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Q9GKX6 (GALM_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldose 1-epimerase

EC=5.1.3.3
Alternative name(s):
Galactose mutarotase
Gene names
Name:GALM
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose By similarity.

Catalytic activity

Alpha-D-glucose = beta-D-glucose.

Pathway

Carbohydrate metabolism; hexose metabolism.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the aldose epimerase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhexose metabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaldose 1-epimerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

carbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 342341Aldose 1-epimerase
PRO_0000197435

Regions

Region81 – 822Substrate binding By similarity

Sites

Active site1761Proton donor By similarity
Active site3071Proton acceptor By similarity
Binding site2431Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9GKX6 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: C824C57AC488E3D2

FASTA34237,816
        10         20         30         40         50         60 
MVSVTRSVFG DLPSGAGTVE KFQLQSDQLR VDIISWGCTI TALEVKDRQG RASDVVLGFA 

        70         80         90        100        110        120 
ELKEYLQKHP YFGAVVGRVA NRIAKGTFTL DGKEYKLAIN NGPNSLHGGV RGFDKVLWTP 

       130        140        150        160        170        180 
RVLSNGIEFS RVSPDGEEGY PGELKVWVTY TLDGGELVVN YRAQASQTTP VNLTNHSYFN 

       190        200        210        220        230        240 
LAGQGSPNIY DHEVTIEADA FLPVDETLIP TGEIAPVQGT AFDLRKPVEL GKHLQEFHIN 

       250        260        270        280        290        300 
GFDHNFCLKR SKEKQFCARV HHAGSGRVLE VYTTQPGIQF YTGNFLDGTL KGKTGAVYPK 

       310        320        330        340 
HSGFCLETQN WPNAVNQPHF PPVLLKPGEE YNHTTWFVFS VA 

« Hide

References

[1]"Molecular cloning of an aldose 1-epimerase (mutarotase) cDNA from hog kidney and its overexpression in Escherichia coli and some properties of recombinant enzyme."
Kitazawa S., Mori H., Kato N., Ono C., Ito H., Kimura A., Matsui H., Chiba S.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB044390 mRNA. Translation: BAB18973.1.
RefSeqNP_999571.1. NM_214406.1.
UniGeneSsc.82583.
Ssc.9245.

3D structure databases

ProteinModelPortalQ9GKX6.
SMRQ9GKX6. Positions 1-342.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000009052.

Proteomic databases

PaxDbQ9GKX6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000009288; ENSSSCP00000009052; ENSSSCG00000008486.
GeneID399536.
KEGGssc:399536.

Organism-specific databases

CTD130589.

Phylogenomic databases

eggNOGCOG2017.
GeneTreeENSGT00510000047589.
HOGENOMHOG000072798.
HOVERGENHBG051697.
KOK01785.
OMAMEVHTTQ.
OrthoDBEOG7V7666.
TreeFamTF324207.

Enzyme and pathway databases

UniPathwayUPA00242.

Family and domain databases

Gene3D2.70.98.10. 1 hit.
InterProIPR018052. Ald1_epimerase_CS.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
PfamPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFPIRSF005096. GALM. 1 hit.
SUPFAMSSF74650. SSF74650. 1 hit.
PROSITEPS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGALM_PIG
AccessionPrimary (citable) accession number: Q9GKX6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2001
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways