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Q9GLD9 (UDB33_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2B33

Short name=UDPGT 2B33
EC=2.4.1.17
Gene names
Name:UGT2B33
OrganismMacaca mulatta (Rhesus macaque) [Reference proteome]
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on estriol and does not catalyze the glucuronidation of beta-estradiol. Capable of conjugating 4-hydroxyestrone, androsterone, diclofenac, and hyodeoxycholic acid.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 529505UDP-glucuronosyltransferase 2B33
PRO_0000036049

Regions

Transmembrane494 – 51421Helical; Potential

Amino acid modifications

Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation681N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9GLD9 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: B1956F947F1F78D6

FASTA52960,858
        10         20         30         40         50         60 
MSVKWTSIIL LIQLSFYFSS GSCGKVLVWA AEYSHWMNMK TILEELVQRG HEVTVLASSA 

        70         80         90        100        110        120 
SILFDPNNSS ALKIEVFPTS LTKTEFENII RQQIKRWSEL PKDTFWLYFS QIQEIMWRFG 

       130        140        150        160        170        180 
DISIKFCKDV VSNKKLMKKL QESRFDVVLA DPIFPCSELL AELFNIPLVY SLRFTPGYVF 

       190        200        210        220        230        240 
EKHCGGFLFP PSYVPVVMSE LSDQMTFMER VKNMIYVLYF DFCFQLYDMK KWDQFYSEVL 

       250        260        270        280        290        300 
GRHTTLSEIM GKADIWLIRN SWNFQFPHPL LPNVDFIGGL LCKPAKPLPK EMEEFVQSSG 

       310        320        330        340        350        360 
ENGVVVFTLG SMITNMKEER ANVIASALAQ IPQKVLWRFD GNKPDTLGVN TRLYKWIPQN 

       370        380        390        400        410        420 
DLLGHPKTKA FITHGGANGI YEAIYHGVPM VGIPLFADQP DNIAHMKTRG AAVQLDFDTM 

       430        440        450        460        470        480 
SSTDLANALK TVINDPLYKE NVMKLSRIQR DQPVKPLDRA VFWIEFVMRH KGAKHLRPAA 

       490        500        510        520 
HDLTWFQYHS LDVIGFLLAC VATVIFIIMK CCLFCFWKFT RKGKKGKSD 

« Hide

References

[1]"Identification of UGT2B9*2 and UGT2B33 isolated from female rhesus monkey liver."
Dean B., Arison B., Chang S., Thomas P.E., King C.
Arch. Biochem. Biophys. 426:55-62(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF294902 mRNA. Translation: AAG21378.1.
RefSeqNP_001028002.1. NM_001032830.1.
UniGeneMmu.2983.

3D structure databases

ProteinModelPortalQ9GLD9.
SMRQ9GLD9. Positions 285-446.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9544.ENSMMUP00000035069.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID574147.
KEGGmcc:574147.

Organism-specific databases

CTD574147.

Phylogenomic databases

eggNOGCOG1819.
HOGENOMHOG000220831.
HOVERGENHBG004033.
KOK00699.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio19964081.

Entry information

Entry nameUDB33_MACMU
AccessionPrimary (citable) accession number: Q9GLD9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2001
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families