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Protein

Aldose 1-epimerase

Gene

GALM

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity).By similarity

Catalytic activityi

Alpha-D-glucose = beta-D-glucose.PROSITE-ProRule annotation

Pathway: hexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei176 – 1761Proton donorPROSITE-ProRule annotation
Binding sitei243 – 2431SubstrateBy similarity
Active sitei307 – 3071Proton acceptorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose 1-epimerase (EC:5.1.3.3)
Alternative name(s):
Galactose mutarotase
Gene namesi
Name:GALM
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 342341Aldose 1-epimerasePRO_0000197435Add
BLAST

Proteomic databases

PaxDbiQ9GKX6.

Expressioni

Gene expression databases

GenevisibleiQ9GKX6. SS.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009052.

Structurei

3D structure databases

ProteinModelPortaliQ9GKX6.
SMRiQ9GKX6. Positions 1-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni81 – 822Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the aldose epimerase family.Curated

Phylogenomic databases

eggNOGiCOG2017.
GeneTreeiENSGT00510000047589.
HOGENOMiHOG000072798.
HOVERGENiHBG051697.
InParanoidiQ9GKX6.
KOiK01785.
OMAiPEEEYNH.
OrthoDBiEOG7V7666.
TreeFamiTF324207.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
InterProiIPR018052. Ald1_epimerase_CS.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF005096. GALM. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
PROSITEiPS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GKX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSVTRSVFG DLPSGAGTVE KFQLQSDQLR VDIISWGCTI TALEVKDRQG
60 70 80 90 100
RASDVVLGFA ELKEYLQKHP YFGAVVGRVA NRIAKGTFTL DGKEYKLAIN
110 120 130 140 150
NGPNSLHGGV RGFDKVLWTP RVLSNGIEFS RVSPDGEEGY PGELKVWVTY
160 170 180 190 200
TLDGGELVVN YRAQASQTTP VNLTNHSYFN LAGQGSPNIY DHEVTIEADA
210 220 230 240 250
FLPVDETLIP TGEIAPVQGT AFDLRKPVEL GKHLQEFHIN GFDHNFCLKR
260 270 280 290 300
SKEKQFCARV HHAGSGRVLE VYTTQPGIQF YTGNFLDGTL KGKTGAVYPK
310 320 330 340
HSGFCLETQN WPNAVNQPHF PPVLLKPGEE YNHTTWFVFS VA
Length:342
Mass (Da):37,816
Last modified:March 1, 2001 - v1
Checksum:iC824C57AC488E3D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB044390 mRNA. Translation: BAB18973.1.
RefSeqiNP_999571.1. NM_214406.1.
UniGeneiSsc.82583.
Ssc.9245.

Genome annotation databases

EnsembliENSSSCT00000009288; ENSSSCP00000009052; ENSSSCG00000008486.
GeneIDi399536.
KEGGissc:399536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB044390 mRNA. Translation: BAB18973.1.
RefSeqiNP_999571.1. NM_214406.1.
UniGeneiSsc.82583.
Ssc.9245.

3D structure databases

ProteinModelPortaliQ9GKX6.
SMRiQ9GKX6. Positions 1-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009052.

Proteomic databases

PaxDbiQ9GKX6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000009288; ENSSSCP00000009052; ENSSSCG00000008486.
GeneIDi399536.
KEGGissc:399536.

Organism-specific databases

CTDi130589.

Phylogenomic databases

eggNOGiCOG2017.
GeneTreeiENSGT00510000047589.
HOGENOMiHOG000072798.
HOVERGENiHBG051697.
InParanoidiQ9GKX6.
KOiK01785.
OMAiPEEEYNH.
OrthoDBiEOG7V7666.
TreeFamiTF324207.

Enzyme and pathway databases

UniPathwayiUPA00242.

Gene expression databases

GenevisibleiQ9GKX6. SS.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
InterProiIPR018052. Ald1_epimerase_CS.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF005096. GALM. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
PROSITEiPS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of an aldose 1-epimerase (mutarotase) cDNA from hog kidney and its overexpression in Escherichia coli and some properties of recombinant enzyme."
    Kitazawa S., Mori H., Kato N., Ono C., Ito H., Kimura A., Matsui H., Chiba S.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiGALM_PIG
AccessioniPrimary (citable) accession number: Q9GKX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2001
Last modified: June 24, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.