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Q9GLD9

- UDB33_MACMU

UniProt

Q9GLD9 - UDB33_MACMU

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Protein
UDP-glucuronosyltransferase 2B33
Gene
UGT2B33
Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on estriol and does not catalyze the glucuronidation of beta-estradiol. Capable of conjugating 4-hydroxyestrone, androsterone, diclofenac, and hyodeoxycholic acid.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B33 (EC:2.4.1.17)
Short name:
UDPGT 2B33
Gene namesi
Name:UGT2B33
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei494 – 51421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 529505UDP-glucuronosyltransferase 2B33
PRO_0000036049Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi68 – 681N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000035069.

Structurei

3D structure databases

ProteinModelPortaliQ9GLD9.
SMRiQ9GLD9. Positions 285-446.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
KOiK00699.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GLD9-1 [UniParc]FASTAAdd to Basket

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MSVKWTSIIL LIQLSFYFSS GSCGKVLVWA AEYSHWMNMK TILEELVQRG    50
HEVTVLASSA SILFDPNNSS ALKIEVFPTS LTKTEFENII RQQIKRWSEL 100
PKDTFWLYFS QIQEIMWRFG DISIKFCKDV VSNKKLMKKL QESRFDVVLA 150
DPIFPCSELL AELFNIPLVY SLRFTPGYVF EKHCGGFLFP PSYVPVVMSE 200
LSDQMTFMER VKNMIYVLYF DFCFQLYDMK KWDQFYSEVL GRHTTLSEIM 250
GKADIWLIRN SWNFQFPHPL LPNVDFIGGL LCKPAKPLPK EMEEFVQSSG 300
ENGVVVFTLG SMITNMKEER ANVIASALAQ IPQKVLWRFD GNKPDTLGVN 350
TRLYKWIPQN DLLGHPKTKA FITHGGANGI YEAIYHGVPM VGIPLFADQP 400
DNIAHMKTRG AAVQLDFDTM SSTDLANALK TVINDPLYKE NVMKLSRIQR 450
DQPVKPLDRA VFWIEFVMRH KGAKHLRPAA HDLTWFQYHS LDVIGFLLAC 500
VATVIFIIMK CCLFCFWKFT RKGKKGKSD 529
Length:529
Mass (Da):60,858
Last modified:March 1, 2001 - v1
Checksum:iB1956F947F1F78D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF294902 mRNA. Translation: AAG21378.1.
RefSeqiNP_001028002.1. NM_001032830.1.
UniGeneiMmu.2983.

Genome annotation databases

GeneIDi574147.
KEGGimcc:574147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF294902 mRNA. Translation: AAG21378.1 .
RefSeqi NP_001028002.1. NM_001032830.1.
UniGenei Mmu.2983.

3D structure databases

ProteinModelPortali Q9GLD9.
SMRi Q9GLD9. Positions 285-446.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9544.ENSMMUP00000035069.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 574147.
KEGGi mcc:574147.

Organism-specific databases

CTDi 574147.

Phylogenomic databases

eggNOGi COG1819.
HOGENOMi HOG000220831.
HOVERGENi HBG004033.
KOi K00699.

Miscellaneous databases

NextBioi 19964081.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of UGT2B9*2 and UGT2B33 isolated from female rhesus monkey liver."
    Dean B., Arison B., Chang S., Thomas P.E., King C.
    Arch. Biochem. Biophys. 426:55-62(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Tissue: Liver.

Entry informationi

Entry nameiUDB33_MACMU
AccessioniPrimary (citable) accession number: Q9GLD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2001
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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