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Q9GKX6

- GALM_PIG

UniProt

Q9GKX6 - GALM_PIG

Protein

Aldose 1-epimerase

Gene

GALM

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose By similarity.By similarity

    Catalytic activityi

    Alpha-D-glucose = beta-D-glucose.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei176 – 1761Proton donorPROSITE-ProRule annotation
    Binding sitei243 – 2431SubstrateBy similarity
    Active sitei307 – 3071Proton acceptorBy similarity

    GO - Molecular functioni

    1. aldose 1-epimerase activity Source: UniProtKB-EC
    2. carbohydrate binding Source: InterPro

    GO - Biological processi

    1. hexose metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00242.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldose 1-epimerase (EC:5.1.3.3)
    Alternative name(s):
    Galactose mutarotase
    Gene namesi
    Name:GALM
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 3

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 342341Aldose 1-epimerasePRO_0000197435Add
    BLAST

    Proteomic databases

    PaxDbiQ9GKX6.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000009052.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GKX6.
    SMRiQ9GKX6. Positions 1-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni81 – 822Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the aldose epimerase family.Curated

    Phylogenomic databases

    eggNOGiCOG2017.
    GeneTreeiENSGT00510000047589.
    HOGENOMiHOG000072798.
    HOVERGENiHBG051697.
    KOiK01785.
    OMAiMEVHTTQ.
    OrthoDBiEOG7V7666.
    TreeFamiTF324207.

    Family and domain databases

    Gene3Di2.70.98.10. 1 hit.
    InterProiIPR018052. Ald1_epimerase_CS.
    IPR015443. Aldose_1-epimerase.
    IPR008183. Aldose_1/G6P_1-epimerase.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    [Graphical view]
    PfamiPF01263. Aldose_epim. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005096. GALM. 1 hit.
    SUPFAMiSSF74650. SSF74650. 1 hit.
    PROSITEiPS00545. ALDOSE_1_EPIMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9GKX6-1 [UniParc]FASTAAdd to Basket

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    MVSVTRSVFG DLPSGAGTVE KFQLQSDQLR VDIISWGCTI TALEVKDRQG    50
    RASDVVLGFA ELKEYLQKHP YFGAVVGRVA NRIAKGTFTL DGKEYKLAIN 100
    NGPNSLHGGV RGFDKVLWTP RVLSNGIEFS RVSPDGEEGY PGELKVWVTY 150
    TLDGGELVVN YRAQASQTTP VNLTNHSYFN LAGQGSPNIY DHEVTIEADA 200
    FLPVDETLIP TGEIAPVQGT AFDLRKPVEL GKHLQEFHIN GFDHNFCLKR 250
    SKEKQFCARV HHAGSGRVLE VYTTQPGIQF YTGNFLDGTL KGKTGAVYPK 300
    HSGFCLETQN WPNAVNQPHF PPVLLKPGEE YNHTTWFVFS VA 342
    Length:342
    Mass (Da):37,816
    Last modified:March 1, 2001 - v1
    Checksum:iC824C57AC488E3D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB044390 mRNA. Translation: BAB18973.1.
    RefSeqiNP_999571.1. NM_214406.1.
    UniGeneiSsc.82583.
    Ssc.9245.

    Genome annotation databases

    EnsembliENSSSCT00000009288; ENSSSCP00000009052; ENSSSCG00000008486.
    GeneIDi399536.
    KEGGissc:399536.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB044390 mRNA. Translation: BAB18973.1 .
    RefSeqi NP_999571.1. NM_214406.1.
    UniGenei Ssc.82583.
    Ssc.9245.

    3D structure databases

    ProteinModelPortali Q9GKX6.
    SMRi Q9GKX6. Positions 1-342.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000009052.

    Proteomic databases

    PaxDbi Q9GKX6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000009288 ; ENSSSCP00000009052 ; ENSSSCG00000008486 .
    GeneIDi 399536.
    KEGGi ssc:399536.

    Organism-specific databases

    CTDi 130589.

    Phylogenomic databases

    eggNOGi COG2017.
    GeneTreei ENSGT00510000047589.
    HOGENOMi HOG000072798.
    HOVERGENi HBG051697.
    KOi K01785.
    OMAi MEVHTTQ.
    OrthoDBi EOG7V7666.
    TreeFami TF324207.

    Enzyme and pathway databases

    UniPathwayi UPA00242 .

    Family and domain databases

    Gene3Di 2.70.98.10. 1 hit.
    InterProi IPR018052. Ald1_epimerase_CS.
    IPR015443. Aldose_1-epimerase.
    IPR008183. Aldose_1/G6P_1-epimerase.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    [Graphical view ]
    Pfami PF01263. Aldose_epim. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005096. GALM. 1 hit.
    SUPFAMi SSF74650. SSF74650. 1 hit.
    PROSITEi PS00545. ALDOSE_1_EPIMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of an aldose 1-epimerase (mutarotase) cDNA from hog kidney and its overexpression in Escherichia coli and some properties of recombinant enzyme."
      Kitazawa S., Mori H., Kato N., Ono C., Ito H., Kimura A., Matsui H., Chiba S.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiGALM_PIG
    AccessioniPrimary (citable) accession number: Q9GKX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3