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Q9GLF6 (OREX_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orexin
Alternative name(s):
Hypocretin
Short name=Hcrt

Cleaved into the following 2 chains:

  1. Orexin-A
    Alternative name(s):
    Hypocretin-1
    Short name=Hcrt1
  2. Orexin-B
    Alternative name(s):
    Hypocretin-2
    Short name=Hcrt2
Gene names
Name:HCRT
Synonyms:OX, PPOX
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length130 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.

Subcellular location

Rough endoplasmic reticulum By similarity. Cytoplasmic vesicle By similarity. Cell junctionsynapse By similarity. Note: Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses By similarity.

Post-translational modification

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Sequence similarities

Belongs to the orexin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 By similarity
Peptide33 – 6533Orexin-A
PRO_0000020258
Peptide69 – 9628Orexin-B
PRO_0000020259
Propeptide97 – 13034
PRO_0000020260

Amino acid modifications

Modified residue331Pyrrolidone carboxylic acid By similarity
Modified residue651Leucine amide By similarity
Modified residue961Methionine amide By similarity
Disulfide bond38 ↔ 44 By similarity
Disulfide bond39 ↔ 46 By similarity

Natural variations

Natural variant301A → T. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9GLF6 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 2BF59D4C1E422DF3

FASTA13013,328
        10         20         30         40         50         60 
MNPPSTKVPW AAVTLLLLLL LPPALLSPGA AAQPLPDCCR QKTCSCRLYE LLHGAGNHAA 

        70         80         90        100        110        120 
GILTLGKRRP GPPGLQGRLQ RLLQASGNHA AGILTMGRRA GAEPAPRPCP GRRCPVVAVP 

       130 
SAAPGGRSGV 

« Hide

References

[1]"Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines."
Hungs M., Fan J., Lin L., Lin X., Maki R.A., Mignot E.
Genome Res. 11:531-539(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-30.
[2]"Hypocretin/orexin, sleep and narcolepsy."
Hungs M., Mignot E.
Bioessays 23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[3]"To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M.
Annu. Rev. Neurosci. 24:429-458(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Web resources

Protein Spotlight

Qui dort dine - Issue 15 of October 2001

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF285110 Genomic DNA. Translation: AAG13965.1.
RefSeqNP_001029166.1. NM_001033994.1.
XP_005624415.1. XM_005624358.1.
UniGeneCfa.24652.

3D structure databases

ProteinModelPortalQ9GLF6.
SMRQ9GLF6. Positions 33-65, 71-96.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000022949.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000024739; ENSCAFP00000022949; ENSCAFG00000015615.
GeneID607641.
KEGGcfa:607641.

Organism-specific databases

CTD3060.

Phylogenomic databases

eggNOGNOG70925.
GeneTreeENSGT00390000014272.
HOGENOMHOG000230990.
HOVERGENHBG000256.
InParanoidQ9GLF6.
KOK05246.
OMAKVSWATV.
OrthoDBEOG7XSTHD.
TreeFamTF330756.

Family and domain databases

InterProIPR001704. Orexin.
[Graphical view]
PANTHERPTHR15173. PTHR15173. 1 hit.
PfamPF02072. Orexin. 1 hit.
[Graphical view]
PIRSFPIRSF037824. Orexin. 1 hit.
PRINTSPR01091. OREXINPP.
ProtoNetSearch...

Other

NextBio20893355.

Entry information

Entry nameOREX_CANFA
AccessionPrimary (citable) accession number: Q9GLF6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries