Q9GLE3 (CATK_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cathepsin K
EC=3.4.22.38

Gene names

Name:

CTSK

Organism

Sus scrofa (Pig) [Complete proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation By similarity. Mediates thyroxine liberation by limited proteolysis of thyroglobulin at neutral pH in vitro. Ref.1
Catalytic activity	Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
Subcellular location	Lysosome. Secreted Ref.1.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Cellular component	Lysosome Secreted
Domain	Signal
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Propeptide	17 – 115	99	Activation peptide		PRO_0000026303
	Chain	116 – 330	215	Cathepsin K		PRO_0000026304
Sites
	Active site	140	1	By similarity
	Active site	277	1	By similarity
	Active site	297	1	By similarity
Amino acid modifications
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Disulfide bond	137 ↔ 178		By similarity
	Disulfide bond	171 ↔ 211		By similarity
	Disulfide bond	270 ↔ 319		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9GLE3 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: ABF089EFE5FFB170	FASTA	330	37,069
	10 20 30 40 50 60 MWGLKVVLLL PVMSSALYPE EILDTQWELW KKTYRKQYNS KVDEISRRLI WEKNLKHISI 70 80 90 100 110 120 HNLEASLGVH TYELAMNHLG DMTSEEVVQK MTGLKVPPSH SRSNDTLYIP DWEGRTPDSI 130 140 150 160 170 180 DYRKKGYVTP VKNQGQCGSC WAFSSVGALE GQLKKKTGKL LNLSPQNLVD CVSENDGCGG 190 200 210 220 230 240 GYMTNAFQYV QKNRGIDSED AYPYVGQDEN CMYNPTGKAA KCRGYREIPE GNEKALKRAV 250 260 270 280 290 300 ARVGPVSVAI DASLTSFQFY SKGVYYDENC NSDNLNHAVL AVGYGIQKGK KHWIIKNSWG 310 320 330 ENWGNKGYIL MARNKNNACG IANLASFPKM

References

[1]	"Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin." Tepel C., Broemme D., Herzog V., Brix K. J. Cell Sci. 113:4487-4498(2000) [PubMed: 11082042] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION. Tissue: Thyroid.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF292030 mRNA. Translation: AAG12340.1.
RefSeq	NP_999467.1. NM_214302.1.
UniGene	Ssc.1020.
3D structure databases
ProteinModelPortal	Q9GLE3.
SMR	Q9GLE3. Positions 17-330.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9GLE3.
Protein family/group databases
MEROPS	C01.036.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSSSCT00000007283; ENSSSCP00000007088; ENSSSCG00000006647.
GeneID	397569.
KEGG	ssc:397569.
Organism-specific databases
CTD	1513.
Phylogenomic databases
GeneTree	ENSGT00560000076577.
HOVERGEN	HBG011513.
OMA	LKVPPSH.
OrthoDB	EOG4SJ5FC.
Family and domain databases
InterPro	IPR000169. Pept_cys_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR015644. Peptidase_C1A_cathepsin-K. IPR013201. Prot_inhib_I29. [Graphical view]
KO	K01371.
PANTHER	PTHR12411:SF55. CathpsnK_like. 1 hit. PTHR12411. Peptidase_C1A. 1 hit.
Pfam	PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit. [Graphical view]
PRINTS	PR00705. PAPAIN.
SMART	SM00848. Inhibitor_I29. 1 hit. SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATK_PIG

Accession

Primary (citable) accession number: Q9GLE3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	March 1, 2001
Last modified:	November 16, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program