Reviewed, UniProtKB/Swiss-Prot Q9GKU5 (HDA11_MACFA)

Names and origin

Protein names

Recommended name:
    Histone deacetylase 11
      Short name=HD11
    EC=3.5.1.98

Gene names

Name:	HDAC11
ORF Names:	QccE-18183

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.
Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Subunit structure	Interacts with HDAC6 By similarity.
Subcellular location	Nucleus By similarity.
Miscellaneous	Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor By similarity.
Sequence similarities	Belongs to the histone deacetylase family.
Sequence caution	The sequence BAB18987.1 differs from that shown. Reason: Frameshift at position 1.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Chromatin regulator Hydrolase Repressor
Gene Ontology (GO)
Biological process	chromatin modification Traceable author statement. Source: UniProtKB regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Traceable author statement. Source: UniProtKB histone deacetylase complex Traceable author statement. Source: UniProtKB
Molecular function	histone deacetylase activity Traceable author statement. Source: UniProtKB transcription factor binding Traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	Histone deacetylase 11		PRO_0000114716
Regions
	Region	14 – 318	305	Histone deacetylase
Sites
	Active site	143	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9GKU5-1 [UniParc]. Last modified December 6, 2002. Version 2. Checksum: 4C3DADC2D8770B0D	FASTA	347	39,179
	10 20 30 40 50 60 MLHTTQLYQH VPETRWPIVY SPRYNITFMG LEKLHPFDAG KWGKVINFLK EEKLLSDSML 70 80 90 100 110 120 VEAREASEED LLVVHTRRYL NELKWSFAVA TITEIPPVIF LPNFLVQRKV LRPLRTQTGG 130 140 150 160 170 180 TIMAGKLAVE RGWAINVGGG FHHCSSDRGG GFCAYADITL AIKFLFERVE GISRATIIDL 190 200 210 220 230 240 DAHQGNGHER DFMDDKRVYI MDVYNRHIYP GDRFAKQAIR RKVELEWGTE DDEYLDKVER 250 260 270 280 290 300 NIEKSLQEHL PDVVVYNAGT DILEGDRLGG LSISPAGIVK RDELVFRMVR GRHVPILMVT 310 320 330 340 SGGYQKRTAR IIADSILNLF GLGLIGPESP SISAQNSDTP LLPPAVP

References

[1]

"Isolation of full-length cDNA clones from macaque brain cDNA libraries." Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB052134 mRNA. Translation: BAB18987.1. Frameshift.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q9GKU5.
Family and domain databases
InterPro	IPR000286. His_deacetylse. [Graphical view]
Gene3D	G3DSA:3.40.800.20. His_deacetylse. 1 hit.
PANTHER	PTHR10625. His_deacetylse. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PRINTS	PR01270. HDASUPER.
ProtoNet	Search...

Entry information

Entry name

HDA11_MACFA

Accession

Primary (citable) accession number: Q9GKU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2002
Last sequence update:	December 6, 2002
Last modified:	September 22, 2009
This is version 44 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)