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Q9GL27 (BRAC_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Brachyury protein
Alternative name(s):
Protein T
Gene names
Name:T
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Nucleus.

Polymorphism

A mutation in position 63 is responsible for a short-tail trait in a bob-tailed dog. The homozygous mutation is lethal.

Sequence similarities

Contains 1 T-box DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   Molecular functionActivator
Developmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from electronic annotation. Source: Ensembl

SMAD protein signal transduction

Inferred from electronic annotation. Source: Ensembl

bone morphogenesis

Inferred from electronic annotation. Source: Ensembl

canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

determination of heart left/right asymmetry

Inferred from electronic annotation. Source: Ensembl

embryonic skeletal system development

Inferred from electronic annotation. Source: Ensembl

heart morphogenesis

Inferred from electronic annotation. Source: Ensembl

mesoderm migration involved in gastrulation

Inferred from electronic annotation. Source: Ensembl

neural plate morphogenesis

Inferred from electronic annotation. Source: Ensembl

neural tube closure

Inferred from electronic annotation. Source: Ensembl

notochord formation

Inferred from electronic annotation. Source: Ensembl

penetration of zona pellucida

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation

Inferred from electronic annotation. Source: Ensembl

post-anal tail morphogenesis

Inferred from electronic annotation. Source: Ensembl

signal transduction involved in regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

somitogenesis

Inferred from electronic annotation. Source: Ensembl

vasculogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

nuclear chromatin

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionRNA polymerase II core promoter proximal region sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

RNA polymerase II distal enhancer sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 435435Brachyury protein
PRO_0000184413

Regions

DNA binding51 – 219169T-box

Natural variations

Natural variant631I → M in a bob-tailed dog; alters the ability of the protein to bind to its consensus DNA target. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9GL27 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: CDCDB4A53A395AE2

FASTA43547,148
        10         20         30         40         50         60 
MSSPGAESAG KSLQYRVDHL LSAVESELQA GSEKGDPTER ELRVGLEDSE LWLRFKELTN 

        70         80         90        100        110        120 
EMIVTKNGRR MFPVLKVNVS GLDPNAMYSF LLDFVAADNH RWKYVNGEWV PGGKPEPQAP 

       130        140        150        160        170        180 
SCVYIHPDSP NFGAHWMKAP VSFSKVKLTN KLNGGGQIML NSLHKYEPRI HIVRVGGAQR 

       190        200        210        220        230        240 
MITSHCFPET QFIAVTAYQN EEITALKIKY NPFAKAFLDA KERSDHKDMM EEPGDSQQSG 

       250        260        270        280        290        300 
YSQWGWLIPG TSTLCPPATP HPQFGGPLSL PSTHGCERYP ALRNHRPSPY PSPYAHRNNS 

       310        320        330        340        350        360 
PTYSDNPSAC LSMLQSHDSW PSLGTPAHTS MLPMSHSAGP PTGSSQYPSL WSVSNGTITP 

       370        380        390        400        410        420 
GAQPAGMSNG LGAQFFRGSS AHGAPLGHAV PAPSASGSPL YEGAPTATDV PDSQYDASAQ 

       430 
ARLIASWTPV SPPSM 

« Hide

References

[1]"Canine homolog of the T-box transcription factor T; failure of the protein to bind to its DNA target leads to a short-tail phenotype."
Haworth K.E., Putt W., Cattanach B., Breen M., Binns M., Lingaas F., Edwards Y.H.
Mamm. Genome 12:212-218(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-63.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ245513 mRNA. Translation: CAC10530.1.
RefSeqNP_001003092.1. NM_001003092.1.
UniGeneCfa.3518.

3D structure databases

ProteinModelPortalQ9GL27.
SMRQ9GL27. Positions 41-224.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000001157.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000001265; ENSCAFP00000001157; ENSCAFG00000000807.
GeneID403653.
KEGGcfa:403653.

Organism-specific databases

CTD6862.

Phylogenomic databases

eggNOGNOG257463.
GeneTreeENSGT00750000117513.
HOGENOMHOG000063663.
HOVERGENHBG004599.
InParanoidQ9GL27.
KOK10172.
OMAQFFRGSP.
OrthoDBEOG7GN2PM.
TreeFamTF106341.

Family and domain databases

Gene3D2.60.40.820. 1 hit.
InterProIPR008967. p53-like_TF_DNA-bd.
IPR002070. TF_Brachyury.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERPTHR11267. PTHR11267. 1 hit.
PfamPF00907. T-box. 1 hit.
[Graphical view]
PRINTSPR00938. BRACHYURY.
PR00937. TBOX.
SMARTSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMSSF49417. SSF49417. 1 hit.
PROSITEPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20817158.

Entry information

Entry nameBRAC_CANFA
AccessionPrimary (citable) accession number: Q9GL27
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families