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Q9GKX6

- GALM_PIG

UniProt

Q9GKX6 - GALM_PIG

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Protein

Aldose 1-epimerase

Gene
GALM
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose By similarity.

Catalytic activityi

Alpha-D-glucose = beta-D-glucose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei176 – 1761Proton donor By similarity
Binding sitei243 – 2431Substrate By similarity
Active sitei307 – 3071Proton acceptor By similarity

GO - Molecular functioni

  1. aldose 1-epimerase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro

GO - Biological processi

  1. hexose metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose 1-epimerase (EC:5.1.3.3)
Alternative name(s):
Galactose mutarotase
Gene namesi
Name:GALM
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 3

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 342341Aldose 1-epimerasePRO_0000197435Add
BLAST

Proteomic databases

PaxDbiQ9GKX6.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009052.

Structurei

3D structure databases

ProteinModelPortaliQ9GKX6.
SMRiQ9GKX6. Positions 1-342.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni81 – 822Substrate binding By similarity

Sequence similaritiesi

Belongs to the aldose epimerase family.

Phylogenomic databases

eggNOGiCOG2017.
GeneTreeiENSGT00510000047589.
HOGENOMiHOG000072798.
HOVERGENiHBG051697.
KOiK01785.
OMAiMEVHTTQ.
OrthoDBiEOG7V7666.
TreeFamiTF324207.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
InterProiIPR018052. Ald1_epimerase_CS.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF005096. GALM. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
PROSITEiPS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GKX6-1 [UniParc]FASTAAdd to Basket

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MVSVTRSVFG DLPSGAGTVE KFQLQSDQLR VDIISWGCTI TALEVKDRQG    50
RASDVVLGFA ELKEYLQKHP YFGAVVGRVA NRIAKGTFTL DGKEYKLAIN 100
NGPNSLHGGV RGFDKVLWTP RVLSNGIEFS RVSPDGEEGY PGELKVWVTY 150
TLDGGELVVN YRAQASQTTP VNLTNHSYFN LAGQGSPNIY DHEVTIEADA 200
FLPVDETLIP TGEIAPVQGT AFDLRKPVEL GKHLQEFHIN GFDHNFCLKR 250
SKEKQFCARV HHAGSGRVLE VYTTQPGIQF YTGNFLDGTL KGKTGAVYPK 300
HSGFCLETQN WPNAVNQPHF PPVLLKPGEE YNHTTWFVFS VA 342
Length:342
Mass (Da):37,816
Last modified:March 1, 2001 - v1
Checksum:iC824C57AC488E3D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB044390 mRNA. Translation: BAB18973.1.
RefSeqiNP_999571.1. NM_214406.1.
UniGeneiSsc.82583.
Ssc.9245.

Genome annotation databases

EnsembliENSSSCT00000009288; ENSSSCP00000009052; ENSSSCG00000008486.
GeneIDi399536.
KEGGissc:399536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB044390 mRNA. Translation: BAB18973.1 .
RefSeqi NP_999571.1. NM_214406.1.
UniGenei Ssc.82583.
Ssc.9245.

3D structure databases

ProteinModelPortali Q9GKX6.
SMRi Q9GKX6. Positions 1-342.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000009052.

Proteomic databases

PaxDbi Q9GKX6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000009288 ; ENSSSCP00000009052 ; ENSSSCG00000008486 .
GeneIDi 399536.
KEGGi ssc:399536.

Organism-specific databases

CTDi 130589.

Phylogenomic databases

eggNOGi COG2017.
GeneTreei ENSGT00510000047589.
HOGENOMi HOG000072798.
HOVERGENi HBG051697.
KOi K01785.
OMAi MEVHTTQ.
OrthoDBi EOG7V7666.
TreeFami TF324207.

Enzyme and pathway databases

UniPathwayi UPA00242 .

Family and domain databases

Gene3Di 2.70.98.10. 1 hit.
InterProi IPR018052. Ald1_epimerase_CS.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view ]
Pfami PF01263. Aldose_epim. 1 hit.
[Graphical view ]
PIRSFi PIRSF005096. GALM. 1 hit.
SUPFAMi SSF74650. SSF74650. 1 hit.
PROSITEi PS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of an aldose 1-epimerase (mutarotase) cDNA from hog kidney and its overexpression in Escherichia coli and some properties of recombinant enzyme."
    Kitazawa S., Mori H., Kato N., Ono C., Ito H., Kimura A., Matsui H., Chiba S.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiGALM_PIG
AccessioniPrimary (citable) accession number: Q9GKX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2001
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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