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Q9GLD2

- CP17A_PAPHU

UniProt

Q9GLD2 - CP17A_PAPHU

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Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

CYP17A1

Organism
Papio hamadryas ursinus (Chacma baboon)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Has a higher activity for progesterone hydroxylation relative to pregnenolone. Has no 16-alpha-hydroxylase and no lyase activity for 17-alpha-hydroxyprogesterone.

Catalytic activityi

A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.
17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

Cofactori

hemeBy similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
  4. steroid 17-alpha-monooxygenase activity Source: UniProtKB

GO - Biological processi

  1. hormone biosynthetic process Source: UniProtKB
  2. progesterone metabolic process Source: UniProtKB
  3. steroid biosynthetic process Source: UniProtKB-UniPathway
  4. steroid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Lyase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00062.

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.99.9, EC:4.1.2.30)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Gene namesi
Name:CYP17A1
Synonyms:CYP17
OrganismiPapio hamadryas ursinus (Chacma baboon)
Taxonomic identifieri36229 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

Subcellular locationi

Membrane Curated

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Steroid 17-alpha-hydroxylase/17,20 lyasePRO_0000051938Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9GLD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GLD2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWELVALLLL TLAYLFWPKR RCPGAKYPKS LLSLPLVGSL PFLPRHGHMH
60 70 80 90 100
NNFFKLQKKY GPIYSVRMGT KTTVIVGHHQ LAKEVLIKKG KDFSGRPQVT
110 120 130 140 150
TLDILSNNRK GIAFADYGAH WQLHRRLAMA TFALFKDGDQ KLEKIICQEI
160 170 180 190 200
STLCDMLATH NGQTIDISFP VFVAITNVIS LICFNISYKN GDPELKIVHN
210 220 230 240 250
YNEGIIDSLG KESLVDLFPW LKVFPNKTLE KLKRHVKTRN DLLTKIFENY
260 270 280 290 300
KEKFRSDSIT NMLDVLMQAK MNSDNGNAGP DQDSELLSDN HILTTIGDIF
310 320 330 340 350
GAGVETTTSV VKWIVAFLLH NPQVKKKLYE GIDQNVGFSR TPTISDRNRL
360 370 380 390 400
LLLEATIREV LRIRPVAPML IPHKANVDSS IGEFAVDKGT HVIINLWALH
410 420 430 440 450
HNEKEWHQPD QFMPERFLNP AGTQLISPSL SYLPFGAGPR SCIGEILARQ
460 470 480 490 500
ELFLIMAWLL QRFDLEVPDD GQLPSLEGNP KVVFLIDSFK VKIKVRQAWR

EAQAEGST
Length:508
Mass (Da):57,566
Last modified:March 1, 2001 - v1
Checksum:i40DF6068D66BAA80
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti331 – 3311G → E in AAK57726. (PubMed:12423360)Curated
Sequence conflicti396 – 3961L → R in AAK57726. (PubMed:12423360)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297650 mRNA. Translation: AAG10599.1.
AY034635 Genomic DNA. Translation: AAK57726.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297650 mRNA. Translation: AAG10599.1 .
AY034635 Genomic DNA. Translation: AAK57726.1 .

3D structure databases

ProteinModelPortali Q9GLD2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106944.

Enzyme and pathway databases

UniPathwayi UPA00062 .

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of baboon cytochrome P-450 17-alpha hydroxylase/c17-20 lyase."
    Swart A.C., Kolar N.W., Swart P.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Adrenal gland.
  2. "Baboon cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17)."
    Swart A.C., Kolar N.W., Lombard N., Mason J.I., Swart P.
    Eur. J. Biochem. 269:5608-5616(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.

Entry informationi

Entry nameiCP17A_PAPHU
AccessioniPrimary (citable) accession number: Q9GLD2
Secondary accession number(s): Q95M62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3