensin-1Add BLAST1715

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei338PhosphoserineBy similarity1
Modified residuei364PhosphoserineBy similarity1
Modified residuei366PhosphotyrosineBy similarity1
Modified residuei378PhosphoserineBy similarity1
Modified residuei433PhosphoserineBy similarity1
Modified residuei621PhosphoserineBy similarity1
Modified residuei704PhosphoserineBy similarity1
Modified residuei767PhosphoserineBy similarity1
Modified residuei772PhosphoserineBy similarity1
Modified residuei797PhosphoserineBy similarity1
Modified residuei863PhosphothreonineBy similarity1
Modified residuei902PhosphoserineBy similarity1
Modified residuei906PhosphotyrosineBy similarity1
Modified residuei910PhosphoserineBy similarity1
Modified residuei966PhosphoserineBy similarity1
Modified residuei970PhosphoserineBy similarity1
Modified residuei1106PhosphoserineBy similarity1
Modified residuei1158PhosphoserineBy similarity1
Modified residuei1170PhosphothreonineBy similarity1
Modified residuei1173PhosphoserineBy similarity1
Modified residuei1248PhosphoserineBy similarity1
Modified residuei1273PhosphoserineBy similarity1
Modified residuei1288PhosphoserineBy similarity1
Modified residuei1293PhosphoserineBy similarity1
Modified residuei1360PhosphoserineBy similarity1
Modified residuei1372PhosphoserineBy similarity1
Modified residuei1379PhosphoserineBy similarity1
Modified residuei1426PhosphoserineBy similarity1
Modified residuei1568PhosphoserineBy similarity1

Post-translational modificationi

Rapidly cleaved by calpain II.By similarity
Tyrosine phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9GLM4
PeptideAtlasiQ9GLM4
PRIDEiQ9GLM4

Interactioni

Subunit structurei

Binds to actin filaments and interacts with phosphotyrosine-containing proteins. Interacts with STARD8 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003229

Structurei

3D structure databases

ProteinModelPortaliQ9GLM4
SMRiQ9GLM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 176Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST173
Domaini181 – 307C2 tensin-typePROSITE-ProRule annotationAdd BLAST127
Domaini1443 – 1552SH2PROSITE-ProRule annotationAdd BLAST110

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi651 – 670Gln-richAdd BLAST20
Compositional biasi779 – 1004Pro-richAdd BLAST226
Compositional biasi1051 – 1138Ser-richAdd BLAST88

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG1930 Eukaryota
KOG2283 Eukaryota
COG2453 LUCA
HOGENOMiHOG000060090
HOVERGENiHBG060186
InParanoidiQ9GLM4
KOiK18080

