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Protein

Nectin-1

Gene

NECTIN1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in cell adhesion. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Nectin-1
Alternative name(s):
Herpes virus entry mediator C
Short name:
Herpesvirus entry mediator C
Short name:
HveC
Nectin cell adhesion molecule 1By similarity
Poliovirus receptor-related protein 1
CD_antigen: CD111
Gene namesi
Name:NECTIN1By similarity
Synonyms:HVEC, PRR1, PVRL1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 355ExtracellularSequence analysisAdd BLAST325
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Topological domaini377 – 515CytoplasmicSequence analysisAdd BLAST139

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001513531 – 515Nectin-1Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi51 ↔ 124PROSITE-ProRule annotation
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi172 ↔ 226PROSITE-ProRule annotation
Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi269 ↔ 316PROSITE-ProRule annotation
Glycosylationi286N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi332N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei422PhosphoserineBy similarity1
Modified residuei434PhosphoserineBy similarity1
Modified residuei435PhosphoserineBy similarity1
Modified residuei436PhosphotyrosineBy similarity1
Modified residuei509PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9GL76
PeptideAtlasiQ9GL76
PRIDEiQ9GL76

Interactioni

Subunit structurei

Interacts with HSV glycoprotein D (gD).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9GL76, 2 interactors
STRINGi9823.ENSSSCP00000016047

Structurei

Secondary structure

1515
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi38 – 41Combined sources4
Beta strandi45 – 49Combined sources5
Beta strandi61 – 71Combined sources11
Beta strandi74 – 82Combined sources9
Turni83 – 85Combined sources3
Beta strandi86 – 89Combined sources4
Turni94 – 96Combined sources3
Beta strandi97 – 101Combined sources5
Turni104 – 106Combined sources3
Beta strandi109 – 113Combined sources5
Helixi116 – 118Combined sources3
Beta strandi120 – 129Combined sources10
Beta strandi132 – 142Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5X5WX-ray2.70B/D37-143[»]
ProteinModelPortaliQ9GL76
SMRiQ9GL76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 141Ig-like V-typeAdd BLAST111
Domaini145 – 243Ig-like C2-type 1Add BLAST99
Domaini247 – 334Ig-like C2-type 2Add BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi437 – 443Poly-Glu7
Compositional biasi444 – 447Poly-Gly4

Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF17 Eukaryota
ENOG410YK75 LUCA
HOGENOMiHOG000115804
HOVERGENiHBG100542
InParanoidiQ9GL76
KOiK06081

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR033314 Nectin1
PANTHERiPTHR23277:SF69 PTHR23277:SF69, 1 hit
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GL76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARMGLAGAA GRWWGLALGL TAFFLPGAHT QVVQVNDSMY GFIGTDVVLH
60 70 80 90 100
CSFANPLPGV KITQVTWQKA TNGSKQNVAI YNPAMGVSVL APYRERVEFL
110 120 130 140 150
RPSFTDGTIR LSRLELEDEG VYICEFATFP AGNRESQLNL TVMAKPTNWI
160 170 180 190 200
EGTQAVLRAK KGKDDKVLVA TCTSANGKPP SVVSWETHLK GEAEYQEIRN
210 220 230 240 250
PNGTVTVISR YRLVPSREDH RQSLACIVNY HMDRFRESLT LNVQYEPEVT
260 270 280 290 300
IEGFDGNWYL QRMDVKLTCK ADANPPATEY HWTTLNGSLP KGVEAQNRTL
310 320 330 340 350
FFRGPINYSM AGTYICEATN PIGTRSGQVE VNITEFPYTP SPPEHGRRAG
360 370 380 390 400
QVPTAIIGGV VGSILLVLFV VGGIVVALCR RRHTFKGDYS TKKHVYGNGY
410 420 430 440 450
SKAGIPQHHP PMAQNLQYPE DSDDEKKAGP LGGSSYEEEE EEEGGGGERK
460 470 480 490 500
VGGPHPKYDE DAKRPYFTVD EAEARQDGYG DRTLGYQYDP EQLDLAENMV
510
SQNDGSFISK KEWYV
Length:515
Mass (Da):57,047
Last modified:March 1, 2001 - v1
Checksum:iBFAB00320DDE3785
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF308632 mRNA Translation: AAG30281.1
RefSeqiNP_001001262.1, NM_001001262.1
XP_003130000.5, XM_003129952.5
UniGeneiSsc.15891

Genome annotation databases

GeneIDi397247
KEGGissc:397247

Similar proteinsi

Entry informationi

Entry nameiNECT1_PIG
AccessioniPrimary (citable) accession number: Q9GL76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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