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Q9GLK0

- TGM1_CANFA

UniProt

Q9GLK0 - TGM1_CANFA

Protein

Protein-glutamine gamma-glutamyltransferase K

Gene

TGM1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum By similarity.By similarity

    Catalytic activityi

    Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei375 – 3751PROSITE-ProRule annotation
    Active sitei434 – 4341PROSITE-ProRule annotation
    Active sitei457 – 4571PROSITE-ProRule annotation
    Metal bindingi497 – 4971CalciumBy similarity
    Metal bindingi499 – 4991CalciumBy similarity
    Metal bindingi546 – 5461CalciumBy similarity
    Metal bindingi551 – 5511CalciumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. keratinization Source: UniProtKB-KW
    2. peptide cross-linking Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Keratinization

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-glutamine gamma-glutamyltransferase K (EC:2.3.2.13)
    Alternative name(s):
    Epidermal TGase
    Transglutaminase K
    Short name:
    TG(K)
    Short name:
    TGK
    Short name:
    TGase K
    Transglutaminase-1
    Short name:
    TGase-1
    Gene namesi
    Name:TGM1
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    Membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 815815Protein-glutamine gamma-glutamyltransferase KPRO_0000213700Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 231PhosphoserineBy similarity
    Modified residuei80 – 801PhosphoserineBy similarity
    Modified residuei83 – 831PhosphoserineBy similarity
    Modified residuei90 – 901PhosphoserineBy similarity
    Modified residuei93 – 931PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000017949.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GLK0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG80379.
    HOGENOMiHOG000231695.
    HOVERGENiHBG004342.
    InParanoidiQ9GLK0.
    KOiK05619.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view]
    PANTHERiPTHR11590. PTHR11590. 1 hit.
    PfamiPF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
    SMARTiSM00460. TGc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9GLK0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGPRSDVGR WGGNPWQPPT TPSPEPEPEP EPERRSRRGG RSFWARCCGC    50
    CSCRNRADDD WGPEPHRDRG SGSGRRRPDS RGSDSRRPGS RASGVNAAGD 100
    GTIREGMLVV TGVDLLSSRS DQNRREHHTD EFEYDELIIR RGQPFHMVLH 150
    FSRPYESSDR VALELLIGNN PEVGKGTHVI IPVGKGGSGG WKAQVTKASG 200
    QNLNLRVHTS PNAIIGKFQF TVRTHSEAGE FQLPFDPHNE IYILFNPWCP 250
    EDIVYVDHED WRQEYVLNES GRIYYGTEAQ IGERTWNYGQ FDHGVLDACL 300
    YILDRRGMPY GGRGDPVSVS RVISAMVNSL DDNGVLIGNW SGDYSRGTNP 350
    SAWVGSVEIL LSYLRTGYSV PYGQCWVFAG VTTTVLRCLG LATRTVTNFN 400
    SAHDTDTSLT MDIYFDENMK PLEHLNHDSV WNFHVWNDCW MKRPDLPSGF 450
    DGWQVVDATP QETSSGIFCC GPCSVESIKN GLVYMKYDTP FIFAEVNSDK 500
    VYWQRQDDGS FKIVYVEEKA IGTLIVTKAV GSNMQDDVTH IYKHPEGSEA 550
    ERKAVETAAA HGSKPNVYTN RDSAEDVALQ VEAQDAVMGQ DLTVSVVLTN 600
    RGSSTRTVKL HLYLSVTFYT GVTGPVFKES KKEVVLAPGA TERVSMPVAY 650
    KEYRPQIVDQ GSMLLNVSGH VKENGQVLAK QHTFRLRTPD LSLTLLGAAV 700
    VGQECEVQIV FKNPLPVTLT NVVFRLEGSG LQRPKILNVG DIGGNETVTL 750
    HQKFVPVRPG PRQLIASLDS PQLSQVHGVI QVDVAPAPGG GGFFSNAGGN 800
    SPLGETIPMA SRGGA 815
    Length:815
    Mass (Da):89,757
    Last modified:March 1, 2001 - v1
    Checksum:i82C49D15DDD25BE4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF262219 mRNA. Translation: AAG13662.1.
    RefSeqiNP_001003079.1. NM_001003079.1.
    UniGeneiCfa.3494.

    Genome annotation databases

    GeneIDi403630.
    KEGGicfa:403630.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF262219 mRNA. Translation: AAG13662.1 .
    RefSeqi NP_001003079.1. NM_001003079.1.
    UniGenei Cfa.3494.

    3D structure databases

    ProteinModelPortali Q9GLK0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000017949.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 403630.
    KEGGi cfa:403630.

    Organism-specific databases

    CTDi 7051.

    Phylogenomic databases

    eggNOGi NOG80379.
    HOGENOMi HOG000231695.
    HOVERGENi HBG004342.
    InParanoidi Q9GLK0.
    KOi K05619.

    Miscellaneous databases

    NextBioi 20817135.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view ]
    PANTHERi PTHR11590. PTHR11590. 1 hit.
    Pfami PF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
    SMARTi SM00460. TGc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and physical mapping of the canine transglutaminase 1 gene."
      Credille K.M., Venta P.J., Breen M., Lowe J.K., Murphy K.E., Ostrander E.A., Galibert F., Dunstan R.W.
      Cytogenet. Cell Genet. 93:73-76(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiTGM1_CANFA
    AccessioniPrimary (citable) accession number: Q9GLK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3