Family and domain databases

CDDicd01213 PTB_tensin, 1 hit
cd09927 SH2_Tensin_like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR014020 Tensin_C2-dom
IPR035012 Tensin_like_SH2
IPR029023 Tensin_phosphatase
IPR033929 Tensin_PTB
IPR003595 Tyr_Pase_cat
PfamiView protein in Pfam
PF08416 PTB, 1 hit
PF10409 PTEN_C2, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM01326 PTEN_C2, 1 hit
SM00404 PTPc_motif, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9GLM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSRTTEDS CELDLVYVTE RIIAVSFPST ANEENFRSNL REVAQMLKSK
60 70 80 90 100
HGGNYLLFNL SERRPDITKL HAKVLEFGWP DLHTPALEKI CSVCKAMDTW
110 120 130 140 150
LNADPHNVVV LHNKGNRGRI GVVIAAYMHY SNISASADHA LDRFAMKRFY
160 170 180 190 200
EDKIVPIGQP SQRRYVHYFS GLLSGSIKMN NKPLFLHHVI MHGIPNFESK
210 220 230 240 250
GGCRPFLRIY QAMQPVYTSG IYNVQGDSQT SICITIEPGL LLKGDILLKC
260 270 280 290 300
YHKKFRSPAR DVIFRVQFHT CAIHDLGVVF GKEDLDDAFK DDRFPEYGKV
310 320 330 340 350
EFVFSYGPEK IQGMEHLENG PSVSVDYNTS DPLIRWHSYD NFNGHRDDGM
360 370 380 390 400
EEVVGHTPGT LDGSLYAKVK KKDSLHGSNG AVNATRPVLS ATPNHVEHTL
410 420 430 440 450
SVSSDSGNST ASTKTDKTDE PAPGPASAPA ALSPEEKREL DRLLSGFGLE
460 470 480 490 500
REKQGAMYHP QHLRSRPVGG PAAPSSGRHI VPAQVHVRGG VLSVERETDI
510 520 530 540 550
LDDELPNQDG HSVGSMGTLS SLDGVTNTSE GGYPEALSPL TNGLDKPYPM
560 570 580 590 600
EPMVNGGGYP YESASRAVSA QAGHTAPMRP SYSTQEGLAG YQREGPHPAW
610 620 630 640 650
PQSATTSHYG HDPNGMFRSQ SFPETEPQLP PAPARGGSSR EAVQRGLNSW
660 670 680 690 700
QQQQQQQQQQ QQPRPPPRQQ ERVHLESLGL SRPSPQPLAE PPMSGLPEFP
710 720 730 740 750
RAASQQEIEQ SIEALNMLML DLEPATAGAP LHKSQSVPGA WPGASPLSSQ
760 770 780 790 800
PFSGSSCQSH PLTQSRSGYI PSGHSLGTPE PAPRAPLESV PTGRPYSPYD
810 820 830 840 850
YQPCPTGPNQ SYHPKSPATS SSSSFLPTTQ SSVGPQQPPA SLPGLTTQPQ
860 870 880 890 900
LPPKEVTSDP SRTPEEEPLN LEGLVAHRVA GVQAREKQPA EPPAPLRKRA
910 920 930 940 950
ASDGQYENQS PEPTSPRSPG VRSPVQCVSP ELALTIALNP GGRPKEPHLH
960 970 980 990 1000
SYKEAFEEME GTSPTSPPPS GVRSPPGLAK TPLSALGLKP HNPADILLHP
1010 1020 1030 1040 1050
TGEPRSYVES VVRTAVAGPR TQEPEPKSFS APAAQAYGHE TPLRIGTLGG
1060 1070 1080 1090 1100
SFVSPSPLST SSPILSADST SVGSFPSGES SDQGARTPTQ PLLDSGFRSG
1110 1120 1130 1140 1150
SLGQPSPLAQ RNYQSSSPLP TAGSSYSSPD YSLQQFSSPE GQARSQFSVA
1160 1170 1180 1190 1200
GVHTVPGSPQ ARHRTVGTNT PPSPGFGRRA VNPSLAAPSS PSLSHRQVMG
1210 1220 1230 1240 1250
PLGTGFHGNT GSSPQSSAAT TPGSPSLGRH PGAQVSNLHG NVVTRPGSPS
1260 1270 1280 1290 1300
LGRHPGAHQG TLASNLHSNA VASPGSPSLG RHLGGSGSVV PGSPSLDRHV
1310 1320 1330 1340 1350
PYGGYSTPED RRPTLSRQSS ASGYQAPSTP SFPVSPAYYP GLSSPATSPS
1360 1370 1380 1390 1400
PDSAAFRQGS PTPALPEKRR MSMGDRAGSL PNYATVNGKV SSSPVASGMS
1410 1420 1430 1440 1450
SPSGGSTVSF SHTLPDFSKY SMPDNSPETR AKVKFVQDTS KYWYKPEISR
1460 1470 1480 1490 1500
EQAIALLKDQ EPGAFIIRDS HSFRGAYGLA MKVSSPPPTI MQQNKKGDMT
1510 1520 1530 1540 1550
HELVRHFLIE TGPRGVKLKG CPNEPNFGSL SALVYQHSII PLALPCKLVI
1560 1570 1580 1590 1600
PNRDPTDESK DSSGPANSTS DLLKQGAACN VLFVNSVDME SLTGPQAISK
1610 1620 1630 1640 1650
AISETLAADP TPAATIVHFK VSAQGITLTD NQRKLFFRRH YPLNTVTFCD
1660 1670 1680 1690 1700
LDPQERKWTK TEGGAPAKLF GFVARKQGSA TDNACHLFAE LDPNQPASAI
1710
VSFVSKVMLS AGQKR
Length:1,715
Mass (Da):183,508
Last modified:March 1, 2001 - v1
Checksum:iD32F16D64CEAF610
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225897 mRNA Translation: AAG33701.1
RefSeqiNP_777191.1, NM_174766.2
UniGeneiBt.76111

Genome annotation databases

GeneIDi286798
KEGGibta:286798

Similar proteinsi

Entry informationi

Entry nameiTENS1_BOVIN
AccessioniPrimary (citable) accession number: Q9GLM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health