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Q9GLF6

- OREX_CANFA

UniProt

Q9GLF6 - OREX_CANFA

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Protein

Orexin

Gene

HCRT

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.

GO - Biological processi

  1. feeding behavior Source: InterPro
  2. neuropeptide signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin
Alternative name(s):
Hypocretin
Short name:
Hcrt
Cleaved into the following 2 chains:
Alternative name(s):
Hypocretin-1
Short name:
Hcrt1
Alternative name(s):
Hypocretin-2
Short name:
Hcrt2
Gene namesi
Name:HCRT
Synonyms:OX, PPOX
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 9

Subcellular locationi

Rough endoplasmic reticulum By similarity. Cytoplasmic vesicle By similarity. Cell junctionsynapse By similarity
Note: Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. endoplasmic reticulum Source: UniProtKB-KW
  4. perinuclear region of cytoplasm Source: Ensembl
  5. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232By similarityAdd
BLAST
Peptidei33 – 6533Orexin-APRO_0000020258Add
BLAST
Peptidei69 – 9628Orexin-BPRO_0000020259Add
BLAST
Propeptidei97 – 13034PRO_0000020260Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331Pyrrolidone carboxylic acidBy similarity
Disulfide bondi38 ↔ 44By similarity
Disulfide bondi39 ↔ 46By similarity
Modified residuei65 – 651Leucine amideBy similarity
Modified residuei96 – 961Methionine amideBy similarity

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Pyrrolidone carboxylic acid

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000022949.

Structurei

3D structure databases

ProteinModelPortaliQ9GLF6.
SMRiQ9GLF6. Positions 33-65, 71-96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the orexin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG70925.
GeneTreeiENSGT00390000014272.
HOGENOMiHOG000230990.
HOVERGENiHBG000256.
InParanoidiQ9GLF6.
KOiK05246.
OMAiMERALHI.
OrthoDBiEOG7XSTHD.
TreeFamiTF330756.

Family and domain databases

InterProiIPR001704. Orexin.
[Graphical view]
PANTHERiPTHR15173. PTHR15173. 1 hit.
PfamiPF02072. Orexin. 1 hit.
[Graphical view]
PIRSFiPIRSF037824. Orexin. 1 hit.
PRINTSiPR01091. OREXINPP.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GLF6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNPPSTKVPW AAVTLLLLLL LPPALLSPGA AAQPLPDCCR QKTCSCRLYE
60 70 80 90 100
LLHGAGNHAA GILTLGKRRP GPPGLQGRLQ RLLQASGNHA AGILTMGRRA
110 120 130
GAEPAPRPCP GRRCPVVAVP SAAPGGRSGV
Length:130
Mass (Da):13,328
Last modified:March 1, 2001 - v1
Checksum:i2BF59D4C1E422DF3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301A → T.1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF285110 Genomic DNA. Translation: AAG13965.1.
RefSeqiNP_001029166.1. NM_001033994.1.
XP_005624415.1. XM_005624358.1.
UniGeneiCfa.24652.

Genome annotation databases

EnsembliENSCAFT00000024739; ENSCAFP00000022949; ENSCAFG00000015615.
GeneIDi607641.
KEGGicfa:607641.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

Qui dort dine - Issue 15 of October 2001

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF285110 Genomic DNA. Translation: AAG13965.1 .
RefSeqi NP_001029166.1. NM_001033994.1.
XP_005624415.1. XM_005624358.1.
UniGenei Cfa.24652.

3D structure databases

ProteinModelPortali Q9GLF6.
SMRi Q9GLF6. Positions 33-65, 71-96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000022949.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000024739 ; ENSCAFP00000022949 ; ENSCAFG00000015615 .
GeneIDi 607641.
KEGGi cfa:607641.

Organism-specific databases

CTDi 3060.

Phylogenomic databases

eggNOGi NOG70925.
GeneTreei ENSGT00390000014272.
HOGENOMi HOG000230990.
HOVERGENi HBG000256.
InParanoidi Q9GLF6.
KOi K05246.
OMAi MERALHI.
OrthoDBi EOG7XSTHD.
TreeFami TF330756.

Miscellaneous databases

NextBioi 20893355.

Family and domain databases

InterProi IPR001704. Orexin.
[Graphical view ]
PANTHERi PTHR15173. PTHR15173. 1 hit.
Pfami PF02072. Orexin. 1 hit.
[Graphical view ]
PIRSFi PIRSF037824. Orexin. 1 hit.
PRINTSi PR01091. OREXINPP.
ProtoNeti Search...

Publicationsi

  1. "Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines."
    Hungs M., Fan J., Lin L., Lin X., Maki R.A., Mignot E.
    Genome Res. 11:531-539(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-30.
  2. "Hypocretin/orexin, sleep and narcolepsy."
    Hungs M., Mignot E.
    Bioessays 23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  3. "To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
    Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M.
    Annu. Rev. Neurosci. 24:429-458(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiOREX_CANFA
AccessioniPrimary (citable) accession number: Q9GLF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3