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Protein

Apolipoprotein E

Gene

APOE

Organism
Tupaia glis (Tree shrew)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding
Biological processLipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein E
Short name:
Apo-E
Gene namesi
Name:APOE
OrganismiTupaia glis (Tree shrew)
Taxonomic identifieri9395 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresScandentiaTupaiidaeTupaia

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Chylomicron, HDL, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000199819 – 313Apolipoprotein EAdd BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei139Methionine sulfoxideBy similarity1
Modified residuei143PhosphoserineBy similarity1
Glycosylationi208O-linked (GalNAc...) threonineBy similarity1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein, Oxidation, Phosphoprotein

Proteomic databases

PRIDEiQ9GLC0.

Expressioni

Tissue specificityi

Secreted in plasma.

Structurei

3D structure databases

ProteinModelPortaliQ9GLC0.
SMRiQ9GLC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati76 – 971Add BLAST22
Repeati98 – 1192Add BLAST22
Repeati120 – 1413Add BLAST22
Repeati142 – 1634Add BLAST22
Repeati164 – 1855Add BLAST22
Repeati186 – 2076Add BLAST22
Repeati208 – 2297Add BLAST22
Repeati230 – 2518Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni76 – 2518 X 22 AA approximate tandem repeatsAdd BLAST176
Regioni154 – 164LDL receptor bindingBy similarityAdd BLAST11
Regioni158 – 161Heparin-bindingBy similarity4
Regioni225 – 232Heparin-bindingBy similarity8

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG010582.

Family and domain databases

InterProiView protein in InterPro
IPR000074. ApoA_E.
PfamiView protein in Pfam
PF01442. Apolipoprotein. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GLC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLWAVLAF AFLTGCRADV EPQLEPEVRE PPKWQAGQPW ELALGRFWDY
60 70 80 90 100
LRWVQTLSDQ VQEELLSSQV TQELTVLMEE TMKEVKAYKA ELEEQLGPMK
110 120 130 140 150
EETQARLSKE LQAAQARLGA DMEDVRTRLA QYRSEVHTML GQSTEELRAR
160 170 180 190 200
LSSHLRKMRK RLLRDAEDLQ KRLAVYRAGV QEGAERGVSA IRERLGPLME
210 220 230 240 250
QGRLRANTVS ALAVQPLQER AQAWGERLRG RLQEVGSQAR DRLDEVREQV
260 270 280 290 300
EEVRAKVEEQ ATQMRLQAEA FQARLQSWFE PLVKDVQRQW AELVEKVQAA
310
VGTSAAPVSS ENH
Length:313
Mass (Da):35,923
Last modified:March 1, 2001 - v1
Checksum:i015D4D91F1D905BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303830 mRNA. Translation: AAG21401.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303830 mRNA. Translation: AAG21401.1.

3D structure databases

ProteinModelPortaliQ9GLC0.
SMRiQ9GLC0.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9GLC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG010582.

Family and domain databases

InterProiView protein in InterPro
IPR000074. ApoA_E.
PfamiView protein in Pfam
PF01442. Apolipoprotein. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAPOE_TUPGL
AccessioniPrimary (citable) accession number: Q9GLC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2001
Last modified: May 10, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.