Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9GKU5

- HDA11_MACFA

UniProt

Q9GKU5 - HDA11_MACFA

Protein

Histone deacetylase 11

Gene

HDAC11

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (06 Dec 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei143 – 1431By similarity

    GO - Molecular functioni

    1. histone deacetylase activity Source: UniProtKB
    2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
    6. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. chromatin modification Source: UniProtKB
    2. histone deacetylation Source: GOC
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase 11 (EC:3.5.1.98)
    Short name:
    HD11
    Gene namesi
    Name:HDAC11
    ORF Names:QccE-18183
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. histone deacetylase complex Source: UniProtKB
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347Histone deacetylase 11PRO_0000114716Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with HDAC6.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GKU5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni14 – 318305Histone deacetylaseAdd
    BLAST

    Sequence similaritiesi

    Belongs to the histone deacetylase family.Curated

    Phylogenomic databases

    HOVERGENiHBG051893.
    KOiK11418.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PRINTSiPR01270. HDASUPER.

    Sequencei

    Sequence statusi: Complete.

    Q9GKU5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLHTTQLYQH VPETRWPIVY SPRYNITFMG LEKLHPFDAG KWGKVINFLK    50
    EEKLLSDSML VEAREASEED LLVVHTRRYL NELKWSFAVA TITEIPPVIF 100
    LPNFLVQRKV LRPLRTQTGG TIMAGKLAVE RGWAINVGGG FHHCSSDRGG 150
    GFCAYADITL AIKFLFERVE GISRATIIDL DAHQGNGHER DFMDDKRVYI 200
    MDVYNRHIYP GDRFAKQAIR RKVELEWGTE DDEYLDKVER NIEKSLQEHL 250
    PDVVVYNAGT DILEGDRLGG LSISPAGIVK RDELVFRMVR GRHVPILMVT 300
    SGGYQKRTAR IIADSILNLF GLGLIGPESP SISAQNSDTP LLPPAVP 347
    Length:347
    Mass (Da):39,179
    Last modified:December 6, 2002 - v2
    Checksum:i4C3DADC2D8770B0D
    GO

    Sequence cautioni

    The sequence BAB18987.1 differs from that shown. Reason: Frameshift at position 1.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB052134 mRNA. Translation: BAB18987.1. Frameshift.
    RefSeqiNP_001270923.1. NM_001283994.1.
    XP_005547935.1. XM_005547878.1.
    UniGeneiMfa.9023.

    Genome annotation databases

    GeneIDi102133368.
    KEGGimcf:102133368.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB052134 mRNA. Translation: BAB18987.1 . Frameshift.
    RefSeqi NP_001270923.1. NM_001283994.1.
    XP_005547935.1. XM_005547878.1.
    UniGenei Mfa.9023.

    3D structure databases

    ProteinModelPortali Q9GKU5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 102133368.
    KEGGi mcf:102133368.

    Organism-specific databases

    CTDi 79885.

    Phylogenomic databases

    HOVERGENi HBG051893.
    KOi K11418.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PRINTSi PR01270. HDASUPER.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of full-length cDNA clones from macaque brain cDNA libraries."
      Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiHDA11_MACFA
    AccessioniPrimary (citable) accession number: Q9GKU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: December 6, 2002
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.By similarity

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3