Q9GKY0 (FSTL1_MACFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Follistatin-related protein 1

Alternative name(s):
Follistatin-like protein 1

Gene names

Name:	FSTL1
Synonyms:	OCC1

Organism

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Cercopithecoidea › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin By similarity.
Subunit structure	Interacts with SCN10A.
Subcellular location	Secreted Potential.
Sequence similarities	Contains 2 EF-hand domains. Contains 1 follistatin-like domain. Contains 1 Kazal-like domain. Contains 1 VWFC domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Repeat Signal
Ligand	Heparin-binding
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro heparin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 308	288	Follistatin-related protein 1		PRO_0000010112
Regions
	Domain	30 – 53	24	Follistatin-like
	Domain	48 – 100	53	Kazal-like
	Domain	144 – 178	35	EF-hand 1
	Domain	193 – 228	36	EF-hand 2
	Domain	233 – 287	55	VWFC
Amino acid modifications
	Glycosylation	144	1	N-linked (GlcNAc...) Potential
	Glycosylation	175	1	N-linked (GlcNAc...) Potential
	Glycosylation	180	1	N-linked (GlcNAc...) Potential
	Disulfide bond	54 ↔ 84		By similarity
	Disulfide bond	58 ↔ 77		By similarity
	Disulfide bond	66 ↔ 98		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9GKY0 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 4B2836D9CDF535D9	FASTA	308	35,000
	10 20 30 40 50 60 MWKRWLALAL ALVAVAWVRA EEELRSKSKI CANVFCGAGR ECAVTEKGEP TCLCIEQCKP 70 80 90 100 110 120 HKRPVCGSNG KTYLNHCELH RDACLTGSKI QVDYDGHCKE KKSISPSASP VVCYQSNRDE 130 140 150 160 170 180 LRRRIIQWLE AEIIPDGWFS KGSNYSEILD KYFKNFDNGD SRLDSSEFLK FVEQNETAIN 190 200 210 220 230 240 ITTYPDQENN KLLRGLCVDA LIELSDENAD WKLSFQEFLK CLNPSFNPPE KKCALEDETY 250 260 270 280 290 300 ADGAETEVDC NRCVCACGNW VCTAMTCDGK NQKGAQTQTE EEMTRYVQEL QKHQETAEKT KRVSTKEI

References

[1]

"The occ1 gene is preferentially expressed in the primary visual cortex in an activity-dependent manner: a pattern of gene expression related to the cytoarchitectonic area in adult macaque neocortex." Tochitani S., Liang F., Watakabe A., Hashikawa T., Yamamori T. Eur. J. Neurosci. 13:297-307(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB039661 mRNA. Translation: BAB20770.1.
3D structure databases
ProteinModelPortal	Q9GKY0.
ModBase	Search...
Protein family/group databases
MEROPS	I01.967.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG051665.
Family and domain databases
Gene3D	1.10.238.10. 1 hit.
InterPro	IPR011992. EF-hand-like_dom. IPR002048. EF_hand_dom. IPR003645. Fol_N. IPR015369. Follistatin/Osteonectin_EGF. IPR002350. Kazal_dom. [Graphical view]
Pfam	PF09289. FOLN. 1 hit. PF07648. Kazal_2. 1 hit. [Graphical view]
SMART	SM00054. EFh. 2 hits. SM00274. FOLN. 1 hit. SM00280. KAZAL. 1 hit. [Graphical view]
PROSITE	PS50222. EF_HAND_2. 2 hits. PS51465. KAZAL_2. 1 hit. PS01208. VWFC_1. False negative. PS50184. VWFC_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FSTL1_MACFA

Accession

Primary (citable) accession number: Q9GKY0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program