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Q9GLK0

- TGM1_CANFA

UniProt

Q9GLK0 - TGM1_CANFA

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Protein

Protein-glutamine gamma-glutamyltransferase K

Gene

TGM1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum (By similarity).By similarity

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Binds 1 calcium ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei375 – 3751PROSITE-ProRule annotation
Active sitei434 – 4341PROSITE-ProRule annotation
Active sitei457 – 4571PROSITE-ProRule annotation
Metal bindingi497 – 4971CalciumBy similarity
Metal bindingi499 – 4991CalciumBy similarity
Metal bindingi546 – 5461CalciumBy similarity
Metal bindingi551 – 5511CalciumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. keratinization Source: UniProtKB-KW
  2. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Keratinization

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase K (EC:2.3.2.13)
Alternative name(s):
Epidermal TGase
Transglutaminase K
Short name:
TG(K)
Short name:
TGK
Short name:
TGase K
Transglutaminase-1
Short name:
TGase-1
Gene namesi
Name:TGM1
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 815815Protein-glutamine gamma-glutamyltransferase KPRO_0000213700Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei80 – 801PhosphoserineBy similarity
Modified residuei83 – 831PhosphoserineBy similarity
Modified residuei90 – 901PhosphoserineBy similarity
Modified residuei93 – 931PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000017949.

Structurei

3D structure databases

ProteinModelPortaliQ9GLK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiQ9GLK0.
KOiK05619.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GLK0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGPRSDVGR WGGNPWQPPT TPSPEPEPEP EPERRSRRGG RSFWARCCGC
60 70 80 90 100
CSCRNRADDD WGPEPHRDRG SGSGRRRPDS RGSDSRRPGS RASGVNAAGD
110 120 130 140 150
GTIREGMLVV TGVDLLSSRS DQNRREHHTD EFEYDELIIR RGQPFHMVLH
160 170 180 190 200
FSRPYESSDR VALELLIGNN PEVGKGTHVI IPVGKGGSGG WKAQVTKASG
210 220 230 240 250
QNLNLRVHTS PNAIIGKFQF TVRTHSEAGE FQLPFDPHNE IYILFNPWCP
260 270 280 290 300
EDIVYVDHED WRQEYVLNES GRIYYGTEAQ IGERTWNYGQ FDHGVLDACL
310 320 330 340 350
YILDRRGMPY GGRGDPVSVS RVISAMVNSL DDNGVLIGNW SGDYSRGTNP
360 370 380 390 400
SAWVGSVEIL LSYLRTGYSV PYGQCWVFAG VTTTVLRCLG LATRTVTNFN
410 420 430 440 450
SAHDTDTSLT MDIYFDENMK PLEHLNHDSV WNFHVWNDCW MKRPDLPSGF
460 470 480 490 500
DGWQVVDATP QETSSGIFCC GPCSVESIKN GLVYMKYDTP FIFAEVNSDK
510 520 530 540 550
VYWQRQDDGS FKIVYVEEKA IGTLIVTKAV GSNMQDDVTH IYKHPEGSEA
560 570 580 590 600
ERKAVETAAA HGSKPNVYTN RDSAEDVALQ VEAQDAVMGQ DLTVSVVLTN
610 620 630 640 650
RGSSTRTVKL HLYLSVTFYT GVTGPVFKES KKEVVLAPGA TERVSMPVAY
660 670 680 690 700
KEYRPQIVDQ GSMLLNVSGH VKENGQVLAK QHTFRLRTPD LSLTLLGAAV
710 720 730 740 750
VGQECEVQIV FKNPLPVTLT NVVFRLEGSG LQRPKILNVG DIGGNETVTL
760 770 780 790 800
HQKFVPVRPG PRQLIASLDS PQLSQVHGVI QVDVAPAPGG GGFFSNAGGN
810
SPLGETIPMA SRGGA
Length:815
Mass (Da):89,757
Last modified:March 1, 2001 - v1
Checksum:i82C49D15DDD25BE4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF262219 mRNA. Translation: AAG13662.1.
RefSeqiNP_001003079.1. NM_001003079.1.
UniGeneiCfa.3494.

Genome annotation databases

GeneIDi403630.
KEGGicfa:403630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF262219 mRNA. Translation: AAG13662.1 .
RefSeqi NP_001003079.1. NM_001003079.1.
UniGenei Cfa.3494.

3D structure databases

ProteinModelPortali Q9GLK0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000017949.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403630.
KEGGi cfa:403630.

Organism-specific databases

CTDi 7051.

Phylogenomic databases

eggNOGi NOG80379.
HOGENOMi HOG000231695.
HOVERGENi HBG004342.
InParanoidi Q9GLK0.
KOi K05619.

Miscellaneous databases

NextBioi 20817135.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence and physical mapping of the canine transglutaminase 1 gene."
    Credille K.M., Venta P.J., Breen M., Lowe J.K., Murphy K.E., Ostrander E.A., Galibert F., Dunstan R.W.
    Cytogenet. Cell Genet. 93:73-76(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTGM1_CANFA
AccessioniPrimary (citable) accession number: Q9GLK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3