Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Follistatin-related protein 1

Gene

FSTL1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionHeparin-binding

Protein family/group databases

MEROPSiI01.967

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin-related protein 1
Alternative name(s):
Follistatin-like protein 1
Gene namesi
Name:FSTL1
Synonyms:OCC1
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001011221 – 308Follistatin-related protein 1Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 84PROSITE-ProRule annotation
Disulfide bondi58 ↔ 77PROSITE-ProRule annotation
Disulfide bondi66 ↔ 98PROSITE-ProRule annotation
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei165PhosphoserineBy similarity1
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ9GKY0

Interactioni

Subunit structurei

Interacts with SCN10A.

Structurei

3D structure databases

ProteinModelPortaliQ9GKY0
SMRiQ9GKY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 53Follistatin-likeAdd BLAST24
Domaini48 – 100Kazal-likePROSITE-ProRule annotationAdd BLAST53
Domaini144 – 178EF-hand 1PROSITE-ProRule annotationAdd BLAST35
Domaini193 – 228EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini233 – 287VWFCAdd BLAST55

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG051665

Family and domain databases

Gene3Di3.90.290.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR003645 Fol_N
IPR015369 Follistatin/Osteonectin_EGF
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR036773 TB_dom_sf
PfamiView protein in Pfam
PF09289 FOLN, 1 hit
PF07648 Kazal_2, 1 hit
SMARTiView protein in SMART
SM00274 FOLN, 1 hit
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits
PS51465 KAZAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GKY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKRWLALAL ALVAVAWVRA EEELRSKSKI CANVFCGAGR ECAVTEKGEP
60 70 80 90 100
TCLCIEQCKP HKRPVCGSNG KTYLNHCELH RDACLTGSKI QVDYDGHCKE
110 120 130 140 150
KKSISPSASP VVCYQSNRDE LRRRIIQWLE AEIIPDGWFS KGSNYSEILD
160 170 180 190 200
KYFKNFDNGD SRLDSSEFLK FVEQNETAIN ITTYPDQENN KLLRGLCVDA
210 220 230 240 250
LIELSDENAD WKLSFQEFLK CLNPSFNPPE KKCALEDETY ADGAETEVDC
260 270 280 290 300
NRCVCACGNW VCTAMTCDGK NQKGAQTQTE EEMTRYVQEL QKHQETAEKT

KRVSTKEI
Length:308
Mass (Da):35,000
Last modified:March 1, 2001 - v1
Checksum:i4B2836D9CDF535D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039661 mRNA Translation: BAB20770.1
RefSeqiNP_001306351.1, NM_001319422.1
UniGeneiMfa.5905

Genome annotation databases

GeneIDi102131597
KEGGimcf:102131597

Similar proteinsi

Entry informationi

Entry nameiFSTL1_MACFA
AccessioniPrimary (citable) accession number: Q9GKY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health