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Protein

Natriuretic peptides A

Gene

NPPA

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Vasoactive

Names & Taxonomyi

Protein namesi
Recommended name:
Natriuretic peptides A
Alternative name(s):
Prepronatriodilatin
Cleaved into the following chain:
Alternative name(s):
Atrial natriuretic peptide
Short name:
ANP
Gene namesi
Name:NPPA
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
PropeptideiPRO_000000148826 – 123CuratedAdd BLAST98
PeptideiPRO_0000001489124 – 151Atrial natriuretic factorBy similarityAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi130 ↔ 146By similarity

Post-translational modificationi

Cleaved by CORIN upon secretion to produce the functional hormone.By similarity
Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei123 – 124Cleavage; by CORINBy similarity2
Sitei130 – 131Cleavage; by MMEBy similarity2

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9GLD0

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000000063

Structurei

3D structure databases

SMRiQ9GLD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW5F Eukaryota
ENOG410ZUY6 LUCA
HOGENOMiHOG000033937
HOVERGENiHBG004227
InParanoidiQ9GLD0
KOiK12334
OMAiCNSFRYR
OrthoDBiEOG091G0SV3
TreeFamiTF106304

Family and domain databases

InterProiView protein in InterPro
IPR000663 Natr_peptide
IPR030480 Natr_peptide_CS
IPR002407 Natriuretic_peptide_atrial
PfamiView protein in Pfam
PF00212 ANP, 1 hit
PRINTSiPR00711 ANATPEPTIDE
PR00710 NATPEPTIDES
SMARTiView protein in SMART
SM00183 NAT_PEP, 1 hit
PROSITEiView protein in PROSITE
PS00263 NATRIURETIC_PEPTIDE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GLD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSFSTITAS FLLFLACQLL WQTGANPVYG SVSNADLMDF KNLLDHLEDK
60 70 80 90 100
MPLEDEVVPP QVLSEQNEEA GAALSPLPEV PPWAGEVNPA QRDGGALGRG
110 120 130 140 150
SWDSSDRSAL LKSKLRALLA APRSLRRSSC FGGRMDRIGA QSGLGCNSFR

YRR
Length:153
Mass (Da):16,583
Last modified:March 1, 2001 - v1
Checksum:i32DEBD205B285686
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298813 Genomic DNA Translation: AAG23837.1
RefSeqiXP_003989547.1, XM_003989498.3

Genome annotation databases

GeneIDi101100575
KEGGifca:101100575

Similar proteinsi

Entry informationi

Entry nameiANF_FELCA
AccessioniPrimary (citable) accession number: Q9GLD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health