Reviewed, UniProtKB/Swiss-Prot Q9GKU6 (FUT6_PONPY)

Names and origin

Protein names

Recommended name:
    Alpha-(1,3)-fucosyltransferase
    EC=2.4.1.65
Alternative name(s):
    Galactoside 3-L-fucosyltransferase
    Fucosyltransferase 6
    Fucosyltransferase VI
      Short name=FucT-VI
      Short name=Fuc-TVI

Gene names

Name:

FUT6

Organism

Pongo pygmaeus (Bornean orangutan)

Taxonomic identifier

9600 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates By similarity.
Catalytic activity	GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. Note: Membrane-bound form in trans cisternae of Golgi By similarity.
Sequence similarities	Belongs to the glycosyltransferase 10 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	protein amino acid glycosylation Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Alpha-(1,3)-fucosyltransferase		PRO_0000221112
Regions
	Topological domain	1 – 14	14	Cytoplasmic Potential
	Transmembrane	15 – 34	20	Signal-anchor for type II membrane protein Potential
	Topological domain	35 – 359	325	Lumenal Potential
Amino acid modifications
	Glycosylation	91	1	N-linked (GlcNAc...) Potential
	Glycosylation	153	1	N-linked (GlcNAc...) Potential
	Glycosylation	184	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9GKU6-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 87598D528A45F86C	FASTA	359	41,848
	10 20 30 40 50 60 MDPLGPAKTQ WSWRCCLTAL LFQLLVAVCF FSYLRVSRDD PTVYPNGSPF PDSTGTPAHS 70 80 90 100 110 120 IPLILLWTWP FNKPIALPRC SEMVPGTADC NITADRKVYP QADAVIVHHR EVMYNPSAQL 130 140 150 160 170 180 PRSPRRQGQR WIWFNLESPS HCWHLKAMDG YFNLTMSYRS DSDIFTPYGW LEPWSGQPAH 190 200 210 220 230 240 PPLNLSAKTE LVAWAVSNWR PNSARVRYYQ SLQAHLKVDV YGRSHKPLPQ GTMMETLSRY 250 260 270 280 290 300 KFYLAFENSV HPDYITEKLW RNALEAWAVP VVLGPSRSNY ERFLPPDAFI HVDDFQSPKD 310 320 330 340 350 LAQYLQELDK DHARYLSYFR WRETLQPRSC SWALDFCKAC WKLQEESRYQ TRSIAAWFT

References

[1]

"Contrasting patterns of polymorphisms at the ABO-secretor gene (FUT2) and plasma alpha(1,3)fucosyltransferase gene (FUT6) in human populations." Koda Y., Tachida H., Pang H., Liu Y., Soejima M., Ghaderi A.A., Takenaka O., Kimura H. Genetics 158:747-756(2001) [PubMed: 11404338] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB051859 Genomic DNA. Translation: BAB18672.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT10. Glycosyltransferase Family 10.
Genome annotation databases
Ensembl	ENSPPYT00000010998; ENSPPYP00000010583; ENSPPYG00000009437; Pongo pygmaeus. [Genome view]
Phylogenomic databases
HOVERGEN	Q9GKU6.
InParanoid	Q9GKU6.
Enzyme and pathway databases
BRENDA	2.4.1.65. 269192.
Family and domain databases
InterPro	IPR001503. Glyco_trans_10. [Graphical view]
PANTHER	PTHR11929. Glyco_trans_10. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FUT6_PONPY

Accession

Primary (citable) accession number: Q9GKU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	March 1, 2001
Last modified:	February 9, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)