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Reviewed, UniProtKB/Swiss-Prot Q9GKU5 (HDA11_MACFA)

Last modified September 22, 2009. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Histone deacetylase 11
      Short name=HD11
    EC=3.5.1.98
Gene names
Name: HDAC11
ORF Names: QccE-18183
OrganismMacaca fascicularis (Crab eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subunit structure

Interacts with HDAC6 By similarity.

Subcellular location

Nucleus By similarity.

Miscellaneous

Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor By similarity.

Sequence similarities

Belongs to the histone deacetylase family.

Sequence caution

The sequence BAB18987.1 differs from that shown. Reason: Frameshift at position 1.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Molecular functionChromatin regulator
Hydrolase
Repressor
Gene Ontology (GO)
   Biological processchromatin modification

Traceable author statement. Source: UniProtKB

regulation of transcription

Inferred from electronic annotation. Source: UniProtKB-KW

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Traceable author statement. Source: UniProtKB

histone deacetylase complex

Traceable author statement. Source: UniProtKB

   Molecular functionhistone deacetylase activity

Traceable author statement. Source: UniProtKB

transcription factor binding

Traceable author statement. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347Histone deacetylase 11
PRO_0000114716

Regions

Region14 – 318305Histone deacetylase

Sites

Active site1431 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9GKU5-1 [UniParc].

Last modified December 6, 2002. Version 2.
Checksum: 4C3DADC2D8770B0D

FASTA34739,179
        10         20         30         40         50         60 
MLHTTQLYQH VPETRWPIVY SPRYNITFMG LEKLHPFDAG KWGKVINFLK EEKLLSDSML 

        70         80         90        100        110        120 
VEAREASEED LLVVHTRRYL NELKWSFAVA TITEIPPVIF LPNFLVQRKV LRPLRTQTGG 

       130        140        150        160        170        180 
TIMAGKLAVE RGWAINVGGG FHHCSSDRGG GFCAYADITL AIKFLFERVE GISRATIIDL 

       190        200        210        220        230        240 
DAHQGNGHER DFMDDKRVYI MDVYNRHIYP GDRFAKQAIR RKVELEWGTE DDEYLDKVER 

       250        260        270        280        290        300 
NIEKSLQEHL PDVVVYNAGT DILEGDRLGG LSISPAGIVK RDELVFRMVR GRHVPILMVT 

       310        320        330        340 
SGGYQKRTAR IIADSILNLF GLGLIGPESP SISAQNSDTP LLPPAVP 

« Hide

References

[1]"Isolation of full-length cDNA clones from macaque brain cDNA libraries."
Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

AB052134 mRNA. Translation: BAB18987.1. Frameshift.

3D structure databases

ModBaseSearch...

Phylogenomic databases

HOVERGENQ9GKU5.

Family and domain databases

InterProIPR000286. His_deacetylse.
[Graphical view]
Gene3DG3DSA:3.40.800.20. His_deacetylse. 1 hit.
PANTHERPTHR10625. His_deacetylse. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSPR01270. HDASUPER.
ProtoNetSearch...

Entry information

Entry nameHDA11_MACFA
AccessionPrimary (citable) accession number: Q9GKU5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 6, 2002
Last modified: September 22, 2009
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents