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Q9GKY0

- FSTL1_MACFA

UniProt

Q9GKY0 - FSTL1_MACFA

Protein

Follistatin-related protein 1

Gene

FSTL1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. heparin binding Source: UniProtKB-KW

    Keywords - Ligandi

    Heparin-binding

    Protein family/group databases

    MEROPSiI01.967.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Follistatin-related protein 1
    Alternative name(s):
    Follistatin-like protein 1
    Gene namesi
    Name:FSTL1
    Synonyms:OCC1
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 308288Follistatin-related protein 1PRO_0000010112Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 84PROSITE-ProRule annotation
    Disulfide bondi58 ↔ 77PROSITE-ProRule annotation
    Disulfide bondi66 ↔ 98PROSITE-ProRule annotation
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with SCN10A.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GKY0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 5324Follistatin-likeAdd
    BLAST
    Domaini48 – 10053Kazal-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini144 – 17835EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini193 – 22836EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini233 – 28755VWFCAdd
    BLAST

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 1 follistatin-like domain.Curated
    Contains 1 Kazal-like domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    HOVERGENiHBG051665.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR003645. Fol_N.
    IPR015369. Follistatin/Osteonectin_EGF.
    IPR002350. Kazal_dom.
    [Graphical view]
    PfamiPF09289. FOLN. 1 hit.
    PF07648. Kazal_2. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    SM00274. FOLN. 1 hit.
    SM00280. KAZAL. 1 hit.
    [Graphical view]
    PROSITEiPS50222. EF_HAND_2. 2 hits.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9GKY0-1 [UniParc]FASTAAdd to Basket

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    MWKRWLALAL ALVAVAWVRA EEELRSKSKI CANVFCGAGR ECAVTEKGEP    50
    TCLCIEQCKP HKRPVCGSNG KTYLNHCELH RDACLTGSKI QVDYDGHCKE 100
    KKSISPSASP VVCYQSNRDE LRRRIIQWLE AEIIPDGWFS KGSNYSEILD 150
    KYFKNFDNGD SRLDSSEFLK FVEQNETAIN ITTYPDQENN KLLRGLCVDA 200
    LIELSDENAD WKLSFQEFLK CLNPSFNPPE KKCALEDETY ADGAETEVDC 250
    NRCVCACGNW VCTAMTCDGK NQKGAQTQTE EEMTRYVQEL QKHQETAEKT 300
    KRVSTKEI 308
    Length:308
    Mass (Da):35,000
    Last modified:March 1, 2001 - v1
    Checksum:i4B2836D9CDF535D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB039661 mRNA. Translation: BAB20770.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB039661 mRNA. Translation: BAB20770.1 .

    3D structure databases

    ProteinModelPortali Q9GKY0.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I01.967.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG051665.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR003645. Fol_N.
    IPR015369. Follistatin/Osteonectin_EGF.
    IPR002350. Kazal_dom.
    [Graphical view ]
    Pfami PF09289. FOLN. 1 hit.
    PF07648. Kazal_2. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    SM00274. FOLN. 1 hit.
    SM00280. KAZAL. 1 hit.
    [Graphical view ]
    PROSITEi PS50222. EF_HAND_2. 2 hits.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The occ1 gene is preferentially expressed in the primary visual cortex in an activity-dependent manner: a pattern of gene expression related to the cytoarchitectonic area in adult macaque neocortex."
      Tochitani S., Liang F., Watakabe A., Hashikawa T., Yamamori T.
      Eur. J. Neurosci. 13:297-307(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiFSTL1_MACFA
    AccessioniPrimary (citable) accession number: Q9GKY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3