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Q9GLD2

- CP17A_PAPHU

UniProt

Q9GLD2 - CP17A_PAPHU

Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

CYP17A1

Organism
Papio hamadryas ursinus (Chacma baboon)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Has a higher activity for progesterone hydroxylation relative to pregnenolone. Has no 16-alpha-hydroxylase and no lyase activity for 17-alpha-hydroxyprogesterone.

    Catalytic activityi

    A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.
    17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

    Cofactori

    Heme group.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB-EC
    2. heme binding Source: UniProtKB
    3. iron ion binding Source: InterPro
    4. steroid 17-alpha-monooxygenase activity Source: UniProtKB

    GO - Biological processi

    1. hormone biosynthetic process Source: UniProtKB
    2. progesterone metabolic process Source: UniProtKB
    3. steroid biosynthetic process Source: UniProtKB-UniPathway
    4. steroid metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Lyase, Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Steroidogenesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00062.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.99.9, EC:4.1.2.30)
    Alternative name(s):
    17-alpha-hydroxyprogesterone aldolase
    CYPXVII
    Cytochrome P450 17A1
    Cytochrome P450-C17
    Short name:
    Cytochrome P450c17
    Gene namesi
    Name:CYP17A1
    Synonyms:CYP17
    OrganismiPapio hamadryas ursinus (Chacma baboon)
    Taxonomic identifieri36229 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

    Subcellular locationi

    Membrane Curated

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508Steroid 17-alpha-hydroxylase/17,20 lyasePRO_0000051938Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GLD2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9GLD2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWELVALLLL TLAYLFWPKR RCPGAKYPKS LLSLPLVGSL PFLPRHGHMH    50
    NNFFKLQKKY GPIYSVRMGT KTTVIVGHHQ LAKEVLIKKG KDFSGRPQVT 100
    TLDILSNNRK GIAFADYGAH WQLHRRLAMA TFALFKDGDQ KLEKIICQEI 150
    STLCDMLATH NGQTIDISFP VFVAITNVIS LICFNISYKN GDPELKIVHN 200
    YNEGIIDSLG KESLVDLFPW LKVFPNKTLE KLKRHVKTRN DLLTKIFENY 250
    KEKFRSDSIT NMLDVLMQAK MNSDNGNAGP DQDSELLSDN HILTTIGDIF 300
    GAGVETTTSV VKWIVAFLLH NPQVKKKLYE GIDQNVGFSR TPTISDRNRL 350
    LLLEATIREV LRIRPVAPML IPHKANVDSS IGEFAVDKGT HVIINLWALH 400
    HNEKEWHQPD QFMPERFLNP AGTQLISPSL SYLPFGAGPR SCIGEILARQ 450
    ELFLIMAWLL QRFDLEVPDD GQLPSLEGNP KVVFLIDSFK VKIKVRQAWR 500
    EAQAEGST 508
    Length:508
    Mass (Da):57,566
    Last modified:March 1, 2001 - v1
    Checksum:i40DF6068D66BAA80
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti331 – 3311G → E in AAK57726. (PubMed:12423360)Curated
    Sequence conflicti396 – 3961L → R in AAK57726. (PubMed:12423360)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF297650 mRNA. Translation: AAG10599.1.
    AY034635 Genomic DNA. Translation: AAK57726.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF297650 mRNA. Translation: AAG10599.1 .
    AY034635 Genomic DNA. Translation: AAK57726.1 .

    3D structure databases

    ProteinModelPortali Q9GLD2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Enzyme and pathway databases

    UniPathwayi UPA00062 .

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of baboon cytochrome P-450 17-alpha hydroxylase/c17-20 lyase."
      Swart A.C., Kolar N.W., Swart P.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Adrenal gland.
    2. "Baboon cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17)."
      Swart A.C., Kolar N.W., Lombard N., Mason J.I., Swart P.
      Eur. J. Biochem. 269:5608-5616(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.

    Entry informationi

    Entry nameiCP17A_PAPHU
    AccessioniPrimary (citable) accession number: Q9GLD2
    Secondary accession number(s): Q95M62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3