SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9GL27

- BRAC_CANFA

UniProt

Q9GL27 - BRAC_CANFA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Brachyury protein

Gene
T
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi51 – 219169T-boxAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  2. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
  4. RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription Source: Ensembl

GO - Biological processi

  1. BMP signaling pathway Source: Ensembl
  2. bone morphogenesis Source: Ensembl
  3. canonical Wnt signaling pathway Source: Ensembl
  4. determination of heart left/right asymmetry Source: Ensembl
  5. embryonic skeletal system development Source: Ensembl
  6. heart morphogenesis Source: Ensembl
  7. mesoderm migration involved in gastrulation Source: Ensembl
  8. neural plate morphogenesis Source: Ensembl
  9. neural tube closure Source: Ensembl
  10. notochord formation Source: Ensembl
  11. penetration of zona pellucida Source: Ensembl
  12. positive regulation of cell proliferation Source: Ensembl
  13. positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Source: Ensembl
  14. post-anal tail morphogenesis Source: Ensembl
  15. signal transduction involved in regulation of gene expression Source: Ensembl
  16. SMAD protein signal transduction Source: Ensembl
  17. somitogenesis Source: Ensembl
  18. vasculogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brachyury protein
Alternative name(s):
Protein T
Gene namesi
Name:T
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nuclear chromatin Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Brachyury proteinPRO_0000184413Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000001157.

Structurei

3D structure databases

ProteinModelPortaliQ9GL27.
SMRiQ9GL27. Positions 41-224.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG257463.
GeneTreeiENSGT00750000117513.
HOGENOMiHOG000063663.
HOVERGENiHBG004599.
InParanoidiQ9GL27.
KOiK10172.
OMAiQFFRGSP.
OrthoDBiEOG7GN2PM.
TreeFamiTF106341.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR002070. TF_Brachyury.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00938. BRACHYURY.
PR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GL27-1 [UniParc]FASTAAdd to Basket

« Hide

MSSPGAESAG KSLQYRVDHL LSAVESELQA GSEKGDPTER ELRVGLEDSE    50
LWLRFKELTN EMIVTKNGRR MFPVLKVNVS GLDPNAMYSF LLDFVAADNH 100
RWKYVNGEWV PGGKPEPQAP SCVYIHPDSP NFGAHWMKAP VSFSKVKLTN 150
KLNGGGQIML NSLHKYEPRI HIVRVGGAQR MITSHCFPET QFIAVTAYQN 200
EEITALKIKY NPFAKAFLDA KERSDHKDMM EEPGDSQQSG YSQWGWLIPG 250
TSTLCPPATP HPQFGGPLSL PSTHGCERYP ALRNHRPSPY PSPYAHRNNS 300
PTYSDNPSAC LSMLQSHDSW PSLGTPAHTS MLPMSHSAGP PTGSSQYPSL 350
WSVSNGTITP GAQPAGMSNG LGAQFFRGSS AHGAPLGHAV PAPSASGSPL 400
YEGAPTATDV PDSQYDASAQ ARLIASWTPV SPPSM 435
Length:435
Mass (Da):47,148
Last modified:March 1, 2001 - v1
Checksum:iCDCDB4A53A395AE2
GO

Polymorphismi

A mutation in position 63 is responsible for a short-tail trait in a bob-tailed dog. The homozygous mutation is lethal.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631I → M in a bob-tailed dog; alters the ability of the protein to bind to its consensus DNA target. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ245513 mRNA. Translation: CAC10530.1.
RefSeqiNP_001003092.1. NM_001003092.1.
UniGeneiCfa.3518.

Genome annotation databases

EnsembliENSCAFT00000001265; ENSCAFP00000001157; ENSCAFG00000000807.
GeneIDi403653.
KEGGicfa:403653.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ245513 mRNA. Translation: CAC10530.1 .
RefSeqi NP_001003092.1. NM_001003092.1.
UniGenei Cfa.3518.

3D structure databases

ProteinModelPortali Q9GL27.
SMRi Q9GL27. Positions 41-224.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000001157.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000001265 ; ENSCAFP00000001157 ; ENSCAFG00000000807 .
GeneIDi 403653.
KEGGi cfa:403653.

Organism-specific databases

CTDi 6862.

Phylogenomic databases

eggNOGi NOG257463.
GeneTreei ENSGT00750000117513.
HOGENOMi HOG000063663.
HOVERGENi HBG004599.
InParanoidi Q9GL27.
KOi K10172.
OMAi QFFRGSP.
OrthoDBi EOG7GN2PM.
TreeFami TF106341.

Miscellaneous databases

NextBioi 20817158.

Family and domain databases

Gene3Di 2.60.40.820. 1 hit.
InterProi IPR008967. p53-like_TF_DNA-bd.
IPR002070. TF_Brachyury.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view ]
PANTHERi PTHR11267. PTHR11267. 1 hit.
Pfami PF00907. T-box. 1 hit.
[Graphical view ]
PRINTSi PR00938. BRACHYURY.
PR00937. TBOX.
SMARTi SM00425. TBOX. 1 hit.
[Graphical view ]
SUPFAMi SSF49417. SSF49417. 1 hit.
PROSITEi PS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Canine homolog of the T-box transcription factor T; failure of the protein to bind to its DNA target leads to a short-tail phenotype."
    Haworth K.E., Putt W., Cattanach B., Breen M., Binns M., Lingaas F., Edwards Y.H.
    Mamm. Genome 12:212-218(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-63.

Entry informationi

Entry nameiBRAC_CANFA
AccessioniPrimary (citable) accession number: Q9GL27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi