Q9GKX6 (GALM_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aldose 1-epimerase
EC=5.1.3.3

Alternative name(s):
Galactose mutarotase

Gene names

Name:

GALM

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose By similarity.
Catalytic activity	Alpha-D-glucose = beta-D-glucose.
Pathway	Carbohydrate metabolism; hexose metabolism.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the aldose epimerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	hexose metabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aldose 1-epimerase activity Inferred from electronic annotation. Source: EC carbohydrate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	Aldose 1-epimerase		PRO_0000197435
Regions
	Region	81 – 82	2	Substrate binding By similarity
Sites
	Active site	176	1	Proton donor By similarity
	Active site	307	1	Proton acceptor By similarity
	Binding site	243	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9GKX6 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: C824C57AC488E3D2	FASTA	342	37,816
	10 20 30 40 50 60 MVSVTRSVFG DLPSGAGTVE KFQLQSDQLR VDIISWGCTI TALEVKDRQG RASDVVLGFA 70 80 90 100 110 120 ELKEYLQKHP YFGAVVGRVA NRIAKGTFTL DGKEYKLAIN NGPNSLHGGV RGFDKVLWTP 130 140 150 160 170 180 RVLSNGIEFS RVSPDGEEGY PGELKVWVTY TLDGGELVVN YRAQASQTTP VNLTNHSYFN 190 200 210 220 230 240 LAGQGSPNIY DHEVTIEADA FLPVDETLIP TGEIAPVQGT AFDLRKPVEL GKHLQEFHIN 250 260 270 280 290 300 GFDHNFCLKR SKEKQFCARV HHAGSGRVLE VYTTQPGIQF YTGNFLDGTL KGKTGAVYPK 310 320 330 340 HSGFCLETQN WPNAVNQPHF PPVLLKPGEE YNHTTWFVFS VA

References

[1]

"Molecular cloning of an aldose 1-epimerase (mutarotase) cDNA from hog kidney and its overexpression in Escherichia coli and some properties of recombinant enzyme." Kitazawa S., Mori H., Kato N., Ono C., Ito H., Kimura A., Matsui H., Chiba S. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB044390 mRNA. Translation: BAB18973.1.
RefSeq	NP_999571.1. NM_214406.1.
UniGene	Ssc.82583. Ssc.9245.
3D structure databases
ProteinModelPortal	Q9GKX6.
SMR	Q9GKX6. Positions 1-342.
ModBase	Search...
Protein-protein interaction databases
STRING	9823.ENSSSCP00000009052.
Proteomic databases
PaxDb	Q9GKX6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSSSCT00000009288; ENSSSCP00000009052; ENSSSCG00000008486.
GeneID	399536.
KEGG	ssc:399536.
Organism-specific databases
CTD	130589.
Phylogenomic databases
eggNOG	COG2017.
GeneTree	ENSGT00510000047589.
HOGENOM	HOG000072798.
HOVERGEN	HBG051697.
KO	K01785.
OMA	NHTTWFK.
OrthoDB	EOG4HHP31.
Enzyme and pathway databases
UniPathway	UPA00242.
Family and domain databases
Gene3D	2.70.98.10. 1 hit.
InterPro	IPR018052. Ald1_epimerase_CS. IPR015443. Aldose_1-epimerase. IPR008183. Aldose_1/G6P_1-epimerase. IPR011013. Gal_mutarotase_SF_dom. IPR014718. Glyco_hydro-type_carb-bd_sub. [Graphical view]
PANTHER	PTHR10091. PTHR10091. 1 hit.
Pfam	PF01263. Aldose_epim. 1 hit. [Graphical view]
PIRSF	PIRSF005096. GALM. 1 hit.
SUPFAM	SSF74650. Gal_mut_like. 1 hit.
PROSITE	PS00545. ALDOSE_1_EPIMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GALM_PIG

Accession

Primary (citable) accession number: Q9GKX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program