Reviewed,
UniProtKB/Swiss-Prot Q9GLF6 (OREX_CANFA)
Last modified
January 19, 2010.
Version 63.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Orexin Alternative name(s): Hypocretin Short name=Hcrt Cleaved into the following 2 chains: 1- Recommended name: Orexin-A Alternative name(s): Hypocretin-1 Short name=Hcrt1 2- Recommended name: Orexin-B Alternative name(s): Hypocretin-2 Short name=Hcrt2 | ||||
| Gene names |
| ||||
| Organism | Canis familiaris (Dog) | ||||
| Taxonomic identifier | 9615 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis |
Protein attributes
| Sequence length | 130 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. |
| Subcellular location | Rough endoplasmic reticulum By similarity. Cytoplasmic vesicle By similarity. Cell junction › synapse By similarity. Note: Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses By similarity. |
| Post-translational modification | Specific enzymatic cleavages at paired basic residues yield the different active peptides. |
| Sequence similarities | Belongs to the orexin family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell junction Cytoplasmic vesicle Endoplasmic reticulum Synapse |
| Coding sequence diversity | Polymorphism |
| Domain | Signal |
| Molecular function | Neuropeptide |
| PTM | Amidation Cleavage on pair of basic residues Disulfide bond Pyrrolidone carboxylic acid |
| Gene Ontology (GO) | |
| Biological process | feeding behavior Inferred from electronic annotation. Source: InterPro neuropeptide signaling pathwayInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cell junction Inferred from electronic annotation. Source: UniProtKB-KW cytoplasmic membrane-bounded vesicleInferred from electronic annotation. Source: UniProtKB-SubCell rough endoplasmic reticulumInferred from electronic annotation. Source: UniProtKB-SubCell synapseInferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 32 | 32 | By similarity | ||||||||
| Peptide | 33 – 65 | 33 | Orexin-A | PRO_0000020258 | |||||||
| Peptide | 69 – 96 | 28 | Orexin-B | PRO_0000020259 | |||||||
| Propeptide | 97 – 130 | 34 | PRO_0000020260 | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 33 | 1 | Pyrrolidone carboxylic acid By similarity | ||||||||
| Modified residue | 65 | 1 | Leucine amide By similarity | ||||||||
| Modified residue | 96 | 1 | Methionine amide By similarity | ||||||||
| Disulfide bond | 38 ↔ 44 | By similarity | |||||||||
| Disulfide bond | 39 ↔ 46 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 30 | 1 | A → T | ||||||||
Sequences
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References
| [1] | "Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines." Hungs M., Fan J., Lin L., Lin X., Maki R.A., Mignot E. Genome Res. 11:531-539(2001) [PubMed: 11282968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-30. |
| [2] | "Hypocretin/orexin, sleep and narcolepsy." Hungs M., Mignot E. Bioessays 23:397-408(2001) [PubMed: 11340621] [Abstract] Cited for: REVIEW. |
| [3] | "To eat or to sleep? Orexin in the regulation of feeding and wakefulness." Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M. Annu. Rev. Neurosci. 24:429-458(2001) [PubMed: 11283317] [Abstract] Cited for: REVIEW. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF285110 Genomic DNA. Translation: AAG13965.1. |
| RefSeq | NP_001029166.1. |
| UniGene | Cfa.24652 |
3D structure databases | |
| SMR | Q9GLF6. Positions 33-65, 71-96. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9GLF6. |
Genome annotation databases | |
| Ensembl | ENSCAFT00000024739; ENSCAFP00000022949; ENSCAFG00000015615; Canis familiaris. [Genome view] |
| GeneID | 607641. |
| KEGG | cfa:607641. |
Organism-specific databases | |
| CTD | 607641. |
Phylogenomic databases | |
| eggNOG | maNOG21262. |
| HOVERGEN | Q9GLF6. |
| InParanoid | Q9GLF6. |
| OMA | PCPGRRC. |
| OrthoDB | EOG96X1TV. |
Family and domain databases | |
| InterPro | IPR001704. Orexin. [Graphical view] |
| PANTHER | PTHR15173. Orexin. 1 hit. |
| Pfam | PF02072. Orexin. 1 hit. [Graphical view] |
| PRINTS | PR01091. OREXINPP. |
| ProtoNet | Search... |
Entry information
| Entry name | OREX_CANFA | ||||||||
| Accession | Primary (citable) accession number: Q9GLF6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Protein Spotlight Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


