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Q9GLD9

- UDB33_MACMU

UniProt

Q9GLD9 - UDB33_MACMU

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Protein

UDP-glucuronosyltransferase 2B33

Gene

UGT2B33

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on estriol and does not catalyze the glucuronidation of beta-estradiol. Capable of conjugating 4-hydroxyestrone, androsterone, diclofenac, and hyodeoxycholic acid.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B33 (EC:2.4.1.17)
Short name:
UDPGT 2B33
Gene namesi
Name:UGT2B33
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei494 – 51421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 529505UDP-glucuronosyltransferase 2B33PRO_0000036049Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000035069.

Structurei

3D structure databases

ProteinModelPortaliQ9GLD9.
SMRiQ9GLD9. Positions 285-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiQ9GLD9.
KOiK00699.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GLD9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVKWTSIIL LIQLSFYFSS GSCGKVLVWA AEYSHWMNMK TILEELVQRG
60 70 80 90 100
HEVTVLASSA SILFDPNNSS ALKIEVFPTS LTKTEFENII RQQIKRWSEL
110 120 130 140 150
PKDTFWLYFS QIQEIMWRFG DISIKFCKDV VSNKKLMKKL QESRFDVVLA
160 170 180 190 200
DPIFPCSELL AELFNIPLVY SLRFTPGYVF EKHCGGFLFP PSYVPVVMSE
210 220 230 240 250
LSDQMTFMER VKNMIYVLYF DFCFQLYDMK KWDQFYSEVL GRHTTLSEIM
260 270 280 290 300
GKADIWLIRN SWNFQFPHPL LPNVDFIGGL LCKPAKPLPK EMEEFVQSSG
310 320 330 340 350
ENGVVVFTLG SMITNMKEER ANVIASALAQ IPQKVLWRFD GNKPDTLGVN
360 370 380 390 400
TRLYKWIPQN DLLGHPKTKA FITHGGANGI YEAIYHGVPM VGIPLFADQP
410 420 430 440 450
DNIAHMKTRG AAVQLDFDTM SSTDLANALK TVINDPLYKE NVMKLSRIQR
460 470 480 490 500
DQPVKPLDRA VFWIEFVMRH KGAKHLRPAA HDLTWFQYHS LDVIGFLLAC
510 520
VATVIFIIMK CCLFCFWKFT RKGKKGKSD
Length:529
Mass (Da):60,858
Last modified:March 1, 2001 - v1
Checksum:iB1956F947F1F78D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294902 mRNA. Translation: AAG21378.1.
RefSeqiNP_001028002.1. NM_001032830.1.
UniGeneiMmu.2983.

Genome annotation databases

GeneIDi574147.
KEGGimcc:574147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294902 mRNA. Translation: AAG21378.1 .
RefSeqi NP_001028002.1. NM_001032830.1.
UniGenei Mmu.2983.

3D structure databases

ProteinModelPortali Q9GLD9.
SMRi Q9GLD9. Positions 285-446.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9544.ENSMMUP00000035069.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 574147.
KEGGi mcc:574147.

Organism-specific databases

CTDi 574147.

Phylogenomic databases

eggNOGi COG1819.
HOGENOMi HOG000220831.
HOVERGENi HBG004033.
InParanoidi Q9GLD9.
KOi K00699.

Miscellaneous databases

NextBioi 19964081.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of UGT2B9*2 and UGT2B33 isolated from female rhesus monkey liver."
    Dean B., Arison B., Chang S., Thomas P.E., King C.
    Arch. Biochem. Biophys. 426:55-62(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Tissue: Liver.

Entry informationi

Entry nameiUDB33_MACMU
AccessioniPrimary (citable) accession number: Q9GLD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3