Reviewed, UniProtKB/Swiss-Prot Q9GLD9 (UDB33_MACMU)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 2B33
      Short name=UDPGT 2B33
    EC=2.4.1.17

Gene names

Name:

UGT2B33

Organism

Macaca mulatta (Rhesus macaque)

Taxonomic identifier

9544 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on estriol and does not catalyze the glucuronidation of beta-estradiol. Capable of conjugating 4-hydroxyestrone, androsterone, diclofenac, and hyodeoxycholic acid.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 529	505	UDP-glucuronosyltransferase 2B33		PRO_0000036049
Regions
	Transmembrane	494 – 514	21	Potential
Amino acid modifications
	Glycosylation	67	1	N-linked (GlcNAc...) Potential
	Glycosylation	68	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9GLD9-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: B1956F947F1F78D6	FASTA	529	60,858
	10 20 30 40 50 60 MSVKWTSIIL LIQLSFYFSS GSCGKVLVWA AEYSHWMNMK TILEELVQRG HEVTVLASSA 70 80 90 100 110 120 SILFDPNNSS ALKIEVFPTS LTKTEFENII RQQIKRWSEL PKDTFWLYFS QIQEIMWRFG 130 140 150 160 170 180 DISIKFCKDV VSNKKLMKKL QESRFDVVLA DPIFPCSELL AELFNIPLVY SLRFTPGYVF 190 200 210 220 230 240 EKHCGGFLFP PSYVPVVMSE LSDQMTFMER VKNMIYVLYF DFCFQLYDMK KWDQFYSEVL 250 260 270 280 290 300 GRHTTLSEIM GKADIWLIRN SWNFQFPHPL LPNVDFIGGL LCKPAKPLPK EMEEFVQSSG 310 320 330 340 350 360 ENGVVVFTLG SMITNMKEER ANVIASALAQ IPQKVLWRFD GNKPDTLGVN TRLYKWIPQN 370 380 390 400 410 420 DLLGHPKTKA FITHGGANGI YEAIYHGVPM VGIPLFADQP DNIAHMKTRG AAVQLDFDTM 430 440 450 460 470 480 SSTDLANALK TVINDPLYKE NVMKLSRIQR DQPVKPLDRA VFWIEFVMRH KGAKHLRPAA 490 500 510 520 HDLTWFQYHS LDVIGFLLAC VATVIFIIMK CCLFCFWKFT RKGKKGKSD

References

[1]	"Identification of UGT2B9*2 and UGT2B33 isolated from female rhesus monkey liver." Dean B., Arison B., Chang S., Thomas P.E., King C. Arch. Biochem. Biophys. 426:55-62(2004) [PubMed: 15130782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF294902 mRNA. Translation: AAG21378.1.
RefSeq	NP_001028002.1.
UniGene	Mmu.2983
3D structure databases
SMR	Q9GLD9. Positions 285-446.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Genome annotation databases
Ensembl	ENSMMUG00000000337. Macaca mulatta. [Contig view]
GeneID	574147.
KEGG	mcc:574147.
Phylogenomic databases
HOVERGEN	Q9GLD9.
Enzyme and pathway databases
BRENDA	2.4.1.17. 1774.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UDB33_MACMU

Accession

Primary (citable) accession number: Q9GLD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	March 1, 2001
Last modified:	June 16, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)