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Q9GLK0

- TGM1_CANFA

UniProt

Q9GLK0 - TGM1_CANFA

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Protein
Protein-glutamine gamma-glutamyltransferase K
Gene
TGM1
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum By similarity.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei375 – 3751 By similarity
Active sitei434 – 4341 By similarity
Active sitei457 – 4571 By similarity
Metal bindingi497 – 4971Calcium By similarity
Metal bindingi499 – 4991Calcium By similarity
Metal bindingi546 – 5461Calcium By similarity
Metal bindingi551 – 5511Calcium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. keratinization Source: UniProtKB-KW
  2. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Keratinization

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase K (EC:2.3.2.13)
Alternative name(s):
Epidermal TGase
Transglutaminase K
Short name:
TG(K)
Short name:
TGK
Short name:
TGase K
Transglutaminase-1
Short name:
TGase-1
Gene namesi
Name:TGM1
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 815815Protein-glutamine gamma-glutamyltransferase K
PRO_0000213700Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231Phosphoserine By similarity
Modified residuei80 – 801Phosphoserine By similarity
Modified residuei83 – 831Phosphoserine By similarity
Modified residuei90 – 901Phosphoserine By similarity
Modified residuei93 – 931Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000017949.

Structurei

3D structure databases

ProteinModelPortaliQ9GLK0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiQ9GLK0.
KOiK05619.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GLK0-1 [UniParc]FASTAAdd to Basket

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MDGPRSDVGR WGGNPWQPPT TPSPEPEPEP EPERRSRRGG RSFWARCCGC    50
CSCRNRADDD WGPEPHRDRG SGSGRRRPDS RGSDSRRPGS RASGVNAAGD 100
GTIREGMLVV TGVDLLSSRS DQNRREHHTD EFEYDELIIR RGQPFHMVLH 150
FSRPYESSDR VALELLIGNN PEVGKGTHVI IPVGKGGSGG WKAQVTKASG 200
QNLNLRVHTS PNAIIGKFQF TVRTHSEAGE FQLPFDPHNE IYILFNPWCP 250
EDIVYVDHED WRQEYVLNES GRIYYGTEAQ IGERTWNYGQ FDHGVLDACL 300
YILDRRGMPY GGRGDPVSVS RVISAMVNSL DDNGVLIGNW SGDYSRGTNP 350
SAWVGSVEIL LSYLRTGYSV PYGQCWVFAG VTTTVLRCLG LATRTVTNFN 400
SAHDTDTSLT MDIYFDENMK PLEHLNHDSV WNFHVWNDCW MKRPDLPSGF 450
DGWQVVDATP QETSSGIFCC GPCSVESIKN GLVYMKYDTP FIFAEVNSDK 500
VYWQRQDDGS FKIVYVEEKA IGTLIVTKAV GSNMQDDVTH IYKHPEGSEA 550
ERKAVETAAA HGSKPNVYTN RDSAEDVALQ VEAQDAVMGQ DLTVSVVLTN 600
RGSSTRTVKL HLYLSVTFYT GVTGPVFKES KKEVVLAPGA TERVSMPVAY 650
KEYRPQIVDQ GSMLLNVSGH VKENGQVLAK QHTFRLRTPD LSLTLLGAAV 700
VGQECEVQIV FKNPLPVTLT NVVFRLEGSG LQRPKILNVG DIGGNETVTL 750
HQKFVPVRPG PRQLIASLDS PQLSQVHGVI QVDVAPAPGG GGFFSNAGGN 800
SPLGETIPMA SRGGA 815
Length:815
Mass (Da):89,757
Last modified:March 1, 2001 - v1
Checksum:i82C49D15DDD25BE4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF262219 mRNA. Translation: AAG13662.1.
RefSeqiNP_001003079.1. NM_001003079.1.
UniGeneiCfa.3494.

Genome annotation databases

GeneIDi403630.
KEGGicfa:403630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF262219 mRNA. Translation: AAG13662.1 .
RefSeqi NP_001003079.1. NM_001003079.1.
UniGenei Cfa.3494.

3D structure databases

ProteinModelPortali Q9GLK0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000017949.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403630.
KEGGi cfa:403630.

Organism-specific databases

CTDi 7051.

Phylogenomic databases

eggNOGi NOG80379.
HOGENOMi HOG000231695.
HOVERGENi HBG004342.
InParanoidi Q9GLK0.
KOi K05619.

Miscellaneous databases

NextBioi 20817135.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence and physical mapping of the canine transglutaminase 1 gene."
    Credille K.M., Venta P.J., Breen M., Lowe J.K., Murphy K.E., Ostrander E.A., Galibert F., Dunstan R.W.
    Cytogenet. Cell Genet. 93:73-76(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTGM1_CANFA
AccessioniPrimary (citable) accession number: Q9GLK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 1, 2001
Last modified: March 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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