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Q9GL27

- BRAC_CANFA

UniProt

Q9GL27 - BRAC_CANFA

Protein

Brachyury protein

Gene

T

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi51 – 219169T-boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
    2. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
    3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
    4. RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription Source: Ensembl

    GO - Biological processi

    1. BMP signaling pathway Source: Ensembl
    2. bone morphogenesis Source: Ensembl
    3. canonical Wnt signaling pathway Source: Ensembl
    4. determination of heart left/right asymmetry Source: Ensembl
    5. embryonic skeletal system development Source: Ensembl
    6. heart morphogenesis Source: Ensembl
    7. mesoderm migration involved in gastrulation Source: Ensembl
    8. neural plate morphogenesis Source: Ensembl
    9. neural tube closure Source: Ensembl
    10. notochord formation Source: Ensembl
    11. penetration of zona pellucida Source: Ensembl
    12. positive regulation of cell proliferation Source: Ensembl
    13. positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Source: Ensembl
    14. post-anal tail morphogenesis Source: Ensembl
    15. signal transduction involved in regulation of gene expression Source: Ensembl
    16. SMAD protein signal transduction Source: Ensembl
    17. somitogenesis Source: Ensembl
    18. vasculogenesis Source: Ensembl

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Brachyury protein
    Alternative name(s):
    Protein T
    Gene namesi
    Name:T
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nuclear chromatin Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 435435Brachyury proteinPRO_0000184413Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000001157.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GL27.
    SMRiQ9GL27. Positions 41-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG257463.
    GeneTreeiENSGT00750000117513.
    HOGENOMiHOG000063663.
    HOVERGENiHBG004599.
    InParanoidiQ9GL27.
    KOiK10172.
    OMAiQFFRGSP.
    OrthoDBiEOG7GN2PM.
    TreeFamiTF106341.

    Family and domain databases

    Gene3Di2.60.40.820. 1 hit.
    InterProiIPR008967. p53-like_TF_DNA-bd.
    IPR002070. TF_Brachyury.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view]
    PANTHERiPTHR11267. PTHR11267. 1 hit.
    PfamiPF00907. T-box. 1 hit.
    [Graphical view]
    PRINTSiPR00938. BRACHYURY.
    PR00937. TBOX.
    SMARTiSM00425. TBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    PROSITEiPS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9GL27-1 [UniParc]FASTAAdd to Basket

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    MSSPGAESAG KSLQYRVDHL LSAVESELQA GSEKGDPTER ELRVGLEDSE    50
    LWLRFKELTN EMIVTKNGRR MFPVLKVNVS GLDPNAMYSF LLDFVAADNH 100
    RWKYVNGEWV PGGKPEPQAP SCVYIHPDSP NFGAHWMKAP VSFSKVKLTN 150
    KLNGGGQIML NSLHKYEPRI HIVRVGGAQR MITSHCFPET QFIAVTAYQN 200
    EEITALKIKY NPFAKAFLDA KERSDHKDMM EEPGDSQQSG YSQWGWLIPG 250
    TSTLCPPATP HPQFGGPLSL PSTHGCERYP ALRNHRPSPY PSPYAHRNNS 300
    PTYSDNPSAC LSMLQSHDSW PSLGTPAHTS MLPMSHSAGP PTGSSQYPSL 350
    WSVSNGTITP GAQPAGMSNG LGAQFFRGSS AHGAPLGHAV PAPSASGSPL 400
    YEGAPTATDV PDSQYDASAQ ARLIASWTPV SPPSM 435
    Length:435
    Mass (Da):47,148
    Last modified:March 1, 2001 - v1
    Checksum:iCDCDB4A53A395AE2
    GO

    Polymorphismi

    A mutation in position 63 is responsible for a short-tail trait in a bob-tailed dog. The homozygous mutation is lethal.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti63 – 631I → M in a bob-tailed dog; alters the ability of the protein to bind to its consensus DNA target. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ245513 mRNA. Translation: CAC10530.1.
    RefSeqiNP_001003092.1. NM_001003092.1.
    UniGeneiCfa.3518.

    Genome annotation databases

    EnsembliENSCAFT00000001265; ENSCAFP00000001157; ENSCAFG00000000807.
    GeneIDi403653.
    KEGGicfa:403653.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ245513 mRNA. Translation: CAC10530.1 .
    RefSeqi NP_001003092.1. NM_001003092.1.
    UniGenei Cfa.3518.

    3D structure databases

    ProteinModelPortali Q9GL27.
    SMRi Q9GL27. Positions 41-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000001157.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000001265 ; ENSCAFP00000001157 ; ENSCAFG00000000807 .
    GeneIDi 403653.
    KEGGi cfa:403653.

    Organism-specific databases

    CTDi 6862.

    Phylogenomic databases

    eggNOGi NOG257463.
    GeneTreei ENSGT00750000117513.
    HOGENOMi HOG000063663.
    HOVERGENi HBG004599.
    InParanoidi Q9GL27.
    KOi K10172.
    OMAi QFFRGSP.
    OrthoDBi EOG7GN2PM.
    TreeFami TF106341.

    Miscellaneous databases

    NextBioi 20817158.

    Family and domain databases

    Gene3Di 2.60.40.820. 1 hit.
    InterProi IPR008967. p53-like_TF_DNA-bd.
    IPR002070. TF_Brachyury.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view ]
    PANTHERi PTHR11267. PTHR11267. 1 hit.
    Pfami PF00907. T-box. 1 hit.
    [Graphical view ]
    PRINTSi PR00938. BRACHYURY.
    PR00937. TBOX.
    SMARTi SM00425. TBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    PROSITEi PS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Canine homolog of the T-box transcription factor T; failure of the protein to bind to its DNA target leads to a short-tail phenotype."
      Haworth K.E., Putt W., Cattanach B., Breen M., Binns M., Lingaas F., Edwards Y.H.
      Mamm. Genome 12:212-218(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-63.

    Entry informationi

    Entry nameiBRAC_CANFA
    AccessioniPrimary (citable) accession number: Q9GL27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3