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Protein

Natriuretic peptides A

Gene

NPPA

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive

Names & Taxonomyi

Protein namesi
Recommended name:
Natriuretic peptides A
Alternative name(s):
Prepronatriodilatin
Cleaved into the following chain:
Alternative name(s):
Atrial natriuretic peptide
Short name:
ANP
Gene namesi
Name:NPPA
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Chromosome C1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525By similarityAdd
BLAST
Propeptidei26 – 12398CuratedPRO_0000001488Add
BLAST
Peptidei124 – 15128Atrial natriuretic factorBy similarityPRO_0000001489Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi130 ↔ 146By similarity

Post-translational modificationi

Cleaved by CORIN upon secretion to produce the functional hormone.By similarity
Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei123 – 1242Cleavage; by CORINBy similarity
Sitei130 – 1312Cleavage; by MMEBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000000063.

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW5F. Eukaryota.
ENOG410ZUY6. LUCA.
GeneTreeiENSGT00510000048659.
HOGENOMiHOG000033937.
HOVERGENiHBG004227.
InParanoidiQ9GLD0.
KOiK12334.
OMAiGCNSFRY.
OrthoDBiEOG091G0SV3.
TreeFamiTF106304.

Family and domain databases

InterProiIPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
IPR002407. Natriuretic_peptide_atrial.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00711. ANATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GLD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSFSTITAS FLLFLACQLL WQTGANPVYG SVSNADLMDF KNLLDHLEDK
60 70 80 90 100
MPLEDEVVPP QVLSEQNEEA GAALSPLPEV PPWAGEVNPA QRDGGALGRG
110 120 130 140 150
SWDSSDRSAL LKSKLRALLA APRSLRRSSC FGGRMDRIGA QSGLGCNSFR

YRR
Length:153
Mass (Da):16,583
Last modified:March 1, 2001 - v1
Checksum:i32DEBD205B285686
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298813 Genomic DNA. Translation: AAG23837.1.
RefSeqiXP_003989547.1. XM_003989498.2.

Genome annotation databases

EnsembliENSFCAT00000000069; ENSFCAP00000000063; ENSFCAG00000000070.
GeneIDi101100575.
KEGGifca:101100575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298813 Genomic DNA. Translation: AAG23837.1.
RefSeqiXP_003989547.1. XM_003989498.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000000063.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSFCAT00000000069; ENSFCAP00000000063; ENSFCAG00000000070.
GeneIDi101100575.
KEGGifca:101100575.

Organism-specific databases

CTDi4878.

Phylogenomic databases

eggNOGiENOG410IW5F. Eukaryota.
ENOG410ZUY6. LUCA.
GeneTreeiENSGT00510000048659.
HOGENOMiHOG000033937.
HOVERGENiHBG004227.
InParanoidiQ9GLD0.
KOiK12334.
OMAiGCNSFRY.
OrthoDBiEOG091G0SV3.
TreeFamiTF106304.

Family and domain databases

InterProiIPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
IPR002407. Natriuretic_peptide_atrial.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00711. ANATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANF_FELCA
AccessioniPrimary (citable) accession number: Q9GLD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.