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Protein
Submitted name:

Leukemia inhibitory factor

Gene

LIF

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-SSC-6788467. IL-6-type cytokine receptor ligand interactions.

Names & Taxonomyi

Protein namesi
Submitted name:
Leukemia inhibitory factorImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:LIFImported
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 14

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 202180Sequence analysisPRO_5007716784Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000010668.

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410ITBQ. Eukaryota.
ENOG410YVPP. LUCA.
GeneTreeiENSGT00390000000059.
HOGENOMiHOG000059647.
HOVERGENiHBG006267.
KOiK05419.
OMAiKYHVAHV.
OrthoDBiEOG7JX359.
TreeFamiTF336245.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003624. Leukemia_IF.
IPR001581. Leukemia_IF/oncostatin.
IPR019827. Leukemia_IF/oncostatin_CS.
[Graphical view]
PANTHERiPTHR10633. PTHR10633. 1 hit.
PfamiPF01291. LIF_OSM. 1 hit.
[Graphical view]
PRINTSiPR01883. LEUKAEMIAIF.
SMARTiSM00080. LIF_OSM. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00590. LIF_OSM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GKZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLAAGVVP LLLVLHWKHG AGSPLSITPV NATCATRHPC HSNLMNQIKN
60 70 80 90 100
QLAQLNSSAN ALFILYYTAQ GEPFPNNLDK LCGPNVTNFP PFHANGTEKA
110 120 130 140 150
RLVELYRIIA YLGASLGNIT RDQRSLNPGA VNLHSKLNAT ADSMRGLLSN
160 170 180 190 200
VLCRLCNKYH VAHVDVAYGP DTSGKDVFQK KKLGCQLLGK YKQVISVLAR

AF
Length:202
Mass (Da):21,989
Last modified:March 1, 2001 - v1
Checksum:i09875132E5C8C735
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT827833 Genomic DNA. No translation available.
AY585336 mRNA. Translation: AAS98213.1.
AJ296176 Genomic DNA. Translation: CAC14463.1.
PIRiS23069.
RefSeqiNP_999567.1. NM_214402.2.
XP_005670842.1. XM_005670785.2.
XP_013838479.1. XM_013983025.1.
XP_013838480.1. XM_013983026.1.
UniGeneiSsc.52878.

Genome annotation databases

EnsembliENSSSCT00000010953; ENSSSCP00000010668; ENSSSCG00000009996.
GeneIDi399503.
KEGGissc:399503.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT827833 Genomic DNA. No translation available.
AY585336 mRNA. Translation: AAS98213.1.
AJ296176 Genomic DNA. Translation: CAC14463.1.
PIRiS23069.
RefSeqiNP_999567.1. NM_214402.2.
XP_005670842.1. XM_005670785.2.
XP_013838479.1. XM_013983025.1.
XP_013838480.1. XM_013983026.1.
UniGeneiSsc.52878.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000010668.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000010953; ENSSSCP00000010668; ENSSSCG00000009996.
GeneIDi399503.
KEGGissc:399503.

Organism-specific databases

CTDi3976.

Phylogenomic databases

eggNOGiENOG410ITBQ. Eukaryota.
ENOG410YVPP. LUCA.
GeneTreeiENSGT00390000000059.
HOGENOMiHOG000059647.
HOVERGENiHBG006267.
KOiK05419.
OMAiKYHVAHV.
OrthoDBiEOG7JX359.
TreeFamiTF336245.

Enzyme and pathway databases

ReactomeiR-SSC-6788467. IL-6-type cytokine receptor ligand interactions.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003624. Leukemia_IF.
IPR001581. Leukemia_IF/oncostatin.
IPR019827. Leukemia_IF/oncostatin_CS.
[Graphical view]
PANTHERiPTHR10633. PTHR10633. 1 hit.
PfamiPF01291. LIF_OSM. 1 hit.
[Graphical view]
PRINTSiPR01883. LEUKAEMIAIF.
SMARTiSM00080. LIF_OSM. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00590. LIF_OSM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cross-species comparison of the sequence of the leukaemia inhibitory factor gene and its protein."
    Willson T.A., Metcalf D., Gough N.M.
    Eur. J. Biochem. 204:21-30(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Molecular characterization and chromosome assignment of the porcine gene for leukemia inhibitory factor LIF."
    Spotter A., Drogemuller C., Kuiper H., Brenig B., Leeb T., Distl O.
    Cytogenet. Cell Genet. 93:87-90(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Cloning and functional analysis of porcine leukemia inhibitory factor."
    Li M., Feng X., Wang Y., Yang H., Ma T.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SpleenImported.
  4. Porcine genome sequencing project
    Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DurocImported.
  5. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ9GKZ8_PIG
AccessioniPrimary (citable) accession number: Q9GKZ8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.