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Q9GLD9

- UDB33_MACMU

UniProt

Q9GLD9 - UDB33_MACMU

Protein

UDP-glucuronosyltransferase 2B33

Gene

UGT2B33

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on estriol and does not catalyze the glucuronidation of beta-estradiol. Capable of conjugating 4-hydroxyestrone, androsterone, diclofenac, and hyodeoxycholic acid.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2B33 (EC:2.4.1.17)
    Short name:
    UDPGT 2B33
    Gene namesi
    Name:UGT2B33
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 529505UDP-glucuronosyltransferase 2B33PRO_0000036049Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi9544.ENSMMUP00000035069.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GLD9.
    SMRiQ9GLD9. Positions 285-446.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei494 – 51421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    HOGENOMiHOG000220831.
    HOVERGENiHBG004033.
    KOiK00699.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9GLD9-1 [UniParc]FASTAAdd to Basket

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    MSVKWTSIIL LIQLSFYFSS GSCGKVLVWA AEYSHWMNMK TILEELVQRG    50
    HEVTVLASSA SILFDPNNSS ALKIEVFPTS LTKTEFENII RQQIKRWSEL 100
    PKDTFWLYFS QIQEIMWRFG DISIKFCKDV VSNKKLMKKL QESRFDVVLA 150
    DPIFPCSELL AELFNIPLVY SLRFTPGYVF EKHCGGFLFP PSYVPVVMSE 200
    LSDQMTFMER VKNMIYVLYF DFCFQLYDMK KWDQFYSEVL GRHTTLSEIM 250
    GKADIWLIRN SWNFQFPHPL LPNVDFIGGL LCKPAKPLPK EMEEFVQSSG 300
    ENGVVVFTLG SMITNMKEER ANVIASALAQ IPQKVLWRFD GNKPDTLGVN 350
    TRLYKWIPQN DLLGHPKTKA FITHGGANGI YEAIYHGVPM VGIPLFADQP 400
    DNIAHMKTRG AAVQLDFDTM SSTDLANALK TVINDPLYKE NVMKLSRIQR 450
    DQPVKPLDRA VFWIEFVMRH KGAKHLRPAA HDLTWFQYHS LDVIGFLLAC 500
    VATVIFIIMK CCLFCFWKFT RKGKKGKSD 529
    Length:529
    Mass (Da):60,858
    Last modified:March 1, 2001 - v1
    Checksum:iB1956F947F1F78D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF294902 mRNA. Translation: AAG21378.1.
    RefSeqiNP_001028002.1. NM_001032830.1.
    UniGeneiMmu.2983.

    Genome annotation databases

    GeneIDi574147.
    KEGGimcc:574147.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF294902 mRNA. Translation: AAG21378.1 .
    RefSeqi NP_001028002.1. NM_001032830.1.
    UniGenei Mmu.2983.

    3D structure databases

    ProteinModelPortali Q9GLD9.
    SMRi Q9GLD9. Positions 285-446.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9544.ENSMMUP00000035069.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 574147.
    KEGGi mcc:574147.

    Organism-specific databases

    CTDi 574147.

    Phylogenomic databases

    eggNOGi COG1819.
    HOGENOMi HOG000220831.
    HOVERGENi HBG004033.
    KOi K00699.

    Miscellaneous databases

    NextBioi 19964081.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of UGT2B9*2 and UGT2B33 isolated from female rhesus monkey liver."
      Dean B., Arison B., Chang S., Thomas P.E., King C.
      Arch. Biochem. Biophys. 426:55-62(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
      Tissue: Liver.

    Entry informationi

    Entry nameiUDB33_MACMU
    AccessioniPrimary (citable) accession number: Q9GLD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3