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Q9GLF6

- OREX_CANFA

UniProt

Q9GLF6 - OREX_CANFA

Protein

Orexin

Gene

HCRT

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
  1. Functioni

    Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.

    GO - Biological processi

    1. feeding behavior Source: InterPro
    2. neuropeptide signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Neuropeptide

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orexin
    Alternative name(s):
    Hypocretin
    Short name:
    Hcrt
    Cleaved into the following 2 chains:
    Alternative name(s):
    Hypocretin-1
    Short name:
    Hcrt1
    Alternative name(s):
    Hypocretin-2
    Short name:
    Hcrt2
    Gene namesi
    Name:HCRT
    Synonyms:OX, PPOX
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 9

    Subcellular locationi

    Rough endoplasmic reticulum By similarity. Cytoplasmic vesicle By similarity. Cell junctionsynapse By similarity
    Note: Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    3. perinuclear region of cytoplasm Source: Ensembl
    4. rough endoplasmic reticulum Source: UniProtKB-SubCell
    5. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232By similarityAdd
    BLAST
    Peptidei33 – 6533Orexin-APRO_0000020258Add
    BLAST
    Peptidei69 – 9628Orexin-BPRO_0000020259Add
    BLAST
    Propeptidei97 – 13034PRO_0000020260Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei33 – 331Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi38 ↔ 44By similarity
    Disulfide bondi39 ↔ 46By similarity
    Modified residuei65 – 651Leucine amideBy similarity
    Modified residuei96 – 961Methionine amideBy similarity

    Post-translational modificationi

    Specific enzymatic cleavages at paired basic residues yield the different active peptides.

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Disulfide bond, Pyrrolidone carboxylic acid

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000022949.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GLF6.
    SMRiQ9GLF6. Positions 33-65, 71-96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the orexin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG70925.
    GeneTreeiENSGT00390000014272.
    HOGENOMiHOG000230990.
    HOVERGENiHBG000256.
    InParanoidiQ9GLF6.
    KOiK05246.
    OMAiMERALHI.
    OrthoDBiEOG7XSTHD.
    TreeFamiTF330756.

    Family and domain databases

    InterProiIPR001704. Orexin.
    [Graphical view]
    PANTHERiPTHR15173. PTHR15173. 1 hit.
    PfamiPF02072. Orexin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037824. Orexin. 1 hit.
    PRINTSiPR01091. OREXINPP.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9GLF6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPPSTKVPW AAVTLLLLLL LPPALLSPGA AAQPLPDCCR QKTCSCRLYE    50
    LLHGAGNHAA GILTLGKRRP GPPGLQGRLQ RLLQASGNHA AGILTMGRRA 100
    GAEPAPRPCP GRRCPVVAVP SAAPGGRSGV 130
    Length:130
    Mass (Da):13,328
    Last modified:March 1, 2001 - v1
    Checksum:i2BF59D4C1E422DF3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti30 – 301A → T.1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF285110 Genomic DNA. Translation: AAG13965.1.
    RefSeqiNP_001029166.1. NM_001033994.1.
    XP_005624415.1. XM_005624358.1.
    UniGeneiCfa.24652.

    Genome annotation databases

    EnsembliENSCAFT00000024739; ENSCAFP00000022949; ENSCAFG00000015615.
    GeneIDi607641.
    KEGGicfa:607641.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Qui dort dine - Issue 15 of October 2001

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF285110 Genomic DNA. Translation: AAG13965.1 .
    RefSeqi NP_001029166.1. NM_001033994.1.
    XP_005624415.1. XM_005624358.1.
    UniGenei Cfa.24652.

    3D structure databases

    ProteinModelPortali Q9GLF6.
    SMRi Q9GLF6. Positions 33-65, 71-96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000022949.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000024739 ; ENSCAFP00000022949 ; ENSCAFG00000015615 .
    GeneIDi 607641.
    KEGGi cfa:607641.

    Organism-specific databases

    CTDi 3060.

    Phylogenomic databases

    eggNOGi NOG70925.
    GeneTreei ENSGT00390000014272.
    HOGENOMi HOG000230990.
    HOVERGENi HBG000256.
    InParanoidi Q9GLF6.
    KOi K05246.
    OMAi MERALHI.
    OrthoDBi EOG7XSTHD.
    TreeFami TF330756.

    Miscellaneous databases

    NextBioi 20893355.

    Family and domain databases

    InterProi IPR001704. Orexin.
    [Graphical view ]
    PANTHERi PTHR15173. PTHR15173. 1 hit.
    Pfami PF02072. Orexin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037824. Orexin. 1 hit.
    PRINTSi PR01091. OREXINPP.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines."
      Hungs M., Fan J., Lin L., Lin X., Maki R.A., Mignot E.
      Genome Res. 11:531-539(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-30.
    2. "Hypocretin/orexin, sleep and narcolepsy."
      Hungs M., Mignot E.
      Bioessays 23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    3. "To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
      Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M.
      Annu. Rev. Neurosci. 24:429-458(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiOREX_CANFA
    AccessioniPrimary (citable) accession number: Q9GLF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3