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Protein

Appetite-regulating hormone

Gene

GHRL

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity).By similarity
Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Appetite-regulating hormone
Alternative name(s):
Growth hormone secretagogue
Growth hormone-releasing peptide
Motilin-related peptide
Cleaved into the following 2 chains:
Gene namesi
Name:GHRL
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • axon Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Peptidei25 – 5228GhrelinPRO_0000019207Add
BLAST
Propeptidei53 – 7624Removed in mature formBy similarityPRO_0000019208Add
BLAST
Peptidei77 – 9923ObestatinBy similarityPRO_0000045144Add
BLAST
Propeptidei100 – 11819Removed in mature formBy similarityPRO_0000045145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi27 – 271O-octanoyl serineBy similarity
Modified residuei99 – 991Leucine amideBy similarity

Post-translational modificationi

O-octanoylation is essential for ghrelin activity.By similarity
Amidation of Leu-99 is essential for obestatin activity.By similarity

Keywords - PTMi

Amidation, Lipoprotein

Proteomic databases

PaxDbiQ9GKY5.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012327.

Family & Domainsi

Sequence similaritiesi

Belongs to the motilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZYV. Eukaryota.
ENOG410ZG1B. LUCA.
HOGENOMiHOG000236303.
HOVERGENiHBG018522.
InParanoidiQ9GKY5.
KOiK05254.

Family and domain databases

InterProiIPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
IPR005441. Preproghrelin.
[Graphical view]
PANTHERiPTHR14122. PTHR14122. 1 hit.
PfamiPF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.
[Graphical view]
PRINTSiPR01624. GHRELIN.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9GKY5-1) [UniParc]FASTAAdd to basket

Also known as: Ghrelin

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSTGTICSL LLLSVLLMAD LAMAGSSFLS PEHQKVQQRK ESKKPAAKLK
60 70 80 90 100
PRALEGWLGP EDSGEVEGTE DKLEIRFNAP CDVGIKLSGA QSDQHGQPLG
110
KFLQDILWEE VTEAPADK
Length:118
Mass (Da):12,786
Last modified:March 1, 2001 - v1
Checksum:i856D3E1D6DAB1A76
GO
Isoform 2 (identifier: Q9GKY5-2) [UniParc]FASTAAdd to basket

Also known as: des-Gln14-ghrelin

The sequence of this isoform differs from the canonical sequence as follows:
     38-38: Missing.

Show »
Length:117
Mass (Da):12,657
Checksum:i4BD9EF586C4D177C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171L → P in AAK30002 (Ref. 2) Curated
Sequence conflicti72 – 721K → E in AAK30002 (Ref. 2) Curated
Sequence conflicti112 – 1121T → N in ABC94728 (Ref. 3) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei38 – 381Missing in isoform 2. 2 PublicationsVSP_003247

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035703 mRNA. Translation: BAB19048.1.
AB035704 mRNA. Translation: BAB19049.1.
AF308930 mRNA. Translation: AAK19243.1.
AY028942 mRNA. Translation: AAK30002.1.
DQ355969 mRNA. Translation: ABC94728.1.
DQ663493 Genomic DNA. Translation: ABG23100.1.
RefSeqiNP_998972.1. NM_213807.2. [Q9GKY5-1]
XP_013837377.1. XM_013981923.1.
UniGeneiSsc.440.

Genome annotation databases

GeneIDi396728.
KEGGissc:396728.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Protein Spotlight

Gut feelings - Issue 66 of January 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035703 mRNA. Translation: BAB19048.1.
AB035704 mRNA. Translation: BAB19049.1.
AF308930 mRNA. Translation: AAK19243.1.
AY028942 mRNA. Translation: AAK30002.1.
DQ355969 mRNA. Translation: ABC94728.1.
DQ663493 Genomic DNA. Translation: ABG23100.1.
RefSeqiNP_998972.1. NM_213807.2. [Q9GKY5-1]
XP_013837377.1. XM_013981923.1.
UniGeneiSsc.440.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012327.

Proteomic databases

PaxDbiQ9GKY5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396728.
KEGGissc:396728.

Organism-specific databases

CTDi51738.

Phylogenomic databases

eggNOGiENOG410IZYV. Eukaryota.
ENOG410ZG1B. LUCA.
HOGENOMiHOG000236303.
HOVERGENiHBG018522.
InParanoidiQ9GKY5.
KOiK05254.

Family and domain databases

InterProiIPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
IPR005441. Preproghrelin.
[Graphical view]
PANTHERiPTHR14122. PTHR14122. 1 hit.
PfamiPF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.
[Graphical view]
PRINTSiPR01624. GHRELIN.
ProtoNetiSearch...

Publicationsi

  1. Kojima M.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. Rousselle J., Lacroix D., Dubreuil P.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Stomach.
  3. Ying M., Yang Z.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Sequencing and chromosome mapping of pig ghrelin and motilin genes."
    Ying M., Yang Z., Yang W.
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGHRL_PIG
AccessioniPrimary (citable) accession number: Q9GKY5
Secondary accession number(s): A5X8W4
, Q2I0G0, Q9BDG8, Q9GKY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.